ABSTRACT
Purpose: The purpose of this study is to investigate the clinical efficacy of Mohs surgery in combination with topical photodynamic therapy (PDT) for facial basal cell carcinoma. Patients and Methods: Eighty-six patients with facial basal cell carcinoma treated in our department from April 2011 to December 2013 were included. Mohs surgery was used to remove the lesions followed by direct suturing, skin flap grafting, or medium thickness free-skin grafting to repair the incisions. Topical PDT was performed three times, at an interval of 2 weeks, immediately after the sutures were removed. The patients were followed up for 2 years after the operation to evaluate tumor recurrence. Results: Recurrence was not observed within 1 year after Mohs surgery combining PDT; however, one case of recurrence was found at the 2-year follow-up. Conclusion: The efficacy of Mohs surgery combining topical PDT is a definite treatment for facial basal cell carcinomas, as it reduced the tumor recurrence rate and maintained the relative integrity of the local tissues and appearance. This method could be a new effective treatment method for the facial basal cell carcinoma
ABSTRACT
Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizing agent, oxygen, and light of a specific wavelength to produce selective cell death. PDT has been reported to be useful in treating nonmelanoma skin cancers and a variety of benign skin conditions. We treated condyloma acuminata on the vulvar area with topical PDT using 5-aminolevulinic acid (ALA) and a 632nm diode laser. After two treatment sessions the lesion was completely cleared. The light intensity was 100mW/cm2, and the light dose was 50 and 60J/cm2 respectively. Topical PDT may be a safe and effective treatment modality for condyloma acuminata.