ABSTRACT
It is known that silibinin has antioxidant, anti-tumor, anti-inflammatory and immunomodulatory effects, and which is widely used for liver damage caused by a variety of reasons. In recent years, it is found that silibinin has potential anti-allergic reactions. However, even larger doses of silibinin still show no significant side effects . The rare literature reports that silibinin can cause allergic reactions. The paper reports a middle-aged patient who orally took silibinin for the prevention of tuberculosis chemotherapy-induced liver damage, and he occurred symptoms of lip pain and anabrosis, foreign body sensation, and difficulty eating one day after treatment. The patient was misdiagnosed as"vesicular stomatitis"and was treated by anti-viral therapy. The patient was discharged from the hospital after treating allergic reactions. As a safe and effective drug for prevention of liver damages in clinic, silibinin should be alert to induce possible allergies when there are local skin manifestations such as lip pain and anabrosis.
ABSTRACT
Objective To evaluate the clinical effect of buccal administration of Kangfuxin Liquid combined with conventional treatment for infantile herpetic stomatitis. Method A total of 103 infantiles with herpetic stomatitis were randomly divided into a Kangfuxin group (51 cases) and a conventional group (52 cases). The conventional group received ribavirin aerosol, and the Kangfuxin group recived buccal administration of Kangfuxin Liquid based on the intervention of convertional group. All children were treated for 5 days. The white blood cell count (WBC) and the serum C-reactive protein (CRP) were determined. Result The total efficiency rate in the Kangfuxin group was significantly higher than that in the conventional group (94.1% vs. 78.8%,χ2=3.895, P<0.05). The healing time of oral ulcers (5.8 ± 1.3 d vs. 7.9 ± 1.5 d, t=10.715), body temperature recovery time (2.1 ± 1.1 d vs. 3.3 ± 1.5 d, t=4.623), and eliminating time of oral mucosal hyperemia and edema (4.3 ± 1.3 d vs. 5.3 ± 1.4 d, t=3.755) in the Kangfuxin group was significantly shorter than those in the conventional treatment group (P<0.01). The WBC (6.5×109 ± 2.2×109/L vs. 9.4×109 ± 2.3×109/L, t=6.537) and serum CRP levels (6.7 ± 1.2 mg/L vs. 9.7 ± 2.5 mg/L, t=12.686) were significantly lower in the Kangfuxin group was significantly lower than those in the conventional treatment group (P<0.01). Conclusions The total efficiency rate of buccal administration of Kangfuxin Liquid combined with conventional treatment for infantile herpetic stomatitis was higher than conventional treatment alone. And the remission time of symptoms of treatment group was shorter.
ABSTRACT
Fundamento: la Gingivoestomatitis Herpética Aguda (GEHA) es una enfermedad viral e infectocontagiosa que aparece con mayor frecuencia en lactantes y niños menores de seis años. Objetivo: diseñar un programa de superación profesional para los médicos de la familia, a través del cual adquieran los conocimientos y habilidades requeridos en el manejo integral de la GEHA a fin de promover acciones en beneficio del diagnóstico y tratamiento de la enfermedad, con enfoque integral. Métodos: se realizó un estudio descriptivo y transversal, de septiembre 2012 a julio 2013. Se utilizaron métodos teóricos: análisis-síntesis e inducción-deducción, para los referentes teóricos y el nivel de actualización de la bibliografía; empíricos: análisis documental para comprobar si se tratan en los programas de pregrado y postgrado de la carrera de Medicina los contenidos relacionados con la GEHA, y la encuesta: a los médicos de la familia para la recolección de los datos a fin de diagnosticar su nivel de conocimientos sobre el tema; y matemáticos : para los valores absolutos y relativos. Resultados: el nivel de conocimientos de los médicos de la familia sobre GEHA es insuficiente para el diagnóstico y tratamiento de los pacientes, esos contenidos no están en los programas de pregrado ni postgrado, por lo que fue diseñado un programa de superación profesional el cual fue valorado por criterios de especialistas. Conclusiones: el programa diseñado cumple con los requerimientos didácticos y curriculares para ser aplicado, pues es pertinente, asequible y tiene un adecuado tratamiento científico y metodológico en sus temáticas.
Background: acute Herpetic Gingivo-stomatitis is an infectious viral disease which appears with great frequency in breast-feeding children or under six years old. Objective: to design a Professional upgrading program for general practitioners through which they can acquire the necessary abilities and knowledge for a complete management of the Acute Herpetic Gingivo-stomatitis, in order to promote actions for a better diagnoses and treatment of this disease. Methods: a cross-sectional descriptive study was carried out from September2012 to July 2013. Different methods were used, Theoretical methods: analysis-synthesis and induction-deduction, for the theoretical foundations and updating of bibliography, empirical methods: review of documents: to confirm the presence of the contents related to Acute Herpetic Gingivo-stomatitis in the syllabuses of the Medicine career, the survey: it was applied to general practitioners for the data collection in order to diagnose their knowledge about the topic, Mathematical methods: for the analysis of absolute and relative values. Results: the knowledge general practitioners have on acute herpetic gingivo-stomatitis is insufficient to diagnose and treat patients. These contents are not present neither in the syllabuses of regular courses nor in the ones of upgrading courses, it was designed a professional upgrading syllabus for this reason, that was valued by the Criteria of Specialists method. Conclusions: the program was designed according to curricular and didactic requirements. It is pertinent, accessible and it has and adequate scientific and methodological treatment of the topics.
Subject(s)
Stomatitis, Herpetic , Health Knowledge, Attitudes, Practice , KnowledgeABSTRACT
La gingivoestomatitis herpética es una enfermedad infectocontagiosa. Aparece con mayor frecuencia en lactantes y niños menores de seis años pero también puede verse en adolescentes y adultos. Objetivo: elevar el nivel de información sobre la gingivoestomatitis herpética a través del diseño y aplicación del programa Salud para los niños. Método: se realizó una investigación de intervención cuasi experimental en el sistema y servicios de salud mediante un diseño pre y post prueba. Estuvo dirigida a los médicos de familia del policlínico José Martí y el área de salud de la clínica estomatológica Mártires de Pino Tres de Camagüey, en el período de enero a diciembre del 2007. La investigación se organizó en cinco etapas. Se confeccionó una encuesta con su respectiva escala valorativa, la que fue aplicada al inicio y final del estudio. Resultados: se diseñó el programa educativo Salud para los niños y se aplicó a los médicos de la familia. Al finalizar se realizó una evaluación a través de la encuesta. Conclusiones: el nivel de información sobre gingivoestomatitis herpética fue evaluado de regular antes de la intervención educativa, luego de aplicado el programa la totalidad de los médicos poseían un nivel de información bueno. El programa Salud para los niños generó una aceptación muy positiva, al integrar el trabajo del estomatólogo y el médico de la familia.
The herpetic gingivostomatitis is an infective-contagious disease. It appears with more frequency in infants and in children under the age of six years but also in adolescents and adults. Objective: to elevate the level of information on the herpetic gingivostomatitis through the design and application of "Health for children" program. Method: an investigation of quasi experimental intervention in the system and health services by means of a design pre and post test was performed. It was directed to family physicians of the polyclinic "José Martí" and the health area of the Odontology clinic "Mártires de Pino III" of Camagüey, from January to December of 2007. The investigation was organized in five stages. A survey was made with its respective assesment scale, which was applied at the beginning and at the end of the study. Results: the educational program "Health for children" was designed and it was applied to the family physicians. When being concluded an evaluation through the survey was carried out. Conclusions: the level of information of herpetic gingivostomatitis was evaluated of regular before the educational intervention, after having applied the program the entirety of doctors possessed a good level of information. The program "Health for children" generated a very positive acceptance, when integrating the odontologist work and the family physicians.
Subject(s)
Humans , Physicians, Family , Program Development , Stomatitis, HerpeticABSTRACT
Gengivoestomatite Herpética Aguda (GEHA) representa uma doença infecto-contagiosa causada pelo vírus herpes simples. Revela relevante freqüência entre as crianças de zero a seis anos de idade, apresentando sintomatologia prodrômica e manifestação clínica autolimitada entre dez a quatorze dias. O conhecimento desta patologia por parte do cirurgião dentista é de fundamental importância, em decorrência do potencial de contaminação, morbidade e baixa no estado geral do paciente, somadas às possíveis complicações, observadas, sobretudo, em pacientes imunocomprometidos ou imunologicamente imaturos.
Acute Herpetic Gingivostomatitis (AHG) is an infect-contagious disease caused by a virus called Herpes simplex. This illness demonstrates important frequency among very young children (varying age from 0 to 6), presenting specific symptoms and auto-limited clinical manifestations during a period of ten to fourteen days. The knowledge of the referred pathology is of fundamental importance to the dentist, even more its contamination levels, morbidity and down general patient health condition plus the possible adversed progression of the AHC in immunocompromised or immunologic immature patients.