Advances in research on application of bacteria combined with nanotechnology for tumor diagnosis and treatment / 中国生物制品学杂志

@#Cancer diagnosis and treatment has always been a hot spot in clinical and basic scientific research. In recent years,scientists have developed a large number of tumor diagnosis and treatment methods based on bacteria combined with nanotechnology. Compared with pure bacterial diagnosis and treatment,bacterial diagnosis and treatment combined with nanotechnology can produce multiple synergistic effects,thereby improving the efficacy of tumor diagnosis and treatment.The characteristics of bacteria such as environmental sensitivity,tropism,motility and hypoxia growth combined organically with nanotechnology can increase the solubility of insoluble drugs,promote drug lysosomal escape,and avoid phagocytosis and clearance of the reticuloendothelial system to construct a new type of bacterial micro/nano diagnosis and treatment platform,thereby achieving the precise tumor diagnosis and controlled drug release. This paper reviewed the research progress of bacteria combined with nanotechnology for tumor diagnosis and treatment in recent years and the challenges and possible solutions,so as to provide reference for promoting the rapid development of tumor diagnosis and treatment research.

Application of Au nanoplates in tumor therapy and diagnosis / 中国药科大学学报

@#Au nanoplates (Au NPLs), a kind of novel two-dimensional metal materials with nanometer scale thickness, have attracted much attention due to their excellent properties; and have been widely used in the fields of tumor diagnosis and treatment in recent years.This article introduces the characteristics and preparation methods of Au nanoplates and summarizes their application in tumor diagnosis and treatment in recent years, in order to provide reference and ideas for the research and application of Au nanoplates in tumor.

Tumor carcinoide de duodeno: un raro e interesante hallazgo incidental / Carcinoid tumor of the duodenum: a rare and interesting incidental finding

RESUMEN Fundamento: el tumor carcinoide de localización duodenal es poco frecuente, representa 2 % de los tumores neuroendocrinos gastrointestinales. Por lo cual se presenta un caso de este, recientemente diagnosticado en el Hospital Clínico Quirúrgico Joaquín Albarrán de La Habana. Objetivo: realizar la comunicación de un caso de tumor carcinoide del duodeno y revisar la literatura con énfasis en el diagnóstico histopatológico. Presentación del caso: paciente masculino de 86 años de edad que fallece al quinto día de su ingreso. En la autopsia, durante el examen macroscópico de los intestinos, se revela a nivel de la primera porción del duodeno, una lesión que por su histopatología se correspondió con tumor carcinoide de duodeno. Conclusiones: el carcinoide duodenal es un tumor raro cuyo diagnóstico endoscópico o histológico se realiza en la gran mayoría de los casos de forma incidental; se asocia por lo general con una progresión benigna, aunque se recomienda la extracción endoscópica de tumores menores de 1 cm sin localización periampular o evidencia de invasión de la capa de propia muscular, evaluada mediante histología o ecografía endoscópica.

ABSTRACT Background: duodenal carcinoid tumor is rare; it represents 2 % of gastrointestinal neuroendocrine tumors. Therefore, a case of this is presented, recently diagnosed at the Joaquín Albarrán Clinical Surgical Hospital in Havana. Objective: to report a case of carcinoid tumor of the duodenum and review the literature with emphasis on the histopathological diagnosis. Clinical case: 86-year-old male patient who died on the fifth day after admission. At autopsy, during the macroscopic examination of the intestines, a lesion was revealed at the level of the first portion of the duodenum which, due to its histopathology, corresponded to a carcinoid tumor of the duodenum. Conclusions: duodenal carcinoid is a rare tumor whose endoscopic or histological diagnosis is made incidentally in the vast majority of cases; it is generally associated with a benign progression, although endoscopic removal of tumors smaller than 1 cm without periampullary location or evidence of invasion of the muscular layer is recommended, evaluated by histology or endoscopic ultrasound.

Research progress of drug delivery system based on black phosphorus in tumor diagnosis and treatment / 中国药科大学学报

@#As a new member of two-dimensional materials, black phosphorus has shown good application prospects in the fields of photoacoustic imaging, photothermal photodynamic therapy, and drug loading due to its excellent characteristics such as good biodegradability, biocompatibility, thickness-dependent tunable direct band-gap, and high surface-to-mass ratio. Because black phosphorus has the characteristics of easy oxidation and degradation, it is coated with relatively stable liposomes or polymeric materials to construct a black phosphorus-based drug delivery system, which shows great potential in tumor treatment and diagnosis and has become a new focus in drug delivery research. In this paper, we introduce the role of black phosphorus in tumor diagnosis and treatment in detail, and summarize the design of black phosphorus-based drug delivery system in recent years as well as its research progress in tumor diagnosis and treatment, in order to provide reference for the research and application of black phosphorus.

Research advances in exosomes as biomarkers for tumor diagnosis / 医学研究生学报

Malignancy is one of the leading causes of death worldwide. Effective screening and early diagnosis of tumors are clinically difficult. The existing tumor markers have low sensitivity and poor specificity. Exosomes, the nanoscale vesicles with a phospholipid bilayer structure, are widely distributed in various body fluids. Studies have shown that tumor-derived exosomes (TEXs) are closely related to the occurrence and progression of cancers. The contents of TEXs including proteins, RNA and DNA, glycoproteins, glycolipids and lipids can serve as highly sensitive tumor-specific markers, playing a crucial role in the basic research and clinical examination of cancers. Therefore, TEXs are expected to become new non-invasive tumor diagnostic biomarkers. This review describes the biological characteristics of exosomes, their advantages as diagnostic biomarkers and their applications in diagnosis of tumors, treatment monitoring and prognosis evaluation.

Progress in the application of novel liquid biopsy techniques in clinical tumor diagnosis and treatment / 中华检验医学杂志

Liquid biopsy can non-invasively reveal the status of tumors in vivo, and provides a powerful basis for early diagnosis, personalized treatment monitoring and prognosis prediction. According to the type of tumor-associated material, liquid biopsy covers circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), extracellular vesicles (EVs) and circulating tumor RNA (ctRNA) etc. At present, several liquid biopsy products havebeen approved for clinical use, while many transformation studies have been vigorously carried out. However, there are still many clinical challenges to be solved effectively. Despite the standardization of detection and quality management system of liquid biopsy are lagged with the rapid development of technology, liquid biopsy, as a highly promising detection technology, will become a reliable diagnostic tool with the increasing clinical requirements for facilitating the tumor management.

Tumor de células granulares intratiroideo / Intra-thyroid granular cell tumor

RESUMEN Fundamento: los tumores de células granulares son lesiones benignas infrecuentes de crecimiento lento que pueden aparecer en cualquier sitio del organismo. La región de cabeza y cuello incluye las localizaciones más frecuentes (entre el 30 y el 50 % de todos los tumores de este tipo, hasta los del sistema nervioso central). Objetivo: presentar un caso de tumor de células granulares intratiroideo. Caso clínico: se presenta el caso de una paciente femenina de 37 años de edad con enfermedad nodular de la glándula tiroides de crecimiento lento con escasa sintomatología, con confirmación histológica tumor de células de la granulosa. Al examen físico se identificó aumento de volumen en la región anterolateral del cuello, en relación con el lóbulo derecho de la glándula tiroidea, que correspondía con lesión tumoral de 3 cm, mal delimitada, adherida a planos profundos, no dolorosa a la palpación. En la ecografía se observó: lóbulo derecho del tiroides de 4,3 cm x 1,2 cm x 1,4 cm, no homogéneo con lesión nodular de 2,8 x 1,4 cm mal delimitada, de bordes irregulares. Se realizó biopsia transoperatoria que se reportó como positiva de células neoplásicas malignas, sin embargo, el estudio histológico extemporáneo reveló un tumor benigno de células granulares intratiroideo. El tratamiento quirúrgico es curativo en este caso. Conclusiones: el diagnóstico de tumor de células granulares intratiroideo benigno, se presenta con las características de una lesión tumoral maligna, debe tenerse en cuenta en el diagnóstico diferencial de los tumores de la glándula tiroides.

ABSTRACT Background: the granular cells tumors are uncommon benign lesions of slow growth that can appear in any place of the organism. The head and neck region includes the most frequent localizations (between the 30 and 50% of all the tumors of this type, including those of the central nervous system). Objective: to present a case of intra-thyroid granular cell tumor. Clinical case: a case of a 37 year-old female patient with nodular illness of the thyroid of slow growth with scarce symptoms, with histologic confirmation of granular cells tumor is presented. To the physical exam, an increase of volume was identified in the anterolateral region of the neck, in connection with the right lobe of the thyroid gland that corresponded with a tumoral lesion of 3cm approximately, not well defined, stuck to deep planes, not painful to the palpation. In the echography, it was observed: right lobe of the thyroid of 4.3 cm x 1.2cm x 1.4 cm, not homogeneous with a nodular lesion of 2.8 x 1.4 cm not well defined, of irregular borders. During the surgery, a frozen section was examined and reported as positive of malignancy, however, the untimely histologic study revealed a benign intra-thyroid granular cell tumor. The surgical treatment is healing in this case. Conclusions: the diagnosis of intra-thyroid benign granular cell tumor is presented with the characteristics of a malign tumor, it should be kept in mind in the differential diagnosis of the tumors of the thyroid.

Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment / Tumores carcinoides brônquicos: segunda neoplasia primária e desfechos do tratamento cirúrgico

ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.

RESUMO Objetivo: Analisar os determinantes do prognóstico em pacientes com tumores carcinoides brônquicos tratados cirurgicamente e possível segunda neoplasia primária concomitante. Métodos: Trata-se de uma análise retrospectiva de 51 tumores carcinoides brônquicos tratados cirurgicamente entre 2007 e 2016. A sobrevida livre de doença (SLD) foi calculada pelo método de Kaplan-Meier, e os determinantes do prognóstico foram avaliados. As neoplasias primárias concomitantes aos tumores carcinoides brônquicos foram identificadas por meio da análise dos prontuários dos pacientes. Resultados: A mediana de idade foi de 51,2 anos, 58,8% dos pacientes eram do sexo feminino e 52,9% eram assintomáticos. A classificação histológica mais comum foi carcinoide típico (em 80,4%). A SLD em cinco anos foi de 89,8%. A expressão de Ki-67 foi determinada em 27 pacientes, e a SLD em cinco anos foi melhor nos pacientes nos quais a expressão de Ki-67 foi ≤ 5% do que naqueles nos quais a expressão de Ki-67 foi > 5% (100% vs. 47,6%; p = 0,01). Neoplasias primárias concomitantes foram observadas em 14 (27,4%) dos 51 casos. Entre as neoplasias primárias malignas concomitantes, a mais comum foi o adenocarcinoma pulmonar, observado em 3 casos. Neoplasias primárias concomitantes foram mais comuns em pacientes assintomáticos e naqueles com tumores pequenos. Conclusões: A resseção cirúrgica é o principal tratamento de tumores carcinoides broncopulmonares e propicia um bom prognóstico. É provável que tumores carcinoides brônquicos se relacionem com segunda neoplasia primária.

Herramientas para el abordaje diagnóstico de los tumores neuroendocrinos de páncreas / Tools for the diagnostic approach of pancreatic neuroendocrine tumors

Introducción. Los tumores neuroendocrinos de páncreas son relativamente raros y heterogéneos. Sin embargo, su incidencia se ha incrementado a nivel mundial, y los avances en el diagnóstico y el tratamiento han mejorado la supervivencia. Tienen un pronóstico más favorable que el adenocarcinoma de páncreas, pero el reconocimiento y el abordaje diagnóstico son complejos y requieren un equipo humano multidisciplinario entrenado. Objetivo. Actualizar al médico en el abordaje clínico, patológico, imaginológico y genético, y en la evaluación hormonal basada en la evidencia disponible, brindando herramientas y recomendaciones específicas para las diferentes circunstancias clínicas. Conclusión. La incidencia de los tumores neuroendocrinos de páncreas en los últimos 40 años ha aumentado en más del 600 %, y corresponden a la segunda neoplasia pancreática con gran mortalidad. Actualmente, disponemos de múltiples biomarcadores para caracterizarlos y plantear un tratamiento más personalizado

Background: Pancreatic Neuroendocrine Tumors (nNET) are rare and heterogeneous. However, the incidence has increased worldwide, and the newer diagnostic methods and treatment have improved survival. They have a more favorable prognosis than pancreatic adenocarcinoma, but recognition and overall diagnostic methods are complex and require a trained multidisciplinary team. Aim: To update the clinical, pathological, imaging, genetic and hormonal evaluation based on the available evidence. To provide tools and recommendations for different clinical scenarios. Coclusions: The incidence of pNET in the last 40 years has increased by more than 600% and corresponds to the second pancreatic neoplasia with a high mortality rate

Study on the application of aptamers in the screening of tumor serum markers / 生物医学工程学杂志

The nucleic acid adapters of tumor serum markers are oligonucleotide molecules with high specificity and high affinity with tumor serum markers obtained by screening with systematic evolution of ligands by exponential enrichment (SELEX). Researchers take the advantage of the nucleic acid adapter to explore new tumor serum markers that have more diagnostic value for tumor diagnosis. Recently, some achievements have been achieved in the research of liver cancer and stomach cancer. This paper has reviewed nucleic acid adapter and its research in the serum tumor marker screening, and discussed the value of the nucleic acid adapter of serum tumor markers in the diagnosis, as well as current problems existing in the research. This paper is very useful to help people better understand the screening of nucleic acid adapters of tumor serum markers, and to provide help in discovering new tumor serum markers.

Advances of functionalized carbon nanotubes in diagnosis and treatment of tumor / 中国药科大学学报

@#Carbon nanotubes have become a kind of superior antitumor drug and gene carrier due to their special cylindrical structure with high loading capacity and easy penetration into the cell membrane. With the gradual development of researches on carbon nanotubes, their applications in tumor photothermal therapy and diagnosis have also become current research hotspots. However, chemical inertness and aggregation of carbon nanotubes have limited their clinical application. To overcome their drawbacks, researchers would functionalize the carbon nanotubes before further researches. In this article, applications of functionalized carbon nanotubes in cancer chemotherapy and gene therapy, photothermal therapy and cancer diagnosis are summarized.

Screening of nucleic acid aptamer of lung cancer cells based on cell exponential enrichment ligand system evolution and its application in tumor diagnosis and treatment / 生物医学工程学杂志

Nucleic acid aptamer is an oligonucleotide sequence screened by the exponential enrichment ligand system evolution technology (SELEX). Previous studies have shown that nucleic acid aptamer has a good application prospect in tumor diagnosis and treatment. Therefore, we reviewed the selection and identification of nucleic acid aptamer of lung cancer cells in recent years, and discussed the effect of aptamer as targeting drugs and targeting vectors on the diagnosis of tumors, which provide a new idea for early diagnosis and treatment of tumor.

The guidance of endoscopic ultrasonography for the selection with sphincter-preserving surgery in patients with low rectal cancer / 实用医学杂志

Objective To investigate the guidance of the endoscopic ultrasonography for the surgery selec-tion of patients with low rectal cancerthrough analyzing the accuracy of endoscopic ultrasonography in preoperative TN staging. Methods Eighty-seven cases with low rectal cancer received preoperative endoscopic ultrasonography examination,the preoperative staging and the postoperative pathologic comparison. The EUS accuracy of preopera-tive staging of rectal cancer was evaluated. Results The preoperative staging with endoscopic ultrasonography for patients with low rectal cancer,100% in T1 stage,96.0% in T2 stage,85.7% inT3 stage,and 100% in T4 stage. The preoperative staging and the postoperative pathologic comparison in T stage were consistent(Kappa = 0.903, P < 0.05). The preoperative staging with endoscopic ultrasonography for patients with low rectal cancer ,87.0% in N0 stage,78.6% in N1 stage,and 100% in N2. The preoperative and the postoperative pathologic comparisons in N stage were consistent(Kappa = 0.768,P < 0.05). Conclusion The endoscopic ultrasonography had a certain advantage in the clinical preoperative evaluation for patients with low rectal cancer ,especially for invasion depth and the judgment of lymph node metastasis ,with a higher accuracy.

Radiomics:clinical application and progress / 中华放射肿瘤学杂志

Radiomics is an emerging tumor diagnosis and auxiliary detection technique that has undergone rapid development in the past few decades.The availability of new imaging equipment and reagents, as well as the use of standardized imaging protocol, has made quantitative and standardized imaging analysis possible.Radiomics is a field of study that involves the extraction of a large number of quantitative features from areas of interest in medical images using data-characterization algorithms, and transformation of these data into first-order or high-order data.The accuracy of clinical diagnosis and prognostic value of radiomics can be further improved by analyzing the relationship between data layers.Although radiomics has many advantages and has made great progress, its standardization, reliability, and application in large data and multicenter studies will need to be further optimized.

Research progress of static magnetic field targeting drug delivery system in tumor diagnosis and therapy / 国际生物医学工程杂志

Chemotherapy is one of the traditional tumors treatment solutions.Chemotherapy has the feature of tissue non-specificity,which can cause side effects on normal cells while inhibiting tumor cell growth.Magnetic targeting drug delivery system (MTDDS) employs biocompatible and stable magnetic nanoparticles (MNP) as drug carries to transport and accumulate anticancer drugs to the specific tumor tissues under the guidance of external magnetic field.This technology not only improves the efficiency of drug delivery and antitumor activity,but also reduces the drug dosage and side effects.The properties of drug-loaded MNPs and the applied external magnetic field are the main factors that affecting the MNPs targeting to the tumor tissues.The effectiveness of the targeted delivery of the drug-loaded magnetic nanoparticles mainly depends on the form and strength of the magnetic field at the target site.That is,whether there is sufficient strength to attract and retain NMPs,and to promote antitumor drug release at the tumor region.In this paper,the research progress of static magnetic field targeting drug delivery system in tumor diagnosis and therapy was summarized,which can provide some basic information for the relative scientific researches.

Preparation and application of anti-human PD-L1 monoclonal antibodies / 中国免疫学杂志

Objective:To obtain a high specificity and high affinity anti-human PD-L1 monoclonal antibody which can be used for clinical diagnosis and block PD-L1 and PD-1 binding.Methods:BALB/c mice were immunized with recombinant PD-L1 protein.The positive cell clones stably secreting anti-human PD-L1 monoclonal antibody were obtained by classical hybridoma cell fusion technique.The specificity,affinity,subtype and other characteristics of the antibody were identified by ELISA.Immunofluorescence and indirect immunofluorescence were used to detect the tumor cells.Antibody blocking activity was confirmed by tumor killing test.Results:Two cell strains stably secreting monoclonal antibodies against human PD-LI were screened out.Abl and Ab2 had high titer and affinity.The antibody titers were 1:2.56×106 and 1:3×105,and the affinity was 1.5×109 L/mol and 2.5×10s L/mol respectively.There was no cross reaction between these two antibodies and PD-L2.Immunoblotting,indirect immunofluorescence confirmed that the antibody can be used to the diagnosis.Experiment showed that PD-L1 antibodies can increases tumor-killing activity of CIK cells.Conclusion:Two hybridoma cell lines capable of stably secreting highly specific and high affinity anti-human PD-L1 monoclonal antibody are obtained.They can specifically bind to PD-L1 molecules on tumor cells and can be used to the diagnosis of tumor phenotype and prognosis.Antibody blocking function can be applied to combined CIK cell immunotherapy.

Regulation of exosomes in tumor:research progress / 中国药理学与毒理学杂志

Exosomes are extracellular nanoparticles secreted by multiple types of cells,which are enriched for some bioactive molecules,such as proteins,messcge RNA(mRNA),micro RNA(miRNA), DNA and lipid. These molecules are documented to be involved in the process of intercellular material exchange and signal communication,thus affecting the function of cells. Also,exosomes are considered to participate in tumor angiogenesis,cancer progression and metastasis,but the mechanism remains obscure. Exosomes are of great value for the diagnosis and treatment of tumor. The correlations between exosomes and tumorigenesis and tumor metastasis as well as their clinical applications are summarized in this review.

Adenoma corticosuprarrenal no funcionante / Non-functional corticosuprarenal adenoma

Alrededor del 50 por ciento de las tumoraciones corticosuprerrenales son benignas y funcionales, muchas son sólidas con signos y síntomas de exceso de glucocorticoides (Cushing) o mineralocorticoides (Conn). El otro 50 por ciento de neoplasias sólidas corresponde a carcinomas adrenocorticales primarios, la mitad funcionales. Dentro de las tumoraciones sólidas benignas la más frecuente es el adenoma. Se presenta un paciente de 36 años de edad, de piel blanca, sexo masculino, con buena salud anterior, que ingresó por astenia desde hace 6 meses y dolor abdominal en el flanco derecho, de ligera intensidad, irradiado a la espalda, además de la pérdida de peso. Al examen físico se constata tumoración en flanco derecho. Se diagnostica tumoración suprarrenal voluminosa por ultrasonografía, tomografía axial computarizada y elevación del cortisol en sangre. Se extirpa el tumor por una incisión combinada anterior y lateral en posición semidecúbito, que brindó un buen campo, y se obtuvieron excelentes resultados. El diagnóstico anatomopatológico fue adenoma corticosuprarrenal, que se analizan y comparan con otros reportes(AU)

About the 50 percent of the cortical-suprarenal tumor are benign and functional, much of them are solid with signs and symptoms of glucocorticoids (Cushing) or mineralocorticoid (Conn). The remainder 50 percent of solid neoplasm corresponds to primary adrenocortical carcinomas whose half is functional. Within the benign solid tumors the more frequent is the adenoma. This is the case of a white male patient aged 36 with a prior good health admitted due to asthenia from 6 months ago and slightly intensive abdominal pain the right flank irradiating to back as well as weight loss. In physical examination it was verified a right flank tumor. A bulky suprarenal tumor was diagnosed by ultrasonography, computerized axial tomography and a rise of blood cortisol. Tumor is removed b y anterior and lateral combined incision in semi-decubitus position allowed a good field with satisfactory results. Anatomical-pathological diagnosis was a corticosuprarenal adenoma which was analyzed and compared with other reports(AU)

O papel da ecoendoscopia no diagnóstico dos tumores neuroendócrinos do pâncreas / The role of endoscopy in diagnosing pancreatic neuroendocrine tumors

Pancreatic neuroendocrine tumors (PETs) are rare. The vast majority are functional (70-85%), generally small (< 2 cm) and symptomatic due to elevated hormone production. Nonfunctional pancreatic neuroendocrine tumors (nPETs) usually produce symptoms based on their size and similarity to pancreatic adenocarcinoma. Localizing these tumors preoperatively fails in most cases because of their small size. While surgical resection is the treatment of choice, pre-operative identification is of fundamental importance. The objective of the present work is to demonstrate the value of endoscopy and fine-needle aspiration in the pre-operative diagnosis and staging of neuroendocrine tumors when compared to results using other diagnostic tools

Os tumores neuroendócrinos do pâncreas (TUNE) são raros. A literatura relata vasta maioria de tumores funcionantes (70%- 85%), geralmente pequenos (< 2 cm) e sintomáticos devido à produção hormonal elevada. Os não secretores (nTUNE) geralmente apresentam sintomas decorrentes (ocasionados) do seu tamanho e se assemelham ao adenocarcinoma do pâncreas. A localização pré-operatória desses tumores falha na maioria das vezes devido ao pequeno tamanho. A ressecção cirúrgica é o tratamento de escolha (de elección). Assim sendo, sua identificação pré-operatória é de fundamental importância. O objetivo desse trabalho é demonstrar o valor da ecoendoscopia (EE) isolada e associada à punção aspirativa com agulha fina (EEPAAF) no diagnóstico pré-operatório dos tumores neuroendócrinos e comparar seus resultados com outros testes (pruebas) diagnósticos utilizados para essa finalidade

The value of miniature probe endoscopic ultrasonography in diagnosis of submucosal tumor of upper digestive tract / 中国实用内科杂志

Objective To evaluate miniature probe endoscopic ultrasonography (mEUS) in diagnosis of submucosal tumor (SMT) of upper digestive tract.Methods We observed 91 patients with SMT,and mEUS was performed to assess the lesions arised from the specific layer of the wall.Results Among all cases,leiomyoma was the most common,57 cases,found in esophagus more than in stomach;14 of cysts,9 of vascular lesions,5 of lipoma,and 2 cases of malignant stromal tumors.Malignant lesions and part of benign lesions were confirmed by histological examination.Conclusion mEUS is a simple,safe and effective method for SMT,and it can be clue to the location and nature of SMT.