ABSTRACT
Background: This study evaluated the efficacy and safety of intralesional bleomycin in the treatment of common warts in 50 (32 men, 18 women) patients aged between 14 and 80 (mean ± SD, 28.5 ± 13.27) years. Methods: The warts were present over dorsal hands, feet, palms, soles and periungual skin for 1 month to 10 years. They were infiltrated with bleomycin (1 mg/ml) till blanching. The total cumulative dose did not exceed 2 mg in one session. The treatment was repeated after paring of eschar at 2 weeks in case there was no or partial response. The patients were reviewed at 4, 12 and 24 weeks for cure, adverse effects or recurrences and outcome satisfaction levels. Results: Complete cure without recurrence occurred in 40 (80%) patients and partial response occurred in 7 (14%) patients at the end of the 24-week study period. Three patients did not complete follow-up. No major systemic or local adverse effects other than injection site pain for 2–3 days were noted. All cured patients were very satisfied (Likert scale 5). Conclusion: Intralesional bleomycin appears to be an effective and safe treatment for common warts including palmoplantar and periungual warts. It carries the advantage of low dose, no significant adverse effects and high patient satisfaction. Small number of patients, lack of a control group, comparing different bleomycin concentrations and a short follow-up are a few limitations of this study. Better designed studies are warranted for this useful treatment modality.
ABSTRACT
A report by the author entitled “Kampo formulas containing Coicis Semen that are Effective in the Treatment of Verrucae” was published in Volume 47 Number 1 of the Japanese Journal of Oriental Medicine. In this paper, the author notes the finding of a reference that supplements the above report. In ‘Yojuin Yamawaki Sensei Hokan, ’ written by Yamawaki Toyo the author found the following: “To control verrucae, boil 5 sen of Coicis Semen in 3 go of water. Drink or wash the affected area with 1 go of this use.” (This text was originally written in classical Chinese.) It is clear from this statement that Yamawaki Toyo used Coicis Semen for verrucae in a manner resembling folk medicine. Although the date of compilation of the text is not known, this treatment method had obviously been in use before the death of Yamawaki Toyo (1762).<br>The description of the use containing Coicis Semen appearing in the above text is more accurate than that found in ‘Yamato Honzo.’<br>The first description of a formula for Coicis Semen for the treatment of verrucae is found in ‘Meika Hosen, ’ which was edited by Yamada Genrin in his late teens after stealing formulas from various famous doctors. According to various medical texts, the name of Yamada Genrin was Ikyo. In ‘Meika Hosen, ’ which Yamada edited, his name was written using different Chinese characters, but also pronounced ‘Ikyo’, this was probably his original first name. The name ‘Ikyo’ with the characters used later is associated with the text ‘Baiso Yakugen.’
ABSTRACT
A report by the author entitled “Kampo formulas containing Coicis Semen that are Effective in the Treatment of Verrucae” was published in Volume 47 Number 1 of the Japanese Journal of Oriental Medicine. In this paper, the author notes the finding of a reference that supplements the above report. In ‘Yojuin Yamawaki Sensei Hokan, ’ written by Yamawaki Toyo the author found the following: “To control verrucae, boil 5 sen of Coicis Semen in 3 go of water. Drink or wash the affected area with 1 go of this use.” (This text was originally written in classical Chinese.) It is clear from this statement that Yamawaki Toyo used Coicis Semen for verrucae in a manner resembling folk medicine. Although the date of compilation of the text is not known, this treatment method had obviously been in use before the death of Yamawaki Toyo (1762).<br>The description of the use containing Coicis Semen appearing in the above text is more accurate than that found in ‘Yamato Honzo.’<br>The first description of a formula for Coicis Semen for the treatment of verrucae is found in ‘Meika Hosen, ’ which was edited by Yamada Genrin in his late teens after stealing formulas from various famous doctors. According to various medical texts, the name of Yamada Genrin was Ikyo. In ‘Meika Hosen, ’ which Yamada edited, his name was written using different Chinese characters, but also pronounced ‘Ikyo’, this was probably his original first name. The name ‘Ikyo’ with the characters used later is associated with the text ‘Baiso Yakugen.’
ABSTRACT
A report by the author entitled “Kampo formulas containing Coicis Semen that are Effective in the Treatment of Verrucae” was published in Volume 47 Number 1 of the Japanese Journal of Oriental Medicine. In this paper, the author notes the finding of a reference that supplements the above report. In ‘Yojuin Yamawaki Sensei Hokan, ’ written by Yamawaki Toyo the author found the following: “To control verrucae, boil 5 sen of Coicis Semen in 3 go of water. Drink or wash the affected area with 1 go of this use.” (This text was originally written in classical Chinese.) It is clear from this statement that Yamawaki Toyo used Coicis Semen for verrucae in a manner resembling folk medicine. Although the date of compilation of the text is not known, this treatment method had obviously been in use before the death of Yamawaki Toyo (1762).<br>The description of the use containing Coicis Semen appearing in the above text is more accurate than that found in ‘Yamato Honzo.’<br>The first description of a formula for Coicis Semen for the treatment of verrucae is found in ‘Meika Hosen, ’ which was edited by Yamada Genrin in his late teens after stealing formulas from various famous doctors. According to various medical texts, the name of Yamada Genrin was Ikyo. In ‘Meika Hosen, ’ which Yamada edited, his name was written using different Chinese characters, but also pronounced ‘Ikyo’, this was probably his original first name. The name ‘Ikyo’ with the characters used later is associated with the text ‘Baiso Yakugen.’
ABSTRACT
A report by the author entitled “Kampo formulas containing Coicis Semen that are Effective in the Treatment of Verrucae” was published in Volume 47 Number 1 of the Japanese Journal of Oriental Medicine. In this paper, the author notes the finding of a reference that supplements the above report. In ‘Yojuin Yamawaki Sensei Hokan, ’ written by Yamawaki Toyo the author found the following: “To control verrucae, boil 5 sen of Coicis Semen in 3 go of water. Drink or wash the affected area with 1 go of this use.” (This text was originally written in classical Chinese.) It is clear from this statement that Yamawaki Toyo used Coicis Semen for verrucae in a manner resembling folk medicine. Although the date of compilation of the text is not known, this treatment method had obviously been in use before the death of Yamawaki Toyo (1762).<br>The description of the use containing Coicis Semen appearing in the above text is more accurate than that found in ‘Yamato Honzo.’<br>The first description of a formula for Coicis Semen for the treatment of verrucae is found in ‘Meika Hosen, ’ which was edited by Yamada Genrin in his late teens after stealing formulas from various famous doctors. According to various medical texts, the name of Yamada Genrin was Ikyo. In ‘Meika Hosen, ’ which Yamada edited, his name was written using different Chinese characters, but also pronounced ‘Ikyo’, this was probably his original first name. The name ‘Ikyo’ with the characters used later is associated with the text ‘Baiso Yakugen.’
ABSTRACT
A report by the author entitled “Kampo formulas containing Coicis Semen that are Effective in the Treatment of Verrucae” was published in Volume 47 Number 1 of the Japanese Journal of Oriental Medicine. In this paper, the author notes the finding of a reference that supplements the above report. In ‘Yojuin Yamawaki Sensei Hokan, ’ written by Yamawaki Toyo the author found the following: “To control verrucae, boil 5 sen of Coicis Semen in 3 go of water. Drink or wash the affected area with 1 go of this use.” (This text was originally written in classical Chinese.) It is clear from this statement that Yamawaki Toyo used Coicis Semen for verrucae in a manner resembling folk medicine. Although the date of compilation of the text is not known, this treatment method had obviously been in use before the death of Yamawaki Toyo (1762).<br>The description of the use containing Coicis Semen appearing in the above text is more accurate than that found in ‘Yamato Honzo.’<br>The first description of a formula for Coicis Semen for the treatment of verrucae is found in ‘Meika Hosen, ’ which was edited by Yamada Genrin in his late teens after stealing formulas from various famous doctors. According to various medical texts, the name of Yamada Genrin was Ikyo. In ‘Meika Hosen, ’ which Yamada edited, his name was written using different Chinese characters, but also pronounced ‘Ikyo’, this was probably his original first name. The name ‘Ikyo’ with the characters used later is associated with the text ‘Baiso Yakugen.’
ABSTRACT
Coicis Semen was known in ancient times as a medicine promoting longevity. In the ‘Huang ti nei ching su wên’, there is a reference to Coicis Semen in a description of one of the pulses (cardiac pulse without stomachic energy), and it is contained in four formulas in the ‘Chin kuei yao lueh’. As for the effectiveness of Coicis Semen for the treatment of verrucae, there are no references in the ‘Ben cao gang mu’ or the ‘Nodoku’. In the Edo period, a common treatment for warts was moxibustion. The first text thought to mention Coicis Semen for the treatment of verrucae was the ‘Yamato Honzo. However, it is difficult to tell from the description of the condition whether it is in fact warts or not. Previously, the references contained in the later texts, ‘Matsukageidan’ and ‘Seinosatan’, containing a verruca formula (Chiyushimpo), have been considered to be theearliest notations of applying formulas containing Coicis Semen for the treatment of warts. However, independent investigation revealed the presence of a formula for verrucae in the text ‘Meikahosen’, compiled by Yamada Genrin twenty years before the ‘Seinosatan’. The description in the ‘Meikahosen’ says ‘Formula for warts: Coicis Semen-3 sen; Glycyrrhizae Radix-1 bu to beused not only internally but externally as well.<br>The realization of the ability of Coicis Semen to cure warts was thought to have occurred with the observation of many cases of remarkable effectiveness seen when large quantities were consumed in the form of rice and gruel containing Coicis Semen, rather than in the form of sweets made from what was called ‘Chosenmugi or <i>Coix lacryma-jobi</i> L. var. <i>koreana</i>.