ABSTRACT
OBJECTIVE: To investigate the value of serum galactose-deficient IgA1 in the diagnosis of IgA nephropathy and explore its relationship with the decline of renal function and pathological grade of renal biospy samples of the patients. METHODS: The serum samples were collected from, Shengjing Hospital of China Medical Unerversity from January 2016 to December 2017,which included 40 IgA nephropathy patients(group A), 20 other primary glomerulonephritis patients(group B) and 20 healthy persons(group C).Serum levels of GD-IgA1 were detected in all the samples.The 24-hour urinary protein and serum creatinine were measured in group A and B,the eGFR calculated. Recorded the pathological grade of renal biospy samples and Lee's classification. Study the value of serum Gd-IgA1 level in diagnosing IgA nephropathy by drawing ROC curve and calculating the area under the curve. RESULTS: The serum levels of GdIgA1 in IgA nephropathy patients were significantly higher than those in other types of primary glomerular diseases and healthy controls.The area under ROC curve was 0.886.When serum Gd-IgA1 level is higher than 662.5 U/ml, it suggested that people were more likely to have a IgA nephropathy.The level of serum Gd-IgA1 was related to the decline of renal function and pathological grade of renal biospy samples in patients with IgA nephropathy. CONCLUSION: Serum Gd-IgA1 levels may be helpful in the diagnosis of IgA nephropathy in patients who can not undergo renal pathological examination.
ABSTRACT
IgA levels are considered as one of the most important determinant of immunity in children and undernutrition may result in deviated IgA levels due to repetitive infection resulting in acute respiratory infections (ARI) and diarrhoea. Hence, the study was undertaken to determine serum IgA levels of 80 undernourished and 30 nourished children using Immunoturbidimetric assay and correlate with their nutritional and morbidity status. Due to the known variability of immunoglobulin levels, subjects were divided into three groups based on their age range i.e. 5-7; 7-10 and 10-12 years. Results indicated that mean IgA levels of undernourished children were 110.89±37.78 mg/dl 131.81±43.43 mg/dl and 168.00±64.75 mg/dl for age group 5-7; 7-10 and 10-12 years respectively. Mean diarrhoeal episodes were reported to be 0.53±1.20; 0.82±1.14 and 1.17±1.26 and mean episodes of acute respiratory infection (ARI) in past one month were 2.21±1.89; 1.43±1.47 and 1.83±1.19 for above mentioned age range. The mean serum IgA level of undernourished children between 5-10 years and 7-10 years were higher than the healthy children, although this difference was not statistically significant. A significant positive correlation was seen between undernutrition status and serum IgA levels of 10-12 years of school children.