ABSTRACT
@#Objective To explore the three auxiliary examinations of magnetic resonance imaging（MRI），anal sphincter electromyography（EAS-EMG） and transcranial ultrasound imaging（TCS） for multi-system atrophy of P-type（MSA-P） and Parkinson’s disease（PD） differential diagnostic value. Methods Twenty-one patients with clinically diagnosed MSA-P and 33 patients with PD were enrolled. All of the patients underwent MRI，EAS-EMG，and TCS，and the medical records were comprehensive and preserved. The MRI，EAS-EMG and TCS results were compared and analyzed by the receiver operating characteristic（ROC） curves. Results Slit-like hyperintensity in the posterolateral margin of the putamen，MUP mean time，mean amplitude，percentage of polyphase wave，incidence of spontaneous generation and satellite potential were higher in the MSA-P group than in the PD group. However，the high echogenic area of the substantia nigra，the ratio of the total area of the substantia nigra and the total area of the midbrain were lower than those of the PD group（both P<0.01）. The ROC curve showed that the slit-like hyperintensity in the posterolateral margin of the putamen had the highest specificity（97.0%） for the differential diagnosis of the two，the highest sensitivity of the hyperechoic area of the substantia nigra（81.0%），and the highest AUC of the MUP mean time（0.781）. The sensitivity of the three indicators combined to the differential diagnosis was 95.2%，and the AUC was 0.939.The differential diagnosis value was extremely high. Conclusion The diagnostic value of MRI，EAS-EMG and TCS in MSA-P and PD is different and complement each other，and the combination of the three indicators has good diagnostic value.