ABSTRACT
@#Glaucoma surgery is divided into two major categories: reducing the formation of aqueous humor and increasing the flow of aqueous humor. The former one is represented by the laser ablation of the ciliary processes, and the latter one is represented by trabeculectomy. From traditional glaucoma filtering surgery to newer glaucoma procedures, which target different aqueous outflow pathways, the use of glaucoma drainage implants has improved the safety profile of glaucoma surgery and decreased the complications during the operation and post operation, also the surgical techniques have been getting easier than ever. This article systematically reviews the clinical progress of new glaucoma drainage implants including the implants targeting the trabecular network and schlemm’s canal (iStent, Hydrus Micro-stent)，the implants targeting the superachoridial space (CyPass Micro-Stent, iStent Supra) and the implants targeting the subconjunctival space (XEN gel stent，InnFocus MicroShunt).
ABSTRACT
PURPOSE: This study was aimed to evaluate the effect of subconjunctival retention of perfluoropropane gas on the success rates in trabeculectomized rabbits. METHODS: Fifthteen white rabbits were trabeculectomized by fornix-base conjunctival flap, full thickness sclerotomy and iridectomy. The right eye was control and the left eye was injected with 0.2 ml perfluoropropane gas(C3F8) into subconjunctival space through the 30 guage long needle. Each rabbit was examined for bleb morphology under slit-lamp microscope and measured for intraocular pressure by tonopen at preoperative, postoperative 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks. The results were analyzed by Wilcoxon rank sum test in SAS release 6.12 program. RESULTS: Mean gas retention time was 15+/-2 days. Intraocular pressure measured at postoerpative 2 weeks was statistically significantly lower in gas injected group than control group. At postoperative 2 weeks, fibrovascularization was more prominent in control group than gas injected group. Fibroblast proliferation and collagen tissue formation were more prominent in control group than gas injected group at postoperative 6 weeks. CONCLUSIONS: Subconjunctival perfluoropropane gas(C3F8) bubbles, via "spacer" effect, aid the maintenance of filtering blebs in the early postoperative period. This technique may be useful in augmenting or salvaging blebs at high risk of failure.