ABSTRACT
【Objective】 To explore the clinical features and treatment outcomes of female urethral carcinoma so as to improve the awareness and prognosis of this rare malignant disease. 【Methods】 Clinical data of 8 cases of female urethral carcinoma treated during Jan. 2012 to Dec.2022 at the Department of Urology of Peking University People’s Hospital were retrospectively analyzed. The patients underwent urodynamic tests, cystourethroscopy and pathological biopsy to confirm the diagnosis. Traditional radical surgery was performed in 5 cases, and radical surgery for lower urethral cancer with bladder preservation was performed in 3 cases. 【Results】 The patients aged 36 to 68 years, with a mean of 53.75 years. Urinary obstruction, lower urinary tract symptoms and urethral masses were common manifestations. Urodynamic tests indicated bladder outlet obstruction. After surgical treatment, radical surgery for lower urethral cancer with bladder preservation showed advantages over traditional radical surgery in terms of intraoperative bleeding, operation time and postoperative hospital stay. 【Conclusion】 Female primary urethral carcinoma is rare but invasive. Early diagnosis and radical surgery are crucial for improving the prognosis. Radical surgery for lower urethral cancer with bladder preservation has better treatment outcomes and postoperative quality of life compared to traditional radical surgery. For such patients, symptoms should be closely monitored and timely diagnosis and treatment should be performed.
ABSTRACT
【Objective】 To investigate the clinical characteristics,treatment and prognosis of primary urethral cancer (PUC). 【Methods】 The clinical data of 24 PUC patients treated in our hospital during Jan.2013 and Jul.2022 were retrospectively analyzed. The patients were followed up to monitor the metastasis,recurrence and survival. 【Results】 The patients included 17 male and 7 female,aged (57.6±12.8) years. The main pathologic type was squamous cell carcinoma,followed by urothelial carcinoma. Altogether 23 patients underwent surgical treatment,and 8 of them received postoperative radiotherapy or chemotherapy. During the follow-up of 1 to 92 months,17 patients were followed up,3 of the them had local recurrence,1 had metastasis,and 5 died. Survival analysis showed that patients survived (63.3±10.6) months,with a 21-month survival rate of 64.8% and progression-free survival of 22 (9,72) months. 【Conclusion】 PUC is a rare malignant tumor with poor prognosis. For early and distal PUC,urethra-preserving surgery can be adopted;for proximal or advanced PUC,surgery combined with radiotherapy or chemotherapy is recommended.
ABSTRACT
Clear cell adenocarcinoma of the female urethra is extremely rare. Because the primary urethral carcinomas are rare, standard diagnostic algorism and management has not been established yet. We report a case of clear cell adenocarcinoma of the proximal urethra in a 76-year-old female. She was presented with voiding difficulty for several years after pubovaginal sling operation due to stress urinary incontinence twelve years ago. Before this period, she had managed with medication for detrusor hypocontractility. Recently she complained bloody vaginal discharge, and her vaginal examination revealed palpable mass on the anterior vaginal wall. Pelvic MRI showed a 5×4.5cm sized tumor surrounding the proximal urethra which was mimicking prostate with no lymphadenopathy. Biopsy of the mass confirmed it to be clear cell adenocarcinoma. She underwent anterior pelvic exenteration and ileal conduit with bilateral pelvic lymph node dissection. The patient received adjuvant radiotherapy and chemotherapy as treatment. We should carefully evaluate patients with voiding symptom after anti-incontinence surgery and multimodal treatment should be applied for locally advanced urethral carcinoma.
Subject(s)
Aged , Female , Humans , Adenocarcinoma, Clear Cell , Biopsy , Combined Modality Therapy , Drug Therapy , Gynecological Examination , Lymph Node Excision , Lymphatic Diseases , Magnetic Resonance Imaging , Pelvic Exenteration , Prostate , Radiotherapy, Adjuvant , Urethra , Urinary Diversion , Urinary Incontinence , Vaginal DischargeABSTRACT
Primary carcinoma of the female urethra is an uncommon neoplasm that accounts for less than 0.02% of all malignant disease occurring in women. The rarity of the disease as well as varieties of treatment modalities has prevented unanimity of opinion as to the selection of proper treatment in individual cases. Herein we report two cases of female urethral primary carcinoma with brief review of the literatures.
Subject(s)
Female , Humans , UrethraABSTRACT
Primary carcinoma of the female urethra is a relatively rare disease that accounts for less than 0.02% of all malignancies in women. The rarity with which the neoplasm is encountered has prevented unanimity of opinion with regard to its proper management. Herein we report one case of female urethral carcinoma treated by radiation therapy alone external beam 4,500 cGy followed by interstitial implant. 1,000 cGy).
Subject(s)
Female , Humans , Rare Diseases , UrethraABSTRACT
Primary carcinoma of the female urethra is a relatively rare disease that accounts for less than 0.02% of all malignancies in women. The rarity with which the neoplasm is encountered has prevented unanimity of opinion with regard to its proper management. Herein we report one case of female urethral carcinoma treated by radiation therapy alone external beam 4,500 cGy followed by interstitial implant. 1,000 cGy).
Subject(s)
Female , Humans , Rare Diseases , UrethraABSTRACT
Primary carcinoma of the urethra is quite rare. The causes of the disease are poorly understood. It is the only urologic malignancy. known to be less common in males than females, despite of the greater length and complexity of the urethra in the male. We report a case of carcinoma of the urethra in 81 years old male patient.