ABSTRACT
Se realizó un estudio cuasiexperimental de 56 pacientes con diagnóstico de hidrosalpinx, que acudieron a la consulta de Medicina Natural y Tradicional del Hospital General Docente Dr Juan Bruno Zayas Alfonso de Santiago de Cuba - remitidas de las consultas de Ginecología e Infertilidad -, desde septiembre de 2014 hasta diciembre de 2015, para evaluar la respuesta a la terapia Su Jok. Entre las variables analizadas figuraron: edad, factores de riesgo, manifestaciones clínicas, síndromes tradicionales, evolución clínica y respuesta al tratamiento. En la casuística predominaron las féminas de 30-39 años, la enfermedad inflamatoria pélvica y las infecciones de trasmisión sexual como antecedentes patológicos (71,4 por ciento), el dolor y la secreción vaginal como síntomas principales, así como el estancamiento de Qi de hígado, Qi de riñón no firme y frío-humedad en bazo como síndromes más frecuentes. Finalmente, se logró una evolución favorable y una respuesta adecuada al tratamiento
A quasi-experiment of 56 patients with hydrosalpinx diagnosis that went to the Natural and Traditional Medicine Service of Dr Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba - referred from the Gynecology and Infertility Services -, was carried out from September, 2014 to December, 2015, to evaluate the response to Su Jok therapy. Among the analyzed variables there were: age, risk factors, clinical features, traditional syndromes, clinical course and response to the treatment. In the case material there was a prevalence of women aged 30-39, pelvic inflammatory disease and sexually transmitted infections as pathological history (71.4 percent), pain and vaginal secretion as main symptoms, as well as Qi liver stagnation, not firm Qi kidney and coldness-humidity in spleen as most frequent syndromes. Finally, there was a favorable clinical course and an appropriate response to the treatment
Subject(s)
Humans , Female , Adult , Middle Aged , Complementary Therapies , Pelvic Inflammatory Disease/complications , Fallopian Tube Diseases/therapy , Medicine, Chinese Traditional , Salpingitis/therapy , Secondary Care , Pelvic Pain/therapyABSTRACT
The CD19-targeted chimeric antigen receptor (CAR) T-cell treatment has achieved clinical success in treating B-cell lineage hematopoietic malignancies. This accomplishment involved the precise and efficient elimination of tumor cells by tumor-associated an-tigen-redirected immune cells. As a result, the reinitiation of several CAR T-cell (CART) based clinical trials in solid tumors was promot-ed. However, developing a feasible and efficient CAR T based therapeutic modality for solid tumors is urgently needed given the differ-ential properties between liquid and solid tumors. In this review, we discuss the advances in the management of cytotherapeutic mo-dality for solid tumors. The aspects considered include toxicity management, target selection, and primer or conditioning treatment.
ABSTRACT
PURPOSE: Recent studies have showed a 7~15% lymph node metastasis rate in T1 rectal cancer. Surgical options for T1 rectal cancer are radical resections, local excisions, and local excisions with adjuvant radiotherapy. Outcomes according to the type of surgery are variable. The present study was performed to assess outcomes of T1 rectal cancer according to therapeutic modalities and to provide guidelines for appropriate treatment of T1 rectal cancer. METHODS: A retrospective study of 117 patients with T1 rectal cancer who underwent surgery between June 1989 and December 2002 at Asan Medical Center was conducted. Radical resections, local excisions, and local excisions with adjuvant radiotherapy were performed as therapeutic modalities. Adjuvant radiotherapy after local excision was performed in patients with sm2 or sm3 cancers, lympho-vascular invasion (+), poorly differentiated cancer, and resection margin (+) or because of a patient's refusal to undergo a radical resection. RESULTS: Twenty-five (21.3%) patients were treated by local excision, 14 (12.0%) by adjuvant radiotherapy after local excision, and 78 (66.7%) by radical resection. The distance from the anal verge was significantly longer in the radical resection group than in the local excision group (7.8+/-3.4 vs. 4.9+/-2.1 cm; P<0.001). There was no significant difference by age, sex, or pathologic findings between the three groups. There was one local recurrence in the local excision group, one distant metastasis in the local excision with adjuvant radiotherapy group, and two distant metastases in the radical resection group. The 5-year cancer-specific survival and disease-free survival rates were as follows; local excision group, 94.1 and 95.8%, respectively; local excision with adjuvant radiotherapy group, 100 and 92.8%, respectively; radical resection group, 98.3 and 98.6%, respectively. There were no significant differences in survival between the groups. CONCLUSIONS: Oncological outcomes of T1 rectal cancer patients were comparable among the surgical options. Adjuvant radiotherapy is recommended after local excision in patients with risk factors, such as sm2 or sm3 cancer, poorly differentiated cancer, and positive lympho-vascular invasion.