Protective Effects of Vitamin-P and Vitamin-C on Hypercholesterolemia-induced Oxidative Hepatic Damage and Lipid Profile Changes in Female Rats: A Comparative Study.

The current study aims to compare the oxidative protective effects of vitamin-P and vitamin-C on hypercholesterolemia-induced hepatic damage by high cholesterol diet (HCD) in female Wistar rats. Rats received experimental prepared HCD with or without vitamin-P or C for six consecutive weeks. In plasma, levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose (GLU), albumin (ALB), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high density lipoprotein (HCD) and low density lipoprotein (LDL) were determined. Levels of lipid peroxidation product, malondialdehyde (MDA), and endogenous antioxidant, reduced glutathione (GSH), as well as TC and TG were also estimated in liver. Finally, histopathological changes were assessed in hepatic tissue. HCD significantly elevated liver enzymes and lipid profile in plasma. Supplementation of vitamin-C significantly normalized this elevation more than vitamin-P. Moreover, liver concentrations of MDA, TC and TG were increased, while GSH levels were decreased by HCD. Vitamin-C showed greater ability to attenuate HCD-induced impairments in hepatic MDA, GSH, TC and TG concentrations than vitamin-P. Both vitamins protected liver tissues against HCD-induced hepatotoxicity as confirmed by the histopathological screening. In conclusion, although both vitamins demonstrated ameliorative effects against HCD-induced oxidative injury, vitamin-C had a greater protective value than vitamin-P.

The Effect of Vitamin-C Vaginal Tablets (Vagi-C(R)) in Patients with Each Vaginitis in Pregnancy and in Normal Pregnant Women / 대한주산의학회잡지

OBJECTIVE: The purpose of this study is to evaluate the effect of Vitamin-C vaginal tablets on vaginal pH and vaginitis symptoms of pregnant women. METHODS: Ninety pregnant women who visited the antenatal clinic were included in this study after giving their informed consent. The treatment regimen of the vitamin-C vaginal tablets (250 mg, Vagi-C(R), Taurus Pharma GmbH, Germany) was one tablet given once a day for 6 consecutive days. Vaginal pH was measured the day before and the day after the Vit-C vaginal treatment. Ninety women of initial, ten failed to follow-up (participate). After routine screening using microscopic analysis of the vaginal smears, 31 of the 80 participating women fell into one of 3 pathologic groups (15 monilial infection, 10 bacterial vaginosis, 6 trichomonial infection) and leaving 49 pathogen-free pregnant women. 10 of the pathogen-free pregnant women were excluded during the study because they did not complete the treatment period due to vaginal irritation such as itching or burning sensations. The diagnosis of each vaginal infection was made by specific pathologic findings. RESULT: Mean vaginal pH values for the pathology group decreased significantly from 4.9 to 4.2. Pathologic findings of each infection were also improved without specific treatment. Bacterial vaginosis disappeared in 80.0% (8/10) of patients. The specific pathogens of the remained two vaginitis types were not detected in 33.3% (5/15) of monilial infection and 33.3% (2/6) trichomonial infection 1 week after discontinuation of Vitamin-C vaginal tablets. Although it is not significant, mean vaginal pH values decreased from 4.4 to 4.2 in the pathogen-free pregnant women. CONCLUSION: Vitamin-C, when vaginally applied, is effective in lowering vaginal pH and in the treatment of vaginitis in pregnant women.

Study on preventing nephrotoxic injury of amikacin / 实用儿科临床杂志

Objective To search for the methods preventing nephrotoxic injury of amikacin,Methods Case-control research was used in this study. There were 50 normal children in control group The urine routine, the ?2-microglobulin (?2 -M), mosmol and THP in urine and blood, the AIb, rGT and NAG in urine, the renal function and serum concentration of amikacin were determined respectively.The 43 patients with serious illness childten in study group, were divided into 2 groups (Group 1 and group 2 ). Group 1 (23 cases) was treated only with amikacin for 7 days, and group 2 (20 cases) was treated with vitaminC, vitamin E and amikacin for 7 days. Before treatment, the 3rd and 7th day during the treatment, all the items mentioncd above were examined in gtoup 1 and 2.Results The incidences of nephrotoxic injury of amikacin are 87 per cent (20/23)and 55 per cent (11/20) respectively in group 1 and 2. There is significant difference (P