ABSTRACT
Background: Previous study showed leprosy patients have low zinc status. Yet the status of zinc in close-contact, which indicated by IgM anti-PGL1 level, have not determined. The aim of the study was to determine the association of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy patients in Indonesia. Methods: This was an observational study. Subjects were 186 close-contact leprosy patients. Measurement of zinc plasma status used atomic absorption spectrophotometer while examination of IgM anti-PGL1 level used ELISA (Polyclonal rabbit anti human IgM/HRP/(Dako®). Results: The average level of IgM anti-PGL1 and zinc plasma were 804 unit/mL (± 439.4) and 16.6 μmol/L (± 3.5) consecutively. There was significant correlation between zinc plasma and IgM anti-PGL1 (r = - 0.230; p = 0.002). Conclusion: There is a significant correlation between zinc plasma and IgM anti-PGL1 in close contact of leprosy
Subject(s)
LeprosyABSTRACT
Thirty six weanling male rats fed a vitamin D-deficient diet, were divided into three groups and each of them were supplemented with 0, 5000 or 30000 IU.kg-1.w-1 of vitamin D3, respectively. In three weeks feeding, increments of body weight and tissue weight were not significantly different among the 3 groups. The zinc contents of plasma, liver and kidney of rats in the supplemented groups and the zinc content of testis in vitamin D3 5000 IU.kg-1.w-1 group were significantly higher than that of rats in the group without supplement. But there was no significant differance between the zinc levels of prostate and tibia in all groups. The results showed that the nutrition state of vitamin D could influence the zinc level of blood and tissues.