ABSTRACT
Objective To investigate the diagnostic value of transbronchial needle aspiration (TBNA) and transbronchial biopsy(TBB) in central lung cancer.Methods Retrospectively analyzed the diagnostic data of 150 patients with central lung cancer who underwent TBNA followed by TBB in our hospital from January 2011 to October 2012.Results Among 150 patients with central lung cancer,33 cases had intracavity mass.Thirtythree cases (100％) were confirmed by TBB and 32 cases (97.0％) confirmed by TBNA.There was no statistically significant difference between the diagnosis of TBB and TBNA(P =0.90).There were 26 cases with simple stenosis,among which 1 case(3.9％) confirmed by TBB and 26 cases(100％) confirmed by TBNA.And there was statistically significant difference was observed between the diagnosis by TBB and TBNA (P =0.01) Sixteen cases belonged to the lumen external pressure type with 2 cases(12.5％) were confirmed by TBB and 16 cases(100％) confirmed by TBNA.And there was statistically significant difference was observed between the diagnosis by TBB and TBNA (P =0.02).Forty-seven cases had luminal stenosis combined with mucosal diffuse lesions with 25 cases(53.2％) confirmed by TBB and 40 cases(85.1％) confirmed by TBNA.And there was statistical difference was observed between the diagnosis of TBB and TBNA(P =0.04).Twenty-eight cases had mixed type central lung cancer with 27 cases(96.4％) confirmed by TBB and 28 cases(100％) confirmed by TBNA.No statistically significant difference was observed between the diagnosis of TBB and TBNA (P =0.87).Conclusion According to endoscopic performance of central lung cancer,accurate and reasonable choice of biopsy method can minimize inspection costs on the basis of maintaining positive rate of diagnosis in order to achieve optimal titer.
ABSTRACT
Objective: To determine optimal level of serial section in transbronchial and pleural biopsy that yield maximal definite diagnosis. Methods: A cross sectional study of 118 transbronchial biopsy and pleural biopsy specimens submitted with serial sectioning in 3 levels were performed. Specimens of 1 mm. in diameter were serially cut and slides at levels I, II, III (120, 240 and 360 µm.) from initial exposure of tissue in paraffin blocks were studied, and specimens of 2-3 mm. in diameter were cut at levels I, II, III (0, 120 and 240 µm.) after tissues in paraffin blocks were trimmed to expose maximal diameter. Comparisons of diagnoses of each level were done. Results: The percentages of definite diagnoses were 89, 95.8 and 93.2 in sections of level I, II and III, respectively. Chronic granulomatous lesions were found in section level II more than other levels, but there was no statistical significance. (P value 0.131, Chi-Square test) Conclusion: Transbronchial and pleural biopsy specimens should be cut deep to level II, one slide for hematoxylin-eosin staining and 3 unstained slides for further investigation.
ABSTRACT
A retrospective study is reported of the efficacy of 167 cases of bronchoalveolar lavage (BAL) and 212 cases of transbronchial biopsy (TBB) between August 1991 and August 1992. BAL & TBB gave diagnostic yields of 38.7% in smear negative pulmonary tuberculosis, 33% in primary or metastatic lung cancer and 55% in immunocompromised patients with pulmonary infiltrates. Overall diagnostic yield for BAL, TBB, BAL and TBB were 33, 35.8 and 39.8%. With future development, BAL and TBB will enhance the strengths of diagnostic competency for an increasing array of pulmonary diseases.