Paeonol derivatives and their pharmacological activities / 中草药

Paeonol has a wide range of pharmacological activities. It is mainly used to protect cardiovascular and cerebrovascular system, promote microcirculation, antibacterial and anti-inflammatory, antitumor, anti-oxidation, anti-allergic reaction, enhance immunity, and treat diabetic osteoporosis, etc. In recent years, it not only improves the method of artificially synthesizing paeonol, but also carries out a large number of structural modification and transformation of paeonol. Five major parts, carbonyl, phenolic hydroxyl, carbonyl α-H, methoxy, and benzene rings, have been mainly modified. About 16 kinds of paeonol derivatives were produced including carboxylic acid esters, sulfonates esters, phosphates esters, ethers, NO donors, glycosidation, paeonol sodium, Schiff bases, thiazoles, oximes, hydroxyalkylation, α,β-unsaturated ketones, aminomethylation, α-H halogenation, demethylation, and benzene ring halogenation. In this paper, the derivatives of paeonol and their pharmacological activities were reviewed in combination with the literatures on paeonol derivatives at home and abroad. This article may provide basis for further study of this type of compound.

Advance in research on anticancer drug β-elemene and its derivatives / 中草药

β-elemene is the sesquiterpene active monomer, as a national second-class non-cell toxic antitumor drugs which extracted from Zingiberaceae Curcuma rcenyujin. Moreover, β-elemene is currently used in clinic for treatment of lung cancer, liver cancer as well as breast cancer, and so on. Because of its broad-spectrum, safe, efficient, economical and other outstanding advantages in antitumor activities, leading to a broad application prospect in clinic. With the deep study of component and anticancer mechanisms of β-elemene, in order to promote its bioavailability and anticancer activity, researchers have screened a great deal of significant effective derivatives, and designed its liposome, microemulsion and other new drug delivery systems, which provide scientific theoretical guidance for further development and utilization of β-elemene. In this study, a systematic illustration was made for the current advance of pharmacological effects and mechanisms of β-elemene on treating cancer. In addition, the important derivatives, new drug delivery systems, and adverse reactions of β-elemene also be clarified, aiming to provide ideas for further scientific research and innovation of β-elemene.

Histone deacetylase inhibitors:research advances / 国际药学研究杂志

Histone deacetylases(HDAC)and its inhibitors have been the hot spots in the field of cancer-treatment.At pres?ent,six HDAC inbibitors(HDACi)have been approved by FDA for the treatment of various hematological neoplasms and solid tu?mors.Besides,a number of new HDACi are undergoing clinical trials in different stages or preclinical experiments,which have shown great inhibitory activities.However,a series of side effects and dose-dependent problems have appeared due to the poor selectivity of inhibitors in HDAC subtypes.So a new HDACi with high-selectity to HDAC subtypes or drug-combination will be of importance to im?prove the therapeutic effect.This review highlights the structure modification in HDACi and multiple drugs combination to summarize the latest evolution of HDACi.

Advances in Structural Modification of Steroids at A-ring / 中国药学杂志

Steroids are natural products with widespread application and attract much attention in the field of chemical industry and medicine. In order to provide reference for further research and development of steroids, this paper mainly reviews the recent advances in the structural modification of steroids at A-ring according to the changes of different structural positions and introduction of functional groups.