Adenocarcinoma mucinoso uracal / Urachal mucinous adenocarcinoma

Introducción: El uraco o conducto onfalomesentérico es una estructura embrionaria que conecta el intestino medio y el saco vitelino, que involuciona antes del tercer trimestre de embarazo. Objetivo: Presentar un caso con diagnóstico de adenocarcinoma uracal, neoplasia maligna rara. Desarrollo: Paciente de 50 años de edad sin antecedentes patológicos, con cuadro clínico inicial de ascitis y dolor abdominal, al examen físico masa palpable en hipocondrio-fosa iliaca izquierda que en la tomografía abdominal se observa una masa adyacente a la cúpula vesical y pared anterior del abdomen. El resultado de la biopsia reportó un adenocarcinoma mucinoso del conducto onfalomesentérico (uracal). Al momento del diagnóstico, el paciente se encontró en un estadio IVB según el sistema Sheldon y otros y un IV según sistema Mayo, etapa avanzada de la enfermedad que determina mal pronóstico. Se instauró tratamiento con quimioterapia neoadyuvante, quirúrgico y continuación con quimioterapia adyuvante, el cual continúa, actualmente, con una evolución estable. Conclusiones: Esta es una neoplasia rara. Sospechar su diagnóstico llevará a un diagnóstico temprano, lo que mejorará el pronóstico y sobrevida de los pacientes afectados(AU)

Introduction: The urachus or omphalomesenteric duct is an embryonic structure connecting the midgut and the yolk sac, which regresses before the third trimester of pregnancy. Objective: To report a case with a diagnosis of urachal adenocarcinoma, a rare malignant neoplasm. Case report: A 50-year-old patient with no pathological history, who had an initial clinical condition of ascites and abdominal pain. At physical examination, we found a palpable mass in the left hypochondrium - iliac fossa, which revealed a mass next to the bladder dome and anterior wall on the abdominal tomography of the abdomen. The biopsy result reported a mucinous adenocarcinoma of the omphalomesenteric duct (urachal). At the time of diagnosis, the patient was in stage IVB according to the Sheldon et al system and IV according to the Mayo system, an advanced stage of the disease that determines poor prognosis. Treatment with neoadjuvant and surgical chemotherapy was established and adjuvant chemotherapy to follow, which currently continues with a stable evolution. Conclusions: This is a rare neoplasm. Suspecting its diagnosis will lead to an early diagnosis, which will improve the prognosis and survival of affected patients(AU)

Urachal mucinous adenocarcinoma of the bladder

@#Mucinous adenocarcinoma of the bladder is rare, occurring in 0.5-2.0% of bladder cancer. Mostpatients present with hematuria, suprapubic pain and dysuria. Presented is a case of a 44 year oldmale with 4 month history of hematuria and terminal dysuria who underwent radicalcystoprostatectomy with histopathology findings of mucinous adenocarcinoma. Upon diagnosis, 25%of patients have distant metastases and 50% have stage IV disease with 50% five years survival rate forstage I-III tumor with no stage IV patients surviving beyond two years. Hence, for this type of cancer,early diagnosis is crucial. Surgery is the mainstay of treatment and is resistant with chemotherapy andradiation. Thus, for patient with confirmed or highly suspicious mucinous adenocarcinoma of thebladder, timely radical resection is warranted.

Synchronous Urothelial Carcinoma of the Bladder and Urachal Adenoma with Subsequent Malignant Transformation

Malignant transformation of urachal adenoma is exceedingly rare, with intestinal metaplasia as the most common contributing mechanism. It is recommended that a urachal adenoma be regarded as a pre-malignant condition and be subject to endoscopic surveillance. A local en block excision of the tumor mass with urachalectomy and umbilectomy results in possible long-term survival. The median survival after platinum-based chemotherapy is limited for patients with extravesical disease. Here we report a case of synchronous urothelial carcinoma of the bladder and urachal adenoma that transformed into adenocarcinoma.

A Case of Urachal Adenocarcinoma of the Urinary Bladder / 대한비뇨기과학회지

Urachal cancer was described first in 1863 by Hue and Jacquin. Since then no more than 160 cases have been reported in the literature. In Korea only 3 cases have been reported Like this, urachal carcinoma is an uncommon neoplasm associated with a poor prognosis, partly because the location of the tumor favors a long silent course before detection that belies its aggressive nature. Recently we experienced a case of urachal adenocarcinoma which was treated successfully with partial cystectomy and en block excision of urachus including umbilicus and reviewed literature briefly.

Urachal Adenocarcinoma -Report of Two Cases- / 대한비뇨기과학회지

Urachal carcinoma is an uncommon neoplasm associated with a poor prognosis. We have encountered two another cases of urachal adenocarcinoma recently 5 years after our first report. The common sign of urachal cancer was painless hematuria. We diagnosed the specific site of origin preoperatively by means of computerized tomography. One patient was performed partial cystectomy and another was total cystectomy with double barrel ureterocutaneostomy. A brief review of the literature of urachal adenocarcinoma was also made.

A Case of Urachal Adenocarcinoma / 대한비뇨기과학회지

The second case of urachal adenocarcinoma is herein presented 10 years after Choi & associates reported the first case. A 43 year old male patient with chief complaint of intermittent gross hematuria for 6 months was initially seen on February 1981 and fulfilled with diagnostic criteria of Wheeler & Hill. A brief review of the literature is made.

A Case of Urachal Adenocarcinoma / 대한비뇨기과학회지

A case of adenocarcinoma in the bladder is presented in a 24 years old man with complained of intermittent total gross hematuria. Preoperative diagnosis was established by cystoscopy, which showed a walnut sized circular pedunculated mass posterior to the air bubble on the bladder dome. A urachal sinus was absent. Partial cystectomy was performed. Biopsy showed adenocarcinoma with well differentiated glandular epithelium.