ABSTRACT
@#At the end of 2022, the National Medical Products Administration (NMPA), in conjunction with the National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College raised for the first time the important issue of clinical research globally: whether the source of the death time of clinical trials based on the simple follow-up records is credible, and proposed a consensus document on the source of the death time of clinical trials. The results were published in The Lancet Regional Health-Western Pacific, which attracted wide attention and recognition from the international industry. This is the first time that the China consensus on quality standards for clinical research has been ahead of the U.S. Food and Drug Administration and other international colleagues. The NMPA has been leading China in promoting the scientific development of clinical research, so as to constantly establish and improve the scientific regulatory system and ecological system, and promote China's full integration into the global pharmaceutical research and development system. China clinical research institutions and the whole industry are also gradually from standardized development to scientific development, high-quality development process. In this study, we summarized the scientific and subject-oriented development of China clinical research industry in recent years, and continuously strengthened the international competitiveness of China pharmaceutical industry. It is suggested that scientific thinking model should be used to deal with the normative problems in clinical research and promote the development of medical model to scientific model.
ABSTRACT
OBJECTIVES@#To explore the forensic pathological characteristics of corpses in wells, and to summarize the differences in corpses between homicide and suicide, so as to provide references for forensic analysis of such cases.@*METHODS@#Data of 52 corpses found in wells （51 cases） in Xuchang, Henan Province from 2004 to 2016 were retrospectively collected, and descriptive statistics were performed on the dead individuals, time of death, wells, autopsies, and diatom testings.@*RESULTS@#The proportion of males and females in the 52 corpses was 1∶2.5, and 42 people were at the age of >20-50 years （80.8%）. The accuracy of the death time inference were 75.0% and 54.2% within 8 d and 8 d or more after the actual death time, respectively. Most of the wells （84.3%） were small ones with big wellhead diameters of 60-100 cm. The death causes in homicide cases were mainly mechanical injury and suffocation （90.3%） with heads downwards （58.1%）, but that in suicide cases was mostly drow-ning （85.0%） with heads upwards （65.0%） and body surface abrasions （95.0%）.@*CONCLUSIONS@#Cases of corpses in wells should be comprehensively analyzed according to scene inspections, autopsies, and auxi-liary tests combined with inspection results.
Subject(s)
Female , Humans , Male , Autopsy , Cadaver , Cause of Death , Forensic Pathology , Homicide , Retrospective StudiesABSTRACT
@#BACKGROUND. In the present situation, other than establishing the cause of death, one other major problem that the world is still facing in the forensic medical science is determining the time of death. To meet this requirement, scientists have been studying the organ system at cellular level based on medical and other sciences. Determining the time of death solves the problem which judicial organization has to face and it is significant to demonstrate citizen’s religion and traditional rituals. Now there are two methods, early and late reflection in the corpse. When we determine the time of death, we have purposed changes of epithelial cell structures and movements in the smear from the cornea after death. The studies related with those have not yet being undertaken in our country. Therefore, we want to investigate what changes are related with corneal cytology depend on the time of death. PURPOSE: To study the changes of epithelial cell structure and movement in the smear from the cornea after death. CONCLUSION: We observed the marked changes in the cell structure, including increased nucleus/cytoplasmic ratio and also a nuclear karyolysis of the epithelial cells of the cornea at 1-2 hours, 3-4 hours, 5-7 hours, 8-11 hours, 12-17 hours, 1 day and 2 days after the death, respectively. From the research results, by observing the number of epithelial cell of the cornea, we can see that when the time of death is prolonged, the number of epithelial cell increases. When we compared the time of death with the determined number of epithelial cells, there are statistically significant (ρ=0.981, p<0.001).
ABSTRACT
The purpose of this research was to study the estimated time of death using naked eye examination of the gastric content characteristics. To our knowledge, such research has not been documented in Thailand. The study samples were collected from cadavers on which autopsies had been performed in the Department of Forensic Medicine Siriraj Hospital from April 2001 to December 2002. All 120 bodies had had accurately documented the time of death and relatives or witnesses who could give proper details of the subjects’ last meal. After the autopsy and examination of the gastric contents by naked eye, the findings were categorized into 5 groups as follows : Group 1 : Can specify the type of food. The interval of time from last meal to death was 0.25 – 3.00 hours : X = 1.20, SD = 0.74. Group 2 : Very thick contents and can identify the composition of food. The interval of time after last meal to death was 0.75 – 5.00 hours : X = 2.59, SD = 0.86. Group 3 : Very thick contents but cannot specify the type of food. The interval of time after last meal to death was 3.50 – 6.5 hours : X = 4.16, SD = 0.81. Group 4 : Mixed thick and watery contents and cannot specify the type of food. The interval of time after last meal to death was 3.50 – 5.50 hours : X = 4.69, SD = 0.65. Group 5 : Watery contents and cannot specify the type of food. The interval of time from last meal to death was 6.00 – 8.00 hours : X = 6.96, SD = 0.81. The results of this research may be useful for estimating the time of death (in addition to other factors, e.g. rigor mortis). There are some limitations to this study and therefore, further research is recommended.
ABSTRACT
For the purpose of determining the time of death,the life history (the growth and development) and the sum of effective temperature of Lucilia Sericata were studied under the ordinary temperature. On the bases of the growth and development of the fly ,we have established three linear regression equations between the sum of effective temperature and the length of larvae or weigth pupa of Lucilia Sericata (K 1=2 0880+0 8014X 1、K 2=54 0917-2 8814X 2、K 3=133 2180-2 6312X 3).These linear regression equations provide a reliable,scientific method for estimating the time of death in forensic medicine practice.