ABSTRACT
@#AIM: To study the serum lipids changes in patients with Leber congenital amaurosis(LCA).<p>METHODS: Based on the retrospective study and the simple size in the statistics, 50 cases of LCA patients and 52 cases of normal people were included. The serum levels of low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), triglycerides(TG), and total cholesterol(TC)were measured by professionals in hospital according to the single blind study. Data were analyzed statistically between the LCA group and normal group. <p>RESULTS: Among the 50 patients with LCA, abnormal serum lipid content accounted for 46%, of which 26% were low in HDL-C levels, hypertriglyceridemia accounted for 48%, hypercholesteremia accounted for 17%, respectively, 9% of patients had mixed hyperlipidaemia. The serum level of HDL-C was 1.221±0.317mmol/L in the LCA group, which was significantly lower than the normal group(<i>P</i><0.05). The serum levels of TG and TC were 1.377±1.171mmol/L and 4.506±0.694mmol/L<sup> </sup>in the LCA group, which were significantly higher than the normal group(all <i>P</i><0.01). There was no significant difference in the serum level of LDL-C between LCA and normal group(<i>P</i>>0.05). <p>CONCLUSION: In patients with LCA, abnormal concentration changes of HDL-C,TG and TC may be associated with the occurrence of LCA.