ABSTRACT
Objcetive To evaluate the clinical significance of bone biochemical metabolic markers in osteoporosis( OP),and investigate the clinical application value of the determination.Methods BMD at various skeletal sites was measured by XR-36 dual energy X-ray absorptiometry for 65 patients.Enzyme linked immunosorbent assay (ELISA) were used to determine bone biochemical metabolic markers in sera of 65 patients with osteoporosis and 62healthy controls.Results The levels of serum TRACP5b and 25-OH-VD3/25-OH-VD2 in OP group were higher than that in control group( P <0.05),meanwhile the level of BGP,BAP and Ca were varying degrees higher than that in control group,but the level of P was lower than that in control group.Conclusion TRACP5b,BGP,BAP,VD3/2 and other bone metabolic markers can be used as indicators of early detection of osteoporosis,in order to provide valuable data for early treatment of osteoporosis.
ABSTRACT
A necessidade de uma melhor compreensão do metabolismo ósseo tornou-se crescente na Odontologia. O advento da implantodontia demandou a busca por boas condições de tecido ósseo visando à colocação de implantes osseointegráveis e também pela necessidade de preparo prévio de leitos receptores em áreas que necessitam de enxerto ósseo até as grandes reconstruções no campo da cirurgia buco-maxilo-facial que buscam reconstruir estruturas ósseas perdidas decorrentes de trauma ou de destruição tumoral tendo como área doadora a região ilíaca. A osteocalcina, produto da ação osteoblástica, intimamente relacionada à mineralização da matriz óssea tem sua ação estimulada pela vitamina D3 e é imprescindível para o processo de mineralização do tecido ósseo. Neste trabalho procurou-se fazer uma revisão dos aspectos mais importantes relacionados à atuação destas duas substâncias no metabolismo ósseo.
The need of a better understanding of the bone metabolism became growing in Dentistry. The coming of the implantology demanded the search for good conditions of bone tissue seeking to the placement of implants and also for the need of previous preparation in order to receive bone grafts in areas that need bone to great reconstructions in the of maxillofacial surgery which looks upon to rebuild bone structures lost by trauma or tumoral damages, which tends as donor area, the iliac bone. The osteocalcin, product of the osteoblastic action, intimately related to the mineralization of the bone matrix, keeps its action stimulated by the vitamin D3 and is indispensable for the process of the bone tissue mineralization. This paper intend to a revision of the most important aspects related to the performance of these two substances in the bone metabolism.