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Objective:To evaluate the effect of acupuncture with invigorating viscera and purging fu, replenishing qi and nourishing yin for the T2DM patients with qi and yin deficiency syndrome.Methods:A total of 59 patients who met the inclusion criteria from January 1, 2019 to December 31, 2020 in the Endocrinology Department of the Second Affiliated Hospital of Anhui University of Chinese Medicine were divided into the acupuncture group with 30 cases and a control group with 29 cases, according to the random number table method. The control group received conventional hypoglycemic treatment. And the acupuncture group was treated with acupuncture on the basis of the control group treatment. Both groups were treated for 4 weeks. TCM syndrome scores were performed before and after treatment, respectively. Serum IL-6 was measured by ELISA, serum CRP by immunoturbidimetry, and serum fasting blood glucose (FPG), 2 hPG, HbAlc, TC, TG, HDL-C, LDL-C levels by spectrophotometry. The BMI, clinical effect rates were calculated.Results:The total effective rate was 96.7% (29/30) in acupuncture group and 75.9% (22/29) in control group, and the difference was statistically significant ( χ2=5.96, P<0.01). After treatment, the scores of fatigue, dryness of mouth and pharynx, spontaneous sweating and night sweating, shortness of breath and lazy speech in acupuncture group were significantly lower than those in the control group ( t values were 6.02, 4.31, 4.34, 3.63, respectively, all Ps<0.01). The serum CRP level in acupuncture group was significantly lower than that of the control group at 21, 48 d after treatment ( t values were -4.36, -3.75, respectively, all Ps<0.01), and IL-6 level was significantly lower than that of the control group at 14, 21, 28 d after treatment ( t values were -2.92, -5.35, -8.71, respectively, all Ps<0.01). After treatment, the serum TC [(4.62±0.68) mmol/L vs. (5.56±0.72) mmol/L, t=5.16], TG [(1.48±0.42) mmol/L vs. (2.12±0.89) mmol/L, t=3.55], LDL-C [(2.48±0.84) mmol/L vs.(3.02±0.95) mmol/L, t=2.32] in the acupuncture group were significantly lower than those in the control group ( P<0.05), HDL-C [(1.39±0.27) mmol/L vs. (1.26±0.22) mmol/L, t=-2.02] in the acupuncture group was significantly higher than that of the control group ( P<0.05). The serum FPG level at 21 d [(6.12±0.67) mmol/L vs. (6.57±0.61) mmol/L, t=-4.96], 28 d [(5.78±0.52) mmol/L vs. (6.49±0.58) mmol/L, t=-2.70] in acupuncture group were significantly lower than those in the control group ( P<0.01). The 2h PG level at 14 d after treatment [(10.23±1.06) mmol/L vs. (11.76±1.34) mmol/L, t=-4.87], 21 d [(9.05±0.98) mmol/L vs. (10.53±1.24) mmol/L, t=-5.10], 28 d [(7.45±0.69) mmol/L vs. (9.31±0.78) mmol/L, t=-9.71] in the acupuncture group were significantly lower than those in the control group ( P<0.01), and HbA1c level were decreased 14 d [(7.93±0.86)% vs. (8.52±0.97)%, t=-2.47], 21 d [(7.63±0.85)% vs. (8.15±0.92)%, t=-2.26], 28 d [(6.47±0.51)% vs. (7.51±0.62)%, t=-7.05] significantly lower than those in the control group ( P<0.01), BMI [(22.13±1.57) kg/m 2vs. (24.16±1.82) kg/m 2, t=-4.59] 28 d after treatment was significantly lower than that of the control group ( P<0.01). Conclusion:Acupuncture therapy of nourishing viscera and purging fu, nourishing qi and nourishing yin can regulate the disorder of glucose and lipid metabolism in patients with T2DM and syndrome of qi and yin deficiency.
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Objective@#To evaluate the efficacy of self-made Jianpi-Tiaogan-Wenshen decoction in the treatment of diarrhea-predominant irritable bowel syndrome (IBS).@*Methods@#A total of 107 patients with diarrhea- predominant IBS who met the inclusion criteria were divided into control group (53 cases) and observation group (54 cases) by random number table method. On the basis of routine treatment, the control group was given Bifidobacterium triple viable powder and trimebutine maleate dispersible tablets, while the observation group was given self-made Jianpi-Tiaogan-Wenshen decoction. Both groups were treated for 4 weeks. The symptoms and signs were scored before and after treatment. The level of 5-hydroxytryptamine (5-HT) was measured by double antibody sandwich method. The mast cell count was observed under high power microscopy, and the clinical efficacy was evaluated.@*Results@#The total effective rate was 90.7% (49/54) in the observation group and 60.4% (32/53)in the control group, and there was significant difference between the two groups (χ2=13.406, P<0.01). After treatment, the levels of mast cell count (10.03 ± 2.19 pcs/Hp vs. 14.85 ± 1.98 pcs/Hp, t=11.935), 5-HT (7.06 ±1.37 mg/L vs. 9.67 ± 1.31 mg/L, t=10.069) significantly decreased in the observation group (P<0.05). After treatment, the VAS score, stool frequency score and stool character score of the observation group were significantly lower than those of the control group (t=11.560, 11.957, 20.539, respectively, P<0.05).@*Conclusions@#Self-made Jianpi-Tiaogan-Wenshen decoction can improve clinical symptomsof diarrhea-predominant IBS patients, reduce mast cell count and 5-HT level, and improve the clinical efficacy.
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Zang-fu syndrome differentiation from Huangdi Neijing, laid the theoretical foundation. Hua Tuo'S Zhongzhang Jing, Sun Simiao's Qianjin-Yaofang, Zhang Yuansu Yixue-Qiyuan and other ancient physicians enriched the Zang-fu theory.Zang-fu syndrome differentiation became systematic and widely used in clinical. This paper traced the source of the theory, explored the development of syndrome differentiation theory.
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Objective To study the relationship between the distribution of oral ulcer and the syndrome differentiation of Zang-fu viscera. Methods We collected the data of 65 oral ulcer patients admitted in Stomatology Department,the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January of 2015 to July of 2016. The data of emotion,diet,sleep,history of digestive tract disease,and family history of the patients with tongue ulcer and the patients with labio-buccal ulcer were compared. The relationship of the distribution of labio-buccal ulcer,tongue-tip ulcer,and ulcer of lateral part of the tongue with Zang-fu viscera syndrome differentiation was analyzed by statistical software SAS 9.2. Results(1)Tongue ulcer group had higher incidence of anxiety and higher percentage of history of digestive tract disease than labio-buccal ulcer group(P<0.01,P<0.05). (2)Labio-buccal ulcer mostly had a correlation with spleen deficiency blended with dampness or gastrointestinal accumulating heat, the tongue-tip ulcer mostly had a correlation with heart-fire flaring up, and the ulcer of lateral part of tongue mostly had a correlation with pathogenic fire derived from liver-qi stagnation, the difference among the 3 groups being statistically significant(P < 0.01). Conclusion The distribution of oral ulcer has a correlation with Zang-fu viscera syndrome differentiation.
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[Objective] To sum up Mr. Wang Xugao's experience in treating infants diseases. [Method] By analysis on infants medical cases treated by Mr. Wang Xugao such as fetus scare, child tuberculosis, Severe Malnutrition, acute asthmatic attack in children,etc., sum up his features in treating such dis-eases. [Result] In treating infants diseases, he pays attention to differentiation and analysis of organs deficiency and excessiveness, very according with the gist of Mr. Qian Yi's theory of infants physiologytender organs, un-enough Qi bloodand pathology easy deficiency and excessiveness, easy cold and hot. [Conclusion] Mr. Wang's treatment on infants diseases is flexible and changeable, with good cure effect.
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Due to the history reasons,it was believed that Zhang Zhongjing wrote Treatise on Cold Pathogenic Diseases(Shanghan Lun) according to Inner Canon of Huangdi(Huangdi Nei Jing),thus Treatise on Cold Pathogenic Diseases(Shanghan Lun) was explained by means of six channels,zang-fu viscera and meridian from Inner Canon of Huangdi(Huangdi Nei Jing),so that we can not comprehend medical science of Zhang Zhongjing correctly.By textual research data confirmed,Treatise on Cold Pathogenic Diseases(Shanghan Lun) written by Zhang Zhongjing was not according to Inner Canon of Huangdi(Huangdi Nei Jing),its main content formulae-syndromes was coming from Tangye Jing Fa etc classical formulae medicine.Treatise on Cold Pathogenic Diseases mainly inherited differentiation of syndromes by eight principles and added half exterior and half interior concept to form differentiation of syndromes by six channels theory,in this way,it made six channels as key line,formulae-syndromes as item,coming into being the unique system of treatment based on syndrome differentiation."Six channels" in Treatise on Cold Pathogenic Diseases and Inner Canon of Huangdi has different theory concepts,so when readouting Treatise on Cold Pathogenic Diseases,we should not confuse the two concepts.
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Take the common diseases of TCM as the objects such as cough,retention of phlegm and morbid fluid,vomiting,diarrhea,diabetes,edema,stranguria,abdominal mass,jaundice,and consumption,the inherits and the differences in zang-fu syndromes of diseases between ancient time and now were inspected.As a result,a big difference has been appeared in zang-fu syndromes in distribution of same disease between ancient time and now.It mainly displays in: The quantity of zang-fu localizations of disease attribute is different;it has diversity on specific zang-fu organs in syndrome differentiation of disease;the main connected zang-fu organs are different;natures of zang-fu syndromes are different.It has the vital significance to profoundly understand the essence of treatment based on syndrome differentiation through out promulgating the tremendous changes of zang-fu syndrome differentiation of diseases between ancient and modern times.