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1.
Article in Chinese | WPRIM | ID: wpr-692802

ABSTRACT

Objective To observe the levels of interferon gamma-induced protein 10(IP-10)in children with acute viral and bacterial infection.Methods There were three groups:acute viral infection group(51 ca-ses),acute bacterial infection group(52 cases),and healthy control group(51 cases).Serum IP-10 levels were detected by enzyme linked immunosorbent assay(ELISA),and serum C reactive protein(CRP)were deter-mined with BNⅡ automatic protein analyzer.Results The level of serum IP-10 and CRP were significantly different in different groups(P<0.05).Compared with control group,the level of IP-10 and CRP were higher in acute viral infection group or in acute bacterial infection group(P<0.05).The level of IP-10 was higher in acute viral infection group than that in acute bacterial infection group(P>0.05).The level of CRP was higher in bacterial infection group than that in acute viral infection group(P<0.05).The IP-10 levels in viral Infec-tion patients were not correlated with the CRP levels.The area under curve(AUC),sensitivity and specificity of IP-10 and CRP were 0.688 and 0.873,35.0% and 79.6%,96.1% and 98.0%.When cut-off value of predic-tive probability was 0.713,sensitivity and specificity were increased to 82.5% and 100.0%.Conclusion Ser-um IP-10,CRP and predictive probability are valuable in the diagnosis of acute pathogen infection in children.

2.
China Pharmacy ; (12): 4115-4118, 2017.
Article in Chinese | WPRIM | ID: wpr-658601

ABSTRACT

OBJECTIVE:To investigate the clinical efficacy and bacteriological efficacy of biapenem in the treatment of acute bacterial infection,and its effects on serum IL-6 and hs-CRP levels. METHODS:A total of 241 patients with acute bacterial infec-tion of respiratory system and urinary tract system selected from our hospital during Apr. 2015-Apr. 2016 were divided into control group(119 cases)and observation group(122 cases)according to random number table. Control group was given Meropenem for injection 0.5 g added into 100 mL 0.9% NaCl injection intravenously,tid. Observation group was given Biapenem for injection 0.3 g added into 100 mL 0.9% NaCl injection intravenously,bid. Treatment course of 2 groups lasted for 7-14 d. Clinical effica-cies,bacteriological efficacies,serum interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)levels,the occurrence of ADR were compared between 2 groups. RESULTS:The total response rate,bacterial culture positive rate,bacterial clearance rate and the incidence of ADR were 88.24%,56.30%,87.14%,13.45% in control group and 93.44%,55.74%,93.06%,10.66% in observation group,without statistical significance(P>0.05). Before treatment,there was no statistical significance in serum IL-6 or hs-CRP levels between 2 groups(P>0.05). Compared with before treatment,serum IL-6 and hs-CRP levels of 2 groups were decreased significantly after treatment,with statistical significance(P<0.05);there was no statistical significance between 2 groups(P>0.05). CONCLUSIONS:Biapenem in the treatment of acute bacterial infection of respiratory system and urinary tract system has excellent efficacy,and can significantly reduce inflammatory factor level with good safety. Response rate and safety of biapenem are similar to those of meropenem,so drugs should be selected according to specific condition of patients.

3.
China Pharmacy ; (12): 4115-4118, 2017.
Article in Chinese | WPRIM | ID: wpr-661520

ABSTRACT

OBJECTIVE:To investigate the clinical efficacy and bacteriological efficacy of biapenem in the treatment of acute bacterial infection,and its effects on serum IL-6 and hs-CRP levels. METHODS:A total of 241 patients with acute bacterial infec-tion of respiratory system and urinary tract system selected from our hospital during Apr. 2015-Apr. 2016 were divided into control group(119 cases)and observation group(122 cases)according to random number table. Control group was given Meropenem for injection 0.5 g added into 100 mL 0.9% NaCl injection intravenously,tid. Observation group was given Biapenem for injection 0.3 g added into 100 mL 0.9% NaCl injection intravenously,bid. Treatment course of 2 groups lasted for 7-14 d. Clinical effica-cies,bacteriological efficacies,serum interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)levels,the occurrence of ADR were compared between 2 groups. RESULTS:The total response rate,bacterial culture positive rate,bacterial clearance rate and the incidence of ADR were 88.24%,56.30%,87.14%,13.45% in control group and 93.44%,55.74%,93.06%,10.66% in observation group,without statistical significance(P>0.05). Before treatment,there was no statistical significance in serum IL-6 or hs-CRP levels between 2 groups(P>0.05). Compared with before treatment,serum IL-6 and hs-CRP levels of 2 groups were decreased significantly after treatment,with statistical significance(P<0.05);there was no statistical significance between 2 groups(P>0.05). CONCLUSIONS:Biapenem in the treatment of acute bacterial infection of respiratory system and urinary tract system has excellent efficacy,and can significantly reduce inflammatory factor level with good safety. Response rate and safety of biapenem are similar to those of meropenem,so drugs should be selected according to specific condition of patients.

4.
Article in Chinese | WPRIM | ID: wpr-593416

ABSTRACT

OBJECTIVE To study the value of the application of the neutrophil volume distribution width(NDW) in diagnosing acute bacterial infection generated by Coulter LH750 hematology analyzer.METHODS To do whole blood cell analysis of 80 blood samples of the bacteremic patients.Observed the white blood cell counts(WBC),the percentages of neutrophils,the value of the NDW and microscopic examination,to compare them with 50 controls.RESULTS A significant increase in the NDW was observed in the bacteremic patients compared with the controls(P

5.
China Pharmacy ; (12)1991.
Article in Chinese | WPRIM | ID: wpr-526841

ABSTRACT

OBJECTIVE:To evaluate the cost-effectiveness of oral gatifloxacin and levofloxacin in the treatment of acute bacterial infections.METHODS:224cases with acute bacterial infections treated with oral gatifloxacin(group A)and levofloxacin(group B)were collected respectively by reviewing literature,the analysis and evaluation was performed by cost-minimization analysis and cost-effectiveness analysis in pharmacoeconomics.RESULTS:Total effective rates of group A and B were95.6%and91.8%,respectively;Minimum costs for each case were(287.1?95.7)and(109.5?36.5)yuan,respectively;Calculated from the perspective of total effective rates,the cost-effectiveness ratios were(14.67?2.13)and(13.58?1.65),respectively;The incremental cost-effectiveness ratio of group A as against group B was41.CONCLUSION:Levofloxacin is of better cost-effectiveness advantage than gatifloxacin in the treatment of acute bacterial infections.

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