Effect of epinephrine on the in vitro biosynthesis of fibrinogen.

In an in vitro rat liver slice incubation system, the synthesis of fibrinogen, when measured by immunoprecipitation technique was stimulated in the presence of epinephrine. An increase in poly (A)+ RNA content of the liver slice was also observed after epinephrine treatment. This in vitro experiment demonstrated that epinephrine stimulated de novo synthesis of fibrinogen by acting directly on the liver.