Overt Clinical Hypereosinophilia in T- cell Non Hodgkin Lymphoma: A Case Report

The study describes a case of hyper-eosinophilia who was presented with overt manifestation of high eosinophil and detected to have underlying non Hodgkin lymphoma. The male patient was presented with profound weakness and multiple non itchy nodular skin lesion for 2 weeks. Biopsy from skin nodule showed deposits of abnormal lymphocytes. Lymph node biopsy showed effacement with mono nuclear abnormal cells which showed positivity for CD4 and 5, negative for cytokeratin and CD20. He was diagnosed to have T-NHL. [Fig. 3a, Fig. 3b] Bone marrow showed involvement by NHL cells. His diplopia and headache responded to intra-thecal methotrexate and possibly CNS involvement of disease was considered. Family opted out of allopathic treatment plan due to clinical progression. He later died of disease progression. This case illustrates the rare and interesting association of overt clinical hyper-eosinophilia and T NHL. The study suggests that cases with hyper eosinophilia should be evaluated thoroughly for T cell disease.

Disseminated Histoplasmosis Presenting as Skin Nodules.

Aim: We present a case of histoplasmosis presenting with skin nodules and lymphadenopathy from a non endemic area. Case Presentation: A 60-year-old male presented with multiple skin nodules and lymphadenopathy. Discussion: Histoplasmosis is a rare fungal infection caused by dimorphic fungus Histoplasma capsulatum, occurring in AIDS patients and other immunocompromised individuals. It usually causes pulmonary infection, following which dissemination to the other parts of the body can occur through lymphatics and bloodstream. Skin lesions mimicking tuberculosis or malignancy can be presenting feature of disseminated histoplasmosis in 10% of patients. Histoplasmosis is endemic in Central and South America and Africa. In India it is endemic in east Indian states. Conclusion: Due to non specific clinical presentations, low clinical suspicion especially from non endemic areas and lack of proper diagnostic facilities, a diagnosis of histoplasmosis is not sought. Delay in diagnosis often leads to delayed treatment increasing morbidity and mortality.

Acute T-cell lymphoblastic leukaemia presenting with cutaneous involvement in a child: a rare case report.

Primary cutaneous involvement in T-cell lymphoblastic leukemia is rare in childhood. We present a case of 6-year-old girl admitted to our hospital because of multiple skin lesions. She was looked pale and weak. Generalized lymphadenopathy was present. Complete blood count revealed 216,000/mm3 white blood cell count. Peripheral blood smear showed 80% lymphoblasts. Bone marrow aspiration revealed 96% blastic cells with immunophenotype and morphological characteristics of acute lymphoblastic leukemia (T-ALL) which was confirmed by flowcytometry. ALL BFM -95 remission induction treatment protocol was started. Skin lesion remained same after two month of the cytotoxic therapy. The symptoms became more aggressive and she died after 4 months of treatment.

Testicular embryonal cell carcinoma presenting as haemoptysis and skin nodules.

Embryonal cell carcinoma affects young males in the prime of their life with majority of tumours already having metastasised at the time of diagnosis. Subcutaneous metastasis from embryonal carcinoma is rare and is associated with widespread disease and poor prognosis. We report a case of 22-year-old male who presented with haemoptysis and skin nodules. Fine needle aspiration cytology of skin nodules and the lung lesion led to the diognosis of testicular embryonal cell carcinoma.

A Case of Angioimmunoblastic Lymphadenopathy with Dysproteinemia with Skin Nodules / 대한피부과학회지

We report here a case of angioimmunoblastic lyinphadenopathy with dysprote inemia(AILD) in a 65-year-old male associated with skin nodules on the face. Physical examina.tion showed generalized lymphadenopathy, hepatosplenomegaly, erythematous maculopapular eruptions on the trunk and extremities, and er the matous nodules on the face. Lahoratory findings showed hemolytic anernia, arid polyclonal gammopathy. Histopathological findings of lymph node revealed typical features of AILD. I-iistopathological findings of maculopapules revealed lymphohistiocytic infiltra tion and extravasated erythrocytes around the blocked vessels, whereas histological picture of nodules on the face mirrorred that of the lymph node. After taking systemic chemotherapy, his general condition and skin lesions were improved.