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Introduction: Biochemical and hematological abnormalities are among most common clinico-pathological manifestations of HIV/AIDS infected persons on antiretroviral drugs (ARDs). Hepatitis C Virus (HCV) infection are known to influence progression and management of HIV infection. Data are limited regarding the impact of ARDs on HIV/HCV co-infected persons in Nigeria. Hence, this study evaluated the biochemical and hematological impact of HCV on prognosis of HIV persons taking ARDs. Materials and Methods: 2,322 HIV infected persons were screened for HCV. One hundred and nine were co-infected with HCV; and were cross-sectional monitored on ARDs for fifteen months at hospitals in North Central Nigeria for changes in clinical profiles. The determination of Alanine aminotransferase (ALT), Aspartate transaminase (AST), Packed cell volume (PCV) and White blood cells count (WBC) estimations were reviewed every 3 months for each of the person using Reflotron plus machine and hematological analyzer according to the manufacturer抯 instructions. Results: The results showed an increase in both HIV mono-infected and co-infected patients, with raised in AST from 18.46�73 to 34.32�6053U/l, ALT from 19.37�6804 to 34.87�5637U/l, PCV from 34.20�2998 to 34.89�4895% and WBC from 3.50x109�0816 to 6.67x109�1204 cells/L and AST from 17.35�1542 to 34.49�0981U/l, ALT from 17.67�1412 to 34.80�15U/l, PCV from 36.74�2902 to 38.37�4399% and WBC from 3.90x109�0251 to 6.19x109�0178 cells/L. Conclusion: It was found that PCV and WBC count values were positively affected despite HCV replication and AST and ALT enzyme levels for both HIV-mono and co-infected persons were slightly elevated. Therefore, efforts addressing viral hepatitis co-infections at the early stage of ARDs initiation under qualified clinician should be of paramount important.
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Objective To analyze the correlation between the content of visible components of EPS ,and to investigate the rela‐tionship between the main parameters of semen and EPS .Methods On the basis of white blood cell count of EPS ,the patients were divided into group A (inflammatory patients ,n=189) and group B (non‐inflammatory patients ,n=94) .The density ,(a+b) activi‐ty and survival rate of sperm were detected by CASA .Results There was no linear correlation between the number of white blood cells and lecithin bodies or red blood cells .Compared with group B ,the sperm density and (a+b) level of sperm activity and surviv‐al rates of semen were significantly decreased in group A (P<0 .05 or P<0 .01) .Conclusion The number of white blood cells of EPS could affect sperm quality of the patients .
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Objective To explore the clinical value of combined detection of procalcitonin (PCT ) ,C reaction protein (CRP) and white blood cells (WBC) count in diagnosis of neonatal infectious pneumonia .Methods A total of 137 cases of neonatal infectious pneumonia ,including bacterial infection group of 72 cases and non‐bacterial infection group of 65 cases ,were selected .Another 63 healthy neonatus were enrolled as control group .Levels of PCT ,CRP and WBC were measured .Results Levels and positive rates of PCT ,CRP and WBC in bacterial infection group were significantly higher than the other two groups (P<0 .05) .The sensitivity and specificity of PCT were higher than CRP and WBC .The sensitivity of combined detection were further increased .Conclusion Diagnostic sensitivity and specificity of PCT could be higher than CRP and WBC .Combined detection of PCT ,CRP and WBC might be with important clinical value for the differential diagnosis of neonatal infectious pneumonia and observation of curative effect .
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Objective To investigate the therapeutic effect of Bidouyan Oral Liquid(BOL) on acute suppurative max-illary sinusitis(ARMS) in rabbits.Methods Modified Hinni's method was used to inducing the ARMS rabbit models.The high and low-dosage of BOL was administered by gastric gavage and penicillin V was used for the positive medicine.The white blood cells(WBC)count,neutrophil percentage,serum C-reactive protein(CRP)level,inflammatory changes of mucosa of nasal sinuses under light microscope and bacteria culture of secretion in ARMS rabbit models were observed.Results Inflammatory changes were shown in the experimental ARMS rabbits as follows:white blood cells count and neutrophil percentage increased,mucosa of nasal sinuses congested and swollen with the exfoliation of pili.After the treatment with high-and low-dosage of BOL,the above parameters in the rabbits recovered to normal,the difference being insignificant compared with penicillin V.Conclusion BOL in clinical dose can control the general and local inflammatory reaction in ARMS rabbits.