ABSTRACT
As a local parasitic disease in Qinghai,Tibet,Xinjiang and other places,cerebral hydatid disease has high morbidity and mortality.At present,the main drug for Echinococcosis is benzimidazole.However,due to the lack of efficacy and side effects of these drugs,we urgently need to develop new drugs.In this paper,we gives a brief introduction of the application of genomics,stem cells and signaling pathway knowledge in developing new drugs of hydatid,which aims to understand the limitations of current hydatid medication,summarize the research progress of new drugs,put forward the potential research direction,prompting the development of new drug research.
ABSTRACT
Since the tumor has become one of the most deadly diseases to human life ,it is of great impor-tance to explore a new effective antitumor medicine .This paper summarizes the chemical constituents and the mechanism of Inonotus obliquus .The mechanism includes the details of the inhibition of tumor cell proliferation , inducing tumor cell apoptosis ,influence tumor cell cycle etc .Meanwhile,it describes Inonotus obliquus to the ad-juvant chemotherapy of tumor .
ABSTRACT
Objective To explore the role of p38MAPK and TGF?2 in the development of diabetic retinopathy.Methods Fifteen Hamsters were induced into diabetic models by intraperitoneal injection of Streptozotocin(40 mg/kg once a day) for 3 d and 13 Hamsters were successfully established,whose blood glucose was over 13.5 mmol/L.Ten Hamsters as controls were intraperitoneally injected of physical saline of the same volume.At 16th week after induction,the total RNA of retina from all sacrificed Hamsters was collected.The mRNA expressions of p38MAPK,TGF?2 in retina were detected by semi-quantitative RT-PCR and their protein levels by Western blotting.Results The mRNA expressions of p38MAPK,TGF?2 in retina were of high tendency and their protein levels increased.Conclusion p38MAPK signal pathway may involve in the pathogenesis of diabetic retinopathy.