ABSTRACT
Objective • To analyze the related risk factors of decreased heart rate variability (HRV) in type 2 diabetes mellitus (T2DM) patients. Methods • A total of 210 cases with T2DM in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine from Jan. 2013 to Dec. 2014 were divided into two groups by the levels of urinary albumin creatinine ratio (UACR) and serum triacylglycerol (TAG), and with/without hypertension, respectively. By comparing the differences of clinical characteristics, HRV parameters and other general clinical data between the two groups, the correlations between HRV indexes and their risk factors were explored. Results • The average heart rate of the whole day was higher, and SDNN [normal RR intervals of sinus beats (NN intervals) standard deviation] was lower in the high UACR group than those in the normal UACR group (both P<0.05). The average heart rate of the whole day was higher, while SDNN and pNN50 (percentage of total heart beats with adjacent NN intervals greater than 50 ms) were lower in the hypertriglyceridemia group than those in the normal TAG group (all P<0.05). Minimum frequency domain power hour was lower in the hypertension group than that in the normotension group (P<0.05). Regression analysis showed that the linear correlativity between TAG and SDNN was very prominent (P<0.05), as well as between the diastolic blood pressure (DBP) and the average heart rate of the whole day, SDNN, frequency domain power 24 hours and minimum frequency domain power hour (all P<0.05). Similarly, the age was linearly correlated significantly with the average heart rate of the whole day, SDNN, SDANN (the standard deviation of the mean NN intervals every 5 min), frequency domain power 24 hours, minimum frequency domain power hour and maximum frequency domain power hour (all P<0.05). Conclusion • Age, TAG level and hypertension are the risk factors of decreased HRV in T2DM patients. Thus, early detection of the decrease of HRV in these patients can prevent the cardiovascular events of T2DM.
ABSTRACT
Objective: To investigate the effect of 1,3-diacylglycerol(DAG) on reducing blood lipid and obesity. Methods: Fifty SD rats were divided into five groups: triacylglycerol (TAG) low-fat diet, TAG high-fat diet, DAG high-dose , medium-dose and low-dose diet. The rats were fed for 6 w, and body weight was recorded every week. At the end of the experiment, the ratio of visceral fat to body weight was calculated, and blood lipid was analyzed. Results: The body weight of rats in TAG high-fat group was significantly higher than that in TAG low-fat group from the 2nd week (P