Analysis on key points of ethics review of horizontal scientific research projects: Based on the ethics review management system of horizontal scientific research projects in a tertiary hospital / 中华医学科研管理杂志

Objective:This paper aims to promote the standardization of ethics review of horizontal scientific research projects and improve the ethics review quality by analyzing the current ethics review practice in a certain tertiary hospital, identifying common problems during the review process, illustrating relevant causes and proposing corresponding solutions.Methods:Through introducing the current situation of ethics review of horizontal scientific research projects in a tertiary level hospital, the differences between the main points of ethics review of horizontal scientific research projects and government-funded scientific research projects were analyzed, so as to sort out the common problems and possible causes in the process of ethics review of horizontal scientific research projects, and then explore the possible corresponding solutions.Results:Based on the characteristics of horizontal research projects, ethics review should focus on their scientific and social values, potential conflicts of interest, protection of subjects′ rights and interests, and whole-process management and quality assurance. At present, there are still many problems, such as a large number of projects, but not many projects with high research value, inadequate project process management, and ineffective implementation of ethics review opinions.Conclusions:The hospital should further improve the management system of horizontal scientific research project approval, bring in more comprehensive review regarding to both scientific and ethics review, engage more experts at the outset of project funding decision-making, set up ethics specialists, strengthen the process management of horizontal scientific research projects, strengthen ethical publicity and education, and improve the ethical awareness of researchers to fully protect the rights and interests of subjects and promote the high-quality development of clinical research.

Discussion on the application value of knowledge graph in scientific research project selection / 中华医学科研管理杂志

Objective:Taking the research field of pulmonary infection as an example, this study analyzed the core author institutions, research hotspots and burst keywords, and explored the application value of scientific knowledge graph in the first step of scientific research management-optimization of scientific research project selection.Methods:" Pulmonary infection" or " pneumonia" were used as key words in CNKI data base from 2014 to 2020, and medical science was selected as the discipline. Cite Space was used to generate the visual graph to analyze publishing institutions, keyword co-occurrence, topic clustering, and timeline burst keywords.Results:13 169 documents were retrieved, and 4 of the top 5 institutions were in Henan Province. In 2020, " Novel Coronavirus" and " Novel Coronavirus pneumonia" were the new hotspot words. " Chronic obstructive pulmonary disease " , " blood gas index" , " inflammatory factor" , and " vitamin A" were the burst keywords in 2018.Conclusions:Scientific knowledge graph is objective, scientific, and efficient in the development of science. It has certain feasibility in the optimization of project selection in scientific research work, and can also be used as a reference basis for experts to evaluate the project reasonability, so as to ensure objectivity and equity. This study also provides reference for scientific research management strategy, reduces research funding costs, and improves the efficiency and capacity of scientific research management.

Practice and exploration of the " point to point" management mode of scientific research project application / 中华医学科研管理杂志

Objective:To establish a supportive and effective management mode of scientific research project application, promote the capacity building of scientific research in the hospital.Methods:Retrospective analysis was conducted on the national and provincial scientific research projects of Xinhua Hospital Affiliated to Shanghai Jiaotong University Medical School from 2010 to 2019, and the practical effect of " point to point" management mode of scientific research project application was evaluated.Results:The funding rate of Xinhua Hospital, especially national scientific research projects and provincial talents projects, was greatly improved by adoption of the multi-dimensional " point to point" management mode of scientific research project application. The number of national scientific research projects increased from 34 (26.02 million) in 2010 to 72 (51.0851 million) in 2019.The number of provincial talents projects increased from 5 (1.05 million) in 2010 to 26 (6.5 million) in 2019.Conclusions:The " point to point" management mode of scientific research project application plays an important role in promoting the overall funding rate. Enhancement of comprehensive capacity of hospital scientific research can be achieved by further improvement of this management mode, early initiation and arrangement of funding application depending on the " close partner" entity, emphasizing scientific research talents cultivation.

Application and practice of risk assessment in clinical research project approval / 中华医学科研管理杂志

Objective:Through the analysis of the risk factors of clinical scientific research project, risk assessment theory was brought in to develop risk assessment procedures, at the same time, to explore possible applications of risk assessment theories and methodologies in clinical scientific research projects, which might empower the research project administration.Methods:Through literature review and the author's scientific research management daily practice, the characteristics of risks involved in clinical scientific research projects were systematically summarized, relevant standards and models were used for reference to develop relevant working procedures, fatherly, methodologies of project risk assessment were discussed.Results:There are risks at different stages of scientific research project that including compliance, safety, research topic selection, research design, executive ability and risk-control. A proposal regarding to the implementation of project risk assessment covers three main steps which including preliminary preparation, implementation of risk assessment (risk identification, risk analysis and risk assessment) and risk-response proposal.Conclusions:The risk assessment of clinical scientific research projects is crucial. It is necessary to promote the development of risk assessment and improve the capacity building by improving awareness, establishing system, clarifying structure and improving technology.

Analysis of the status quo and the countermeasures after the implementation of the horizontal scientific research project management policy in a tertiary hospital / 中华医学科研管理杂志

Objective:This article aims to sort out the current situation and problems of horizontal scientific research projects in a tertiary hospital, so as to improve the management of horizontal scientific research projects, and to mobilize the enthusiasm of researchers to undertake horizontal scientific research projects, and give full play to their characteristics of interdisciplinary integration, transfer and transformation of scientific and technological achievements.Methods:A total number of 129 horizontal projects undertaken by Beijing Obstetrics and Gynecology Hospital, Capital Medical University from 2010 to 2019 were reviewed.The comparison of management policies and risk prevention of horizontal scientific research projects before and after 2017 was also analyzed.The existing problems were analyzed and relevant management suggestions were put forward.Results:From 2017 to 2019 the hospital undertook 18.7 horizontal research projects per year, which was 1.8 times of that 2010 to 2016.The hospital strengthened the cooperation with foundations, companies and foreign countries, carried out substantive scientific research, standardized the budget, leased or borrowed equipment, and built the joint laboratories by medical research and enterprise, and carried out risk prevention in human genetic resources and biological security.At present, there are still some problems, such as the lack of relevant policy basis for management, the management of project approval and conclusion is not in place, the conversion rate of achievements is low, and the horizontal scientific research projects of platform construction are need to be constructed.Conclusions:Our hospital will improve the relevant system of horizontal scientific research projects management, incorporate the horizontal scientific research projects into the position title evaluation, performance evaluation and reward, build various platforms through multiple channels, promote the interdisciplinary integration, and give full play to the characteristics of horizontal scientific research projects in promoting the transfer and transformation of scientific and technological achievements, so as to promote the discipline construction and scientific and technological innovation of the hospital, and accelerate the transformation of the hospital into innovative and research-oriented hospital.

Analysis of projects without nanotechnology funded by National Natural Science Foundation of China in the field of pharmaceutics from 2001 to 2020 / 药学学报

Nanotechnology has been widely used in the field of pharmaceutics. In recent years, research projects related to nanotechnology account for a high proportion (nearly 90%) in the application and funded projects of pharmaceutics (application code is H3408) of National Natural Science Foundation of China (NSFC). In addition, there are many other research directions in the field of pharmaceutics. This paper makes statistics and analysis on the research projects of pharmaceutics without nanotechnology funded by NSFC from 2001 to 2020, so as to provide reference for the pharmaceutical researchers to reasonably choose research direction.

Exploration and practice on risk management of scientific research project in hospital / 中华医学科研管理杂志

Objective:By sorting out the occurrence of the risk outcomes of scientific research project in the hospital, conducting root-cause analysis, the risk management theory, process and methodologies are introduced into the management system of hospital scientific research projects to reduce the occurrence of risk outcome of scientific research projects.Methods:Through literature review and the reflection of daily scientific research management practice, the risk characteristics of clinical scientific research projects were systematically summarized, comparative analysis were conducted to explore the effectiveness before and after the introduction of risk management, and the practical experiences of scientific research project risk management were summarized.Results:There are mainly six types of internal and external risks in hospital scientific research projects, which lead to project termination, project modifications, project delays, assessment index adjustments, budget adjustments and other risk issues. By establishing scientific research project risk management environment, standardizing risk management procedures, as well as establishing risk-monitoring and early warning information system, the introduction of risk management system enables more effective control of scientific research project risks in hospitals.Conclusions:The application of risk management in the management of scientific research projects in hospitals has showed positive impact. The risk management of scientific research projects in hospitals has certain practical value and feasibility. The exploration of risk management theories and methods should be continued to promote the high-quality development of hospital scientific research project management.

The analysis of unconventional research projects and common problems in the in vitro consistency evaluation of oral solid generic drugs / 药学学报

Based on the "requirements on the submitted documents for consistency evaluation of generic oral solid dosage forms of chemical drugs" and relevant guidance, this article summarized and formulated the decision tree of in vitro consistency evaluation of oral solid generic drugs, discussed the differences and common problems of in vitro evaluation research projects under different conditions, selective analyzed the technical requirements and concern problems of unconventional research projects, and proposed corresponding recommendations for concern problems, in order to provide more references for the follow-up study on consistency evaluation of oral solid generic drugs.

Caracterización de los trabajos de terminación de la especialidad en Medicina General Integral / Characterization of Completion Works of the Family Medicine Specialty

Introducción: Las investigaciones en la especialidad Medicina General Integral son actividades científicas realizadas en el campo de la salud pública que pretenden ofrecer estudio y solución a problemas dentro del proceso salud-enfermedad en individuos, familias y comunidades. Objetivo: Caracterizar los trabajos de terminación de la especialidad en Medicina General Integral, garantizando con ello el conocimiento de sus principales características para alcanzar un mayor perfeccionamiento de los mismos. Métodos: Se realizó una investigación pedagógica rectorada por el método materialista-dialéctico en el Policlínico Universitario Pedro Borrás Astorga de la ciudad Pinar del Río, durante el curso lectivo 2017-2018. Conclusiones: Se caracterizaron los trabajos de terminación de la especialidad en Medicina General Integral pertenecientes al Policlínico Universitario Pedro Borrás Astorga, en ellos se identificaron dificultades, necesidades e informaciones destacadas(AU)

Introduction: Research in the family medicine specialty is the group of scientific activities carried out in the field of public health that aim to offer study and solution to problems within the health-disease process in individuals, families and communities. Objective: To characterize the completion works of the Family Medicine specialty, thereby guaranteeing the knowledge of its main characteristics in order to improve them in the future. Methods: A pedagogical research led by the materialist-dialectical method was carried out at Pedro Borrás Astorga University Polyclinic of Pinar del Río City, during the 2017-2018 school year. Conclusions: The completion works of the Family Medicine specialty at Pedro Borrás Astorga University Polyclinic were characterized, which allowed identifying difficulties, needs and outstanding information(AU)

Aproximación al Análisis de Dominio (AD) desde la investigación en Bibliotecología y Ciencia de la Información / Approach to Domain-analysis from Library and Information Science research

RESUMEN Este artículo tiene como objetivo presentar un marco teórico que emergió en las últimas décadas en el ámbito de la Ciencia de la Información: el paradigma de Análisis de Dominio (AD), también denominada Teórica Analítica de Dominio, que constituye uno de los sustentos epistémicos adoptados para el desarrollo de un proyecto de investigación realizado en el Departamento de Bibliotecología de la Universidad Nacional de Misiones. Empleando como metodología la revisión teórica, se abordarán los fundamentos que originaron dicha propuesta, así como los antecedentes latentes y emergentes en indagaciones y trabajos previos a la formulación de su principal exponente, Birger Hjørland. Además, se analizará el alcance semántico de la expresión, las posibilidades teóricas que el análisis de dominio posee para el desarrollo y el afianzamiento de la investigación bibliotecológica, así como las aproximaciones metodológicas e implicaciones prácticas que su creador enuncia. Se concluye que el análisis de dominio permite reconocer los conceptos relevantes de un dominio dentro de la Ciencia de la Información, sus relaciones jerárquicas y vinculaciones semánticas con otros campos, al tiempo que permite el desarrollo de nuevas líneas investigativas y profundizar diversos aspectos teóricos de la Bibliotecología y la Ciencia de la Información.

ABSTRACT This article aims to present a theoretical framework that emerged in the last decades on the Information Science sphere: Domain-analysis --also referred as Domain-analytic theory--, which comprises one of the epistemic basis implemented as part of the development of a research project conceived on the Department of Library Science of the Universidad Nacional de Misiones. Using theoretical review as methodology, the foundations that originated the proposal will be addressed, as well as the latent and emerging antecedents in inquiries and work prior to the formulation of its main exponent, Birger Hjørland. On the other hand, the semantic scope of the expression will be analyzed, in addition to the theoretical possibilities that Domain-analysis has towards the expansion and strengthening of metatheory in library science research, as well as the methodological approaches and practical matters, both issues described by its creator. It is concluded that Domain-analysis allows recognizing relevant concepts of a domain within Information Science, its hierarchical relationships and semantic links with other fields, while allowing the development of new research lines and deepen various theoretical aspects of Library and Information Science.

Analysis and evaluation of peer review results of a fund's three year research project / 中华医学科研管理杂志

Objective Based on the three years' peer review data of a project fund,the results of fund peer review were analyzed and evaluated,to provide references for further improvement of the peer review and management.Methods Based on the fund's peer review results of 2145 projects in three years,descriptive statistics,single-item identification index were adopted,as well as RJ normality test,t-test and other statistical methods,to analyze and assess the overall data of fund,project categories,individual scores,etc.Results The score distribution of the three year peer review project of the fund is almost normal distribution,and the overall consistency of peer review shows a better trend.The analysis shows that the peer review experts of the fund have better consistency in terms of project innovation,rationality and characteristics.While there were differences in the peer review of applicability.Conclusions The three year peer review data of the fund show that three years' evaluation results are reliable,reasonable,and the quality of evaluation is good,showing a better development trend in both project quality and expert consistency.

Practice of undergraduate students' comprehensive ability training based on scientific research projects / 中华医学教育探索杂志

To explore new forms of undergraduate comprehensive ability training and provide objective basis for it through application of the theoretical research on scientific research project teaching into the undergraduate teaching practice. In the light of the existing theoretical research, a detailed process design was made and carried out in a teaching cycle. The SWOT analysis was done through the questionnaire. The results showed the self-discipline of the project students improved significantly. Compared with other students, the information resources utilization rate of the project students increased 45.6 percentage points , comprehensive quality evaluation of them were 26 percentage points higher. The project completion degree was 87.3％, and one provincial innovation and entrepreneurship project and two school innovation and entrepreneurship projects were approved. The teaching form based on scientific research project has obvious effect in improving the comprehensive ability of undergraduates . Although facing many threats and shortcomings , the new teaching form has strong adaptability and feasibility.

Directive function of intracavitary electrocardiogram bimodal P-wave in the position of PICC tip / 中国实用护理杂志

Objective To determine the accuracy of intracavitary electrocardiogram bimodal P-wave and characteristic P-wave in the position of PICC tip. Methods In the process of ECG guided catheterization, the morphological changes of P-wave in the intracavitary electrocardiogram were observed, and the bimodal P-wave and characteristic P-wave were recorded. The corresponding catheter length of the bimodal P-wave and characteristic P-wave were recorded. CT three-dimensional reconstruction was performed on 416 patients who underwent CT examination before and after catheterization. The distance between carina of trachea to superior vena cava and the right atrium junction was measured as best position of PICC and the standard distance. After catheterization, the distance from the tip of catheter to the corresponding catheter length of the bimodal P-wave and characteristic P-wave was measured as actual distance, and compared with the standard distance. Results In 416 cases, 168 patients (40.38％) were bimodal P-wave, and the accurate rate of bimodal P-wave was 86.31％(145/416), and the accurate rate of the characteristic P-wave was 13.69％(23/416). The standard distance was (41.96 ± 9.16) mm, the actual distance of corresponding characteristic P-wave was (48.00±15.18) mm and bimodal P-wave was (45.10± 11.16) mm. The distance of bimodal P-wave to control was (1.31±0.33) mm and characteristic P-wave was (6.00 ± 2.88) mm, which was significant statistical difference (t =5.197, P < 0.05), and the standard deviation of the distance of bimodal P-wave to control was smaller (0.33 < 2.88). Conclusions The intracavitary electrocardiogram bimodal P-wave is more accurate than characteristic P-wave in the position of PICC tip and it supplements and improves thePICC's tip position.

El problema científico en artículos de resultado de investigación original publicados en revistas biomédicas cubanas / The scientific problem in original articles published in Cuban biomedical journals

Introducción: La formulación del problema científico en un artículo de investigación es un elemento fundamental para su comprensión y reproducibilidad. No definirlo o formularlo de manera incorrecta conduciría inevitablemente a un documento difícil de entender y de replicar. Objetivo: Identificar las líneas de investigación más comunes en revistas biomédicas cubanas indizadas en SciELO, la frecuencia de artículos de investigación con problema científico correctamente definido y los errores más comunes en su formulación. Material y métodos: Se realizó un estudio descriptivo en artículos de investigación publicados en el año 2016 en 32 revistas biomédicas cubanas indizadas en SciELO. A partir de 5 836 palabras clave se obtuvieron las líneas de investigación más frecuentes. Mediante una muestra aleatoria de 50 artículos, se estimó el porcentaje de publicaciones con problema científico correctamente definido. Se calcularon los porcentajes de errores según el tipo en cada artículo. Resultados: Las líneas de investigación más frecuentemente asociadas a las palabras clave fueron educación médica, factores de riesgo y atención secundaria de salud. Solo el 36 por ciento de los trabajos formularon correctamente el problema científico. Ningún artículo realizó una valoración crítica de este y el 58 por ciento incluyó métodos para abordarlo. Conclusiones: Las líneas de investigación identificadas en los artículos estudiados pueden ser de poco interés para la investigación biomédica. Los artículos de investigación con problemas científicos no definidos o formulados de forma incorrecta incrementan las dificultades para el análisis, la discusión y la crítica de los resultados científicos. Los errores más comunes en la formulación del problema científico sugieren que la motivación principal podría no ser la divulgación de un resultado científico, sino la publicación en sí misma(AU)

Introduction: The formulation of the scientific problem in a research article is a key element for its understanding and reproducibility. If it is not defined or if it is incorrectly formulated, it would inevitably lead to the creation of a document which would be very difficult to understand and replicate. Objective: To identify the most common lines of research in Cuban biomedical journals indexed in SciELO, the frequency of research articles with a correctly defined scientific problem, and the most common errors in its formulation. Material and Methods: A descriptive study was carried out in research articles that were published in 2016 in 32 Cuban biomedical journals indexed in SciELO. The most frequent lines of research were obtained from 5 836 keywords. The percentage of publication with a correctly defined scientific problem was estimated by a random selection of a sample of 50 articles, and the percentage of publications with a correctly defined scientific problem was also calculated. Percentages of errors according to type were measured in each article. Results: The most frequent lines of research associated with keywords were: medical education, risk factors, and secondary health care. Only 36 percent of the works formulated the scientific problem correctly. No article made a critical assessment of it, and the 58 percent included methods to address it. Conclusions: The lines of research identified in the articles under study may appear to be of minor interest for biomedical research. The research articles with not defined or incorrectly formulated scientific problems increase the difficulties for their analysis, discussion, and review of scientific results. The most common errors in the formulation of the scientific problem suggest that the main motivation could not be the dissemination of a scientific result, but the publication itself(AU)

Investigation and analysis on the NSFC application capacity and existing problems of a tertiary general hospital in Beijing / 中华医学科研管理杂志

Objective To achieve the hospital's scientific research objectives during the 13th five-year plan period,we designed to know about the potential NSFC application capacity and existed problems in our hospital.Methods Using "Questionnaire Star" network investigation platform to design questionnaire and conduct data analysis.Results Respondents are divided into two groups,one was who intend to apply in next three years while the other would not.it is found that there are obvious differences between the publication of SCI,as well as the previous research project application and conducting experiences.Conclusions In order to improve the rate of NSFC application,the hospital scientific management workers can consider doing the following:Improve the number of SCI papers published from the perspective of helping to encourage and forcing pressure.Strive for financial support from all parties and build a central experimental platform to create conditions for basic experiments for clinical medical workers.Regular and in time training for NSFC application.Some pressure when necessary to promote the extension of low-level study.Pay more attention to the incentives of research performance at the department level.

Problems and suggestions about traditional chinese medicine hospital scientific research management under the new situation / 中华医学科研管理杂志

Objective To explore the problems in traditional Chinese medicine (TCM) scientific research project management and provide possible countermeasures.Methods Through cluster sampling,all the scientific research administrators and staff in a hospital were selected.A questionnaire about TCM hospital scientific research management was designed and used in our study.Results The majority of participants were basically satisfied with current scientific research management in TCM.Problems were analyzed including complex project application,singular evaluating standard,inflexible fund management,and backward professional concept.Conclusions The management of scientific research projects in TCM should combine professional characteristics,innovatively and comprehensively improve management concept,system,team and method.

Research on project evaluation of scientific research projects based on "double-blind, random, centralized, grouping, independent evaluation system" / 中华医学科研管理杂志

Objective The evaluation management of scientific research projects is the core work content of scientific research management institutions at all levels.The primary causes of bias in project evaluation are the acquaintance social network relationship and the unit-based unitism,especially in the case of small academic circles.The purpose of this essay is to study how to circumvent this problem,to select projects objectively and fairly,and to benefit the evaluation and management of scientific research projects at all levels.Methods Including information construction,expert database construction,expert rotation system,expert avoidance system,supervision and examination system,peer-expert review and strengthen the expert project evaluation.For the first time,we proposed a double-blind,random,centralized,and group-based independent evaluation system.Results This method has a positiveeffect on view.Conclusions In the case where the relative or absolute numberof experts in a single field is small,implementing a series of normative systems and measures through organizational management can avoid interference factors that affect the project evaluation effectively and achieve more scientific and fair results.

Management on the clinical research projects supported by Beijing Municipal Science & Technology Commission / 中华医学科研管理杂志

Objective To analyze the standardization and management experience of the clinical research projects,which were supported by Beijing Municipal Science & Technology Commission.Methods Based on recent data of clinical research projects in one hospital,orientation and management experience of the projects were analyzed.Moreover,shortcomings and possible countermeasures about this issue were explored.Results Since 2010,the bid-winning rate of this kind of projects has been basically stable,but the age structure has tended to be younger,which may be benefited from the hospital scientific research culture and advantage training strategy for youth talents.Scientific research management department also took an important role in this improvement,but did have some problems in real practice.Conclusions We hope to share the management experience of clinical research projects in the hospital,which may improve the management process and serve the researchers better.

Compared approved/unapproved projects on medical research management / 中华医学科研管理杂志

Objective To perform classification analysis of project applications,analyze the difference(s) between the approved projects and disapproved projects,identifying possible experiences and lessons to improve the project application management,as well as the guidance of applicants.Methods Based on the assessment scoring system built on informative platform,we collected the project application information including scores of both initial and re-review during the year 2013 and 2014.According to the assessment procedures and final decisions,all projects involved were categorized into three groups:granted project,project failed during the re-review process,and project failed in the initial review.Statistical analysis was performed on the ratings and detailed scoring of all these projects.Results Pair wise comparisons showed that granted projects were superior to other disapproved projects (P ＜ 0.05),in terms of declaration evidence,context and design of projects.Conclusions The current application and granting procedures works well for identifying high quality applications.Projects granted have their advantages satisfying the key indicators highlighted during the review process.With the help of informative platform,it's possible to achieve further detailed quantified analysis for scientific project applications,in which way,it renders the improvement of evaluation efficiency,equality and the guidance of the applicants.

Retrospective sampling survey to the implementation situation of research projects in one large general hospital from Shanghai area / 中华医学科研管理杂志

Objective To investigate the implementation situation of scientific research projects in large general hospital,analyze the quantitative evaluation parameters to explore the improvement measures.Methods Sampling survey of all levels of research projects from one general hospital in Shanghai.Based on parameter index quantization,the progress of projects in different levels was com pared and analyzed.Results The progress index and achievement index are reliable quantitative indexes,and there is a linear correlation between these two indexes.Based on progress index,forecast for SCI publication of project can be carried out.There was no significant difference in the progress situa tion of all levels of projects.Higher level of project showed better SCI publication.Conclusions For the process management of scientific research projects at different levels,the quantitative indexes can be used to facilitate the early warning and supervision.Classified assessment should be implied to SCI publication for research projects at different levels.