ABSTRACT
China has a high incidence of esophageal cancer，more than 90% of which are esophageal squamous cell carcinoma （ESCC）. Abnormal proliferation，migration and new microvessels of intraepithelial neoplasia cells are the important pathogenic links in the transformation from esophageal intraepithelial neoplasia （EIN） to ESCC. Studies on the progression of esophageal precancerous lesions into esophageal cancer mostly focus on environment and genetic susceptibility，such as inflammatory factors，abnormal vascular endothelial growth factor （VEGF） signaling pathway transduction，p53 gene mutation，and DNA methylation. Some pharmacology studies have confirmed that traditional Chinese medicine （TCM） can inhibit inflammatory factors，regulate abnormal signaling pathways and improve the microenvironment. A large number of patients with esophageal cancer have been found to be in advanced stage，and the 5-year survival rate is low even after active treatment. The quality of life of patients in advanced stage is worrying due to esophageal obstruction and lung infection，and therefore， early prevention is important. Early intervention in patients with esophageal precancerous lesions is in line with clinical needs and embodies the TCM theory of “treating disease before its onset.” The mechanism of action and clinical efficacy of TCM has been gradually confirmed and promoted， with certain clinical significance. To explore simple，economical and effective TCM intervention measures conforms to the clinical diagnosis and treatment standards and the modernization of TCM.
ABSTRACT
Disseminated sclerosis(DS) is an autoimmune demyelinating disease of the central nervous system(CNS) that attacks generally the youth.The common symptoms of DS are hypopsia,paralysis,abnormal sense,urine deposited,dysfunction of bowels,etc.Sometimes MS also injures neural advanced functions.Traditional Chinese Medicine(TCM) mainly defines DS as "atrophy syndrome" according to its clinic symptoms.During acute relapsing period,most DS patients present deficiency of yin of both the kidney and liver,occurring with blood stasis and phlegm.Moreover,high dose methylprednisolone can activate pathogenic fire to damage the yin that aggravates deficiency of yin.Along with repeated relapse and evolvement of DS,the body's condition will change into syndrome of deficiency of both the yin and yang.So,the drugs of nourishing both the kidney and liver yin,activating blood circulation and clearing phlegm should be applied first to treat DS. Besides,the drugs of clearing heat,activating yang,motivating flow of qi,dredging the Fu-organ,invigorating blood and regulating liver-qi should also be used according to the different syndromes.