Impaired glucose tolerance: A pilot study in randomly selected population of Chennai.

Impaired glucose tolerance (IGT) is considered as a prediabetic state that occupies a grey area between Diabetes mellitus (DM) and normal glucose tolerance (NGT). If diabetes is detected at the stage of impaired glucose tolerance, it may be possible to halt the progression to overt diabetes. The study was conducted to assess the prevalence of impaired glucose tolerance and its relation with age, sex, body mass index (BMI), waist-hip ratio (WHR) and family history of diabetes mellitus in a randomly selected Chennai population of 200 subjects of both sexes as per the inclusion and exclusion criteria. Blood glucose concentration, body mass index and waist-hip ratio were measured by approved methods. All the data were statistically analyzed. Prevalence of IGT in this study population is 8.5%. BMI and family history of diabetes showed association with IGT. WHR showed association with IGT in males, but not in females. The prevalence of IGT is similar with differing age groups and sex.

Plasma LDL Particle Sizes Affect the Blood Lipid Profile and Dietary Intakes among Korean Adults / 대한지역사회영양학회지

The purpose of this research was to examine the relationship between the plasma LDL particle size and blood lipid profile, dietary factors and anthropometric values (body mass index, waist circumference and waist/hip ratio). The subjects were 173 adults aged 23 to 81 years, selected from the Outpatient Clinic and Cardiovascular Department of the Seoul Municipal Hospital. Dietary data were obtained using a 3-day food record and analyzed using Korean and US nutrient databases. The subjects were divided into three groups by LDL particle size:type A (large buoyant LDL, > 25.5 nm, n = 96), type I (Intermediate LDL, 25.2 < or = - < or = 25.5 nm, n = 18), and type B (small dense LDL, < 25.2 nm, n = 59) groups. The type B group had higher age, waist circumference, and waist/hip ratio (WHR) than the type A and type I groups. Serum concentration of triglyceride, Apo B, LDL/HDL cholesterol ratio and atherogenic index were significantly higher in the type B group as compared to those in the other two groups. HDL cholesterol level and Apo A-I/Apo B ratio were significantly lower in the type B group than the other two groups. The plasma LDL particle size was highly correlated with triglyceride (r = -0.450), Apo B (r = -0.402) and HDL cholesterol (r = 0.418). However, there was no correlation between plasma LDL particle size and dietary intakes. This study showed that small dense LDL was an important biochemical risk factor that was associated with other risk factors.

Relationship between Body Fat Distribution and Metabolic Risk Factors in Adolescents

PURPOSE: The objectives of this study were to estimate the prevalence of obesity in adolescents; to study the association between obesity, blood pressure, and dyslipidemia; and to evaluate the superiority of waist circumference to waist/hip ratio(WHR) in central obesity. METHODS: We selected 1382 adolescents(M : F=690 : 692) aged from 11 to 18 years(mean age; boys15.0, girls 15.4) in Incheon. We measured weight, height, waist, waist/hip ratio, and blood pressure, with blood sampling to evaluate the dyslipidemia. RESULTS: The prevalence of obesity was 6.7% in boys and 6.9% in girls by body mass index(BMI). The prevalence of systolic hypertension was 15.7% in normal group, 32.4% in the overweight group, and 35.4% in the obese group by BMI. The prevalence of diastolic hypertension was 4.9% in the normal group, 6.9% in the overweight group, and 14.6% the in obese group. In boys and girls, BMI, waist circumference, and WHR were positively correlated with systolic and diastolic blood pressure. respectively. In boys, triglyceride was positively correlated with waist circumference(r=0.34, P<0.05). In boys and girls, BMI was highly correlated with obesity index(r=0.98, each), with waist circumference(r=0.89, r=0.82, respectively), and with body fat(r=0.85, r=0.89) respectively. CONCLUSION: These data suggest the importance of the screening of blood pressure in obese adolescents, with prevention and intervention of obesity since it may be the most cost-effective way of reducing the complications related with obesity.