ABSTRACT
The mainstay of nonpharmacological therapy of chronic heart failure patients is low sodium diet. This paper introduced the modified and unmodified influencing factors of patient compliance to low-sodium diet in chronic heart failure patients in order to provide new clues for the development of patient compliance.
ABSTRACT
BACKGROUND: Dietary sodium restriction is an essential component of self-care behavior for improved health-related quality of life (HRQoL) in patients with heart failure (HF). However, there is little direct evidence about the impact of dietary sodium restriction on HRQoL. The purpose of this study was to determine the impact of dietary sodium intake on HRQoL in HF patients with no cardiac events over 1-year of follow-up. METHODS: A total of 106 patients with HF completed a 3-day food diary to estimate daily sodium intake. Patients were divided into 4 groups (4 g). The Minnesota Living with Heart Failure Questionnaire was used to assess HRQoL at baseline and one year later. Hierarchical linear and logistic regressions were used to determine the relationship between dietary sodium intake and HRQoL. RESULTS: Thirty-seven (35%) patients had a daily sodium intake >3 g. Greater than 4 g of daily sodium intake was independently associated with a worse HRQoL at baseline and one year later (F=3.15, P=0.028; F=4.33, P=0.006) and an almost 5.2 times higher risk of a worsening HRQoL at one year follow-up (P=0.040) after controlling for age, gender, etiology, body mass index, New York Heart Association class, ejection fraction, total comorbidity score, and use of beta blockers. CONCLUSIONS: This finding provides additional evidence that greater than 4 g of daily sodium intake is associated with worsening HRQoL in stable HF patients who are free from cardiac events.
Subject(s)
Humans , Body Mass Index , Comorbidity , Diet Records , Diet, Sodium-Restricted , Follow-Up Studies , Heart , Heart Failure , Logistic Models , Minnesota , New York , Quality of Life , Self Care , Sodium , Sodium, Dietary , Surveys and QuestionnairesABSTRACT
BACKGROUND: Dietary sodium restriction is an essential component of self-care behavior for improved health-related quality of life (HRQoL) in patients with heart failure (HF). However, there is little direct evidence about the impact of dietary sodium restriction on HRQoL. The purpose of this study was to determine the impact of dietary sodium intake on HRQoL in HF patients with no cardiac events over 1-year of follow-up. METHODS: A total of 106 patients with HF completed a 3-day food diary to estimate daily sodium intake. Patients were divided into 4 groups (4 g). The Minnesota Living with Heart Failure Questionnaire was used to assess HRQoL at baseline and one year later. Hierarchical linear and logistic regressions were used to determine the relationship between dietary sodium intake and HRQoL. RESULTS: Thirty-seven (35%) patients had a daily sodium intake >3 g. Greater than 4 g of daily sodium intake was independently associated with a worse HRQoL at baseline and one year later (F=3.15, P=0.028; F=4.33, P=0.006) and an almost 5.2 times higher risk of a worsening HRQoL at one year follow-up (P=0.040) after controlling for age, gender, etiology, body mass index, New York Heart Association class, ejection fraction, total comorbidity score, and use of beta blockers. CONCLUSIONS: This finding provides additional evidence that greater than 4 g of daily sodium intake is associated with worsening HRQoL in stable HF patients who are free from cardiac events.
Subject(s)
Humans , Body Mass Index , Comorbidity , Diet Records , Diet, Sodium-Restricted , Follow-Up Studies , Heart , Heart Failure , Logistic Models , Minnesota , New York , Quality of Life , Self Care , Sodium , Sodium, Dietary , Surveys and QuestionnairesABSTRACT
BACKGROUND: Dietary sodium restriction is an essential component of self-care behavior for improved health-related quality of life (HRQoL) in patients with heart failure (HF). However, there is little direct evidence about the impact of dietary sodium restriction on HRQoL. The purpose of this study was to determine the impact of dietary sodium intake on HRQoL in HF patients with no cardiac events over 1-year of follow-up. METHODS: A total of 106 patients with HF completed a 3-day food diary to estimate daily sodium intake. Patients were divided into 4 groups (4 g). The Minnesota Living with Heart Failure Questionnaire was used to assess HRQoL at baseline and one year later. Hierarchical linear and logistic regressions were used to determine the relationship between dietary sodium intake and HRQoL. RESULTS: Thirty-seven (35%) patients had a daily sodium intake >3 g. Greater than 4 g of daily sodium intake was independently associated with a worse HRQoL at baseline and one year later (F=3.15, P=0.028; F=4.33, P=0.006) and an almost 5.2 times higher risk of a worsening HRQoL at one year follow-up (P=0.040) after controlling for age, gender, etiology, body mass index, New York Heart Association class, ejection fraction, total comorbidity score, and use of beta blockers. CONCLUSIONS: This finding provides additional evidence that greater than 4 g of daily sodium intake is associated with worsening HRQoL in stable HF patients who are free from cardiac events.
Subject(s)
Humans , Body Mass Index , Comorbidity , Diet Records , Diet, Sodium-Restricted , Follow-Up Studies , Heart , Heart Failure , Logistic Models , Minnesota , New York , Quality of Life , Self Care , Sodium , Sodium, Dietary , Surveys and QuestionnairesABSTRACT
O consumo excessivo de sódio tem se associado com vários efeitos prejudiciais à saúde, como aumento da pressão arterial (PA) e doença cardiovascular. Objetivos: Os objetivos da tese foram avaliar a disponibilidade de sódio no Brasil, analisar os efeitos de dietas com teores reduzidos de sódio em indivíduos com Síndrome Metabólica (SM) ou resistência à insulina (RI) e avaliar o impacto de uma intervenção que promoveu a redução da adição de sal aos alimentos. Sujeitos e métodos: A tese está composta de três artigos. O primeiro deles avaliou as aquisições de alimentos e bebidas realizadas pelos domicílios na Pesquisa de Orçamento Familiar de 2002/2003 do Instituto Brasileiro de Geografia e Estatística. O segundo artigo revisou a literatura de forma sistemática acerca dos ensaios clínicos realizados em adultos entre anos de 2004 e 2008. E o último artigo avaliou o impacto de uma intervenção, baseada no modelo ecológico de promoção de saúde, na redução da adição de sal nos alimentos consumidos por trabalhadores de empresas da cidade de São Paulo. Resultados: A quantidade diária de sódio disponível para consumo nos domicílios brasileiros foi de 4,7 g per capita e para uma ingestão diária de 2.000 kcal. A maior parte do sódio disponível para consumo proveio do sal de cozinha e de condimentos à base desse sal (76,2 por cento). A fração proveniente de alimentos processados com adição de sal representou 9,7por cento do total de sódio no quinto inferior da distribuição da renda per capita e 25,0 por cento no quinto superior. A restrição no consumo de sódio associou-se ao aumento da RI em dois artigos e à diminuição em três outros. Em sete dos nove artigos, uma dieta com teor reduzido de sódio determinou redução da PA e em dois artigos ocorreram efeitos adversos em marcadores da SM...
The excess of sodium consumption has been associated with several adverse health effects, such as increased of blood pressure (BP) and cardiovascular disease. Objectives: Evaluate the availability of sodium in Brazil, analyze the effects of diets with reduced sodium content in subjects with Metabolic Syndrome (MS) or insulin resistance (IR) and evaluate the impact of an intervention which promoted the reduction of adding salt to foods. Subjects and Methods: The thesis is composed of three articles. The first one assessed the food and beverage purchases made by households in the Household Budget Survey of 2002/2003, by the Brazilian Institute of Geography and Statistics. The second article reviewed the literature in a systematic way about clinical trials performed in adults between the years 2004 and 2008. And the last paper assessed the impact of an intervention, based on the ecological model of health promotion, in reducing the added salt to foods consumed by employees of Sao Paulo based companies. Results: The daily amount of sodium available in Brazilian households was 4.7 g daily per person for 2,000 kcal intake. Most of the sodium available for consumption comes from the salt and salt based seasonings (76.2 per cent). The fraction derived from processed foods with added salt represented 9.7 per cent of total sodium intake at the bottom of per person income distribution and 25.0 per cent at the top fifth. The restriction in sodium intake was associated with increased IR in two articles and the decrease in three others. In seven of the nine articles, the salt intake restriction had caused decreased in BP and in two articles have occurred adverse effects on markers of MS...
Subject(s)
Humans , Sodium Chloride/supply & distribution , Insulin Resistance , Metabolic Syndrome , Sodium Chloride, Dietary , Working ConditionsABSTRACT
Estudos recentes mostram que restrições na ingestão de sódio podem aumentar a resistência à insulina (RI) e induzir alterações nas lipoproteínas séricas e em marcadores de inflamação semelhantes às encontradas na síndrome metabólica (SM). Realizou-se uma revisão sistemática da literatura sobre os efeitos da restrição do consumo de sódio sobre a SM ou a RI. Nove artigos foram incluídos na revisão. A restrição no consumo de sódio associou-se ao aumento da RI em dois artigos e a diminuição em três outros. Em sete dos nove artigos, a restrição na ingestão de sal determinou redução da pressão arterial e em dois artigos ocorreram efeitos adversos em marcadores da SM. A maioria dos estudos mostrou efeitos benéficos da restrição moderada de sódio da dieta associados ou não a outras modificações nutricionais ou ao aumento da atividade física. Novos estudos são necessários para avaliar os efeitos de reduções moderadas no consumo de sódio sobre a SM e a RI.
Recent studies have shown that sodium intake restrictions may increase insulin resistance (IR) and induce changes on serum lipoproteins and on inflammation markers that are similar to those found in metabolic syndrome (MS). We performed a systematic review of literature regarding the effects of restricting sodium intake on MS or on IR. Nine articles were included in the review. Restriction of sodium consumption was associated with increase insulin resistance in two articles and with decrease in three others. In seven of nine articles, salt intake restriction determined blood pressure reduction, and in two articles adverse effects on markers of MS were found. Most studies showed beneficial effects of moderate sodium intake restriction, associated or not to others nutritional modifications or increased physical activity. Further studies are needed to evaluate the effects of moderate sodium consumption reductions on MS and IR.
Subject(s)
Humans , Male , Female , Blood Pressure/drug effects , Insulin Resistance/physiology , Metabolic Syndrome/etiology , Sodium Chloride, Dietary/adverse effects , Hypertension/diagnosis , Hypertension/physiopathology , Metabolic Syndrome/diagnosis , Metabolic Syndrome/physiopathology , Sodium Chloride, Dietary/administration & dosageABSTRACT
Osteopontin (OPN) is a secreted phosphoprotein that is constitutively expressed in the normal kidney and is induced by various experimental and pathologic conditions. Several possible functions of OPN have been suggested, however the mechanism and significance of OPN expression are still uncertain. Since high salt concentration or salt crystal have been known to enhance OPN expression in intact kidney or cultured renal cells, in the present study we examined whether or not a low salt condition had an effect on OPN expression in the kidney. Adult male Sprague-Dawley rats were fed either a normal sodium or a sodium deficient diet for 1 week. Kidneys were processed for in situ hybridization using a digoxigenin-labeled riboprobe and for immunohistochemistry using antibodies to OPN, renin, and Na-K-ATPase. In rats fed a normal sodium diet, OPN mRNA and protein were expressed only in the descending thin limbs of Henle's loop (DTL) and in the papillary and pelvic surface epithelium (PSE). In rats fed a sodium deficient diet, there was a marked decrease in OPN immunoreactivity in the DTL, but no changes in PSE. In contrast, no changes were observed in OPN mRNA expression in the DTL by in situ hybridization, indicating that decreased OPN protein expression was a result of translational regulation. As expected, rats fed a sodium deficient diet were associated with increased immunoreactivity for Na-K-ATPase and renin compatible with activation of the renin-angiotensin system. These results suggest that dietary sodium may be involved in the regulation of OPN expression in the DTL of the rat kidney.