ABSTRACT
Many studies have confirmed that thyroid hormone (TH) and mitochondria have protective effects on myocardium. The partial subtype of sirtuins (SIRTs) can also be able to protect myocardium by mitochondria, which includes improving ischemia reperfusion injury, improving the pathological cardiac hypertrophy and improvement of heart failure. SIRTs can achieve the protective effect for myocardium mainly through inhibiting mitochondrial permeability transition pore and mitochondrial membrane permeabilization, maintaining balance of regulation of mitochondrial morphology, promoting mitochondrial biogenesis, maintaining the function of autophagy of impaired mitochondria. At the same time, there is an interaction between TH and SIRTs. At present, the role of mitochondria has become more and more concerned in apoptosis and necrosis and its protective effect on cells. This review summarized the protective effect of SIRTs on myocardium through mitochondrial and the influence of the interaction between SIRTs and TH on myocardial protection of mitochondrial.
ABSTRACT
ObjectiveTo investigate the relationship between metabolic abnormalies of thyroid hormone and intestinal barrier disfunction and the potential protective effects of exogenous thyroid hormone in sepsis. MethodsMurine septic model was established through cecal ligation puncture. Triiodothyronine (15??g/kg) was given to the septic rats to correct the low T 3 syndrome. ResultsThere was significant negative correlation between the seral concentration of free T 3 or free T 4 and MDA concentration in the tissues of small intestines. The insulting degree of the intestinal barrier in the treatment group were much milder than that of the sepsis group. ConclusionsThere were significant correlation between the metabolic abnormalies of thyroid hormone and the oxic insults of the intestinal barriers in sepsis. Providing the thyroid hormone for the septic rats could protect the intestinal barriers and improve the prognosis of sepsis.