Vitreoretinal surgery on the fellow eye: A retrospective analysis of 18 years of surgical data from a tertiary center in England

Purpose: To determine the long-term incidence of fellow-eye surgical involvement in patients who have undergone first-eye vitreoretinal (VR) surgery for a variety of indications. This was a single-institution retrospective, consecutive series. Methods: Eighteen years of electronic surgical data were reviewed at our institution. All patients having surgery for the following indications were included: rhegmatogenous retinal detachment (RRD), macular hole (MH), epiretinal membrane (ERM), proliferative diabetic retinopathy (PDR), vitritis, and dropped nucleus. Primary outcome was the cumulative incidence of fellow-eye surgery at 10 years by Kaplan朚eier analysis. Results: Total follow-up was 29,629 patient-years. Cumulative incidence (� standard error) of fellow-eye surgery at 10 years was 7.2% � 0.6% for RRD, 9.1% � 1.3% for ERM, 7.5% � 1.8% for MH, 30.6% � 1.9% for PDR, 13.7% � 2.9% for vitritis, and 2.8% � 1.6% for dropped nuclei. The hazard for second-eye surgery was greatest in the early postoperative period after first-eye surgery for all indications. For RRD, the hazard was 2.7% � 0.3% at year 1, 1.1% � 0.2% at year 2, and 0.5% � 0.2% at year 5. Risk factors for fellow-eye involvement for RRD were younger age (P < 0.001) and male gender (P < 0.01). Conclusion: We report the long-term risk of fellow-eye involvement in various VR pathologies, which is important in counseling patients regarding their risks as well as planning service provision.

Inflammatory cytokines research progress on the increase of pain during the second-eye cataract surgery / 国际眼科杂志(Guoji Yanke Zazhi)

@#In the field of cataract, there is such a widespread phenomenon: the majority of patients have complained thatthe second-eye phacoemulsification is often more painful than the first-eye surgery. Recent studies on this phenomenon have found that after cataract surgery in the first eye, in the second-eye aqueous humor there is a high expression of cytokines which is monocyte chemotactic factor-1.It is the focus of the present study to analyze the mechanism of the increase of pain in the second eye with cataract surgery from the molecular level. Monocyte chemotactic factor-1(monocyte chemoattractant protein, MCP-1)which is considered to be a new member of the family of pain,is an important factor resulting in pain, and its specific receptor CCR2 binding exerts its biological activity. This is a review of the inflammatory cytokine research progress on the increase of pain during the second-eye cataract surgery.