ABSTRACT
The effects of the serum vitamin C levels on the activity and isozyme pattern of serum lactate dehydrogenase (LDH) in males and females in their middle and old age were examined.<BR>There was no siginificant correlation among the total serum, LDH activity and serum vitamin C levels in the 87 male and 83 female ranging from 45 to 84 years of age. However, high inverse correlations were found among the percentage of LDH-4 and LDH-5 and serum vitamin C levels all of age groups (45-59 years of age group, 60-69 years of age group and over 70 years of age group) of males and females.<BR>These results suggest that the percentage of LDH-4 and LDH-5 are influenced by the vitamin C intake in males and females in their middle and old age.
ABSTRACT
This paper reports the changes in the activity and isozyme pattern of serum LDH in healthy young men given a low protein diet (0.73-0.75/kg body weight; 40-50g/day) for 21 days.<BR>Serum total LDH activity showed no significant change in eight healthy young volunteers who received low protein diet for 21 days. However, the percentages of LDH-5 and LDH-4 increased significantly (P<0.01) from basal levels of 5.9±2.3 and 7.1±1.4 to 10.6±2.9% and 10.1±0.9%, respectively on day 14.<BR>These results suggest that measurements of the percentages of LDH-4 and LDH-5 isozymes can be used to evaluate the protein intake, but serum LDH activity cannot be used as an index of nutrition.