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Chinese Pharmaceutical Journal ; (24): 28-1999.
Article in Chinese | WPRIM | ID: wpr-583423

ABSTRACT

OBJECTIVE:To study the relationship between various composition factors and the dissolution rates of the soft gelatin capsule shell.METHOD:The gelatin disk and gelatin shaped mass method were used by the current CP rotating-basket dissolution apparatus.The effects of shell compositions on the capsule shell dissolution rate were illustrated and discussed.RESULTS:With the increase in the ratio of gelatin glycerol in soft gelatin shell,the dissolution rate of the shell changed irregularly.After storage of 21 days at 40℃,the dissolution rate of the shell decreased at different extent.The dissolution rate of the shaped gelatin mass increased slightly by adding some polymers (pvp,starch).CONCLUSION:Am investigation of these factors and their influence on dissolution may be of assistance in the formulation of soft gelatin capsule shells for various purposes,THE SOFT gelatin capsules should be stored at relatively low temperature.

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