ABSTRACT
In some molecular targeted therapies, skin disorders including acne-like rashes or maculopapular rashes frequently appear, which are often clinically problematic. In Kampo medicine, it has been reported that the combination of jumihaidokuto and orengedokuto (hereinafter called JHT + OGT) is effective for acne. In this study, we report the experiences of JHT + OGT for the treatment of rashes caused by molecular targeted therapies. We extracted patients from June 2013 to June 2017 who took molecular targeted therapies and the treatment with JHT + OGT for skin rashes. The primary endpoint was severity of rashes before and after treatment by JHT + OGT (judged by CTCAE v4.0). In 22 patients (14 males and 8 females), the rashes after treatment with JHT + OGT significantly improved compared with those before treatment (from the median grade of 2 to 1 [p = 0.011]), with 14 cases of improvement, 6 cases of no change, and 2 cases of deterioration. It was suggested that JHT + OGT for skin rashes caused by molecular targeted therapies could be one of the treatment options.
ABSTRACT
An epidemic of probable chikungunya disease occured in Amlan, Negros Oriental from March to October 1968. Six hundred ninety-eight (698) cases were recorded in a post-epidemic survey conducted between October 14-19, 1968The trial of fever, skin rashes, an arthralgia was the prominent feature of the disease. Fever usually began abruptly and usually lasted 2-5 days, but in some cases persisted intermittently over a one to two week period. The skin rashes were mostly described by respondents as either maculopapular or morbilliform. These rashes frequently appeared during defervescence and lasted 2 to 4 days, but reappeared after apparent clinical recovery in some casesArthralgia and occasionally frank arthritis involving large and small joints usually accompanied the onset of pyrexia. Arthralgia frequently persisted for several weeksOne case from Amlan admitted to the Silliman University Medical Center was presented to call attention to the clinical features of the disease. Initial results of serological tests performed on sera collected from this hospitalized patient and other patients in Amlan suggest that the epidemic was due to ckikungunya virus infection.(Summary)