ABSTRACT
Background: Wound is a common process leading to inflammation and healing process. Jasminum grandiflorum is a plant widely grown in Karnataka and is mention in ancient medical systems to promote healing. So the study was taken up to confirm the anti-inflammatory effect of the plant. Methods: Excision and incision wound models in albino rats were used to study the wound healing effect. It was mainly studied by the degree of epithelisation at various intervals and compared with control group. The strength of the wound was assessed by its wound breaking strength at the end. Results: It was found that jasmine extract increased the degree of epithelisation and thus promoting wound healing. It was also found that the wound breaking strength was more in the drug treated group compared to normal. Conclusions: Jasminum grandiflorum leaf extract is known to have wound healing property.
ABSTRACT
The dexamethasone suppressed and normal wound healing effect of ethanolic extract of leaves of Hyptis suaveolens (L) poit. (EEHS) at 400mg/kg and 800mg/kg was studied in Wistar rats. Two wound models viz. incision and excision wounds were used in this study. The parameters studied were breaking strength in case of incision wounds, period of epithelization and wound contraction in case of excision wound. The dexamethasone treated group showed a significant (P<0.05) reduction in the wound breaking strength in incision type of wound model and significant increase in epithelization period and reduction in percentage of wound contraction in excision type of wound model as compared to control group. Extract treated groups showed significant (P<0.05) improvement in all the wound healing parameters of incision and excision wound models as compared to control. In incision wound model, Co administration of EEHS at both the dosage levels with dexamethasone had significantly (P<0.05) increased the wound breaking strength as compared to dexamethasone only treated group and was seen more at dosage level of 400mg/kg. Similarly, in excision wound model, there was significant improvement (P<0.05) in both the parameters when EEHS was co administered with dexamethasone as compared to dexamethasone only treated group but improvement was more at dosage level of 800mg/kg.
ABSTRACT
The effect of water soluble chitin on wound healing in rats Chitin and chitosan, polysaccharides made up of polymeric N-acetyl glucosamine and D-glucosamine, are widely found in nature, forming skeletons of crustaceans and insects as well as components of bacteria cell walls. Chitin and chitosan have been known to have many useful biological properties such as biocompatibility, biodegradability, antimicrobial activity, and wound healing property. The key-point of practical use of chitin was making water soluble form. The purpose of this study was to compare the wound healing effect of water soluble with insoluble chitin. Full-thickness skin incision was made on the backs of the Sprague-Dawley rats. Three groups composed respectively with saline, water insoluble chitin and water soluble chitin were embedded in the wounds. The wound breaking strength and the collagen-hydroxyproline content of the wounded skins were measured and histological examination was performed at the time of 3, 7, 10 days respectively after the procedure. The tensile strength was maximum in case of water soluble chitin. The amount of collagen hydroxyproline was minimum in water soluble chitin. The wound treated with the water soluble and insoluble chitin was completely reepithelialized and granulation tissue in the wound was observed at 7 days after initial wounding. The arrangement of collagen fibers in the skin was orderly and similar to normal skin.