Formulation and Evaluation of Herbal Neem Anti-Dandruff Shampoo

The purpose of this present research work was to formulate and evaluate anti-dandruff shampoo which was prepared from herbal plant Neem leaves and Tulsi. These two plants are major role in formulation of anti-dandruff shampoo with antimicrobial and anti-inflammatory activity. The dandruff is a common disorder which is caused by yeast over growth, there is a fungus which is lives in the scalp of peoples called Malassezia. When a shampoo used under prescribed condition removes skin debris and the dirt from the scalp. Various antifungal and antimicrobial agents or drugs are uses in the preparation of shampoos, which causes the various side effects like hair loss, scratching, discomfort. An attempt to formulate Neem anti-dandruff shampoo which is safer and healthier than other anti-dandruff shampoo’s who are based on the chemicals. Herbal anti-dandruff shampoo formulated by all the herbal ingredients Neem leaves extract as API and anti-dandruff activity, Tulsi leaves which have the anti-microbial activity, Aloe vera which has moisturizing effect etc. The formulated shampoo were passed through evaluation parameter such as visual inspection, foaming capacity pH, viscosity, consistency of foam, etc.

The Effect of Surfactant on Polyherbal Liquid Shampoo and its Comparative Analysis

Objective: Herbal shampoo is gaining immense popularity among all consumer groups due to rising awareness about the side effects of chemical formulations. It was also observed that not many marketed shampoos incorporated excellent hair nurturing properties of curry leaves. The aim of the study was to formulate and evaluate herbal shampoo using Murraya koenigii, Phyllanthus emblica, Acacia concinna Linn., Trigonella foenum-graecum, Sapindus mukorossi and perform a comparative analysis with marketed formulation. Method: Three formulations were prepared using extracts of Murraya koenigii, Phyllanthus emblica, Acacia concinna, Trigonella foenum-graecum and Sapindus mukorossi in definite proportions. Decyl Glucoside and Sodium Lauryl Sulphate were added as surfactant in adequate amount. The formulated shampoo was evaluated for organoleptic properties (colour and odour), pH, surface tension, viscosity, dirt dispersion, cleansing action, foaming ability and stability studies. Results: The formulated shampoos were brown in colour with good acceptable fragrance. All the formulations showed good cleansing and detergency power with stable foam. F1 showed comparatively better foaming ability. All the formulations had neutral pH and low surface tension (21-25 dyn/cm). The solid content was found to be in the range of 23-27 % and viscosity 4885 cP- 4903 cP. The results of the prepared formulations were compared with a marketed formulation and were found that F1 formulation was on par with marketed formulation. Conclusion: The prepared shampoo had good characteristics. It was further inferred that it is possible to develop safer and equally effective shampoo using ingredients of plant origin.

Formulation and evaluation of propolis extracts based shampoo on dandruff causing bacteria

@#Aim: Dandruff is characterized by the white flakes in the hairs and can be caused by dry skin and mainly by fungal growth of Malassezia yeasts. To treat this condition mainly synthetic type of active ingredient shampoos are used which gave severe adverse effect toward users like hair fall and weakening of the hair roots. In this study, we formulate a shampoo containing an active ingredient “Propolis” an antimicrobial agent which is also known as bee glue. Formed by the combination of bee wax and flower exudate collected from the flower bud. Methodology and results: In this study, propolis extracts have been used as the antimicrobial agent in the shampoo formulation for treating dandruff-causing bacteria, Staphylococcus aureus. Interestingly, the developed propolis shampoo showed is 10-fold more effective against S. aureus compared to the propolis extracts alone. This is due to the presence of Tween 80 as the surfactant used in the formulation which adds to this antibacterial effect. The formulated shampoo was also compared with the commercially available shampoo (Safi Shayla brand) for physicochemical properties. Overall evaluation of the shampoo with propolis found to have pH (6-7), good foaming ability, less wetting time, a good percentage of solid content and viscosity. Also, the formulated shampoo has greater stability under accelerated room temperature and accelerated the ageing condition. Conclusion, significance and impact of study: This study demonstrated the propolis extracted can be used as a potential antimicrobial agent. As it came from the natural resource the acceptance will high among the consumers.

Ion-pairing liquid chromatographic method determination of ketoconazole and stress degradation in pharmaceutical formulations with fluorescence detection

Ion-pairing liquid chromatographic method was validated for determination of ketoconazole in shampoo and cream samples as per ICH guidelines. The chromatographic conditions were carried out in the isocratic mode using a mixture of methanol and 8 mM sodium dodecyl sulfate (pH 5.5) in a ratio of 45:55 v/v %, as mobile phase. The flow rate was set at 1.0 mL min-1. Chromolith RP-18e (100×4.6 mm) was used as the analytical column with a fluorescence detection at an excitation wavelength of 260 nm and an emission wavelength of 375 nm. The average percentage recovery of shampoo A, shampoo B, shampoo C, cream A and cream B were 99.88, 97.06, 99.58, 96.77 and 97.26, respectively. The limit of detection was 0.12 mg L-1. The drug decomposition under acid degradation, base degradation and oxidative degradation were found to be in the range of 91.63-94.70% indicating that the drug is resistant towards acidic conditions. The drug decomposition under thermal condition and photolysis condition were found to be in the range of 69.05-87.15% and 47.31-66.83% respectively, indicating that the drug decomposition is more sensitive under photolysis conditions. This method is suitable for the quality control of ketoconazole in commercial shampoo and creams.

Effectiveness of neem seed oil methanolic extract shampoo versus permethrin shampoo in the reduction of head lice infestation in children / The Health Sciences Journal

INTRODUCTION@#This study compared the effectiveness and safety of neem (Azadirachta indica) seed oil methanolic extract shampoo against permethrin shampoo in reducing head lice infestation among children.@*METHODS@#A single-blind, non-inferiority, randomized clinical trial was conducted on children aged 6-14 years with pediculosis. Using block randomization, the participants were assigned to receive either 10% neem seed oil methanolic shampoo, 1% permethrin shampoo, or pure shampoo for three treatment applications at 10-day intervals. The presence of head lice after each application was determined by standard quadrant counting and compared with the baseline count within and among treatment groups.@*RESULTS@#There was a statistically significant difference in lice count after treatment for both neem and permethrin, with mean reductions of 17.8 ± 23.97 (p = 0.043) and 22.5 ± 23.47 (p = 0.014), respectively. Repeated Measures ANOVA showed a summary p-value of 0.041 for neem, 0.013 for permethrin, and 0.193 for the shampoo alone with a linear trend indicating a significant decrease in the lice counts from the baseline to the third application of neem and permethrin shampoo, but not in the shampoo group. There was no significant difference in the mean decrease in lice count from baseline to the third application between the neem and permethrin shampoo groups.@*CONCLUSION@#Neem seed oil methanolic extract shampoo is non-inferior and comparable to permethrin in the reduction of head lice count. There were no reported dermatologic adverse effects such as burning sensations, redness, skin irritation, and allergic reactions.

New Thai herbal shampoos as pediculicides for killing head louse, Pediculus humanus capitis de Geer (Phthiraptera)

Objective: To evaluate the efficacy of Thai herbal shampoos [Cartoxylum formosum (C. formosum) + eucalyptus essential oil (EO), C. formosum + citrus EO, Solanum trilobatum + eucalyptus EO, Solanum trilobatum + citrus EO, Moringa oleifera + eucalyptus EO and Moringa oleifera + citrus EO] for killing all stages of Pediculus humanus capitis (Phthiraptera). Methods: A filter paper contact method was applied with three concentrations (0.05, 0.10 and 0.20 mL/cm

New Thai herbal shampoos as pediculicides for killing head louse, Pediculus humanus capitis De Geer (Phthiraptera)

Objective:To evaluate the efficacy of Thai herbal shampoos [Cartoxylum formosum (C.formosum) + eucalyptus essential oil (EO),C.formosum + citrus EO,Solanum trilobatum + eucalyptus EO,Solanum trilobatum + citrus EO,Moringa oleifera + eucalyptus EO and Moringa oleifera + citrus EO] for killing all stages of Pediculus humanus capitis (Phthiraptera).Methods:A filter paper contact method was applied with three concentrations (0.05,0.10 and 0.20 mL/cm2) of each Thai herbal shampoo as well as permethrin pediculicide (positive control) and drinking water (negative control) against eggs,nymphs and adults of Pediculus humanus capitis.Mortality rates of the eggs were recorded after 7 days of incubation while those of nymphs and adults were recorded after 5 minutes of contact.Results:All herbal shampoos at the high concentration were highly effective against nymphs and adults,but not effective against the eggs.C.formosum + eucalyptus EO and C.formosum + citrus EO shampoos at all concentrations exhibited the highest efficacy against nymphs and adults with 100％ mortality rate at 5 min and LC50 values of 0.004 and 0.005 mL/cm2,respectively.All formulation of Solanum trilobatum and Moringa oleifera shampoos added with eucalyptus EO showed mortality rates against nymphs at 92.0％-100.0％ and 76.0％-100.0％ and against adults at 84.0％-100.0％ and 20.0％-32.0％,respectively.Permethrin pediculicide was not effective against the eggs,but showed 68.0％-92.0％ and 28.0％-60.0％ mortality rates against nymphs and adults.Conclusions:These results indicate that C.formosum + eucalyptus EO shampoo can be used as an effective nymphicide and adulticide against Pediculus humanus capitis.

In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts

BACKGROUND: A new shampoo with anti-Malassezia properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options. OBJECTIVE: The aim of this study was to obtain in vitro susceptibility profiles of Malassezia restricta and M. globosa, the most important pathogenic organisms in the development of seborrheic dermatitis, to the plant extracts used in commercial anti-dandruff shampoos. METHODS: Minimal inhibitory concentrations (MICs) were determined for eight candidate plant extracts and two plant-derived natural products diluted with Leeming and Notman medium to final concentrations of 0.016 to 1 mg/ml. RESULTS: Castanea crenata shell, Camellia sinensis leaf, and oil-soluble Glycyrrhiza extracts presented relatively low MIC values (≤0.5 mg/ml) against both strains. The C. crenata shell and oil-soluble Glycyrrhiza extracts demonstrated especially high anti-Malassezia activity, suggesting their potential use in the treatment of seborrheic dermatitis. The extracts also showed fungistatic activity against other common facultative pathogenic yeasts, Cryptococcus and Candida. CONCLUSION: C. crenata shell and oil-soluble Glycyrrhiza extracts could potentially be used as active ingredients in anti-seborrheic and anti-dandruff shampoo formulations. They could be helpful for repeated treatments and regular prophylaxis of scalp seborrheic dermatitis.

Análise microbiológica de xampus e cremes condicionadores para uso infantil / Microbiological Analysis of Children?s Shampoos and Conditioners

O Brasil é um dos maiores mercados mundiais consumidores de cosméticos infantis. A utilização de produtos de higiene pessoal, como xampus, condicionadores e sabonetes infantis, e de produtos de beleza já se incorporou ao dia a dia de muitas crianças. Deste modo, é imprescindível que esses produtos estejam em consonância com os limites microbianos estabelecidos pela Farmacopeia Brasileira (2010) e pela Resolução da Diretoria Colegiada/ANVISA No 481/99 para serem comercializados. Neste trabalho, foi avaliada a qualidade microbiológica de amostras de 10 xampus e 10 cremes condicionadores de cabelos destinados à higiene infantil. Dentre as amostras analisadas, verificou-se que, em 50% dos xampus e 30% dos cremes condicionadores capilares, houve proliferação de micro- organismos, tais como bactérias aeróbias e fungos, acima dos limites máximos permitidos. Embora não se tenha encontrado micro-organismos patogênicos, essas percentagens indicam a necessidade do cumprimento das Boas Práticas de Fabricação por parte das indústrias farmacêuticas e cosméticas, para que os consumidores possam adquirir produtos confiáveis, com qualidade adequada para manutenção da saúde e do bem-estar.(AU)

Brazil is one of the largest commercial markets for children?s cosmetics. Personal-care products such as shampoos, conditioners and soaps for infants use, as well as beauty products are used daily by many children. Therefore, it is essential that these products are within microbial limits established by the most recent Brazilian Pharmacopoeia and the Brazilian Health Surveillance Agency Collegiate Board of Directors Resolution No 481/99. This study evaluated the microbiological quality of samples of 10 shampoos and 10 conditioners intended for infant hygiene. Of the samples analyzed, 50% of shampoos and 30% of conditioners showed microbial growth, such as aerobic bacteria and molds/yeasts, over the limits allowed. Although pathogenic micro- organisms were not found, these proportions indicate the need for pharmaceutical and cosmetic companies and businesses to comply with Good Manufacturing Practices, so that consumers are able to purchase reliable products with appropriate quality to maintain their health and well-being.(AU)

Efficacy and safety of petroleum jelly versus permethrin 1% shampoo in the treatment of Prediculosis capitis: An assessor-blinded, randomized controlled trial

BACKGROUND: The high rates of infestation, treatment failures and treatment costs have created the search for new therapies againts head lice. OBJECTIVE: We compared the efficacy and safety of scalp occlusion with petroleum jelly (PJ) versus permethrin 1% shampoo against Pediculus humanus capitis among school-aged children METHOD: Seventy-seven children were diagnosed with Pediculosis capitis. Thirty-eight subjects did eight-hour scalp occlusion with PJ, and 39 used permethrin shampoo, both followed by nit combing. Treatments were applied once weekly for three consecutive weeks. Patients were assessed at weeks 1,2,3 and 11. The primary outcome was the proportion of cured subjects and change in quality of life (QOL) scores om week 3 of follow-up. Cure was defined as the absence of variable lice on the hair/scalp or nits on the hair shaft attached within one centimeter from the scalp on visual examination.Secondary outcomes were relapse rate at week 11 ,cosmetic acceptability and adverse events. Effects on QOL were measured using the Dermatology Life Quality Index at baseline and at the end of the third week of treatment. RESULTS: At Week 3, cure achieved in 47% (18/38) in PJ group 52% (17/33) in permethrin group (RRR 6.7%, 95% Cl: -40.4% to 38%). Relapse rate in the 12th week were 44% (8/18) and 58% (10/17), respectively (p=0.486, Fisher's test ). The differences in treatment effects were not statistically significant. CONCLUSION: Petroleum jelly scalp occlusion was comparable in cure rates to permethrin. PJ can be a safe, affordable alternative to permethrin as a pediculicide.

Efecto de las fragancias en el desempeño sensorial de productos cosméticos tipo champú / Effect of the fragrance on the sensorial performance of cosmetic shampoos

En el desarrollo de cosméticos, las fragancias constituyen un factor clave en términos de la aceptabilidad del producto por parte del consumidor. No obstante, durante la etapa de formulación, la atención se focaliza comúnmente en la evaluación de factores tales como el desempeño y la estabilidad del perfil olfativo, y no se profundiza en las consecuencias de las posibles interacciones causadas entre los ingredientes de la formulación y los ingredientes de la fragancia. Como un aporte en este sentido, el presente trabajo evidencia el efecto de diferentes fragancias en el desempeño funcional de productos cosméticos tipo champú. De acuerdo con los resultados obtenidos, el solvente orgánico presente en la composición de la fragancia podría influenciar de forma significativa en el comportamiento de materias primas de naturaleza polimérica que se emplean en las formulaciones de champús y que determinan tanto la viscosidad del producto como su desempeño sensorial en las pruebas de uso.

Fragrances are a key factor when cosmetics are developed because of their crucial influence on the consumer acceptance. However, the development stages of the product are frequently focused on factors such as the cosmetic performance and the olfactory profile, overlooking the potential chemical interactions between the recipe ingredients and the fragrance ingredients like their consequences in terms of the product performance. As a contribution on this regard, this research evidences the incidence of different fragrances on the functional performance of cosmetic shampoos. The results reveal that the organic solvent included into the fragrance recipe could influence in significant way the behavior of polymeric raw materials which govern both the product viscosity and the product sensorial performance when in use tests are carried out.

Avena sativa: An Effective Natural Ingredient in Herbal Shampoos for the Treatment of Hair Greasiness.

Aims: Evaluation of anti-greasiness properties of oat extract and oil in shampoos. Methodology: Seborrhea can cause greasiness in scalp and hair. There are few compounds currently in use to reduce sebaceous gland secretions. Avena sativa or oat is a plant containing saponins as active ingredients with cleansing activity. In a double blinded, randomized, placebo clinical study, we investigated anti-grease and cleansing effects of oat by comparing shampoos formulated from oat extract and oil with control shampoo. Sixty male and female volunteers aged 19 to 30 years old randomly received either oat oil/extract or placebo to the scalp for 5 minutes, twice per week for four weeks. Signs and symptoms such as scaling, greasiness and itching were assessed every week. Results:In vitro detergency test revealed better detergency power in extract and oil of oat shampoos compared with control shampoo. Clinical studies showed a significant reduction of greasiness scores in extract shampoo compared to the oil and control shampoos. Conclusion: shampoos containing oat extract could be considered as an appropriate alternative therapy for the management of greasiness in seborrheic patients.

Randomized, assessor-blind, controlled clinical trial on the efficacy and safety of aromatic oil (10% eucalyptus oil, 10% lavender oil, 10% rosemary oil) shampoo versus 1% permethrin shampoo in the treatment of pediculosis capitis

BACKGROUND: Permethrin shampoo is currently the first-line treatment for pediculosis capitis. However, its widespread use has resulted in the development of resistance.OBJECTIVE: To compare aromatic oil shampoo and 1% permethrin shampoo in terms of efficacy and safetyMETHOD: One hundred fifty-hour patients with active infestation were treated in this randomized, assessor-blind, controlled trial using aromatic oil or permethrin shampoo, applied once weekly for three weeks. Evaluations were conducted at baseline and a week after shampoo application. Complete cure was defined as the absence of live louse on day 21.RESULTS: There were no significant differences between the two groups in terms of complete cure, changes in patient's quality of life and pruritus at day 21. Neither group reported any diverse effects.CONCLUSION: The efficacy and safety of the aromatic oil shampoo was comparable to that of 1%permethrin shampoo in treating pediculosis capitis.

Controle de qualidade e análise sensorial em voluntários de xampu esfoliante com extrato hidroalcoólico de Capsicum frutescens L. (Solanaceae) / Quality control and sensory acceptability of exfoliating shampoo containing hydroethanolic extract of Capsicum frutescens L. (Solanaceae) peppers.

A fitocosmética é um setor em nítido crescimento por se ter verificado reais vantagens na incorporação de produtos vegetais em relação a certos produtos sintéticos em produtos cosméticos. O proposto trabalho foi desenvolvido enfocando-se o uso de xampu com a utilização de microesferas de biopolímero e extrato hidroalcoólico de Capsicum frutescens L., mais popularmente conhecida como pimenta-malagueta, para o tratamento de queda capilar simples (alopecia androgênica). As análises físico-químicas envolveram determinação de cinzas totais, pH, identificação de capsaicina e densidade do xampu, entre outros. Considerando-se os diversos aspectos exigidos para a garantia da qualidade do material botânico, que englobam não somente os aspectos físico-químicos, mas também o microbiológico, realizou-se, tanto no extrato quanto no produto final, a contagem total de micro-organismos, pesquisa de Salmonella sp e Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa. Foram realizadas análises sensoriais em voluntários, visando avaliar a qualidade sensorial do produto. Os voluntários avaliaram a amostra segundo questionário aplicado. Para as propriedades avaliadas, as microesferas esfoliantes incorporadas ao xampu mostraram-se ser bem aceitas pelos voluntários, principalmente devido à sensação transmitida pela esfoliação, fazendo com que o extrato hidroalcoólico promova uma maior oxigenação local.

Phytocosmetics is a sector of the market in rapid growth, since real advantages have been demonstrated in the incorporation of plant products in cosmetics, in place of certain synthetic products. The focus of this study was on the use of shampoo containing microspheres of biopolymer and a hydroalcoholic extract of the fruit of Capsicum frutescens L., more commonly known as chili pepper, for the treatment of hair loss (androgenic alopecia). The physical and chemical analysis included the determination of total ash, pH and density of the shampoo and the identification of capsaicin. Considering the various requirements for quality assurance of the plant material, encompassing not only physicochemical but also microbiological criteria, both the extract and the final product were subjected to a total count of microorganisms and tests for Salmonella sp, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The sensory quality of the product was assessed by a panel of volunteers, who rated the sample of shampoo in response to a questionnaire. For the properties assessed, the exfoliating microspheres incorporated into the shampoo proved to be well tolerated by the volunteers, mainly on account of the feeling conveyed by exfoliation, causing the hydroalcoholic extract to promote greater local oxygenation.

Evaluation of Shampoos Containing Silicone Quaternary Microemulsion.

This study aimed to characterize properties and to evaluate conditioning performance providence of shampoos containing various concentrations, i.e., 0, 1, 2, 3 and 4 %w/w, of silicone quaternary microemulsion. The results indicated that all samples were clear yellowish liquids with good odor. Addition of silicone quaternary microemulsion in the investigated formulation did not markedly affect the characteristics of the obtained shampoos, except viscosity. Their averaged pH values were in the range of 6.59-7.17 which were acceptable according to TIS 162-2541. All samples provided stable foam, surface tension reduction and low viscosity with Newtonian flow. Under a light microscope, the cuticle arrangement of five tresses washed by the studied shampoos seemed to be better than their counterpart tresses before washing. However, no obvious difference on the cuticle arrangement of the tresses after washing by the identical manner with different shampoos was observed. Most of 50 referees rated and scored that the tress washed with shampoo containing 1%w/w silicone quaternary microemulsion provided the highest conditioning performance, i.e., smooth and softness, via contacting. It could be concluded that silicone quaternary microemulsion was able to be incorporated with the investigated shampoo formulation as an effective hair-conditioning agent.

Determinação da segurança biológica do xampu de cetoconazol: teste de irritação ocular e avaliação do potencial de citotoxicidade in vitro / Determination of the biological reactivity of ketoconazole in shampoo: draize eye test and cytotoxity test

Cetoconazol é um agente antifúngico, que pode ser incorporado em diferentes formas farmacêuticas, como, por exemplo, xampus e cremes. O objetivo do trabalho foi avaliar a segurança biológica in vivo (teste de irritação ocular) e in vitro (teste de citotoxicidade) do xampu de cetoconazol degradado sob ação da luz. Para tanto, a formulação foi exposta à radiação UV-C (254 nm) e foram empregados dois métodos para a determinação quantitativa do cetoconazol: CLAE e ensaio microbiológico. Os resultados demonstraram alteração do cetoconazol em presença da luz - presença de picos secundários no cromatograma e diminuição da atividade antifúngica - entretanto, não demonstraram alteração na segurança biológica entre xampu de cetoconazol e xampu de cetoconazol contendo produtos de degradação.

Ketoconazole is an antifungal agent and can be incorporated into several dosage forms, as an example it could be mentioned shampoos and creams. The aim of this work was to assess the biological reactivity in vivo (Draize eye test) and in vitro (cytotoxity test) of ketoconazole in shampoo degradeted under action of light. The formulation was exposed to UV-C (254 nm) radiation and two methods were used for the quantitative determination of ketoconazole: HPLC and microbiological assay. The results showed alteration in ketoconazole in presence of light - secondary peaks in chromatogram and decrease in antifungal activity - however, no alteration on the biological reactivity between ketoconazole shampoo and ketoconazole shampoo containing degradation products was observed.

Genetic Toxicity of Shampoo to Root Tip Cells of Vicia faba / 环境与健康杂志

Objective To study the genotoxicity of 3 kinds of different brands shampoo to Vicia faba root tip cells. Methods To take root tip cells of Vicia faba as the subjects,genetic safety tests were conducted on those materials treated with shampoo of a certain concentration(0.25% ) for 2-8 h of continual mutagenesis and accumulative mutagenesis respectively,micronucleus and chromosomal aberration was observed and calculated,the rate of tap water was used as the control. Results Three kinds of shampoo could induce root tip cells of Vicia faba to produce micronucleus and chromosomal aberration,the peak was in the continual mutagenesis for 4 h and accumulative mutagenesis for 8 h respectively,which showed dose-effect relationship. There were significant differences between the control group and the experimental groups( P

Investigation on Contents of Dioxane in Shampoo and Bath Lotion Type of Cosmetics / 环境与健康杂志

Objective To investigate the contents of dioxane in shampoo and bath lotion type of cosmetics. Methods Headspace gas_chromatography was applied to determine the concentration of dioxane in cosmetics. Results Significant differences were observed between 122 national products of shampoo with a detectable rate of 63.9% and a value of P95 of dioxane concentration of 173.4 ?g/g and 64 imported and joint_venture products of shampoo with a detectable rate of 56.2% and a value of P95 of dioxane concentrations of 34.68 ?g/g (P

Irritação da pele causada por xampus contendo alcatrão / Skin irritation caused by shampoos containing tar

Os testes de irritabilidade da pele mostram que os xampus contendo alcatrão, quando aplicados na pele de cobaias por vários dias, causam irritações dérmicas, ao mesmo tempo em que ressecam a pele e impedem o crescimento normal dos pêlos. Essas anormalidades foram verificadas em animais de laboratório, submetidos aos produtos questionados. Os xampus testados podem ser obtidos no comércio e são indicados para o tratamento de seborréia, psoríase, combate à caspa e proteção do couro cabeludo (AU).