ABSTRACT
Objective To investigate the clinical value of neutrophil-to-lymphocytc ratio(NLR) in identifying blood stream infection caused by different pathogens and for differentiating coagulase negative staphylococcus(CNS)bloodstream infection and contamination.Methods Medical records of 500 patients who underwent blood culture test and routine blood test at the same time were retrospectively analyzed,blood culture negative group 356 patients,blood culture positive group 144 patients,which included Gram-negative group,Gram positive group,fungi group,CNS bloodstream contamination and mingled group.Collected the results and calculated the NLR at the same time.NLR were applied by t test of each group.ROC curve was used to determine the cut off value of NLR.Results ①Mean values of NLR in negative blood culture,blood stream infection group,CNS bloodstream infection and contamination were 6.12,13.15,10.11 and 6.24.NLR had statistical difference between negative blood culture and blood stream infection group,CNS bloodstream infection group and contamination group (P＜0.05).②Mean values of NLR in and fungi group were 15.33,11.63 and 10.58,respectively.NLR had statistical difference between Gram-positive bacteria group and Gram-negative bacteria group (P＜0.05).NLR had no differences among Gram-positive bacteria (15.33) and Gram negative bacteria (11.63) compared with (10.58) fungi respectively (P＞0.05).③The area under the curve of NLR predicting a positive blood culture,distinguishing Gram-positive bacteria and Gram-negative bacteria,differentiating CNS bloodstream infection and contamination were 0.86,0.60 and 0.75,respectively.The optimal cut off values of NLR for predicting a positive blood culture,distinguishing Gram-positive bacteria and Gramnegative bacteria,differentiating CNS bloodstream infection and contamination were 10.45,7.50 and 8.10 respectively.Conclusion NLR is highly effective in distinguishing blood stream infection and differentiating CNS bloodstream infection and contamination.
ABSTRACT
The inflammatory reaction is the seventh major feature of the cancer, especially the neutrophils in the development and prognosis of lung cancer. This paper expounds the typing of neutrophils and their roles in the tumor microenvironment and the mechanism of regulating the growth, metastasis and angiogenesis of lung cancer through secreting various cytokines. The effects of peripheral blood neutrophils, ratio of neutrophil to lymphocyte, and the infiltration of neutrophils into tumors on the prognosis of lung cancer were reviewed. It is suggested that neutrophils may play an important role in the occurrence, development and prognosis of lung cancer, leading to further understanding of the functions of these important immune cells in tumor microenvironment, which may provide new ideas for the studies on treatment and prognosis of lung cancer.
ABSTRACT
Objective To investigate the changes of WBC count and neutrophil ratio (NEU% ) in the patients with bee sting inju‐ry .Methods According to the number of bee sting and different time going to hospital ,the WBC count and NEU% in 315 cases of bee sting injury were analyzed and compared with those in healthy population .Results The changes of WBC count and NEU% had statistically significant difference between the patients with bee sting injury and the healthy people (P< 0 .05) .The changes of WBC count and NEU% had statistically significant difference between the patients with more than 20 bee sting injuries and the pa‐tients with less than 3 bee sting injuries(P<0 .05) .The WBC count had obvious difference between the patients with treatment within 3 h after bee sting and the patients with treatment at other time (P<0 .05) .Conclusion The WBC count and NEU% are obviously increased after bee sting ,which is closely correlated with the bee sting injury number and the time going to hospital .