ABSTRACT
Toxicant metabolism and toxicokinetics are an integrated part of toxicology. They study the absorption,targeted distribution,metabolic detoxicification or bioactivation,excretion and elimination of toxic substances after the body′s exposure via different routes,and also evaluate the effects of various factors on the disposition of poisons. The results of the studies provide essential data on the relation?ships between exposure kinetics and toxicological effect and their mechanisms. They also help to find possible targets of intoxication or detoxicification pathways,which can lead to efficient countermea?sures. In this review,the author summarized the thirty years of progress and features of the research on toxicant metabolism and toxicokinetics in China.