Research progress of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer / 肿瘤研究与临床

Tissue factor pathway inhibitor-2 (TFPI-2) that inhibits plasmin,trypsin and matrix metalloproteinases is a broad-spectrum inhibitor of serine proteinase.TFPI-2 can accommodate the invasion and metastasis of human non-small-cell lung cancer by maintaining the integrity of extracellular matrix and regulating the angiogenesis and apoptosis of tumor cells.It has been a new target for gene therapy of cancers.

Regulation of TFPI-2 gene expression and its role in diseases / 基础医学与临床

Tissue factor pathway inhibitor-2(TFPI-2) is a matrix-associated Kunitz-type serine proteinase inhibitor,and is considered to play an important role in some pathophysiological processes,including artherosclerosis,tumor metastasis and angiogenesis.Extracellular signals can regulate TFPI-2 gene expression through modulating promoter or signaling pathway or other factors.The mechanism,more over,has become one of the focus in recent years.