The Role of Whole Body DWI in the Evaluation of Bone Disease in Multiple Myeloma / 中国实验血液学杂志

OBJECTIVE@#To explore the characteristics of ADC value changes in DWI of newly diagnosed symptomatic MM patients and its correlation with R-ISS stage.@*METHODS@#The data of 148 newly diagnosed symptomatic MM patients treated by whole-body DWI scan at The First Affiliated Hospital of Soochow University from June 2016 to June 2019 were selected and retrospectively analyzed and 30 cases of age-matched healthy people were selected as controls. The differences of ADC values between the patients in normal control group, DWI- group and DWI+ group were compared, and the relationship between ADC values and R-ISS stage in MM patients was compared.@*RESULTS@#The plasma cell percentage of the patients in DWI+ group was higher than those in DWI- group. ADC values of vertebra, sternum, rib, pectoral girdle, pelvic girdle of the patients in DWI+ group were significantly higher than those in DWI- group and normal control group. The ADC values of each part of the patients in DWI- group were higher than those in normal control group. ADC values of sternum, rib and pectoral girdle in the patients at R-ISS stage III were higher than those at R-ISS stage I and II, while, there was no statistical difference between R-ISS stage I and II groups. And there was no significant difference in ADC values of other bone parts such as vertebra and pelvic girdle in patients at R-ISS stage Ⅰ-Ⅲ.@*CONCLUSION@#DWI+ in MM patients is related to higher tumor invasion. The ADC values of the DWI+ group are higher than those of the DWI- group; the bone ADC values of the DWI- patients are still higher than the normal ones. And there is a certain relationship between ADC value and R-ISS stage.

The analysis of chest,abdominal and pelvic primary occupying lesions by whole-body PET-like imaging / 实用放射学杂志

Objective To study the application value of 1.5T MRI whole-body PET-like imaging in the chest,abdominal and pelvic primary occupying lesions.Methods Whole-body PET-like imaging were performed in 5 7 patients with chest,abdominal and pelvic primary occupying lesions.The detection rate of whole-body PET-like in chest,abdominal and pelvis primary occupying lesions were compared.Apparent diffusion coefficient (ADC)values for benign and malignant lesions were compared and analyzed.Results (1) All of 71 cases of chest,abdominal and pelvic primary occupying lesions,67 lesions (94.4%)were diagnosed by whole-body PET-like imaging. Among them,31(93.9%)of malignant lesions were detected and 36(94.7%)benign lesions were detected.There was not statistically significant of detection rate between benign and malignant lesions(P>0.05).(2)The range of ADC value:malignant tumor was (0.83-1.57)× 10-3mm2/s,among which 27 lesions ADC value less than 1.1×10-3mm2/s,accounting for 87.1%;The benign lesion was (1.41-3.16)× 10-3mm2/s,among which the total 32 lesion ADC values of liver cyst(13),hepatic hemangioma(9)and renal cyst(10)were greater than 2.0×10-3mm2/s,accounting for 88.9%.There was significantly different of ADC values between benign and malignant lesions (P<0.05).Conclusion There is higher detection rate on primary chest,abdominal and pelvic space occupying lesions for whole-body PET-like imaging,which is suitable for tumor screening in healthy population.It is helpful to differentiate benign and malignant tumors by quantitative analysis of ADC value.