Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling / 生物医学工程学杂志

The dynamic coupling of stent degradation and vessel remodeling can influence not only the structural morphology and material property of stent and vessel, but also the development of in-stent restenosis. The research achievements of biomechanical modelling and analysis of stent degradation and vessel remodeling were reviewed; several noteworthy research perspectives were addressed, a stent-vessel coupling model was developed based on stent damage function and vessel growth function, and then concepts of matching ratio and risk factor were established so as to evaluate the treatment effect of stent intervention, which may lay the scientific foundation for the structure design, mechanical analysis and clinical application of biodegradable stent.

Research progress in biomechanics of in-stent restenosis / 医用生物力学

Stent intervention has become one of the most effective ways in treating cardiac and cerebral vascular stenosis. However, postoperative in-stent restenosis remains a major unsettled issue. The occurrence of in-stent restenosis is related not only to the mismatch between stent and artery, as well as the stress induced by mechanical support of the stent struts on arterial wall, but also to the intimal hyperplasia induced by the hemodynamic change. Recent literatures on biomechanics of the stented artery were reviewed in this paper. In particular, from the view of solid mechanics and hemodynamics, the research progress of stented artery in biomechanical simulation was given detailed discussion; moreover, the biomechanical factors associated with in-stent restenosis were analyzed and summarized. Numerical simulation is a good method for investigating the relationship between stent intervention and in-stent restenosis, and it also provides a scientific guideline for the design of stent structure and clinical procedure of stent intervention.

Clinical application of expandable stent for benign and malignant esophageal obstruction / 中国微创外科杂志

Objective To study the clinical application of self-expanding nitinol stent in benign and malignant esophageal obstruction as well as in postoperative anastomotic stenosis and anastomotic leakage. Methods 22 cases of benign or malignant esophageal stenosis were treated by placing metallic stents inserted into the stenosis segment through per-oral intubation under the fluoroscopic guidance. Results The degreee of dysphagia was improved, Stooler′s staging of dysphagia was down from 3.1 preoperatively to 1.2 postoperatively. 2 cases of anastomotic leakage and 1 case of esophagorespiratory fistula were cured. All have been followed up for one to twelve months. 3 cases died with carcinoma cachexia and one succumbed to severe hemorrahage of digestive tract. The other 18 cases are still followed up. Conclusions Placement of esophageal expandable stent is one of the ideal methods to treat benign and malignant esophageal stenosis and anastomotic leakage. It can also play an important role in the improvement of the patients' life quality and prolongation of life.