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Objective: Saposhnikoviae Radix (Fangfeng in Chinese), the roots of Saposhnikovia divaricata, lacks commodity specification and grade standardization in the current market. This study investigated the existing specifications and grades of Saposhnikoviae Radix to provide a standardized scientific reference for its market use. Methods: Based on a textual research of Chinese herbal medicine from the Han Dynasty to the present, medicinal materials of different specifications and grades obtained from Saposhnikoviae Radix in the main producing areas of China were collected and the markets for these materials were investigated. Field investigations were performed in the major producing areas such as Northeast China, Hebei Province, and Inner Mongolia. Four major Chinese herbal medicine markets in China were investigated. Sensory indices were used to categorize the two specifications (wild and cultivated) according to the shape, color, texture, and cross-section. High-performance liquid chromatography was performed to determine the active components. Vernier calipers and measuring tape were used to measure the diameter and length, respectively, of 41 samples. Using Excel and the R Language software, cluster analysis and descriptive statistical analysis were performed to assist in the application of new specifications and grades based on physical characteristics, pharmacological activity, and chemical composition. Results: The two specifications (wild and cultivated) of Saposhnikoviae Radix were divided into three grades each based on the length and diameter. Prim-O-glucosylcimifugin, 5-O-methylvisamminoside, and the length of Saposhnikoviae Radix can be used as a basis for classifying the commodity specifications and grades. The specifications and grade standards of Saposhnikoviae Radix were established based on the following eight aspects: shape, surface characteristics, texture, cross section, taste, prim-O-glucosylcimifugin content, 5-O-methylvisamminoside content and length. Conclusion: The formulation of this standard stipulates the commodity specification level of Saposhnikoviae Radix. It is also suitable for the evaluation of commodity specifications in the process of production, circulation and use of Saposhnikoviae Radix.
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Objective:To clear that the growth period of Astragali Radix (AR) is the main factor causing the traits and chemical differences by analyzing the correlation between commercial traits and chemical characteristics and absolute growth years of AR. Methods: Different grades AR from different origin were collected and divided into two specifications-wild Astragali Radix (WAR) and transplanted Astragali Radix (TAR) according to character description, length and diameter. The growth years distribution of different grades WAR were observed by hand-sections to find its distribution rule. The separation was performed on a Ultimate C18 (250 mm × 4.6 mm, 5 μm) with a mixed mobile phase of water and acetonitrile in a gradient mode. The flow rate was 1 mL/min and the wavelength of measurement was 230 nm. A total of 24 batches of the AR were determined. The content of five flavonoids in WAR and TAR were determined. Results: The results showed that the growth year of top grade AR was more than five years, grade I AR was 4-5 years, grade II AR was 3-4 years, grade III and IV AR were 1-3 years. The HPLC-UV specific chromatograms fingerprints of chemical constituents were established from the 24 batches of AR with five characteristic common peaks. Twenty-four batches of samples was assessed by similarity evaluation system for chromatographic fingerprint of TCM, the similarity of WAR was 0.892-0.994 and TAR was 0.274-0.531. AR were classified as two clusters including WAR and TAR by clustering analysis (CA) and principle component analysis (PCA). The content of total flavonoids of WAR were significantly higher than TAR. Exception the top grade WAR, the content of total flavonoids in WAR was significantly positively correlated with grade. There was no correlation in different grades of TAR. Conclusion: This study provides a scientific basis for the establishment of the grade standard of AR, and lays a foundation for further construction of the quality grade standard of AR.
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The commodity specification and grade of Curcumae Radix is an important indicator for evaluating the quality of medicinal materials. It is the basis for realizing the "price according to quality" of medicinal materials, and plays an extremely important role in regulating the market transactions and ensuring the clinical efficacy of Curcumae Radix. This paper makes a textual research on the historical evolution of the commodity specification and grade of Curcumae Radix, and sorts out the current status of the standard. At the same time, it investigates the current status of the market and origin of Curcumae Radix. It was found that the traditional classification and the quality of Curcumae Radix were mainly classified according to the indicators of origin and shape, color and other traits; In the "76 kinds of medicinal materials commodity specification standards" and "Chinese medicinal materials commodity specifications (225 kinds)", Curcumae Radix is mainly graded by traditional traits indicators, and the grading index is single; At present, Curcumae Radix is in a spontaneously grading market, and the market classification is not uniform; Curcumae Radix of origin are sold to major pharmaceutical markets and pharmaceutical factories in a unified way without grading of origin. Therefore, based on the results of the research and investigation of the specification and grade, it is proposed to improve and upgrade the specification and grade of Curcumae Radix in order to promote the formation of high-quality and high-priced trading systems. And at the same time to provide reference for the formulation of national or industrial standards for commodity specification and grade of Curcumae Radix.
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This paper is aimed to study the commodity specification and grade standard of Galla Chinensis,for standardizing market order and guide the market circulation,and provide a basis for standardization of Galla Chinensis. With 33 samples of Galla Chinensis from market as the object of the research,the herbal textual research and market research were carried out. Then the grading indicator were selected by the descriptive statistics,principal component analysis and cluster analysis,combining with production practice,the commodity specification and grade standard of Galla Chinensis were set out. The data of moisture,ash,gallic acid as the internal index were used to analyze the relationship between the quality difference between grades and the appearance characters and the intrinsic composition. Herbal textual research and market research found that the high quality of Galla Chinensis characterized with large,complete,wall thick,grayish brown characteristics,and Galla Chinensis could be divided into gallnuts and horned gall. Through principal component analysis and cluster analysis,combining actual production and herbal record,screening,the length,diameter,single weight,the number of 500 g were determined as 4 grading indicators,the commodity specification was divided into two: gallnuts and horned gall,the grades was divided into two: selected goods and mixed goods. The result of correlation analysis showed there was no significant correlation between the internal index and the appearance characters of Galla Chinensis. The result of multiple comparison showed that the ash content of the selected goods was smaller than that of the mixed goods,but it did not reach significant. The content of gallic acid of the selected goods and the mixed goods of gallnuts were higher than selected goods of horned gall,and higher than mixed goods of horned galls. Using the length,diameter,single weight,the number of 500 g as the appearance characters index. Combining with the herbal textual research and market research,we have divided two specifications and two grades for the commodity specification and grade standard of Galla Chinensis,which can provide a basis for industry standards and national standards.
Subject(s)
Drugs, Chinese Herbal , Reference Standards , Gallic Acid , Plant Tumors , Quality ControlABSTRACT
Through the records of herbal and market investigations,the samples collected from different market and origin were analyzed,and the appearance character indexes were determined in order to revise the commodity specification and grade standard of Dipsaci Radix combined with production practice. This is also to analyze association of the appearance with quality different of intrinsic components. The investigation results indicated the root's long and thick was better,and atrovirens of fracture surface,there are most of the market is dominated by the ungraded goods. Through principal component analysis,variance analysis and cluster analysis,combining with the feasibility of actual operation and herbal record,the length,middle diameter and phloem color were filtrated and the specification was divided into 2 ranks: the selection and ungraded goods,and the grade was divided into 2 ranks for the selection goods: big,small selected goods. Moreover,there were no significant correlation between the appearance and the intrinsic quality index of Dipsaci Radix,the content of extractum were significantly positive correlation with the moisture,but had extremely negative correlation with the total ash. Multiple comparisons indicated that the content of the moisture,extractum and asperosaponin VI of the selected goods were higher than the ungraded goods,while the total ash content were lower,and they hasn't significant difference. The commodity specification and grade standard of Dipsaci Radix as a basis provide commodity specification and grade standard of communities and standardizing market trade order.
Subject(s)
Cluster Analysis , Dipsacaceae , Chemistry , Drugs, Chinese Herbal , Reference Standards , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Principal Component AnalysisABSTRACT
The commodity specification and grade is a symbol of quality of Chinese medicinal materials,a standard to measure and evaluate the quality of Chinese medicinal materials,and an important part of the quality control system of Chinese medicinal materials.This article reviewed relevant research literature of commodity specification and grade of Chinese medicinal materials,including the formation and policy support of specification and grade.It analyzed the specific research examples of the commodity specification and grade of Chinese medicinal materials according to the classification of medicinal parts,and summarized the research conditions of the commodity classification at present stage.Aiming at the current research difficulties and the lack of unified standards in specification and grade of Chinese medicinal materials,some advice including research objects,methods,management,publicity,promotion and application are put forward,so as to provide references for the research on the commodity specification and grade of Chinese medicinal materials.
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Farfarae Flos, one of the important herbal drugs in Chinese materia medica (CMM), is commonly used to in the clinical and pharmaceutical industry of CMM. The quality of Farfarae Flos is closed related with its safety and efficacy in the clinic. In this review, the previous studies on the quality evaluation of Farfarae Flos were summarized and analyzed from morphological identification, microscopic identification, thin-layer chromatography, physicochemical analysis, fingerprinting, commodity specification and grade, etc, which provides the necessary reference and scientific basis for improving the quality standards of Farfarae Flos.
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Through the markets investigations and literature surveying, this paper investigates and analyzes the qualitative characteristics and commodity condition of Panax notoginseng. And the samples collected from market and origin were analyzed in order to revise the commodity specification and grade standard of P. notoginseng combined with production practice. In this paper, the authors divide the P. notoginseng into 4 commodity specification which are root (including Cunqi and Dongqi ), Rhizome and rootlet according to different parts and harvest time. And the root were divided into 8 grade which are 20, 30, 40, 60, 80, 120, countless and substandard. The density and internal components between the different commodity specification and grade of P. notoginseng were also compared. As well as the effect of different producing area, cultivation years and harvesting time on the commodity specification and grade of P. notoginseng were researched. On this basis, we revise and improve the commodity specification and grade standard of P. notoginseng. Moreover, we suggest the quality control indexes of P. notoginseng should be developed according to the different medicinal part and commodity specification in CHP. In order to guide the standardized production of traditional Chinese medicine and ensure the quality of medicinal materials, the cultivation years and density of each medicinal materials should also be indicated in CHP.
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The study is aimed to analyze the commercial specifications and grades of wild and cultivated Gentianae Macrophllae Radix based on multi-indicative constituents. The seven kinds of main chemical components containing in Gentianae Macrophyllae Radix were determined by UPLC, and then the quality levels of chemical component of Gentianae Macrophyllae Radix were clustered and classified by modern statistical methods (canonical correspondence analysis, Fisher discriminant analysis and so on). The quality indices were selected and their correlations were analyzed. Lastly, comprehensively quantitative grade division for quality under different commodity-specifications and different grades of same commodity-specifications of wild and planting were divided. The results provide a basis for a reasonable division of specification and grade of the commodity of Gentianae Macrophyllae Radix. The range of quality evaluation of main index components (gentiopicrin, loganin acid and swertiamarin) was proposed, and the Herbal Quality Index (HQI) was introduced. The rank discriminant function was established based on the quality by Fisher discriminant analysis. According to the analysis, the quality of wild and cultivated Luobojiao, one of the commercial specification of Gentianae Macrophyllae Radix was the best, Mahuajiao, the other commercial specification, was average , Xiaoqinjiao was inferior. Among grades, the quality of first-class cultivated Luobojiao was the worst, of second class secondary, and the third class the best; The quality of the first-class of wild Luobojiao was secondary, and the second-class the best; The quality of the second-class of Mahuajiao was secondary, and the first-class was the best; the quality of first-class Xiaoqinjiao was secondary, and the second-class was the better one between the two grades, but not obvious significantly. The method provides a new idea and method for evaluation of comprehensively quantitative on the quality of Gentianae Macrophyllae Radix.