Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus / 中国当代儿科杂志

OBJECTIVES@#To study the effect of gap junction blockers, quinine (QUIN) and carbenoxolone (CBX), on hippocampal ripple energy expression in rats with status epilepticus (SE).@*METHODS@#A total of 24 rats were randomly divided into four groups: model, QUIN, valproic acid (VPA), and CBX (@*RESULTS@#Ripple expression was observed in the hippocampal CA1, CA3, and dentate gyrus regions of normal rats. After 10 minutes of PILO injection, all groups had a gradual increase in mean ripple energy expression compared with 1 day before modeling, with the highest expression level before chloral hydrate injection in the model, VPA and CBX groups (@*CONCLUSIONS@#The change in ripple energy can be used as a quantitative indicator for early warning of seizures, while it cannot predict seizures in the interictal period. Gap junction blockers can reduce ripple energy during seizures.

Ripple effect, driving branch, and economic development: case of the agro-food industry in Côte d'Ivoire / Avaliação da eficácia dos efeitos puxadores da indústria agro-alimentar (IAA) na economia da Costa do Marfim

ABSTRACT: In Côte d'Ivoire, agricultural development has been made possible by the Government strategy to support it through an industrialization-based policy. However, the agricultural sector is still facing many difficulties, despite significant investment efforts undertaken to turn the country into a significant agricultural and agro-food industry (AFI) products exporter on the international market. This study evaluated the effectiveness of the driving role of AFI branches in the Ivorian economy. We used Leontief's model, coupled with Diamond's model and Rasmussen's indices, to assess the ripple effects, and identify the driving branch in the Ivorian economy. Data used are derived from the Input-Output Table (IOT) of the 2018 National Accounts produced by the Government and aggregated into 21 branches or subsectors. Our study showed that there is no outstanding driving branch in the economy. However, some branches are close to compliance with driving branch status. For a driving sector to emerge, the Government should invest in priority order in the following branches: Grain Processing and Starchy Product Manufacturing (GPSPM), Cocoa & Coffee Processing (CCP), Oilseed Industry (OI), Dairy Industry and Fruit & Vegetable Industry (DIFVI), Beverage Industry (BI), Tobacco Industry (TI). And currently, the country's development strategy should be based primarily on these branches, because they are able to improve the effectiveness and efficiency of production system in the Agro-Food Industry (AFI) and, by extension, the economy.

RESUMO: Na Costa do Marfim, o desenvolvimento agrícola tornou-se possível graças à estratégia de apoio do governo através de uma política de industrialização. Contudo, o setor agrícola continua a enfrentar muitas dificuldades, apesar dos grandes esforços de investimento empreendidos para transformar o país num grande exportador de produtos agrícolas e de indústria agro-alimentar (IAA) no mercado internacional. O objetivo do presente estudo é avaliar a eficácia do papel motor dos ramos da Indústria Agro-alimentar (IAA) na economia da Costa do Marfim. Utilizámos o modelo de Leontief, juntamente com o modelo de Diamond e os índices de Rasmussen, para avaliar os efeitos puxadores e identificar o ramo motor da economia marfinense. Os dados utilizados provêm da Tabela Entradas-Saídas (TES) da Contabilidade Nacional de 2018, produzida pelo governo e que foi agregada em 21 ramos ou sub-sectores. Tendo em conta o princípio de identificação do ramo motor, os nossos resultados mostram que não existe verdadeiramente um ramo motor na economia marfinense. Entretanto, alguns ramos estão a aproximar-se desta conformidade de identificação de ramo motor. São, por ordem de conformidade no setor agro-alimentar: Trabalho de Grãos e Fabricação de Produtos à base de Amido (TGFPA); Transformação do Cacau e do Café (TCC); Indústria de Oleaginosas (IO); Indústria de Lacticínios e Indústria de Frutas e Legumes (ILIFL); Indústria de Bebidas (IB); Indústria do Tabaco (IT). Isso significa que, atualmente, a estratégia de desenvolvimento do país deverá apoiar-se, em primeiro lugar, nestes ramos, pois, são eles que podem melhorar a eficácia e a eficiência do sistema de produção da Indústria Agro-alimentar (IAA) e, portanto, a economia da Costa do Marfim.

Effects of the Photovoltaic Distributed Generation on Electricity Distribution System Voltage - Updated Review

ABSTRACT Concerns about the environment and a growing demand for electricity have led to the intensive search for renewable energy sources. Photovoltaic solar energy, in the form of distributed generation, has shown a very high growth rate to an extent that in some regions it will be adopted on a large scale, thus being responsible for the supply of a significant portion of the load of this region. Some factors have favored the adoption of distributed generation: the drop in the price of solar panels and inverters, as well as its easy installation and maintenance. However, the large-scale adoption of solar distributed generation brings new challenges to the power distribution system. Network voltage control is an example. In conventional systems, voltage control is a properly addressed problem, but in networks with the presence of distributed generation, where at certain times of the day reverse energy flows can be observed, more detailed studies on voltage behavior are necessary concerning the power quality. This article makes an analysis of relevant studies on the effects that the insertion of photovoltaic distributed generation can cause in the voltage of the electric power distribution system under the optics of two phenomena: the fluctuation and the voltage ripple.

The psychological mechanism of behavioral intervention and ripple effect in public health / 中华行为医学与脑科学杂志

The development of behavioral medicine is a new and efficient way to improve the level of national health and the behavior intervention is the core content.There are three methods including story-tellingmethod,behavior-image method and patient-centered assessment and counseling for exercise and nutri-tion intervention(PACE)which have been proven to be effective.The psychological theory of homophily,self-regulation and problem solving provide a scientific explanation for the effectiveness of these three kinds of be-havior intervention.Ripple effect amplifies the effect of behavioral intervention and its psychological mecha-nism is self-determinism and self-regulation theory.In the future,the research of behavior intervention and its psychological mechanism needs to make new breakthroughs in aspects of theory,method and technology.

Clinical Utility of Interictal High-Frequency Oscillations Recorded with Subdural Macroelectrodes in Partial Epilepsy

BACKGROUND AND PURPOSE: There is growing interest in high-frequency oscillations (HFO) as electrophysiological biomarkers of the epileptic brain. We evaluated the clinical utility of interictal HFO events, especially their occurrence rates, by comparing the spatial distribution with a clinically determined epileptogenic zone by using subdural macroelectrodes. METHODS: We obtained intracranial electroencephalogram data with a high temporal resolution (2000 Hz sampling rate, 0.05-500 Hz band-pass filter) from seven patients with medically refractory epilepsy. Three epochs of 5-minute, artifact-free data were selected randomly from the interictal period. HFO candidates were first detected by an automated algorithm and subsequently screened to discard false detections. Validated events were further categorized as fast ripple (FR) and ripple (R) according to their spectral profiles. The occurrence rate of HFOs was calculated for each electrode contact. An HFO events distribution map (EDM) was constructed for each patient to allow visualization of the spatial distribution of their HFO events. RESULTS: The subdural macroelectrodes were capable of detecting both R and FR events from the epileptic neocortex. The occurrence rate of HFO events, both FR and R, was significantly higher in the seizure onset zone (SOZ) than in other brain regions. Patient-specific HFO EDMs can facilitate the identification of the location of HFO-generating tissue, and comparison with findings from ictal recordings can provide additional useful information regarding the epileptogenic zone. CONCLUSIONS: The distribution of interictal HFOs was reasonably consistent with the SOZ. The detection of HFO events and construction of spatial distribution maps appears to be useful for the presurgical mapping of the epileptogenic zone.