Clinical study on the treatment of chronic perianal eczema with Qufeng Zhiyang Decoction and Fuzhiqing Ointment / 国际中医中药杂志

Objective:To evaluate the efficacy of Qufeng Zhiyang Decoction combined with Fuzhiqing Ointment in the treatment of chronic perianal eczema.Methods:Randomized controlled trial. A total of 122 patients with chronic perianal eczema in Meishan People's Hospital from January 2020 to May 2021 were selected as the observation objects and divided into 2 groups according to random number table method, with 61 cases in each group. The conventional group was treated with Fuzhiqing Ointment. The study group was treated with Qufeng Zhiyang Decoction. The treatment for both groups lasted for two weeks. TCM symptom score was recored before and after treatment; the degree of skin lesions was evaluated by the area and Eczema Area and Severity Index (EASI); the quality of life of patients was evaluated by the quality of life index of dermatosis (DLQI); the number of Treg and Th17 cells was measured by flow cytometry; the ratio of Th17/Treg cells was calculated; the levels of TNF-α, IL-10 and IL-6 were detected by ELISA. The adverse reactions were recorded and the clinical efficacy was evaluated. The patients were followed up for 3 months and the recurrence was recorded.Results:The total effective rate of the study group was 86.89% (53/61) and that of the conventional group was 72.13% (44/61), with statistical significance ( χ2=4.08, P=0.044). After treatment, the scores of pruritus, spurt water, erythema and burning, upset and thirsty, yellow urine and dry urine in the study group were lower than those in the conventional group ( t values were 19.64, 49.13, 19.64, 33.14, 24.61, P<0.01); EASI and DLQI scores were lower than those in the conventional group ( t values were -6.52 and -29.33, P<0.01). After treatment, Treg cells [(6.58±0.78) % vs. (5.49±0.81) %, t=7.57] in the study group was higher than that of the conventional group ( P<0.01), Th17 cells [(1.03±0.28) % vs. (1.27±0.39) %, t=-3.90] and Th17/Treg ratio [(0.15±0.07) vs. (0.23±0.05), t=7.68] were lower than those in the conventional group ( P<0.01). After treatment, the level of IL-10 in the study group was higher than that of the conventional group ( t=-16.97, P<0.01), and the levels of IL-6 and TNF-α were lower than those in the conventional group ( t values were -21.48 and -25.59, P<0.01). During treatment, the incidence of adverse reactions was 6.56% (4/61) in the study group and 9.84% (6/61) in the conventional group, without statistical significance in the incidence of adverse reactions between the two groups ( χ2=0.44, P=0.509). During the follow-up period, the recurrence rate was 15.09% (8/53) in the study group and 50.00% (22/44) in the conventional group, with statistical significance in the recurrence rate between the two groups ( χ2=14.55, P<0.01). Conclusion:Qufeng Zhiyang Decoction combined with Fuzhiqing Ointment can reduce the levels of inflammatory factors in patients with chronic perianal eczema, maintain Th17/Treg cell immune balance, improve clinical efficacy, and have a low recurrence rate.

Effect of Lactobacillus coryniformis FZU63 on the flavor quality of black tea beverage / 生物工程学报

The tea beverages will be endowed with distinct aroma and taste, as well as various biologically active compounds including probiotic factors, when fermented with lactic acid bacteria (LAB). However, at present, few studies on the dynamics of flavors in tea soup at different fermentation stages were conducted. In this study, the composition of monosaccharides, aromatic components, free amino acids, and organic acids were measured, when the black tea beverages were fermented with Lactobacillus coryniformis FZU63 which was isolated from Chinese traditional kimchi. The results indicated that monosaccharides including glucose, fructose, mannose and xylose in black tea beverages are the main carbon sources for fermentation. In addition, the abundance of aromatic compounds in black tea soup are increased significantly at different fermentation stages, which endow the fermented black tea soup with fruit aroma on the basis of flowery and nutty aroma. Moreover, some bitter amino acids are reduced, whereas the content of sweet and tasty amino acids is elevated. Furthermore, the levels of lactic acid, malic acid, citric acid and other organic acids are accumulated during the fermentation. Additionally, sensory evaluation displays that black tea beverage is acquired with comprehensive high-quality after being fermented for 48 h. This study provides a theoretical basis to steer and control the flavor formation and quality of the fermented tea beverages during LAB fermentation.

Effect of Lycium barbarum soup on histological structure, inducible nitric oxide synthase activity, Caspase-3 and nuclear factor-κB protein expression in retina of mice injured by heroin / 解剖学报

Objective To explore the effects of Lycium barbarum soup on retina histological structure and related active substances in mice injured by heroin. Method Totally 120 Kunming mice were randomly divided into control group, heroin group, Lycium barbarum 1 group and Lycium barbarum 2 group. The mice were intraperitoneal

Comparison of Salinity and Sodium Content by the Salinity Measurement Frequency of Soups of Childcare Centers Enrolled in the Center for Children's Food Service Management in Daegu / 대한지역사회영양학회지

OBJECTIVES: This study examined the salinity of soups provided at childcare centers by measuring the salinity for three years and providing basic data for sodium reduction.METHODS: The soup salinity was measured using a Bluetooth salinity meter from January 2015 to December 2017 at 80 childcare foodservice establishments enrolled in the Suseong Center for Children's Foodservice Management in Daegu.RESULTS: An analysis of the soup salinity each year showed that the salinity decreased significantly from 0.48% in 2015 to 0.41% in 2017, particularly in clear soups and soybean soups compared to other soups (P < 0.05). The salinity and sodium content in seafood soups (0.45% and 179.1 mg/100 g, respectively) were highest, followed by soybean soups (0.44%, 175.2 mg/100 g), with perilla seed soups containing the lowest (0.42%, 167.2 mg/100 g) (P < 0.05). The salinity was significantly higher in institutional foodservice establishments than small foodservice establishments (P < 0.001). The salinity and sodium content were the highest in foodservice establishments with a small number of measurements, and the salinity was the lowest in foodservice establishments with salinity measurements performed an average of 151 times each year (three times a week) or more (P < 0.05). The soup salinity was low in the order of winter, spring, summer, and autumn, and the salinity decreased significantly year by year in all seasons. (P < 0.05).CONCLUSIONS: The soup salinity was significantly lower in foodservice establishments where the salinity was measured more than three times a week, indicating that continuous salinity management is effective.

Effect of Erxian Shengbai Decoction Combined with Huangqi Huanagshan Soup on Leukopenia After Chemotherapy and Regulatory Effect on Immunity / 中国实验方剂学杂志

Objective:To observe the clinical efficacy of Erxian Shengbai decoction combined with Huangqi Huang soup for leucopenia (deficiency of spleen and kidney Qi) after chemotherapy, and to investigate the regulatory effect on immune function and cytokines. Method:One hundred and fifty patients were randomly divided into control group（75 cases） and observation group （75 cases）by random number table. Patients in group got batilol tablets by oral administration for 6 weeks, 60 mg/time, 3 times/day. And the patients at stage Ⅲ or Ⅳ additionally received recombinant human granulocyte colony stimulating factor injection (rhG-CSF) for subcutaneous injection,2-5 μg·kg-1·d-1, until the count of neutrophils recovered to 5.0×109个/L (10.0×109个/L for white blood cell). In the control group shengbaikang granules were taken orally,1 bag/time,3 times/day.Patients in observation group additionally received Erxian Shengbai decoction combined with Huangqi Huangshan soup for 6 weeks, 1 doses/day. Number of peripheral blood leukocytes (WBC) and neutrophils (NEUT), time to recovery, number of infections, duration of using antibiotics, dose and duration of rhG-CSF, red blood cell (RBC) count, hemoglobin (Hb), platelets (PLT) and rate of completed chemotherapy were recorded. Scores of traditional Chinese medicine（TCM）syndrome and karnofsky performance scale (KPS) were graded before and after treatment. Levels of T lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) , natural killer cell (NK), interleukin-2 (IL-2), IL-6, and tumor necrosis factor-α (TNF-α) were all detected. Result:In the analysis of rank sum test, to the efficacy for leucopenia in observation group was better than that in control group (Z=2.057, P<0.05). Levels of WBC, NEUT, RBC, Hb and PLT were higher than those in control group (P<0.01). Time to recovery, number of infections and duration of using antibiotics, dose and duration of rhG-CSF were all less than those in control group (P<0.01). After treatment, the recovery rate of WBC and NEUT as well as completed chemotherapy were 76.12% (51/67), 73.13% (49/67) and 92.54% (62/67) in observation group, higher than 57.35% (39/68), 52.94% (36/68) and 79.41% (54/68) in control group (P<0.01). Levels of NK, CD3+, CD4+, CD4+/CD8+ and IL-2 were all higher than those in control group (P<0.01), while levels of CD8+ , IL-6 and TNF-α were lower than those in control group (P<0.05). Conclusion:Erxian Shengbai decoction combined with Huangqi Huangshan soup can promote the recovery of WBC and NEUT, stabilize the immune function, regulate cytokines, improve the microenvironment of bone marrow hematopoiesis, improve the completion rate of chemotherapy, reduce the number of infections and the amount of rhG-CSF, relieve clinical symptoms, and stabilize the quality of life in patients with leukopenia after chemotherapy (deficiency of spleen and kidney Qi).

Morfeas con manifestaciones cefálicas / Morpheas with cephalic manifestations

Introducción: La hemiatrofia facial progresiva (HFP) o síndrome de Parry-Romberg y la morfea en golpe de sable (MGS) forman parte de las morfeas lineales cefálicas. Son enfermedades inflamatorias crónicas de la piel y tejidos subyacentes, que se caracterizan por esclerosis y atrofia cutánea. Objetivos: Describir las características clínicas, manifestaciones asociadas, histología, laboratorio, estudios complementarios y tratamientos instaurados. Diseño: Estudio retrospectivo descriptivo. Materiales y métodos: Se revisaron las historias clínicas de pacientes con morfea evaluados en el Sector Colagenopatías desde julio de 2010 hasta diciembre de 2016. Resultados: De 56 pacientes, 11 cumplieron con los criterios de inclusión, 7 con diagnóstico de HFP, 2 con MGS y 2 con ambas patologías. El 64% fueron mujeres. Las manifestaciones extracutáneas se presentaron en el 64% de los casos. El tratamiento utilizado en todos los pacientes fue el metotrexato, asociado o no, al uso de corticosteroides sistémicos. Conclusiones: La mayoría de nuestros resultados concuerdan con la bibliografía consultada, excepto las manifestaciones asociadas. Destacamos el tratamiento asociado de metotrexato y pulsos de corticosteroides intravenosos con resultados satisfactorios y bien tolerado. (AU)

Introduction: Progressive facial hemiatrophy (PFH) or Parry-Romberg Syndrome and morphea en coup de sabre are cephalic linear morpheas. They are chronics inflammatories diseases of the skin and underlying tissues, characterized by cutaneous atrophy and sclerosis. Objectives: To describe clinical features, associated extracutaneous manifestations, histological and laboratory findings, imaging and diagnostic modalities and treatments established in patients with diagnosis of HFP, MGS, or both, evaluated in our Department. Design: Retrospective descriptive study. Materials and methods: We included medical histories of patients diagnosed with morphea evaluated in Collagenopathy Sector from July 2010 up to December 2016. Results: Of 56 patients, 11 met the inclusion criteria, 7 with diagnosis of PFH, 2 with morphea en coup de sabre and 2 with both pathologies. 64% were women. 64% showed extracutaneous manifestations. The treatment used in all of the patients was methotrexate, associated or not, with the use of systemic corticosteroids. Conclusions: Most of our results agree with the bibliography consulted, with the exception of the associated manifestations. We emphasize the associated treatment of methotrexate and intravenous corticosteroid pulses with satisfactory results and well tolerated. (AU)

Observation of Xiaopi-Zhitong-Poyu decoction combined with gosserin sustained-release implant for the treatment of endometriosis after laparoscopy / 国际中医中药杂志

Objective To evaluate the efficacy of Xiaopi-Zhitong-Poyu decoction combined with gosserin sustained-release implant for the treatment of endometriosis after laparoscopy. Methods A total of 204 patients with endometriosis who met the inclusion criteria were divided into 2 groups by random number table methods, with 102 cases in each group. On the 5th day after the operation, the control group was subcutaneously injected with Gosserin sustained-release implant in the anterior abdominal wall on the basis of routine treatment, the observation group was added with Xiaopi-Zhitong-Poyu soup on the basis of the control group. Both groups were treated for 24 weeks and followed up for 3 years. The World Health Organization Quality of Life Scale-Brief Form Questionnaire (WHOQOL-BREF) was used to evaluate the quality of life of patients. The TCM symptom scores were used to evaluate the menstrual pain, waist sour bloated, thin stool, dizziness and abnormal menstruation. The FSH, E2 and LH was detected by full automatic serum analyzer, and the endomethal antibody (EMAb), matrix metalloproteinase-3 (mmp-3) and carbohydrate antigen 125(ca-125) were detected by enzyme labeling instrument. Clinical efficacy was evaluated and adverse reactions during treatment were recorded. Results The total effective rate was 93.1% (95/102) in the observation group and 80.4% (82/102) in the control group, with statistically significant differences (χ2=3.871, P=0.039). After treatment, scores in environmental field, life field, physiological field and social relation field in the observation group were all significantly higher than those in the control group (t values were 4.725, 4.930, 4.259, 4.571, all Ps<0.05). Scores of menstrual pain, waist sour bloated, thin stool, dizziness and abnormal menstruation in the observation group were all significantly lower than those of the control group (t values were 3.561, 3.457, 3.421, 3.652, 3.529, all Ps<0.05). After treatment, the serum FSH (1.48 ± 0.15 U/L vs. 2.98 ± 0.29) U/L, t=3.174), E2 (52.17 ± 5.25 pg/ml vs. 88.04 ± 8.23 pg/ml, t=3.141), LH (1.82 ± 0.18 U/L vs. 2.45 ± 0.25 U/L, t=3.372) levels in the observation group were significantly lower ( P<0.05); Serum EMAb (0.23 ± 0.02 vs. 0.32 ± 0.03, t=3.763), MMP-3 (69.69 ± 6.68 μg/L vs. 82.57 ± 8.89 μg/L, t=3.890], the CA-125 (25.89 ± 2.78 U/ml vs. 61.43 ± 6.78 U/ml, t=3.652) levels in the observation group were significantly lower (P<0.05). The recurrence rates of the observation group were 4.2% (4/95), 7.4% (7/95), 12.6% (12/95) at 1, 2, and 3 years respectively, while those of the control group were 13.4% (11/82), 18.3% (15/82), 25.6% (21/82), respectively. The differences were statistically significant ( χ 2 values were 3.309, 3.911, 4.102, all Ps<0.05). Conclusions The Xiaopi-Zhitong-Poyu decoction combined with gosserin sustained-release implant can reduce the hormone level of patients with endometriosis after laparoscopic surgery, improve the content of markers of endometriosis, improve the quality of life and clinical efficacy of patients, and reduce adverse reactions.

Usage of Traditional and Complementary Medicine among Dengue Fever Patients in the Northeast Region of Peninsular Malaysia

@#Background: The recent epidemic of dengue fever (DF) in Malaysia was alarming. The treatment of DF remains supportive as there is no anti-viral agent or vaccine available as yet. Traditional and complementary medicine (T&CM) provides an alternative option for the treatment of DF but there is limited evidence with regard to its usage. The aim of this study was to determine the prevalence, types and predictor factors of T&CM usage among DF patients in the northeast region of Peninsular Malaysia. Methodology: This was a cross-sectional study of DF patients in the northeast region of Peninsular Malaysia who had been admitted to a tertiary centre from January 2014 until December 2015. Serologically-confirmed DF patients aged 18 years and above were randomly selected. Phone interviews were conducted to obtain information regarding the use of T&CM during hospitalisation. Notes were made regarding the prevalence and type of T&CM used. Binary logistic regressions were used to identify the predictor factors of T&CM usage. Results: A total of 241 DF patients with a mean age of 36.62 (SD = 14.62) years were included. The estimated prevalence of T&CM usage was 84.6% (95%CI: 80.1%, 89.2%). The most common T&CM used were crab soup (85.3%), papaya leaf extract (64.2%) and isotonic drinks (61.8%). The significant predictors for T&CM usage were age [adjusted odds ratio (AOR) 0.97; 95%CI: 0.94, 0.99], tertiary education (AOR 3.86; 95%CI: 1.21, 12.32) and unemployment (AOR 2.55; 95%CI: 1.02, 6.42). Conclusion: The prevalence of T&CM usage in our population is high. Age, tertiary education and unemployment influence the use of T&CM.

Observation of Xiaopi-Zhitong-Poyu decoction combined with gosserin sustained-release implant for the treatment of endometriosis after laparoscopy / 国际中医中药杂志

Objective@#To evaluate the efficacy of Xiaopi-Zhitong-Poyu decoction combined with gosserin sustained-release implant for the treatment of endometriosis after laparoscopy.@*Methods@#A total of 204 patients with endometriosis who met the inclusion criteria were divided into 2 groups by random number table methods, with 102 cases in each group. On the 5th day after the operation, the control group was subcutaneously injected with Gosserin sustained-release implant in the anterior abdominal wall on the basis of routine treatment, the observation group was added with Xiaopi-Zhitong-Poyu soup on the basis of the control group. Both groups were treated for 24 weeks and followed up for 3 years. The World Health Organization Quality of Life Scale-Brief Form Questionnaire (WHOQOL-BREF) was used to evaluate the quality of life of patients. The TCM symptom scores were used to evaluate the menstrual pain, waist sour bloated, thin stool, dizziness and abnormal menstruation. The FSH, E2 and LH was detected by full automatic serum analyzer, and the endomethal antibody (EMAb), matrix metalloproteinase-3 (mmp-3) and carbohydrate antigen 125(ca-125) were detected by enzyme labeling instrument. Clinical efficacy was evaluated and adverse reactions during treatment were recorded.@*Results@#The total effective rate was 93.1% (95/102) in the observation group and 80.4% (82/102) in the control group, with statistically significant differences (χ2=3.871, P=0.039). After treatment, scores in environmental field, life field, physiological field and social relation field in the observation group were all significantly higher than those in the control group (t values were 4.725, 4.930, 4.259, 4.571, all Ps<0.05). Scores of menstrual pain, waist sour bloated, thin stool, dizziness and abnormal menstruation in the observation group were all significantly lower than those of the control group (t values were 3.561, 3.457, 3.421, 3.652, 3.529, all Ps<0.05). After treatment, the serum FSH (1.48 ± 0.15 U/L vs. 2.98 ± 0.29) U/L, t=3.174), E2 (52.17 ± 5.25 pg/ml vs. 88.04 ± 8.23 pg/ml, t=3.141), LH (1.82 ± 0.18 U/L vs. 2.45 ± 0.25 U/L, t=3.372) levels in the observation group were significantly lower (P<0.05); Serum EMAb (0.23 ± 0.02 vs. 0.32 ± 0.03, t=3.763), MMP-3 (69.69 ± 6.68 μg/L vs. 82.57 ± 8.89 μg/L, t=3.890], the CA-125 (25.89 ± 2.78 U/ml vs. 61.43 ± 6.78 U/ml, t=3.652) levels in the observation group were significantly lower (P<0.05). The recurrence rates of the observation group were 4.2% (4/95), 7.4% (7/95), 12.6% (12/95) at 1, 2, and 3 years respectively, while those of the control group were 13.4% (11/82), 18.3% (15/82), 25.6% (21/82), respectively. The differences were statistically significant (χ2 values were 3.309, 3.911, 4.102, all Ps<0.05).@*Conclusions@#The Xiaopi-Zhitong-Poyu decoction combined with gosserin sustained-release implant can reduce the hormone level of patients with endometriosis after laparoscopic surgery, improve the content of markers of endometriosis, improve the quality of life and clinical efficacy of patients, and reduce adverse reactions.

Alimentación autóctona y saludable en organizaciones comunitarias de la Ciudad Autónoma de Buenos Aires / Healthy and autochthonous food in community organizations within Autonomous City of Buenos Aires

Introducción: en la Ciudad de Buenos Aires (CABA), se desarrollan iniciativas de seguridad alimentaria destinadas a la población vulnerable, dirigidas por organizaciones comunitarias en comedores. Reconocer la diversidad cultural en los espacios comunitarios permite valorar el significado que tienen los alimentos para la población asistida, como las consideraciones relacionadas a las prácticas alimentarias autóctonas. Objetivos: contribuir a mejorar la utilización de recursos y adaptar las costumbres culinarias autóctonas en comedores comunitarios para promover la salud y bienestar nutricional de la población asistida. Materiales y método: estudio prospectivo y descriptivo. Se realizó un análisis sociocultural de las costumbres alimentarias en la población migrante, beneficiarios del Programa Apoyo a Grupos Comunitarios de la CABA. Los datos se recolectaron a través de una encuesta mixta semiestructurada. Resultados: se encuestaron a 59 personas (52 mujeres) edad promedio 35 años. La distribución poblacional fue heterogénea: 62% bolivianos, 21% paraguayos, 11% argentinos hijos de migrantes, 4% peruanos y 2% chilenos. El 89% considera a las comidas típicas beneficiosas para la salud, el 78% consume alimentos autóctonos ocasionalmente en eventos especiales. Refirieron asociar sus comidas típicas a diversas emociones como felicidad y recuerdos. Conclusiones: Los comedores comunitarios permiten a la población acceder a los alimentos, lugar donde confluyen culturas diversas. Es necesario promover espacios para valorar los patrimonios gastronómicos, preservar su transmisión a las generaciones que suceden. Dar relevancia a la cultura alimentaria es necesario para promover la soberanía alimentaria(AU).

Introduction: in the City of Buenos Aires (CABA), food security initiatives are developed for the vulnerable population, directed by community organizations in soup kitchens. Recognizing cultural diversity in these community areas allows valuing the meaning foods have for assisted populations, as well as considerations related to autochthonous food practices. Objectives: to improve resources and adapt autochthonous food customs in soup kitchens in order to promote health and nutritional wellbeing within the assisted population. Materials and methods: prospective, descriptive and longitudinal study. A sociocultural analysis of food customs of migrant population that benefit from the Support Program to Community Groups (CABA) was carried out. The data was collected through a semi-structured mixed survey. Results: 59 people (52 women) were surveyed; average age 35. The population distribution was heterogeneous: 62% Bolivians, 21% Paraguayans, 11% Argentine (children of migrants), 4% Peruvians and 2% Chileans. Eighty-nine per cent consider typical foods as beneficial for health. 78 per cent consume autochthonous foods only on special social events. They referred association of their typical foods to several emotions such as happiness and memories. Conclusions: soup kitchens allow access to food assistance, constituting a place where different cultures converge. It is necessary to promote spaces to value gastronomic heritage, and preserve transmission in successive generations. Giving relevance to food culture is necessary to promote food sovereignty(AU).

Effect of Selfheal soup combined benzene sulfonic acid amlodipine on elderly patients with hypertension and its effect on plasma endothelin-1 / 中国基层医药

Objective To study the clinical curative effect of Chinese traditional medicine Prunella vulgaris Decoction for elderly hypertensive patients ,and its influence on endothelin －1( ET －1).Methods From January 2016 to January 2018,76 senile patients with hypertension in Wenling Hospital of Traditional Chinese Medicine were selected.According to different therapeutic methods ,the patients were divided into two groups ,with 38 cases in each group.The control group was given calcium antagonists benzene sulfonic acid amlodipine therapy , the observation group was given the combined therapy of Chinese and western medicine ( Prunella vulgaris Decoction combined with benzene sulfonic acid amlodipine ).All the patients were treated for 2 months,the therapeutic effect was evaluated . The 24－hour average diastolic blood pressure (24hDBP),24－hour average systolic blood pressure (24hSBP),and diastolic pressure (dDBP),the day systolic blood pressure (dSBP),diastolic blood pressure at night (nDBP) and nocturnal systolic blood pressure (nSBP) were used to evaluate the clinical curative effect .Before and after treatment, the plasma ET－1 level was used to evaluate the influence on endothelial function .The clinical curative effect and its influence on ET－1 were compared between the two groups .Results After treatment,the 24hDBP,24hSBP,dDBP, dSBP,nDBP and nSBP in the observation group were significantly lower than those in the control group [24hDBP (72.26 ±4.62)mmHg vs.(86.63 ±5.18) mmHg,24hSBP (133.26 ±6.71) mmHg vs.(143.29 ±7.22) mmHg, dDBP (76.08 ±5.26)mmHg vs.(87.32 ±5.73)mmHg,dSBP (136.51 ±8.63)mmHg vs.(153.67 ±9.51)mmHg,nDBP (72.34 ±3.96)mmHg vs.(80.75 ±4.27)mmHg,nSBP (133.64 ±5.21)mmHg vs.(148.27 ±6.32)mmHg,t＝12.637,11.268,11.762,12.406,10.625,11.738,all P＜0.05].The plasma ET－1 level of the observation group was (59.37 ±7.82)μg/L,which was significantly lower than (67.58 ±7.72)μg/L of the control group (t ＝10.653,P＜0.05).Conclusion Prunella vulgaris Decoction in the treatment of elderly hypertensive patients can effectively improve therapeutic effect , lower the blood pressure levels , and can improve endothelial function , it is worthy of popularization and application .

Clinical effect of Zhengan Xifeng decoction in the treatment of Parkinson's disease / 中国基层医药

Objective To observe the clinical effect of Zhengan Xifeng decoction in the treatment of Parkinson's disease.Methods From January 2013 to January 2017,100 patients with Parkinson's disease in the People's Hospital of Dongping County were included in the study and they were randomly divided into two groups according to the digital table,with 50 cases in each group.The control group was treated with Madopar,the observation group was treated with Madopar combined with Zhengan Xifeng decoction.Mter 12 weeks of treatment,the clinical efficacy,incidence of adverse reactions,unified Parkinson's disease score,ADL score,cognitive function index of the two groups were compared.Results The total effective rate of the observation group was 92％ (46/50),which was significantly higher than 74％ (37/50) of the control group (x2 =5.741,P ＜ 0.05).The incidence rate of adverse reactions of the observation group was 6％ (3/50),which of the control group was 4％ (2/50),the difference was not statistically significant(x2 =0.211,P ＞ 0.05).After treatment,the unified Parkinson's disease score,ADL score,Montreal cognitive function score,mini mental state score in the observation group were (49.93 ± I0.86) points,(85.71 ± 14.53) points,(25.93 ± 2.76) points,(23.81 ± 4.12) points,respectively,which in the control group were (60.56 ± 11.49) points,(71.46 ± 14.02) points,(22.56 ± 2.65) points,(19.42 ±.4.05) points,respectively,there were statistically significant differences between the two groups (t =4.754,4.990,6.228,5.373.all P ＜ 0.05).Conclusion Zhengan Xifeng decoction in the treatment of Parkinson's disease can effectively improve the patients' cognitive function,daily life ability,alleviate the symptoms of Parkinson's disease.

Expression of miR-34a in the myocardium of mice received Danggui Buxue Decoction therapy following myocardial infarction / 实用医学杂志

Objective To investigate the effect of Danggui buxue decoction on ventricular remodeling and miR-34a expression after myocardial infarction in mice. Methods Mice myocardial infarction model were estab-lished by the left anterior descending coronary artery embolization. Then the mice were divided into Danggui buxue Decoction group and model group. Mice in Danggui buxue decoction group were given Danggui buxue decoction , and mice in the model group were given the equal volume of saline for 8 weeks. Cardiomyocyte apoptosis was detect-ed by TUNEL staining. Myocardial fibrosis was detected by Masson staining. The expression of miR-34a was detect-ed by quantitative PCR and the expression of Sirt1 was detected by Western blot assay. Results Compared with the model group ,the EF value of the mice was significantly improved (P < 0.05),the myocardial cell index decreased(P<0.05),the content of collagen fibers decreased(P<0.05),the expression of miR-34a decreased, but the expression of Sirt1 increased(P<0.05)in Danggui buxue Decoction group. Conclusion Danggui buxue decoction can effectively inhibit ventricular remodeling of mice following myocardial infarction ,which is associated with the suppression of miR-34a and the increase of Sirt1.

Effect of Liujunzi soup on allergic cough in remission stage and total inflammation of children / 中国生化药物杂志

Objective To evaluate the effect of Liujunzi soup on the total course of disease and inflammatory mediators in patients with remission of allergic cough. Methods Eighty six patients with allergic cough were enrolled in our hospital from April 2011 to April 2012. The patients were randomly divided into observation group (n = 43) and control group (n = 43). The control group was given basic western medicine treatment, the observation group in the control group on the basis of another treatment of six gentleman soup. The levels of inflammatory cytokines, pulmonary function and adverse reactions were compared between the two groups in clinical efficacy, hospitalization time, total course of disease, IL-2, TNF-α and IL-6. Results The total effective rate was 90.70％ in the observation group was significantly higher than that in the control group (72.09％)( P<0.05). The duration of hospitalization (13.35 ± 3.24) d and the total course of disease (17.68 ± 4.53) d were significantly shorter than those in the control group (16.23 ±3.10) d, (20.35 ± 4.67) d (P<0.05). The levels of inflammatory factors and pulmonary function in the observation group were statistically significant compared with the control group (P<0.05). No adverse reactions occurred in both groups. Conclusion Liujunzi Decoction combined with western medicine can improve the level of inflammatory cytokines and lung function, shorten the length of hospital stay, the total course of disease and high safety, and have good clinical value.

Ma Yinglong Musk Hemorrhoids Ointment combined with psychological intervention in the treatment of perianal eczema and its effect on quality of life / 中国生化药物杂志

Objective To investigate the effect of Musk Hemorrhoids Ointment Combined with psychological intervention in patients with perianal eczema and the effect on the quality of life of patients. Methods 70 patients with perianal eczema were randomly divided into control group (n=35) and observation group (n=35). The control group using triamicinolone acetonide acetate and miconazole nitrate neomycin sulfate cream with the treatment, the observation group with musk hemorrhoids ointment combined with psychological intervention treatment by SF-36 life quality scale of two groups before and after treatment to assess the quality of life, compared 2 groups of clinical curative effect and influence on the quality of life of patients. Results The observation group after treatment itching, exudation and lesion area and the symptoms and signs improved time shorter than the control group (P<0.05); quality of life score of SF-36 in observation group after treatment were higher than those in control group (P<0.05); the observation group after 2 weeks of treatment, the clinical efficiency and control group had significant difference (P<0.05). Conclusion Patients with perianal eczema with musk hemorrhoids ointment combined with psychological intervention treatment effect is ideal, it is worthy of popularization and application.

Recognition and use of Aconitum carmichaeli from the pre-Qin period to Tang Dynasty-Also on rules in evolution of traditional Chinese medicine / 中国中药杂志

The recognition and use of Aconitum carmichaeli have undergone various changes from the pre-Qin period to Tang dynasty. From "the drug of evil" to "the leader of hundreds of medicine ", people's understanding of A. carmichaeli is more and more deep and specific. The medicinal values of A. Carmichaeli have been excavated, and it is widely used in brewing skill, agricultural production, Taoism, Buddhism and festival customs. Its function is becoming more and more diversified and routinized. By studying it, we can glimpse some rules in the evolution of traditional Chinese medicine, for instance relationships between drugs and poisons, drugs and non-drug; the inheritance and integration of medical books' recording; the generalization and routinization of Chinese medicinal medicines' functions, and so on.

Effect of liver detoxification soup combined with compound glycyrrhizin on hepatitis related factors in patients with chronic hepatitis B / 中国生化药物杂志

Objective To investigate the effect of liver detoxification soup combined with compound glycyrrhizin on hepatitis-related factors in patients with chronic hepatitis B.MethodsFrom April 2014 to August 2015, 86 patients with chronic hepatitis B were enrolled in this study.Random number table was divided into observation group and control group (43 cases).The control group was given routine glycyrrhizin and other conventional (ALT), serum total bilirubin (TBil), serum albumin transferase (ALT) and serum total bilirubin (TBil) were measured before and after treatment.(HA), laminin (LN), type Ⅳ collagen (Ⅳ-C) and type Ⅲ procollagen (PCⅢ) were used to analyze the effect of hepatic fibrosis, And observe adverse reactions.ResultsThe effective rate of the observation group was 93.02% higher than that of the control group (76.74%, P<0.05).After treatment, the patients were treated with chest discomfort, emotional depression, epigastric fullness, fatigue, ALT (35.28±1.35) U/L, HA (165.25±1.44) mg/L, and the treatment group (P<0.05).After treatment, the levels of TBil (30.34±1.59)μmol/L, Alb (48.32±1.33)g/L, and the level of serum was significantly higher than that of the control group (P<0.01).The incidence of adverse reactions was 11.63% and 6.98% in the two groups.ConclusionTraditional Chinese medicine hepatectomy decoction combined with compound glycyrrhizin can effectively treat chronic hepatitis B and improve the level of serum hepatitis-related factors, and the adverse reaction is light, it is worthy of clinical application.

Effect of self-made atractylodes and spleen decoction combined with quadruple therapy on Hp-positive peptic ulcer and Its effect on wound healing, gastric secretion and recurrence / 中国生化药物杂志

Objective To observe the effect of self-assembling Atractylodes Rhizome Decoction combined with quadruple therapy on Helicobacter pylori (Hp)-positive peptic ulcer and its effect on wound healing, gastric acid secretion and recurrence.MethodsThis study was based on 70 patients with Hp-positive peptic ulcer treated in our hospital from March 2012 to May 2014.The patients were divided into study group and control group according to the order of admission.(BAO), the maximum gastric acid secretion (MAO), the peak gastric acid secretion (P<0.05).The treatment group is divided into two groups according to the treatment group.(PAO), Hp eradication and recurrence were observed and compared.ResultsAfter treatment, the total effective rate of wound healing study group was 80.00% higher than that 57.14% of the control group (χ2=4.242, P<0.05).The levels of BAO, MAO and PAO in the two groups were significantly lower than those before treatment (P<0.05).The eradication rates of Hp in the study group were significantly higher than those in the control group at 6 months and 1 year follow-up.The recurrence rate was significantly lower in the study group than in the control group (P<0.05),There was no significant difference between the two groups.ConclusionThe clinical effect of self-made Baishui Yipi Decoction combined with quadruple therapy on Hp-positive peptic ulcer patients is effective in promoting wound healing and Hp eradication, and inhibiting gastric acid secretion and reducing the recurrence rate.It is a kind of medicine worthy of clinical application Program.

Clinical study on treatment of damp-heat and resistant gastritis by regulating spleen yangwei decoction combined with rabeprazole / 中国生化药物杂志

Objective To investigate the clinical effect of regulating Spleen Yangwei Decoction combined with rabeprazole in the treatment of rheumatoid gastritis with hot and humid obstruction.MethodsFrom April 2013 to February 2015, 88 patients with reflux gastritis caused by cholecystectomy in our hospital were selected as the subjects.TCM syndrome differentiation was hot and humid type, and random number table was divided into observation Group and control group of 44 cases, the control group given rabeprazole, citrate xylapril tablets and other Western medicine treatment, observation group on the basis of this plus self-adjusting spleen and stomach soup, are treated for 3 months, (TNF-α) and interleukin-8 (IL-8) levels were measured by enzyme-linked immunosorbent assay (ELISA) in the two groups before and after treatment, and the quality of life scale was used to evaluate the levels of tumor necrosis factor-α (TNF-α) (QOL) and digital pain score (NRS) were compared between the two groups to improve the quality of life and pain, and to observe the recurrence of bile reflux and adverse reactions.ResultsThe effective rate was 93.18% in the observation group and 77.27% higher than that in the control group (P<0.05).The QOL score (121.29±1.88) in the observation group was higher than that in the control group(P<0.05).The results of bile test showed that the levels of pg/mL, IL-8 (8.58±1.64) pg/mL and NRS (2.10±0.71) were lower than those in the control group (P<0.05).There was no significant difference between the observation group (11.36%) and the control group (4.54%).The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P< 0.05).ConclusionModified Spleen Yangwei Decoction combined with rabeprazole can effectively treat rheumatoid reflux gastritis, reduce bile reflux, improve the level of inflammatory factors, quality of life and pain, and mild adverse reactions, it is worth in the clinical promotion application.

Efficacy and safety of traditional Chinese medicine in the treatment of chronic glomerulonephritis / 中国生化药物杂志

ObjectiveTo explore the efficacy and safety of traditional Chinese medicine in the treatment of chronic glomerulonephritis.Methods146 cases of chronic renal glomerulonephritis were randomly divided into two groups.The control group was given oral administration of valsartan 80mg on the basis of routine treatment.On the basis of the control group, Oral, two groups were treated for 12 weeks.The levels of LKN-1, TNF-α, T-PA and renal function were observed before and after treatment.The clinical efficacy and clinical efficacy of the two groups were observed.Adverse reactions.Results The levels of LKN-1 and TNF-α in group two were significantly lower than those before treatment (P<0.05), and the study group was significantly lower than the control group (P<0.05).Compared with the control group, the rats in the study group were significantly higher than those in the control group (P<0.05).After treatment, the levels of SCr, 24h urinary protein, BUN, UCr (P<0.05), and the clinical efficacy of the study group was significantly lower than that of the control group (P<0.05).The clinical curative effect of the study group was higher than that of the control group (P<0.05) There was no significant difference between the control group and the control group.Conclusion TCM treatment of chronic glomerulonephritis can increase the clinical effect, safe and reliable.