ABSTRACT
Objective This study aims to investigate the clinical value of percutaneous vertebroplasty (PVP)combined with strontium-89 (89 Sr)on patients with spinal malignant tumor.Methods Seventy four patients who were diagnosed as spinal malig-nant tumor were divided into two groups randomly.37 patients of the control group were treated by PVP only,and 37 patients of joint group were treated by PVP and 89 Sr together.Then the clinical effect of the joint group and control group was compared after treatment.Results After treatment,the quality of life,ratio of pain relief,clinical effect and survival time in joint group were dis-tinctly better than control group (P <0.05).Conclusion PVP combined with 89 Sr can be an effective and safe treatment for pa-tients with spinal malignant tumor.
ABSTRACT
Objective To evaluate the efficacy and the toxicity of 89Strontium( 89 Sr) radionuclide therapy for the senile patients with bone metastatic cancer, and study the effects of 89 Sr on the image of bone metastasis, and to assess the utility of 89 Sr treatment for the senile patients in rehabilitation. Methods The effect on pain relief and the side effects of 27 senile patients with bone metastatic cancer were observed. The bone SPECT image was compared between those before and after the treatment, blood routine and blood biochemistry was tested. Results The total response rate was 70.4%, while the response rate of bone metastasis originated from prostatic cancer and breast cancer was 78.9%. A few metastasis sites in bone image disappeared or the concentration in the image became weak. A mild reversible harm to bone marrow function was the main side effect. 89 Sr had a little effect on blood biochemistry. Conclusion Radionuclide therapy with 89 Sr was an effective and well-tolerated method for the senile patients with bone metastatic cancer, which was a novel approach for pain-relief and rehabilitation of senile patients with bone metastatic cancer.
ABSTRACT
In patients with prostatic adenocarcinoma with bony metastasis, pain palliation is an important point in improving their life quality. It is a known fact that local external irradiation is an effective treatment modality for metastatic bone pain. Because bony metastasis often affects multiple sites in prostatic adenocarcinoma, hemibody irradiation is often necessary. But it has various complications. Strontium-89 was administered in 6 patients with prostatic adenocarcinoma with symptomatic multiple bony metastasis whose pain was not controlled with local external irradiation or antiandrogen therapy. In 2 of 6 patients, pain disappeared and in other 2 of 6 patients, pain decreased to 20% of pretreatment level. Hematologic adverse effect did not appear in any patient. Along with decreasing pain, need of analgesics decreased and life quality of the patients improved. However, the PSA level of the patients did not change. Strontium-89 treatment for patients with prostatic adenocarcinoma with symptomatic bony metastasis is a valuable treatment modality in improving life quality of the patients and time-saving when compared with other treatment modalities. However there are some unsolved questions in Strontium-89 treatment such as when to start the treatment and its indications. A prospective study thould be designed including more cases.