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Int. j. cardiovasc. sci. (Impr.) ; 35(2): 220-229, Mar.-Apr. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1364988


Abstract Background Cardiotoxicity is the main complication related to cancer therapy. Studies indicate that global longitudinal strain is an early detector of subclinical dysfunction of the left ventricle, preceding the decline in ejection fraction (EF). However, the reproducibility of such methodology has not been tested outside specialized centers. Objectives To assess the frequency of subclinical cardiotoxicity and to compare global longitudinal strain and EF measurements during the clinical course of patients undergoing chemotherapy for breast cancer. Methods This was an observational prospective study of 78 adult women who underwent serial echocardiograms (baseline and 1, 3, and 6 months after the beginning of chemotherapy), to evaluate biplane and 3D EF and global longitudinal strain. Cardiotoxicity and subclinical dysfunction were defined according to American Society of Echocardiography/European Association of Cardiovascular Imaging criteria. Statistical significance was set at p < 0.05. Results The mean age of the patients was 50.1 ± 11.48 years. The frequency of subclinical cardiotoxicity (defined by global longitudinal strain) was 14.9% after 30 days of chemotherapy, 16.7% after 3 months, and 19.7% after 6 months, compared to 4.5%, 3%, and 6.6%, respectively, when clinical cardiotoxicity was determined according to EF. The group that developed subclinical cardiotoxicity by 30 days (group A) had a higher frequency of clinical cardiotoxicity at 3 months (p=0.028) and a lower mean biplane EF after 30 days (p= 0.036) than the group that showed no evidence of subclinical cardiotoxicity (group B). Conclusion Subclinical cardiotoxicity was frequent and began early, being associated with a drop in EF during the clinical course.

Medicina UPB ; 41(1): 29-37, mar. 2022. Ilus, tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1362616


Objetivo: determinar la existencia de inequidades de acceso al diagnóstico y tratamiento del cáncer de mama en mujeres de Colombia y describir los principales factores de riesgo asociados. Metodología: se realizó una búsqueda sistemática con los términos: "neoplasias de la mama" AND "inequidades de salud" OR "inequidades del estado de salud" OR "factores socioeconómicos" AND "Colombia", en las bases de datos Pubmed (Medline), Scielo, Cochrane, EBSCO, Ovid, Elsevier, Lilacs, Imbiomed, en español, inglés y portugués, publicados desde 1 de enero 2000 al 31 de octubre de 2019. Resultados: fueron seleccionadas 14 publicaciones. Se identificó que el estrato socioeconómico, el nivel educativo y el tipo de aseguramiento, en la mayoría de los estudios, se relacionan con las inequidades en cuanto a la enfermedad, con efectos variables sobre el riesgo de cáncer de seno e impacto sobre la detección temprana y el tratamiento. Estas variables influyen sobre la supervivencia total y sobre la libre de enfermedad. Conclusiones: se identifican inequidades en salud en las pacientes con cáncer de mama en Colombia. Los factores identificados son el tipo de aseguramiento, el estrato socioeconómico bajo y la escasa formación escolar, que implican retraso en el diagnóstico y empeoran la condición clínica y la calidad de vida de las pacientes.

Objective: To determine the existence of disparities in access for diagnosis and treatment in women diagnosed with breast cancer in Colombia, and to describe the main associated risk factors. Methodology: A systematic search was conducted with the terms "Breast neoplasms" AND "Health disparities" OR "Health status disparities" OR "Socioeconomic factors" AND "Colombia", in the Pubmed databases (Medline), Scielo, Cochrane, EBSCO, Ovid, Elsevier, Lilacs, Imbiomed, in Spanish, English, and Portuguese, published from January 1, 2000 back to October 31, 2019. Results: 14 publications were selected for the writing of the manuscript. It was identified that the socioeconomic level, the level of education and the type of insurance, in most of the studies, showed significant association to disparities in the disease. They also had variable effects on the risk of breast cancer and an impact in its early detection and treatment. These factors influence the full survival of the patient and their becoming disease-free. Conclusions: Health disparities of patients with breast cancer in Colombia are identified. Factors such as type of insurance, socioeconomic level, educational level were identified, which impact the delay in diagnosis and worsen the clinical condition and the quality of life of the patients.

Objetivo: determinar a existência de inequidades de acesso ao diagnóstico e tratamento do câncer de mama em mulheres da Colômbia e descrever os principais fatores de risco associados. Metodologia: se realizou uma busca sistemática com os termos: "neoplasias da mama" AND "inequidades de saúde" OR "inequidades do estado de saúde" OR "fatores socioeconómicos" AND "Colômbia", nas bases de dados Pubmed (Medline), Scielo, Cochrane, EBSCO, Ovid, Elsevier, Lilacs, Imbiomed, em espanhol, inglês e português, publicados desde o dia 1° de janeiro de 2000 a 31 de outubro de 2019. Resultados: foram selecionadas 14 publicações. Se identificou que o estrato socioeconómico, a nível educativo e o tipo de asseguramento, na maioria dos estudos, se relacionam com as inequidades enquanto à doença, com efeitos variáveis sobre o risco de câncer de seio e impacto sobre a detecção precoce e o tratamento. Estas variáveis influem sobre a supervivência total e sobre a livre da doença. Conclusões: se identificam inequidades na saúde nos pacientes com câncer de mama na Colômbia. Os fatores identificados são o tipo de asseguramento, o estrato socioeconómico baixo e a escassa formação escolar, que implicam no retraso do diagnóstico e empioram a condição clínica e a qualidade de vida das pacientes.

Humans , Female , Breast Neoplasms , Socioeconomic Factors , Health Status Disparities , Survivorship
Säo Paulo med. j ; 140(2): 268-277, Jan.-Feb. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1366040


ABSTRACT BACKGROUND: Breast cancer is a common neoplasm in women worldwide. Its varying patterns of incidence and clinical prognosis in Brazil make it an important and complex public health problem that needs to be solved. OBJECTIVES: To analyze the temporal dynamics of hospital admissions and deaths due to female breast cancer in the state of Alagoas, Brazil, from 2009 to 2019. DESIGN AND SETTING: Cross-sectional study including secondary data from hospital admissions and deaths due to female breast cancer in Alagoas. METHODS: A joinpoint regression model was constructed for temporal analysis of hospital admissions and deaths due to female breast cancer in Alagoas, over this period. The hospital information system of the Department of Informatics of the National Health System was used. RESULTS: There were 5,801 hospitalizations and 633 hospital deaths due to neoplasm in Alagoas over the period. The age group from 50 to 59 years old stood out, corresponding to 28.1% of hospitalizations and 31.1% of registered deaths. An increasing trend in the rate of hospital admissions was observed (average annual percentage change, AAPC = 14.0; P-value < 0.001), from 14.9/100,000 inhabitants in 2009 to 53.6 in 2019. There was a growth trend in the in-hospital mortality rate (AAPC = 19.8; P-value < 0.001), from 6.3% in 2009 to 11.0% in 2019. CONCLUSION: The results indicated an increasing trend of hospital admissions and mortality rates in the state of Alagoas, with a higher percentage of hospitalizations and deaths in the 50-59 age group.

Rev. Assoc. Med. Bras. (1992) ; 68(2): 227-233, Feb. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1365336


SUMMARY OBJECTIVE: The stroma surrounding the tumor cells is important in tumor progression and treatment resistance, besides the properties of tumor cells. Studies on the tumor stroma characteristics will contribute to the knowledge for new treatment approaches. METHODS: A total of 363 breast cancer patients were evaluated for the tumor-stroma ratio. The percentage of stroma was visually assessed on hematoxylin-eosin stained slides. The cases of tumor-stroma ratio more than 50% were categorized as tumor-stroma ratio high, and those less than 50% and below were categorized as tumor-stroma ratio low. RESULTS: Tumor-stroma ratio-high tumors had shorter overall survival (p=0.002). Disease-free survival tended to be shorter in tumor-stroma ratio-high tumors (p=0.082) compared with tumor-stroma ratio-low tumors. Tumor-stroma ratio was an independent prognostic parameter for the total group of patients (p=0.003) and also axillary lymph node metastasis and tumor-stroma ratio was statistically associated (p=0.004). Also, tumor-stroma ratio was an independent prognostic parameter in node-positive Luminal A and B subgroups for overall survival (p<0.001). CONCLUSION: Tumor-stroma ratio is an independent prognostic parameter that can be evaluated quite easily in all molecular subtypes of all breast cancers and does not require extra cost and time to evaluate.

Rev. Assoc. Med. Bras. (1992) ; 68(1): 13-18, Jan. 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1360716


SUMMARY OBJECTIVE: The aim of this study was to evaluate the perception of the aesthetic result of breast reconstruction surgery from the perspective of plastic surgeons compared with physicians who are not specialists in plastic surgery. METHODS: Twenty patients who underwent breast reconstruction after mastectomy had their aesthetic results evaluated by 16 plastic surgeons and 16 nonplastic physicians, yielding a total of 620 ratings (320 ratings from plastic surgeons and 320 ratings from other specialists). For all analyses, the level of rejection adopted for the null hypothesis was 5% (p-value <0.05). RESULTS: Significant differences were observed between the two groups. On average, medical professionals who specialized in plastic surgery always obtained higher scores than other physicians. However, no significant differences were found in the assessment of the aesthetic outcome of breast reconstruction according to the sex of the rating medical professional for any of the assessments considered in this study. A strong positive linear correlation between the time since training in the medical specialty of plastic surgery (r=0.750, p=0.001) and the mean aesthetic outcome score was observed in this study. CONCLUSION: Plastic surgeons assessed the aesthetic results of breast reconstruction more positively than nonplastic physicians.

Rev. bras. ginecol. obstet ; 44(1): 67-73, Jan. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1365666


Abstract Objective To evaluate the underestimation rate in breast surgical biopsy after the diagnosis of radial scar/complex sclerosing lesion through percutaneous biopsy. Data Sources A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. The PubMed, SciELO, Cochrane, and Embase databases were consulted, with searches conducted through November 2020, using specific keywords (radial scar OR complex sclerosing lesion, breast cancer, anatomopathological percutaneous biopsy AND/OR surgical biopsy). Data collection Study selection was conducted by two researchers experienced in preparing systematic reviews. The eight selected articles were fully read, and a comparative analysis was performed. Study selection A total of 584 studies was extracted, 8 of which were selected. One of them included women who had undergone a percutaneous biopsy with a histological diagnosis of radial scar/complex sclerosing lesion and subsequently underwent surgical excision; the results were used to assess the underestimation rate of atypical and malignant lesions. Data synthesis The overall underestimation rate in the 8 studies ranged from 1.3 to 40% and the invasive lesion underestimation rate varied from 0 to 10.5%. Conclusion The histopathological diagnosis of a radial scar/complex sclerosing lesion on the breast is not definitive, and it may underestimate atypical andmalignant lesions, which require a different treatment, making surgical excision an important step in diagnostic evaluation.

Resumo Objetivo Avaliar o grau de discordância entre biópsia percutânea e cirúrgica da mama em pacientes com diagnóstico de cicatriz radiada/lesão esclerosante complexa (CR/LEC) por meio de uma revisão sistemática. Fontes dos dados Foi realizada uma revisão sistemática segundo as recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA, na sigla em inglês). As bases de dados primárias consultadas foram PubMed, SciELO, Cochrane e Embase, combuscas conduzidas até novembro de 2020, utilizando palavras chaves específicas (cicatriz radiada OU lesão esclerosante complexa, câncer de mama, anatomopatológico de biópsia percutânea E/OU biópsia cirúrgica). Seleção dos estudos A busca dos artigos resultou em um total de 584 estudos, sendo 8 selecionados, os quais incluíam mulheres submetidas a biópsia com diagnóstico histológico de CR/LEC e posteriormente submetidas a exérese cirúrgica para avaliar como desfecho o grau de subestimação de lesões atípicas e malignas. Coleta de dados A seleção dos estudos foi conduzida por dois pesquisadores, com experiência na elaboração de revisão sistemática. Os oito artigos selecionados foram lidos na íntegra e submetidos a uma análise comparativa. Síntese dos dados Cicatrizes radiadas/lesões esclerosante complexas foram associadas com lesões atípicas e malignas após a exérese cirúrgica. O grau de subestimação geral foi calculado pela porcentagem de lesões atípicas e malignas no anatomopatológico após a exérese cirúrgica dentre o total de CR/LEC diagnosticadas, enquanto o grau de subestimação de lesões invasoras foi calculado considerando-se apenas os carcinomas invasivos. O grau de subestimação geral dos estudos selecionados variou de 1,3 a 40%, e o de lesões invasoras de 0 a 10,5%. Conclusão O diagnóstico histopatológico de CR/LEC na mama não é definitivo, podendo subestimar lesões atípicas e malignas, cujo tratamento é distinto, tornando a exérese cirúrgica etapa fundamental na investigação diagnóstica.

Rev. bras. enferm ; 75(1): e20210118, 2022. tab
Article in English | LILACS-Express | LILACS, BDENF | ID: biblio-1341027


ABSTRACT Objective: To estimate the incidence and degree of acute radiodermatitis at the end and after the end of treatment in women with breast cancer undergoing hypofractionated radiotherapy. Methods: Observational, prospective, and longitudinal study, conducted between March 2019 and January 2020, in a radiotherapy outpatient clinic. Results: Thirty-two women participated in the study, among whom, in the last session of hypofractionated radiotherapy, 15 (46.9%) had radiodermatitis, erythema in 13 (40.6%), and wet peeling in 2 (6.3%). In the post-treatment evaluation, 27 (84.4%) had radiodermatitis, erythema in 17 (53.1%), dry peeling in 8 (25%), and wet peeling in 2 (6.3%). Conclusion: The general incidence of radiodermatitis after hypofractionated radiotherapy in women with breast cancer was 37.5%, erythema, 12.5%, and dry peeling, 25%. The development of care protocols for the management of radiodermatitis after treatment is of paramount importance.

RESUMEN Objetivo: Estimar la incidencia y el grado de radiodermatitis aguda al final y después el término del tratamiento en mujeres con cáncer de mama sometidas a la radioterapia hipofraccionada. Métodos: Estudio observacional, prospectivo y longitudinal, realizado entre marzo de 2019 y enero de 2020, en un ambulatorio de radioterapia. Resultados: Participaron del estudio 32 mujeres, de entre las cuales, en la última sesión de radioterapia hipofraccionada, 15 (46,9%) presentaban radiodermatitis, siendo eritema en 13 (40,6%) y descamación húmeda en 2 (6,3%). En la evaluación después del tratamiento, 27 (84,4%) presentaban radiodermatitis, siendo eritema en 17 (53,1%), descamación seca en 8 (25%) y descamación húmeda en 2 (6,3%). Conclusión: La incidencia general de radiodermatitis después radioterapia hipofraccionada en mujeres con cáncer de mama fue 37,5%: eritema, 12,5%; y descamación seca, 25%. Es de suma importancia el desarrollo de protocolos asistenciales para el manejo de radiodermatitis después del tratamiento.

RESUMO Objetivo: Estimar a incidência e o grau de radiodermatite aguda ao final e após o término do tratamento em mulheres com câncer de mama submetidas à radioterapia hipofracionada. Métodos: Estudo observacional, prospectivo e longitudinal, realizado entre março de 2019 e janeiro de 2020, em um ambulatório de radioterapia. Resultados: Participaram do estudo 32 mulheres, dentre as quais, na última sessão de radioterapia hipofracionada, 15 (46,9%) apresentavam radiodermatite, sendo eritema em 13 (40,6%) e descamação úmida em 2 (6,3%). Na avaliação após o tratamento, 27 (84,4%) apresentavam radiodermatite, sendo eritema em 17 (53,1%), descamação seca em 8 (25%) e descamação úmida em 2 (6,3%). Conclusão: A incidência geral de radiodermatite após radioterapia hipofracionada em mulheres com câncer de mama foi 37,5%: eritema, 12,5%; e descamação seca, 25%. É de suma importância o desenvolvimento de protocolos assistenciais para o manejo de radiodermatite após o tratamento.

Rev. bras. enferm ; 75(3): e20210050, 2022. tab
Article in English | LILACS-Express | LILACS, BDENF | ID: biblio-1341097


ABSTRACT Objectives: to measure the frequency and compliance of breast cancer screening, according to the risk for this disease. Methods: a cross-sectional study with 950 female users of 38 public Primary Health Care services in São Paulo, between October and December 2013. According to UHS criteria, participants were grouped into high risk and standard risk, and frequency, association (p≤0.05), and screening compliance were measured. Results: 6.7% had high risk and 93.3% standard risk, respectively; in these groups, the frequency and compliance of clinical breast examination were 40.3% and 37.1%, and 43.5% and 43.0% (frequency p=0.631, compliance p=0.290). Mammograms were 67.7% and 35.5% for participants at high risk, and 57.4% and 25.4% for those at standard risk (frequency p=0.090, compliance p=0.000). Conclusions: in the groups, attendance and conformity of the clinical breast exam were similar; for mammography, it was higher in those at high risk, with assertiveness lower than the 70% set in UHS.

RESUMEN Objetivos: mensurar frecuencia y conformidad de rastreo del cáncer mamario, segundo riesgo para esa enfermedad. Métodos: estudio transversal con 950 usuarias de 38 servicios de Atención Primaria púbicos en São Paulo, entre octubre y diciembre de 2013. Segundo criterios del SUS, agruparon las participantes en riesgo elevado y riesgo-estándar, y mensurado frecuencia, relación (p≤0,05) y conformidad del rastreo. Resultados: 6,7% tenían riesgo elevado y 93,3% riesgo-estándar, respectivamente; en eses grupos, la frecuencia y conformidad del examen clínico mamario fueron de 40,3% y 37,1% y de 43,5% y 43,0% (frecuencia, p=0,631; conformidad, p=0,290). Realización de mamografía alcanzó porcentuales de 67,7% y 35,5% para participantes con riesgo elevado, y de 57,4% y 25,4% en con riesgo-estándar (frecuencia, p=0,090; conformidad, p=0,000). Conclusiones: En los grupos, la frecuencia y conformidad del examen clínico mamario fueron semejantes, para mamografía fue mayor en las con riesgo elevado, habiendo asertividad inferior a 70% pactados en el SUS.

RESUMO Objetivos: mensurar a frequência e conformidade de rastreio do câncer mamário segundo risco para esta doença. Métodos: estudo transversal em São Paulo, com 950 usuárias de 38 da atenção primária no SUS entre outubro a dezembro de 2013. Segundo critérios do SUS, as participantes foram agrupadas como risco elevado ou padrão e mensurou-se frequência, associação (p≤0,05) e conformidade do rastreio. Resultados: 6,7% tinha risco elevado e 93,3% risco padrão, respectivamente, nestes grupos a frequência e conformidade do exame clínico mamário foram de 40,3% e 37,1% e de 43,5% e 43,0% (frequência p=0,631, conformidade p=0,290). Realização de mamografia alcançou percentuais de 67,7 e 35,5 para as com risco elevado, e de 57,4 e 25,4 nas com risco padrão (frequência p=0,090, conformidade p=0,000). Conclusões: nos grupos, a frequência e conformidade do exame clínico mamário foram semelhantes, para mamografia foi maior nas com risco elevado, tendo assertividade inferior aos 70% pactuados no SUS.

Mastology (Online) ; 32: 1-8, 2022.
Article in English | LILACS-Express | LILACS | ID: biblio-1363058


Introduction: The heterogeneous nature and intrinsically aggressive tumor pathology of the triple negative breast cancer subtype results in an unfavorable prognosis and limited clinical success. The use of hematological components of the systemic inflammatory response for patients with triple-negative breast cancer can add important prognostic information to the criteria traditionally used for cancer patients, since inflammation can promote tumor progression support by affecting the stages of tumorigenesis. Objectives: The aim of this study was to evaluate the hematological parameters neutrophil/lymphocyte, monocyte/lymphocyte and platelet/lymphocyte ratios as prognostic indicators in patients with triple-negative breast cancer. Methods: This was a singlecenter retrospective observational study in an oncology referral hospital in the South region of Brazil. Electronic medical records of patients diagnosed with triple-negative breast cancer from 2012 to 2016 were reviewed and analyzed using SPSS. Results: The low blood cell ratio groups had significantly higher overall survival than the high blood cell ratio groups. Univariate analysis also confirmed the correlation of patients in the high blood cell ratio groups with unfavorable results. Conclusions: Hematological components of the systemic inflammatory response are promising prognostic indicators. More studies on the subject should be carried out to assist in future medical decision-making so these parameters of easy assessment and low cost can be introduced in clinical practice.

Mastology (Online) ; 32: 1-6, 2022.
Article in English | LILACS-Express | LILACS | ID: biblio-1363057


Introduction: The presence of brain metastases secondary to primary breast cancer implies a worse prognosis for those affected. Therefore, the aim of this study was to determine the median survival after the diagnosis of brain metastasis in patients with breast carcinoma in a center in northeastern Brazil. Methods: The medical records of 345 patients diagnosed with breast cancer, treated between 1998 and July 2018, were analyzed. Those with brain metastasis along with their treatment performed and survival were identified. Results: Nine (2.6%) patients had brain metastasis; the mean age was 56.8 years. The mean survival time determined by the Kaplan-Meier method was 23.8 months (95%CI 6.9­40.8). Seven patients (78%) died from the disease and two were lost to follow-up (22%); invasive carcinoma of no special type was the most frequent (78%). Molecular classification by immunohistochemistry was possible in seven patients: five luminal B subtype cases, one luminal A case and one triple-negative case; luminal B subtype was associated with longer survival: 23.3 months (95%CI 3.0­43.6). As for the initial clinical staging, according to the TNM Classification of Malignant Tumors, there was one IA case, one IIA case, three IIB cases and two IIIB cases. Three patients underwent modified radical mastectomy, and six underwent conservative treatment (quadrantectomy); there was no statistical difference in survival between the different forms of treatment (p=0.771). Conclusion: The median survival after diagnosis of brain metastasis from breast cancer was 23.80 months.

Mastology (Online) ; 32: 1-5, 2022.
Article in English | LILACS-Express | LILACS | ID: biblio-1363059


Objective: To describe a case report of a patient who presented with bilateral breast cancer with progression to metastatic disease, in which immunohistochemical profile of the primary and metastatic tumor was divergent. Methods: This was a study with a descriptive narrative and reflective design, of the case report type, based on secondary data, with information and images obtained from the electronic medical records of the MVSoul system used in the oncology center of a private hospital in the Federal District in Brazil. Data collection was derived from the analysis of data and images of the electronic medical record. Case report: A patient presented with bilateral metastatic breast cancer, and the primary and metastatic breast tumors showed a difference in immunohistochemical profile. Accordingly, we highlight the rarity of the case, the need for biopsies of metastatic lesions because of the molecular heterogeneity of breast cancer and possible discrepancy between the primary tumor and metastases. Spreading knowledge about diagnostic tests and personalized treatment according to tumor molecular characteristics is also essential, especially when the patient does not have a satisfactory therapeutic response, as in the reported case, since the patient had metastases with different molecular profiles confirmed only by of tumor DNA sequencing.

Ciênc. Saúde Colet ; 27(2): 471-482, Fev. 2022. tab
Article in Portuguese | LILACS | ID: biblio-1356085


Resumo Este estudo transversal investigou a prevalência e os fatores associados ao diagnóstico de câncer de mama em estágio avançado entre 18.890 mulheres assistidas em hospital especializado da capital do Rio de Janeiro, Brasil, entre os anos 1999 e 2016. Utilizou-se regressão de Poisson com variância robusta para estimar razões de prevalência e respectivos intervalos de 95% de confiança. Apresentaram maiores prevalências de diagnóstico nessa condição mulheres com idade entre 20-39 e 40-49 anos, de raça/cor da pele preta e parda, que viviam sem companheiro(a), procedentes de outros municípios do estado do Rio de Janeiro, que tiveram o Sistema Único de Saúde como origem do encaminhamento e que foram diagnosticadas nos sexênios 1999-2004 e 2005-2010. Em contrapartida, mulheres com idade entre 60-69 e 70-99 anos, que cursaram algum nível de escolaridade, com histórico familiar de câncer e que chegaram ao hospital com diagnóstico e sem tratamento apresentaram menores prevalências de diagnóstico em estágio avançado. Esses resultados podem ser considerados no planejamento de ações de prevenção secundária, a fim de antecipar o diagnóstico de câncer de mama dos grupos mais vulneráveis e assim colaborar para a redução da prevalência do diagnóstico em estágio avançado.

Abstract This cross-sectional study investigated the prevalence and factors associated with advanced stage breast cancer diagnosis among 18,890 women assisted in a specialized hospital in the capital of Rio de Janeiro, Brazil, from 1999 to 2016. We used Poisson regression with robust variance to estimate prevalence ratios and respective 95% confidence intervals. The highest prevalence of diagnosis in this condition was in women aged 20-39 and 40-49 years, black and brown, living without a partner, from other cities of the state of Rio de Janeiro, who were referred by the Unified Health System and diagnosed in the 1999-2004 and 2005-2010 six-year periods. On the other hand, women aged 60-69 and 70-99 years, with some schooling level, with a family history of cancer and who arrived at the hospital with diagnosis and without treatment had lower prevalence of advanced stage breast cancer diagnosis. These results can be considered when planning secondary prevention actions to anticipate and, thus, collaborate to reduce the prevalence the breast cancer diagnosis in the most vulnerable groups.

Humans , Female , Breast Neoplasms/diagnosis , Breast Neoplasms/epidemiology , Brazil/epidemiology , Prevalence , Cross-Sectional Studies
Autops. Case Rep ; 12: e2021352, 2022. tab, graf
Article in English | LILACS | ID: biblio-1355721


Solid Papillary Carcinoma (SPC) of the breast is a rare tumor with an incidence of less than 1%, mainly affecting elderly females. It is morphologically characterized by well-defined nodules with low-grade nuclear features associated with fibrovascular cores and shows neuroendocrine differentiation. SPC can be in-situ or invasive but has a favorable prognosis. It is a morphological mimicker of some pre-malignant conditions leading to its frequent misdiagnosis. An appropriate immunohistochemical (IHC) panel workup helps in distinguishing this tumor from its various morphological mimics. In this report, we present one such case of SPC with a small focus of invasion, reviewing the literature.

Humans , Male , Female , Aged , Carcinoma, Papillary/pathology , Unilateral Breast Neoplasms/pathology , Diagnostic Errors
Ciênc. Saúde Colet ; 27(2): 459-470, Fev. 2022. tab
Article in Portuguese | LILACS | ID: biblio-1356064


Resumo Buscou-se identificar fatores que interferem na suspeita do câncer de mama (CM) pela atenção primária à saúde (APS) que impulsionam o encaminhamento para a atenção especializada (AE) nos municípios de São Paulo e Campinas. Foram entrevistadas 664 mulheres (353 paulistanas e 311 campineiras) diagnosticadas com CM, encaminhadas para AE pela APS. Utilizou-se a análise de regressão logística multinível para a identificação das associações entre a suspeita do CM pela APS, variáveis socioeconômicas e atenção ao câncer. Mostraram associação significativa: nível superior de escolaridade (RC = 0,59; IC 95% = 0,35-0,98); pagamento de consulta médica para atendimento relacionado ao câncer (RC = 0,59; IC 95% = 0,36-0,96), continuou atendimento na APS após início do tratamento na AE (RC = 0,62; IC 95% = 0,41-0,95); mama examinada na APS (ECM) antes do encaminhamento para a AE (RC = 1,61; IC 95% = 1,10-2,34) e primeira mamografia solicitada na APS (RC = 2,81; IC 95% = 1,95-4,00). A solicitação da mamografia e o ECM são ações que têm sido incorporadas na APS para a detecção precoce do CM nos municípios. Continuar o atendimento na APS e melhores condições socioeconômicas, como ter nível superior de escolaridade e capacidade de pagar por atendimento, reduzem a chance da suspeita.

Abstract We aimed to identify factors that interfere in breast cancer (BC) suspected cases detected in Primary Health Care (PHC) that drive the referral to Specialized Care (SC) São Paulo and Campinas, Brazil. We interviewed 664 women (353 from São Paulo and 311 from Campinas) diagnosed with BC, referred to SC from PHC. Multilevel logistic regression analysis was used to the identification of associations between BC suspected cases by PHC and the socioeconomic and cancer care variables. The following showed a significant association: higher schooling level (OR = 0.59; 95% CI = 0.35-0.98); medical visit payment for cancer-related care (OR = 0.59; 95% CI = 0.36-0.96), continued attendance at PHC after beginning treatment at SC (OR = 0.62; 95% CI = 0.41-0.95); breast examined in PHC before referral to SC (OR = 1.61; 95% CI = 1.10-2.34) and first mammography requested in PHC (ECM) (OR = 2.81; 95% CI = 1.95-4.00). The request for mammography and the clinical breast examination is incorporated into the PHC for the early detection of BC in the cities. Continuing the care at the PHC and better socioeconomic conditions, such as having a higher education level and capacity to pay for care, can reduce the likelihood of suspected cases.

Humans , Female , Breast Neoplasms , Breast Neoplasms/therapy , Primary Health Care , Brazil , Mammography , Mass Screening
J. health sci. (Londrina) ; 23(4): 345-348, 20211206.
Article in English | LILACS-Express | LILACS | ID: biblio-1354111


Abstract Fibroadenoma is the most common breast tumor in young woman. It is considered a non-malignant tumor, showing hyaline component and a biphasic stroma and epithelial process, thus, it is similar to phyllode tumor revealing intralobular stroma. The cystic changes in a complex fibroadenoma may mimic a carcinoma, therefore it may represent some problems in images interpretation, and it may enlarge the risk of cancer development. This is a description of a case report with literature review. A 21-year-old female patientwith no history of breast cancer in family, presented a palpable lump in her right breast and clinical examination revealed a mobile, firm, circumscribed lesion in the right inner quadrant, measuring around 8 x 7 cm. An excision had been done under a stereotactic surgery and the structure revealed a nodular surface, measuring 8 x 6.5x 5.5cm. Cut section revealed heterogeneous aspect: cysts with colloid content and white-gray compact fibroblastic areas. Histopathological examination shows hypocellular stroma and few hypercellular areas, without atypia. Epithelial components presenting proliferation of intracanalicular and pericanalicular pattern ducts. Cystic proliferation with epithelial lining and apocrine characteristics without atypia. Because of the variation may be present inside the lesion it is difficult to establish the diagnosis without a biopsy, and a histopathological analysis. Moreover, it is necessary to know the microscope difference between fibroadenoma and the other sort of lesions; furthermore, that heterogeneity represent why that tumor is considered complex. (AU)

Resumo Fibroadenoma é o tumor de mama mais comum em mulheres jovens. É considerado um tumor não-maligno, apresentando um componente hialino e um estroma bifásico, e processo epitelial, por isso, é similar ao tumor filoide, revelando estroma intralobular. As alterações císticas no fibroadenoma complexo pode mimetizar um carcinoma, isso acarreta alguns problemas na interpretação das imagens, e pode aumentar o risco de desenvolvimento de câncer. Trata-se de um relato de caso de paciente de 21 anos de idade, sem histórico de câncer de mama na família, apresenta uma massa palpável em seio direito. Exame clinico revelou lesão móvel, firme, circunscrita no quadrante interno do seio. Excisão por cirurgia estereotáctica e a estrutura se mostra com superfície multinodular, medindo 8 x 6,5 x 5,5 cm. com aspecto heterogêneo, cistos com conteúdo coloide, e áreas fibrobásticas branco-acinzentada. Exame histológico demonstra-se estroma hipercelular, com áreas hipocelularizadas, sem atipia. Componentes epiteliais apresentando proliferação intercanalicular e intracanicular dos ductos. Proliferação cística com revestimento epitelial e características apócrinas sem atipia. Por conta da variação presente na lesão, pode ser difícil a estabelecimento de um diagnóstico se biópsia e análise histopatológica. Além disso, é fundamental o conhecimento das diferenças microscópicas entre o fibroadenoma e outros tipos de lesões; além disso, a heterogeneidade representa o motivo do tumor ser considerado complexo. (AU)

Medicina UPB ; 40(2): 2-12, 13 oct. 2021. tab, Ilus
Article in Spanish | LILACS, COLNAL | ID: biblio-1342173


Objetivo: describir los datos sociodemográficos, las manifestaciones clínicas, los paraclínicos, el tratamiento y la recurrencia, en un grupo de pacientes con lesiones papilares. Metodología: estudio analítico de cohorte retrospectiva con fuentes secundarias de información, historias clínicas. Se incluyeron pacientes evaluados entre el 1º enero de 2016 y el 31 de diciembre de 2019. Se recopilaron datos demográficos, clínicos y paraclínicos, que fueron analizados con estadística descriptiva. Resultados: la prevalencia en la muestra fue de 4.7%; todos los casos fueron en mujeres, la media de edad fue 55,5 años; el motivo de consulta más frecuente fue alteración en la imagen de mama (n=79, 54.9%), el tamaño medio de la lesión fue 1,9 cm (rango 0,1-20). Se encontró discordancia entre el diagnóstico por biopsia cortante y el espécimen de patología en 70 (48.6%) casos, en estos se encontró infraestimación de lesiones con mayor riesgo en el 36,1% (n=52). Según la clasificación histológica, el tipo más frecuente de lesión fue el papiloma intraductal 34.7% (n=50), seguido por el carcinoma papilar en 11,8% (n=17). El tipo de cirugía más efectuado fue la cuadrantectomía, con un 68.7% (n=99). La media de seguimiento fue de 28.5 meses y se encontró recaída en siete casos (4.9%). Conclusión: las lesiones papilares comprenden un grupo heterogéneo, que incluye desde las benignas hasta aquellas con potencial maligno. Afectan a las mujeres en la quinta década de la vida, se presentan como una masa, pequeña, unilateral, sin predominio de lateralidad, de crecimiento lento. El tratamiento óptimo para las lesiones de riesgo y con atipias es la cirugía con márgenes negativos, el riesgo de recurrencia es clínicamente relevante.

Objective: to describe the sociodemographic data, the clinical and paraclinical ma-nifestations, the treatment and the recurrence, in a group of patients diagnosed with papillary lesions.Methodology:analytical study of a retrospective cohort with secondary sources of information from users' medical records in the period of January 1, 2016 to December 31, 2019. The demographic, clinical and paraclinical data collected were analyzed using descriptive statistics.Results:the prevalence in the sample was 4.7%; all cases were women, the mean age was 55.5 years; the most frequent reason for consultation was abnormal breast imaging examination (n=79, 54.9 %), the mean size was 1.9 cm (range 0,1-20). Disagreement was found between the diagnosis by sharp biopsy and the pathology specimen in 48.6% of cases (n=70); lesion underestimation with higher risk was found in 36.1% of them (n=52). According to the histological classification, the most frequent was intraductal papilloma in 34.7% (n=50), followed by papillary carcinoma in 11.8% (n=17). The type of surgery most performed was quadrantectomy, 68.7% (n=99). The mean follow-up was 28.5 months and relapse was found in 4.9% (n=7).Conclusion:papillary lesions comprise a heterogeneous group, with a spectrum that includes both benign lesions and those with malignant potential. The lesions affect women in their fifties. They become apparent as a small, unilateral mass, without a pre-dominance of laterality, and of slow growth. The optimal treatment in risk lesions and with atypia is surgery with negative margins. The risk of recurrence is clinically important.

Objetivo: descrever os dados sociodemográficos, manifestações clínicas e paraclínicas, tratamento e recorrência, em um grupo de pacientes com lesões papilares.Metodologia: estudo analítico de coorte retrospectivo com fontes secundárias de informação, prontuários. Foram incluídos os pacientes avaliados entre 1º de janeiro de 2016 e 31 de dezembro de 2019. Foram coletados dados demográficos, clínicos e paraclínicos, os quais foram analisados com estatística descritiva.Resultados: a prevalência na amostra foi de 4,7%; todos os casos eram em mulheres, a média de idade foi de 55,5 anos; o motivo de consulta mais frequente foi a alteração da imagem da mama (n = 79, 54,9%), o tamanho médio da lesão foi de 1,9 cm (variação de 0,1-20). Houve discordância entre o diagnóstico por biópsia cortante e o espécime anatomopatológico em 70 (48,6%) casos, nestes casos subestimação das lesões de maior risco em 36,1% (n = 52). De acordo com a classificação histológica, o tipo de lesão mais frequente foi o papiloma intraductal em 34,7% (n = 50), seguido do carcinoma papilífero em 11,8% (n = 17). O tipo de cirurgia mais realizada foi a quadrantectomia, com 68,7% (n = 99). O seguimento médio foi de 28,5 meses e recidiva foi encontrada em sete casos (4,9%).Conclusão: as lesões papilares constituem um grupo heterogêneo, que inclui desde as benignas até as com potencial maligno. Atingem mulheres na quinta década de vida, aparecem como uma massa, pequena, unilateral, sem predomínio da lateralidade, de crescimento lento. O tratamento ideal para lesões de risco e com atipia é a cirurgia com margens negativas, o risco de recorrência é clinicamente relevante.

Humans , Female , Pregnancy , Papilloma, Intraductal , Biopsy , Breast , Carcinoma, Papillary , Classification
Rev. peru. ginecol. obstet. (En línea) ; 67(4): 00006, oct.-dic 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1361099


RESUMEN Introducción. El cáncer de mama en el hombre es una enfermedad rara, apenas un 0,2 a 1,5% de todos los tumores malignos en los hombres. Objetivo . Describir los datos sociodemográficos, manifestaciones clínicas y paraclínicas, tratamiento y recurrencia, en una muestra de pacientes diagnosticados con cáncer de mama en el hombre en una institución privada. Métodos. Estudio descriptivo, retrospectivo de una base de datos institucional, en el periodo 1 enero 2017 a 31 diciembre 2020. De los registros médicos se recopilaron los datos demográficos, clínicos, paraclínicos, que fueron analizados utilizando estadística descriptiva. Resultados. La prevalencia de cáncer de mama en hombres en la muestra fue 0,44%, mediana de edad 73 años. El síntoma más frecuente fue la masa mamaria (n= 5, 100%), mediana de tamaño del tumor 2,5 cm (rango 1,6 a 5 cm) y tipo histológico ductal (n= 5, 100%). Los 5 casos tuvieron expresión de receptores hormonales, sin sobreexpresión HER2; el estadio fue localmente avanzado en 60% (n=3) (estadio IIB-IIIA/B) y metastásico en un caso. Se realizó mastectomía en el 80% de los casos (n=4). La mediana de seguimiento fue de 23 meses y se encontró recaída en el 20% (n=1), con tiempo promedio hasta la recaída de 184 meses. Conclusiones. En la muestra estudiada, el cáncer de mama en hombres se presentó en la séptima década de la vida como una masa en estadio avanzado, con alta sensibilidad hormonal. La mastectomía fue el principal tratamiento y la mayoría requirió quimioterapia.

ABSTRACT Introduction: Breast cancer in men is a rare disease, accounting for only 0.2 - 1.5% of all malignant tumors in men. Objective : To describe the sociodemographic data, clinical and paraclinical manifestations, treatment, and recurrence in a sample of patients diagnosed with male breast cancer at a private institution. Methods : Descriptive, retrospective study of an institutional database, in the period 1 January 2017 to 31 December 2020. Demographic, clinical and paraclinical data were collected from the medical records and analyzed using descriptive statistics. Results : The prevalence of breast cancer in men in the sample was 0.44%, median age 73 years. The most frequent symptom was breast mass (n = 5; 100%), median tumor size 2.5 cm (range 1.6 to 5 cm) and ductal histological type (n = 5; 100%). All 5 cases had hormone receptor expression, without HER2 overexpression; stage was locally advanced in 60% (n = 3) (stage IIB-IIIA / B) and metastatic in one case. Mastectomy was performed in 80% of cases (n = 4). The median follow-up was 23 months and relapse was found in 20% (n = 1), with an average time to relapse of 184 months. Conclusions : In the sample studied, breast cancer in men presented in the seventh decade of life as advanced stage mass, with high hormonal sensitivity. Mastectomy was the main treatment, and most required chemotherapy.

Rev. peru. ginecol. obstet. (En línea) ; 67(4): 00013, oct.-dic 2021. graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1361106


RESUMEN La hiperplasia estromal pseudoangiomatosa (PASH, por sus siglas en inglés) se presenta entre los 12 y 75 años de edad, siendo prevalente en la edad reproductiva. Se desconoce su etiología. Se caracterizan por ser grandes, deformantes, unilaterales y se les diagnostica por ecografía e histología. En las adolescentes es importante la vigilancia, diagnóstico y manejo tempranos, con la finalidad de evitar cirugías radicales que originen cicatrices grandes, deformidad y asimetría mamaria, que repercuten en el comportamiento y estado emocional de las pacientes. Los tumores de la mama generalmente son benignos en la adolescencia, pero su diagnóstico en este grupo etario es preocupante para la familia y la paciente. Presentamos el caso de una adolescente de 14 años a quien se le realizó abordaje submamario, conservando la simetría mamaria.

ABSTRACT Pseudoangiomatous stromal hyperplasia (PASH) occurs between 12 and 75 years of age, being prevalent in the reproductive age. Its etiology is unknown. They are characterized by being large, deforming, unilateral and are diagnosed by ultrasound and histology. In adolescents, early surveillance, diagnosis and management is important in order to avoid radical surgeries that cause large scars, deformity and breast asymmetry, which have repercussions on the behavior and emotional state of the patients. Breast tumors are generally benign in adolescence, but their diagnosis in this age group is worrisome for the family and the patient. We present the case of a 14-year-old adolescent who underwent a submammary approach, preserving breast symmetry.

Rev. bras. cir. plást ; 36(4): 382-389, out.-dez. 2021. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1365581


■ RESUMO Introdução: Como o câncer de mama é a doença maligna mais prevalente em todo o mundo, o tratamento conservador é de extrema importância. No entanto, em muitos casos, a mastectomia continua sendo o procedimento cirúrgico indicado e, como qualquer outra amputação, leva um fardo significativo para essas pacientes. No caso da mastectomia, a reconstrução imediata da mama é o tratamento padrão. A reconstrução aloplástica continua sendo o tipo mais amplamente realizado de reconstrução mamária imediata. Métodos: Neste artigo, os autores apresentam uma série de 105 casos de reconstrução aloplástica imediata em 5 anos de 2015 a 2019 no Centro Hospitalar e Universitário de Coimbra, Portugal. Inclui mastectomias curativas e redutoras de risco realizadas por ginecologistas oncológicos. As opções de reconstrução oferecidas pela equipe de reconstrução plástica incluíram tanto a reconstrução direta no implante quanto a reconstrução em dois estágios com o uso de expansores de tecido. Resultados: Dados sobre a doença oncológica, tipo de mastectomia, critérios de seleção das pacientes e resultados pós-operatórios imediato e tardio com diferentes técnicas de reconstrução imediata foram coletados, analisados e comparados com a literatura. Em nosso estudo, o índice de massa corporal foi o único preditor mais significativo de complicações e seu impacto foi estatisticamente significativo. Conclusão: Os resultados obtidos representam uma etapa essencial para a melhoria da qualidade da assistência à mulher em reconstrução mamária.

■ ABSTRACT Introduction: With breast cancer being the most prevalent malignancy worldwide, conservative treatment is of tremendous importance. Nevertheless, in many cases, mastectomy remains the indicated surgical procedure, and like any other amputation, it carries a significant burden on those patients. In the case of mastectomy, immediate breast reconstruction is the standard of care. Alloplastic reconstruction remains the most widely performed type of immediate breast reconstruction. Methods: In this article, the authors present a series of 105 cases of immediate alloplastic reconstruction in 5 years from 2015 to 2019 in Centro Hospitalar e Universitário de Coimbra, Portugal. It includes curative and risk-reducing mastectomies performed by oncologic gynecologists. The reconstruction options offered by the plastic reconstructive team included both direct-to-implant reconstruction and two-stage reconstruction with the use of tissue expanders. Results: Data regarding the oncologic disease, type of mastectomy, patient selection criteria and immediate and late postoperative outcomes with different techniques of immediate reconstruction were collected, analyzed, and compared to literature. In our study, body mass index was the single most significant predictor of complications and, its impact was statistically significant. Conclusion: The results obtained represent an essential step to improving care quality for women undergoing breast reconstruction.

Psico USF ; 26(3): 417-428, Jul.-Sept. 2021. tab
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1351334


Crescimento pós-traumático (CPT) refere-se à mudança positiva em algum aspecto da experiência humana como resultado do enfrentamento de adversidades. Investigou-se a relação entre CPT, estilos de enfrentamento e centralidade de evento. Participaram do estudo 65 mulheres que concluíram os tratamentos recomendados para o câncer de mama. Tratou-se de uma pesquisa quantitativa cujos instrumentos foram respondidos on-line. Identificou-se correlações altas entre CPT e centralidade de evento e moderadas entre CPT e os estilos de enfrentamento: estratégia focada no problema, busca de suporte social e práticas religiosas. A centralidade de evento e as estratégias focadas no problema mostraram-se melhores preditoras de CPT. Os resultados sugerem que quanto maior a adversidade percebida, maior a possibilidade de crescimento, sendo as estratégias de enfrentamento focadas no problema um componente importante para a sua ocorrência. Este estudo apontou a possibilidade de crescimento pessoal relacionado ao enfrentamento do CA de mama e indicou estratégias relevantes para desenvolvê-lo. (AU)

Posttraumatic growth (PTG) refers to a positive change in some aspect of the human experience as a result of coping with adversity. This study investigated the relationship between PTG, coping styles, and event centrality, using a cross-sectional research design. The sample consisted of 65 women who had completed the recommended treatments for breast cancer (BC) and answered an online survey. High correlations were identified between PTG and event centrality, and moderate correlations between PTG and the coping styles 'problem-focused strategy', 'social support seeking', and 'religious practices'. Event centrality and problem-focused coping strategies were the best predictors of PTG. The results suggest that the greater the perceived adversity, the greater the possibility of growth, and that problem-focused coping strategies are important for the occurrence of growth in the context of BC. This study pointed to the possibility of personal growth from coping with BC and indicated effective strategies to develop it. (AU)

El crecimiento postraumático (CPT) se refiere al cambio positivo en algún aspecto de la experiencia humana como resultado del enfrentamiento de adversidades. Se investigó la relación entre CPT, estilos de enfrentamiento y centralidad de eventos. Participaron del estudio 65 mujeres que completaron los tratamientos recomendados para el cáncer de mama. Se trató de una investigación cuantitativa respondida on-line. Se identificaron altas correlaciones entre CPT y centralidad de eventos; y moderadas entre CPT y los estilos de enfrentamiento: estrategia centrada en el problema, búsqueda de apoyo social y prácticas religiosas. La centralidad de eventos y las estrategias centradas en el problema demostraron mejores predictores del CPT. Los resultados sugieren que cuanto mayor es la adversidad percibida, mayor es la posibilidad de crecimiento, siendo las estrategias de afrontamientos centradas en el problema un componente importante para su ocurrencia. Este estudio señaló la posibilidad de crecimiento personal frente a la lucha contra el cáncer de mama. (AU)

Humans , Female , Adult , Middle Aged , Breast Neoplasms/psychology , Adaptation, Psychological , Posttraumatic Growth, Psychological , Pastoral Care , Social Support , Cross-Sectional Studies , Surveys and Questionnaires , Regression Analysis