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1.
Arq. ciências saúde UNIPAR ; 26(3): 764-781, set-dez. 2022.
Article in Portuguese | LILACS | ID: biblio-1399464

ABSTRACT

Objetivo: evidenciar os cuidados de enfermagem descritos na literatura nacional e internacional que são aplicados em pacientes queimados em terapia intensiva. Método: revisão integrativa, realizada no período de fevereiro a dezembro de 2020, nas bases de dados eletrônicas US National Library of Medicine, Medical Literature Analysis and Retrieval System Online e Biblioteca Virtual em Saúde. Resultados: foram selecionados oito artigos, os quais foram categorizados em Cuidados de Enfermagem com a pele em pacientes queimados, Cuidados de Enfermagem com a mobilidade em pacientes queimados e Cuidados de Enfermagem em pacientes queimados em relação à dor, dispositivos e prevenção de complicações. Conclusão: os cuidados de enfermagem para pacientes queimados em terapia intensiva estão intensamente atrelados aos cuidados com as lesões de pele e seus desdobramentos, assim como a prevenção de infecções.


Objective: to highlight the nursing care described in the National and International Literature that is applied to burned patients in intensive care. Methods: integrative review, carried out from February to December, 2020, using the following electronic bases: US National Library of Medicine, Medical Literature Analysis and Retrieval System Online and Biblioteca Virtual em Saúde. Results: it was selected eight articles, which were categorized into Nursing Care for skin in burned patients, Nursing Care for mobility in burned patients and Nursing Care for burned patients in relation to pain, devices and prevention of complications. Conclusion: nursing care for burned patients in intensive care is associated to the care of skin lesions and their consequences, as well as the prevention of infections.


Objetivo: destacar los cuidados de enfermería descritos en la literatura nacional e internacional que se aplican en pacientes quemados en cuidados intensivos. Método: revisión integradora, realizada de febrero a diciembre de 2020, en las bases de datos electrónicas US National Library of Medicine, Medical Literature Analysis and Retrieval System Online y Virtual Health Library. Resultados: se seleccionaron ocho artículos, los cuales se clasificaron en Cuidados de Enfermería con la Pelea en Pacientes Enfermos, Cuidados de Enfermería con la Movilidad en Pacientes Enfermos y Cuidados de Enfermería en Pacientes Enfermos en relación con el dolor, los dispositivos y la prevención de complicaciones. Conclusión: los cuidados de enfermería a los pacientes quemados en cuidados intensivos están intensamente ligados al cuidado de las lesiones cutáneas y sus desdoblamientos, así como a la prevención de infecciones.


Subject(s)
Burn Units/statistics & numerical data , Burns/diagnosis , Intensive Care Units/statistics & numerical data , Nursing Care/methods , Pain/diagnosis , Infection Control/methods , Critical Care , Libraries, Digital , Degloving Injuries/diagnosis
2.
Rev. bras. cir. plást ; 37(3): 332-337, jul.set.2022. ilus
Article in English, French | LILACS-Express | LILACS | ID: biblio-1398722

ABSTRACT

Introdução: As lesões por queimaduras são um problema de saúde global que atinge todas as faixas etárias, não só pela frequência com que ocorrem, mas também pela gravidade. Podem ser incapacitantes, ter alta mortalidade e, ao mesmo tempo, gerar um impacto econômico desfavorável para o país. O objetivo é descrever o perfil microbiológico de pacientes hospitalizados por queimaduras. Métodos: Estudo descritivo, longitudinal e prospectivo no Hospital Provincial Clínico Cirúrgico Celia Sánchez Manduley, Cuba, de julho de 2017 a junho de 2020. Foram estudadas amostras de cultura, positividade, microrganismos isolados e sensibilidade antimicrobiana. Resultados: O estudo mostrou que as amostras de lesões cutâneas por queimaduras (130) foram predominantes e delas 58,46% foram positivas; Staphylococcus aureus, com 51,73%, foi o germe mais isolado; sensibilidade à amicacina de 55,56% e vancomicina 51,11%; a sobrevida foi alta. Conclusão: Predominou a positividade nas amostras de cultura de pele queimada, principalmente Staphylococcus aureus, e uma alta sensibilidade a poucos antimicrobianos.


Introduction: Injuries caused by burns are a global health problem that affects all age groups, not only because of the frequency in which they occur but according to their severity. They can be disabling and have high mortality, and at the same time, generate an unfavorable economic impact on the country. The objective is to describe the microbiological profile of burned hospitalized patients. Methods: A descriptive, longitudinal, and prospective study was carried out at the Provincial Clinical Surgical Celia Sánchez Manduley Hospital from July 2017 to June 2020. Microbiology culture, positivity, isolated microorganisms, and antimicrobial sensitivity were studied. Results: The study showed that the culture microbiology of skin lesions due to burns (130 samples) were predominant, and of them, 58.46% were positive, Staphylococcus aureus with 51.73% was the most isolated germ; sensitivity to amikacin of 55.56% and vancomycin 51.11%; survival was high. Conclusions: The positivity in the culture microbiology of burned skin, mainly Staphylococcus aureus, and high sensitivity to few antimicrobials predominated.

3.
Rev. mex. anestesiol ; 45(2): 129-134, abr.-jun. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1395028

ABSTRACT

Resumen: El conocimiento de la fisiopatología de las quemaduras son base del manejo perioperatorio. Todos los órganos y sistemas resultan alterados y los cambios hemodinámicos en la fase aguda se caracterizan por una disminución del gasto cardíaco. Después de seis días de la lesión, ocurre un nuevo cambio hemodinámico, esta fase es conocida como estado hipermetabólico y su duración está en relación con la extensión y profundidad de la lesión. La lesión por inhalación es un factor importante a considerar como mal pronóstico y, de igual manera, el número de comorbilidades y/o trauma asociado. Durante este segundo período, los anestesiólogos tienen una participación continua y estrecha. Los problemas farmacológicos, manejo de vía aérea, accesos vasculares, hipotermia, monitoreo y control del dolor, entre otros, se hacen muy marcados. Por último, la fase de secuelas acompaña al paciente para toda su vida y la magnitud de los daños, costos y discapacidad serán directamente relacionados con la atención administrada durante las primeras dos fases.


Abstract: Knowledge of the pathophysiology of burns is the basis of perioperative management. All organs and systems are altered and hemodynamic changes in the acute phase are characterized by a decrease in cardiac output. After six days of injury a new hemodynamic change occurs, this phase is known as hypermetabolic state and its duration is in relation to the extent and depth of the injury. Inhalation injury is an important factor to consider as a poor prognosis and also the number of associated comorbidities and/or trauma. During this second period the Anesthesiologists have a continuous and close participation. Pharmacological problems, airway management, vascular access, hypothermia, monitoring and pain control among others become very marked. Finally, the phase of sequelae is for life and the magnitude of damages, costs and disability will be directly related to the care administered during the first two phases.

4.
Rev. bras. cir. plást ; 37(2): 189-193, abr.jun.2022. ilus
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1379840

ABSTRACT

Introdução: As queimaduras, um problema de saúde pública, são lesões que podem ocorrer na pele ou outros tecidos do corpo decorrentes de trauma de origem térmica, podendo ocasionar lesões leves, graves e até mesmo o óbito. Assim, são estudadas as características epidemiológicas dos pacientes atendidos na Unidade de Queimados do Hospital de Clínicas da Universidade Federal de Uberlândia. Métodos: Estudo transversal de dados registrados nos prontuários dos pacientes atendidos por queimadura na Unidade de Queimados de 2016 até 2019. Resultados: Um total de 252 prontuários foram revisados, sendo mais atingido o gênero masculino da faixa etária adulta. O principal agente causal foi o líquido inflamável (42,4%), com predomínio do álcool (66,35), acontecendo no domicílio (59,9%). O percentual médio da superfície corporal queimada foi de 17,7%, precisando de enxerto ou debridamento cirúrgico 25% dos pacientes. A média de internaçação foi 23,3 dias, com 8,7% necessitando de Unidade de Terapia Intensiva. A tentativa de autoextermínio foi de 5,5%, sendo a taxa geral de óbito de 3,5%. Conclusões: Pacientes por queimadura atendidos na Unidade de Queimados do Hospital de Clínicas da Universidade Federal de Uberlândia abrangem mais a população jovem e adulta, sendo o álcool a causa predominante, com média de óbitos similar a outras regiões. Este estudo ajudará a criar medidas no sentido de reduzir o número de casos e adequar o atendimento de forma quantitativa e qualitativa, contribuindo para a elaboração de protocolos de cuidados, a fim de assegurar a qualidade da assistência dos pacientes e da população em geral.


Introduction: Burns, a public health problem, are injuries that can occur on the skin or other tissues of the body resulting from the trauma of thermal origin, which can cause mild, severe injuries and even death. Thus, the epidemiological characteristics of patients seen at the Burn unit of the Hospital de Clínicas of the Universidade Federal de Uberlândia are studied. Methods: Cross-sectional study of the data recorded in patients' medical records treated for the burn at the Burn Units from 2016 to 2019. Results: 252 medical records were reviewed, with the male gender of the adult group being most affected. The main causal agent was the flammable liquid (42.4%) with a predominance of alcohol (66.35), occurring at home (59.9%). The average percentage of burned body surface was 17.7%, requiring a graft or surgical debridement in 25% of the patients. The average hospital stay was 23.3 days, requiring 8.7% of the Intensive Care Unit. The attempt at self-extermination was 5.5%, with a general death rate of 3.5%. Conclusions: Burn patients treated at the Burn Unit of the Hospital de Clínicas of the Universidade Federal de Uberlândia encompasses more of the young and adult population, with alcohol being the predominant cause, with an average death rate like other regions. This study will help create measures in search of reducing the number of cases and adapting the care quantitatively and qualitatively, contributing to the elaboration of care protocols to ensure the quality of the care of the patients and the population.

5.
Rev. bras. cir. plást ; 37(2): 199-203, abr.jun.2022. ilus
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1379869

ABSTRACT

Introdução: A infecção pelo HIV e as queimaduras são um problema comum de saúde pública, principalmente em países de baixa e média renda. Há uma escassez na literatura sobre a epidemiologia de pacientes HIV positivos hospitalizados em unidades de queimados. O objetivo deste estudo é avaliar dados clínicoepidemiológicos de pacientes HIV positivos internados em uma Unidade de Terapia de Queimaduras. Métodos: Realizada análise retrospectiva de pacientes com diagnóstico de HIV internados na Unidade de Terapia de Queimados do Hospital Estadual de Bauru entre os anos de 2008 e 2018. Resultados: No total, foram revisados 2364 prontuários e encontrados 14 (0,6%) pacientes com diagnóstico de HIV. A idade média foi 43,1 anos. Quanto ao gênero, nove (64,3%) eram masculinos e cinco (35,7%) femininos. O mecanismo mais comum foi por chama direta em 11 (78,7%) casos. A etiologia foi álcool (42,9%) em seis pacientes, em três explosão (21,5%) e os demais foram gasolina, cigarro e contato com escapamento, todos com um (7,1%) caso. A causa mais comum foi acidente, em nove (64,3%) casos, dois (14,3%) tentativa de homicídio, um (7,1%) autoextermínio e dois (14,3%) casos sem informação. Em relação à superfície corporal queimada (%SCQ), cinco (37,5%) apresentavam queimaduras de 0-10%, três (21,4%) de 11-20% e cinco (35,7%) maiores que 20%, e em um era desconhecida. Quatro (28,6%) apresentaram lesões de vias aéreas. Dois (14,3%) pacientes foram a óbito. Conclusão: A prevalência de pacientes HIV positivos queimados internados em uma unidade especializada para este tratamento se assemelha à nacional, com características semelhantes em relação a idade e gênero.


Introduction: HIV infection and burns are common public health issues, especially in low- and middle-income countries. There is a paucity in the literature evaluating the epidemiology of burns hospitalization in HIV patients. This study aims to evaluate the clinical and epidemiological profile of HIV-positive patients hospitalized in a Burn Therapy Unit. Methods: A retrospective analysis of burn patients diagnosed with HIV was performed at the Therapy Unit of the State Hospital of Bauru between 2008 and 2018. Results: 2,364 medical records were reviewed, and 14 (0.6%) patients were diagnosed with HIV. The mean age was 43.1 years. Regarding gender, nine (64.3%) were male, and five (35.7%) were female. The most common mechanism was direct flame in 11 (78.7%) cases. The etiology was alcohol (42.9%) in six patients, in three explosions (21. 5%), and the others were gasoline, cigarettes and contact with exhaustion, all with one (7.1%) case. When the cause of these burns was evaluated, nine (64.3%) were due to accidents, either at work or home, two (14.3%) for attempted murder, one (7.1%) self-extermination, and two (14.3%) cases had no information. Regarding total burn surface area, five (37.5%) had burns of 0-10%, three (21.4%) 11-20% and five (35.7%) greater than 20%, and one was unknown. Four (28.6%) showed airway lesions. Two (14.3%) patients died. Conclusion: The prevalence of burned HIV-positive patients admitted to a specialized unit for this treatment is like the national one, with similar characteristics concerning age and gender.

6.
Int. j. morphol ; 40(1)feb. 2022.
Article in English | LILACS-Express | LILACS | ID: biblio-1385598

ABSTRACT

SUMMARY: Laser photobiomodulation (laser PBM) is known to be able to accelerate burn wound healing in the animal model; however little evidence exists on the action of laser PBM on the expression of important proteins in wound healing in the animal model, such as VEGF and TGF-ß1. The aim of this study was to carry out a systematic review in order to analyse the effect of laser PBM on VEGF and TGF-ß expression during burn wound repair in the animal model. A systematic review was carried out of the EMBASE, PubMed/ MEDLINE and LILACS databases. The studies included were preclinical studies that analysed the action of laser PBM on the expression of VEGF and TGF-ß (1, 2, 3) during burn wound repair in the animal model. The SYRCLE risk of bias tool was used. Random effect models were used to estimate the combined effect. Increased VEGF expression was observed with the use of laser PBM at 4.93 J/cm2 per point in the first two weeks after induction of the burn wound, with greater size of effect in the second week (SDM = 5.72; 95% CI: 3.14 to 8.31, I2 = 0 %; very low certainty of evidence). We also observed that the effect of laser PBM on TGF-ß1 expression was greater than in the control in the first week (SDM = -0.45; 95% CI: -1.91 to 1.02, I2 = 51 %; very low certainty of evidence), but diminished in the third week after induction of the lesion (SDM = -2.50; 95% CI: 3.98 to -1.01, I2 = 0 %; very low certainty of evidence). Laser PBM has an effect on TGF-ß1 and VEGF expression, promoting burn wound repair in the animal model.


RESUMEN: Es sabido que la fotobiomodulación por láser (FBM láser) puede acelerar el proceso de curación de heridas por quemadura en modelo animal, sin embargo aún se carece de mayor evidencia sobre la acción de la FBM láser en la expresión de proteínas importantes en el proceso de curación de heridas en modelo animal, como VEGF y TGF-ß1. Así, el objetivo de este estudio fue realizar una revisión sistemática a fin de analizar el efecto de la FBM láser sobre la expresión de VEGF, TGF-ß durante el proceso de reparación de heridas por quemadura en modelo animal. Se realizó una búsqueda sistemática en las bases de datos EMBASE, PubMed/MEDLINE y LILACS. Se incluyeron estudios preclínicos que analizaron la acción de la FBM láser en la expresión de VEGF, TGF-ß (1, 2, 3) durante el proceso de reparación de heridas por quemadura en modelo animal. Se utilizó la herramienta de riesgo de sesgo SYRCLE. Se utilizaron modelos de efectos aleatorios para estimar el efecto combinado. Observamos aumento de la expresión de VEGF con el uso de FBM láser 4.93 J/cm2 por punto, en las dos primeras semanas tras inducción de la herida por quemadura, con mayor tamaño de efecto en la segunda semana (SDM = 5,72; IC del 95%: 3,14 a 8,31, I2 = 0 %; certeza de la evidencia muy baja). También se observó el efecto de la FBM láser en la expresión del TGF- ß1 que fue mayor que el control en la primera semana (SDM = - 0,45; IC del 95%: -1,91 a 1,02, I2 = 51 %; certeza de la evidencia muy baja), disminuyendo en la tercera semana tras inducción de la lesión (SDM = -2,50; IC del 95%: -3,98 a -1,01; I2 = 0 %; certeza de la evidencia baja). La TFB por láser ejerce influencia en la expresión de TGF-ß1 y VEGF favoreciendo el proceso de reparación de heridas por quemadura en modelo animal.

7.
Semina cienc. biol. saude ; 43(1): 177-184, jan./jun. 2022.
Article in Portuguese | LILACS | ID: biblio-1354485

ABSTRACT

Objetivo: explorar a percepção de um paciente cirúrgico queimado em relação à sede e seu manejo no período pré-operatório e pós-operatório imediato. Relato de caso: trata-se de um estudo com abordagem qualitativa, exploratória, do tipo estudo de caso. Os critérios de inclusão foram: paciente estar internado no centro de tratamento de queimados, ser submetido a procedimento cirúrgico ou balneoterapia, ter experenciado a sede no período pré-operatório ou pós-operatório e ter recebido o manejo da sede. Para a coleta de dados utilizou-se entrevista semiestruturada, gravada e transcrita. Paciente do sexo feminino, de 32 anos, admitida com queimaduras de segundo grau em extensão de tórax, membros superiores e pescoço por tentativa de autoextermínio com álcool. Passou por seis procedimentos e esteve internada por 15 dias até o momento da coleta. Experienciou o desconforto sede durante o jejum pré-operatório e pós-operatório, considerado intenso e muito estressante durante sua internação. Conclusão: a partir da identificação do desconforto sede, utilizou-se como estratégia o picolé de gelo, que fez diferença em seu tratamento. O modelo de manejo da sede é pioneiro no cuidado ao paciente queimado e apresenta benefícios para minorar a sede.


Objective: explore thirst perception of a burnt surgical patient and its management in the preoperative and immediate postoperative period. Case report: study with a qualitative and exploratory approach, named as case study. Inclusion criteria were: inpatient at burnt treatment unit, undergone surgical procedure or balneotherapy, experienced thirst in the preoperative or postoperative period and received thirst management. For data collection, semi-structured interviews were performed, recorded and transcribed. Female patient, 32 years old, admitted with second degree burns in extension of thorax, upper limbs and neck due to attempted self-extermination with alcohol. Underwent six procedures and was hospitalized for 15 days until the data collection. Experienced thirst discomfort during preoperative and postoperative fasting, which was considered intense and very stressful during his hospitalization. Conclusion: since the identification of thirst discomfort, the ice popsicle was used as a strategy, which made difference in her treatment. The thirst management model is pioneer in care of burnt patients and has benefits to alleviate thirst.


Subject(s)
Humans , Female , Adult , Patients , Thirst , Balneology , Burns , Ice , Postoperative Period , Therapeutics , Data Collection , Fasting , Preoperative Period , Hospitalization , Inpatients , Neck
8.
Article in Chinese | WPRIM | ID: wpr-939474

ABSTRACT

Rationale: Endophthalmitis is an uncommon but serious ocular infection often resulting in probable visual loss. Bacteroides fragilis is a rare cause of endophthalmitis. Patient concerns: A 46-year-old male patient complained of eye pain and low vision after pars plana vitrectomy. Diagnosis: Bacteroides fragilis endophthalmitis after pars plana vitrectomy was diagnosed. Interventions: Pars plana vitrectomy and silicone oil implantation were performed. Outcomes: Early treatment and choice of tamponade in endophthalmitis after pars plana vitrectomy may possibly prevent evisceration and progression of endophthalmitis. Lessons: Bacteroides fragilis can be seen in cases of endophthalmitis after pars plana vitrectomy.

9.
Article in Chinese | WPRIM | ID: wpr-939473

ABSTRACT

Objective: To identify unique immunogenic epitopes of Zika virus non-structural 1 (NS1) antigen and produce immunoglobulin Y (IgY) for potential use in he diagnosis of of Zika virus infection. Methods: Immunogenic epitopes were identified using in silico B-cell epitope prediction. A synthetic peptide analog of the predicted epitope was used to induce antipeptide IgY production in hens which was purified using affinity chromatography. Presence of purified IgY and its binding specificity were performed by gel electrophoresis and ELISA, respectively. Results: Out of the nine continuous epitopes identified, the sequence at position 193-208 (LKVREDYSLECDPAVI) was selected and used to produce anti-peptide IgY. The produced IgY was found to bind to the synthetic analog of the Zika virus NS1 immunogenic epitope but not to other flaviviruses and random peptides from other pathogens. Conclusions: In this study, we identified an immunogenic epitope unique to Zika virus that can be used to develop a serodiagnostic tool that specifically detect Zika virus infection.

10.
Article in Chinese | WPRIM | ID: wpr-939472

ABSTRACT

Objective: To determine the spatiotemporal distribution of Schistosoma (S.) japonicum infections in humans, livestock, and Oncomelania (O.) hupensis across the endemic foci of China. Methods: Based on multi-stage continuous downscaling of sentinel monitoring, county-based schistosomiasis surveillance data were captured from the national schistosomiasis surveillance sites of China from 2005 to 2019. The data included S. japonicum infections in humans, livestock, and O. hupensis. The spatiotemporal trends for schistosomiasis were detected using a Joinpoint regression model, with a standard deviational ellipse (SDE) tool, which determined the central tendency and dispersion in the spatial distribution of schistosomiasis. Further, more spatiotemporal clusters of S. japonicum infections in humans, livestock, and O. hupensis were evaluated by the Poisson model. Results: The prevalence of S. japonicum human infections decreased from 2.06% to zero based on data of the national schistosomiasis surveillance sites of China from 2005 to 2019, with a reduction from 9.42% to zero for the prevalence of S. japonicum infections in livestock, and from 0.26% to zero for the prevalence of S. japonicum infections in O. hupensis. Analysis using an SDE tool showed that schistosomiasis-affected regions were reduced yearly from 2005 to 2014 in the endemic provinces of Hunan, Hubei, Jiangxi, and Anhui, as well as in the Poyang and Dongting Lake regions. Poisson model revealed 11 clusters of S. japonicum human infections, six clusters of S. japonicum infections in livestock, and nine clusters of S. japonicum infections in O. hupensis. The clusters of human infection were highly consistent with clusters of S. japonicum infections in livestock and O. hupensis. They were in the 5 provinces of Hunan, Hubei, Jiangxi, Anhui, and Jiangsu, as well as along the middle and lower reaches of the Yangtze River. Humans, livestock, and O. hupensis infections with S. japonicum were mainly concentrated in the north of the Hunan Province, south of the Hubei Province, north of the Jiangxi Province, and southwestern portion of Anhui Province. In the 2 mountainous provinces of Sichuan and Yunnan, human, livestock, and O. hupensis infections with S. japonicum were mainly concentrated in the northwestern portion of the Yunnan Province, the Daliangshan area in the south of Sichuan Province, and the hilly regions in the middle of Sichuan Province. Conclusions: A remarkable decline in the disease prevalence of S. japonicum infection was observed in endemic schistosomiasis in China between 2005 and 2019. However, there remains a long-term risk of transmission in local areas, with the highest-risk areas primarily in Poyang Lake and Dongting Lake regions, requiring to focus on vigilance against the rebound of the epidemic. Development of high-sensitivity detection methods and integrating the transmission links such as human and livestock infection, wild animal infection, and O. hupensis into the surveillance-response system will ensure the elimination of schistosomiasis in China by 2030.

11.
Article in Chinese | WPRIM | ID: wpr-939471

ABSTRACT

Objective: To investigate the resistance profiles to antimicrobial agents of wound-isolated Pseudomonas (P.) aeruginosa among Chinese burn patients. Methods: Electronic databases and manual search were used to identify eligible studies published since 2010. The objectives were pooled resistance rates for eleven common antimicrobial agents, estimated by a random-effects model. Subgroup analyses were conducted by stratifying the studies into three four-year periods based on year of isolation. Results: A total of 35 studies were included. Gentamicin had the highest pooled resistance rate (56%, 95% CI 48%-64%), while meropenem had the lowest pooled resistance rate (29%, 95% CI 20%-40%). There was an increasing trend of resistance to common antimicrobial agents of wound-isolated P. aeruginosa over a span of twelve years (2009-2020). There remained the highest risk of gentamicin resistance over time in China. Subgroup analyses indicated significantly higher resistances to ceftazidime and levofloxacin from 2017 to 2020. Conclusions: Enhanced resistance to common antimicrobial agents in wound-isolated P. aeruginosa presents a challenge in burn wound management in mainland China. Effective stewardship programs should be established based on corresponding resistance profiles, thereby optimizing treatment options for hospitalized burn patients.

12.
China Pharmacy ; (12): 1901-1904, 2022.
Article in Chinese | WPRIM | ID: wpr-936500

ABSTRACT

OBJE CTIVE To explore the rational application and management of antibiotics in burn department of our hospital based on disease diagnosis related groups (DRGs). METHODS Patients discharged from the burn department of our hospital from July 2020 to June 2021 were selected as the research objects to collect DRG data. The overall application of antibiotics in DRG group with more than 10 cases were analyzed ,and the application of antibiotics in typical disease groups were evaluated horizontally and vertically. RESULTS Among 3 732 discharged cases in the burn department of our hospital ,a total of 3 515 cases were included in 66 DRG groups ,21 DRG groups of which were included in the study. Among 21 DRG groups ,the maximum antibiotics use density (AUD)of antibiotics was 102.20 DDDs/(100 person·d)in AH 11 group,the utilization ratio of antibiotics was 100%,and the combined use rate of antibiotics was 81.82%;case-mix index (CMI)value was 11.49. The minimum AUD was 1.01 DDDs/(100 person·d)in XR 19 group,the utilization ratio of antibiotics was 5.06%,and the combined use rate of antibiotics was 0;CMI value was 0.81. Within the same core group ,AUD increased with the increase of CMI. The horizontal comparison and analysis of WB 11 group showed that there was a large gap in AUD among different physicians. The vertical comparison of AUD in WB11 group showed relatively small changes over time. CONCLUSIONS The horizontal and vertical evaluation of antibiotics based on DRGs can provide new clues for the control of antibiotics and help to realize the fine specialized management of antibiotics.

13.
São Paulo; s.n; s.n; 2022. 63 p. tab, tab.
Thesis in Portuguese | LILACS | ID: biblio-1396298

ABSTRACT

Introdução: Meropenem (MER) e Piperacilina/Tazobactana (PTZ) são agentes antimicrobianos largamente prescritos para pacientes grandes queimados internados em Unidade de Terapia Intensiva (UTI) com infecções nosocomiais causadas por Gram-negativos sensíveis CIM 2 mg/L, Enterobacteriaceae, EB e Non-enterobacteriaceae, NEB. A síndrome da resposta inflamatória sistêmica (SRIS) que ocorre durante o choque séptico no grande queimado pode causar alteração na farmacocinética do paciente em terapia intensiva, de modo que a dose recomendada pode não atingir o alvo desejado contra Gram-negativos de sensibilidade intermediária CIM >2 mg/L. Objetivo: Investigar a efetividade dos beta-lactâmicos piperacilina e meropenem na infusão estendida comparada à infusão intermitente recomendada, para os pacientes sépticos grandes queimados através da abordagem farmacocinética-farmacodinâmica (PK/PD). Ética, casuística e procedimentos: Autor e co-autores declararam não haver conflito de interesse. O protocolo foi aprovado, registro CAAE 07525118.3.0000.0068. No presente protocolo de estudo investigaram-se 36 pacientes sépticos grandes queimados, ambos os gêneros (12F/24M) em terapia intensiva do choque séptico com piperacilina-tazobactana 4,5g q6h ou meropenem 1g q8h. Os pacientes incluídos foram estratificados em dois grupos com base na administração através da infusão intermitente, 0,5 h (G1) ou da infusão estendida, 3 h (G2), ambos com 16 pacientes cada. Duas amostras sanguíneas (1,5mL/cada) foram coletadas no estado de equilíbrio (Steady State), 3ª e 5ª hora do início da infusão. Os níveis séricos de PTZ e MER foram mensurados através de cromatografia líquida, e a farmacocinética (PK) dos dois grupos de pacientes foi comparada aos dados reportados em voluntários sadios. A abordagem PK/PD foi aplicada para avaliação da cobertura do antimicrobiano a partir da estimativa do índice de predição de efetividade (% fΔT>CIM) e da probabilidade de alcançar o alvo terapêutico (PTA) com base no alvo PK/PD recomendado, 100%fΔT>CIM. Resultados e discussão: As características de admissão dos pacientes G1/G2 foram expressas através de mediana e interquartil: Clcr 115 (90-148) / 127 (90-170) ml/min; 30 (24-31) / 27 (24- 33,5) anos, 70 (61-75) / 71 (65-75) kg, 30 (20-42) / 33,9 (18-38,4)% área total de superfície queimada, SAPS3 53 (45-57) / 48 (37,8-59,5). Na admissão dos pacientes na UTI registrou-se G1/G2: trauma térmico (17/16), trauma elétrico (1/2), lesão inalatória (11/11), ventilação mecânica (16/9) e vasopressores foram necessários em 15/8 pacientes, G1/G2. Ocorreram diferentes alterações na farmacocinética dos dois beta-lactâmicos após a infusão estendida versus a infusão intermitente quando comparadas com dados relatados em voluntários sadios. Evidenciou-se prolongamento da meia vida decorrente do aumento do volume de distribuição. Estes resultados impactaram diferentemente a cobertura. O monitoramento de biomarcadores inflamatórios expressos em medianas (G1/G2) evidenciou aumento do PCR: 232/183mg/L e leucocitose (leucócitos 11/14 mil cel/mm3, neutrófilos 9/10 mil cel/mm3) na fase precoce do choque séptico. Relativamente à microbiologia dos isolados, a erradicação dos patógenos ocorreu para todos os pacientes após a infusão estendida contra Gram-negativos sensíveis (CIM: 2 mg/L), e de sensibilidade intermediária (CIM 4mg/L) como a K. pneumoniae e P. aeruginosa, enquanto a infusão intermitente garantiu erradicação de patógenos apenas até CIM 2 mg/L. Conclusão: Evidenciou-se a superioridade da infusão estendida frente à infusão intermitente na cobertura dos dois antimicrobianos, no alvo terapêutico considerado 100%fΔT>CIM. Registraram-se alterações na farmacocinética destes agentes nos pacientes frente aos dados reportados para voluntários sadios. Diferença significativa entre grupos (G1/G2) foi encontrada com relação meia vida biológica, e ao volume de distribuição tanto pata a piperacilina quanto para o meropenem


Background: Meropenem (MER) and Piperacillin/Tazobactam (PTZ), antimicrobial betalactam agents are widely prescribed to burn patients from the Intensive Care Unit (ICU) with nosocomial infections caused by Gram-negative strains. Change in the pharmacokinetics of critically ill patient occurs during the systemic inflammatory response syndrome (SIRS) at the course of septic shock. Then, the recommended dose administered by intermittent infusion, 0.5 hr cannot reach the target against gram-negative strains MIC > 2 mg/L. Subject: To investigate drug effectiveness of the beta-lactams piperacilin and meropenem in extended infusion compared to the recommended intermittent infusion in critically ill septic burn patients using pharmacokinetic-pharmacodynamic (PK/PD) approach. Ethics, Casuistry and Methods: All authors declared there is no conflict of interests. Ethical approval CAAE, register 07525118.3.0000.0068. It was investigated in the study protocol 36 septic burn patients of both genders (12M / 24F), undergoing antimicrobial therapy with PTZ 4.5 g q6h or MER 1g q8h. Based on the chosen antimicrobial therapy and drug infusion prescribed by the physician, patients were stratified in groups with intermittent 0.5h infusion (G1) or with the extended 3h infusion (G2), both groups with 16 patients each. Two blood samples were collected at the steady state (1.5mL / each), at the 3rd and 5th hrs of starting the infusion. Serum levels were measured by liquid chromatography. Pharmacokinetics (PK) of MER or PTZ was compared to data reported in healthy volunteers for both groups of patients. PK/PD approach was applied to estimate the drug effectiveness index (fΔT> MIC) and to assess the probability of target attained (PTA) based on the recommended PK/PD target, 100% fΔT> MIC. Results and discussion: Characteristics of patients admission G1/G2 were: Clcr 115(90- 148)/127(90-170) ml/min; 30(24-31)/27(24-34) yrs, 70(61-75)/71(65-75) kg, 30(20- 42)/33.9(18-38.4)% total burn surface area, SAPS3 53(45-57)/48(37.8-59.5), medians (interquartile): thermal trauma occurred (17/16), electric trauma (1/2), inhalation injury (11/11), mechanical ventilation (9/16) and vasopressors required in 15/8 patients. It was demonstrated that different PK changes occurred for both beta-lactam agents after the extended or intermittent infusion by comparison with data reported in healthy volunteers. PK changes were related to the prolongation of biological half-life and increases on volume of distribution with impact on pharmacodynamics. On the other hand, meropenem total body clearance reduced by 50% at the earlier period of septic shock could be explained by the reduction of MER-transporters expression in the tubular renal secretion, once only patients with renal function preserved were included in the study protocol. Inflammatory biomarkers increased at the earlier period of septic shock: C-rp 232/183mg/L; leukocytes 11/14*103cel/mm3, neutrophils 9/10*103cel/mm3, medians, G1/G2. Clinical and microbiological cure was obtained for all patients of G1 against MIC < 2mg/L after intermittent 0.5 h infusion; while PK/PD target was attained for G2 patients undergoing antimicrobial therapy with MER or PTZ by extended infusion against gram negative strains K. pneumoniae, P. aeruginosa up to MIC 4mg L. Conclusion: Superiority of the extended infusion over intermitent infusion was obtained for the two antimicrobials was evidenced, in the therapeutic target considered 100%fΔT>CIM. Changes in the pharmacokinetics of these agents were recorded in patients compared to data reported for healthy volunteers. A significant difference between groups (G1/G2) was found in relation to biological half-life and volume of distribution for both piperacillin and meropenem


Subject(s)
Piperacillin/analysis , Burns/diagnosis , Meropenem/analysis , Patients/classification , Shock, Septic/complications , Pharmacokinetics , Pharmaceutical Preparations , Cross Infection/complications , Chromatography, Liquid/methods , Critical Illness/classification , Systemic Inflammatory Response Syndrome/diagnosis , Pharmacologic Actions , Enterobacteriaceae , Dosage , Intensive Care Units/classification , Anti-Infective Agents/analysis
14.
Rev. cir. (Impr.) ; 73(6)dic. 2021.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388887

ABSTRACT

Resumen Introducción: En el año 2017 se incorporó un registro de notificación en línea (Registro Nacional de Quemados) al flujo de derivación de pacientes quemados en Chile. Objetivo: A partir de la información obtenida de esta plataforma, se describe la epidemiología de las quemaduras y las variables que podrían explicar los traslados fallidos a nuestra unidad de quemados. Materiales y Método: Se analizaron los casos subidos a esta plataforma entre julio de 2017 y julio de 2018. Se caracterizó la población global y comparó variables relevantes entre el grupo de pacientes no trasladados a nuestra unidad y los que fueron trasladados con éxito. Resultados: Se analizaron 319 pacientes, 66% hombres, edad promedio 51 años, IMC de 27% y 47% con enfermedades previas. El fuego fue la principal causa de quemaduras. Se observó un 31% de injuria inhaladora. 107 pacientes no se trasladaron a nuestro centro de quemados. Los pacientes trasladados puntuaron más alto en comorbilidad, índice de gravedad, superficie corporal total quemada y aseo quirúrgico en el hospital base. El grupo de pacientes no trasladados puntuó más alto en injuria inhalatoria. La mortalidad global fue 20,4%. La mortalidad fue mayor en pacientes no trasladados (33,6% versus 13,7%; p < 0,001). Conclusiones: Además de facilitar el flujo de pacientes y ahorrar recursos, un uso noble de esta plataforma es ser fuente de información epidemiológica y de implementación de políticas públicas, lo cual puede ser tomado como ejemplo por otros países en vías de desarrollo. Además, se demuestra que ser trasladado constituye un factor protector de muerte por quemaduras.


Introduction: In 2017, an online notification register, the National Burn Registry, was incorporated into the referral flow of burned patients in Chile. Aim: Through the information obtained from this platform, we describe the epidemiology of burns in Chile, and identify variables that could explain failed transfers to our burn unit. Materials and Method: Cases uploaded to this platform between July 2017 - July 2018 were analyzed. We characterize the global population and relevant variables were compared between the group of patients that failed to be transferred to the burn unit and the ones who were successfully transferred. Results: 319 patients were analyzed, 66% men, average age 51 years, BMI of 27 and 47% with previous illnesses. Fire was the main cause of burn injury. Smoke inhalation injury was observed for 31%. 107 patients failed to reach to our burn center. Transferred patients rated higher in comorbidity, severity index, total burned body surface and surgical debridement at base hospital. The group of not transferred patients rated higher in inhalation injury. Overall mortality was 20.4%. Mortality was higher in non-transferred patients (33.6% versus 13.7%; p < 0.001). Conclusions: Aside from facilitating the flow of burned patients and resources saving, a noble use of this platform has been to serve as a source of epidemiological information and implementation of public policies, which can be taken as an example by other developing countries. Also, being transferred is a protective factor for death from burn injuries.

15.
Medicina (B.Aires) ; 81(5): 780-785, oct. 2021. graf
Article in Spanish | LILACS | ID: biblio-1351051

ABSTRACT

Resumen Se realizó un estudio retrospectivo de las infecciones fúngicas atendidas en un centro de quemados de alta complejidad situado en Buenos Aires, entre 2011 y 2014, mediante el análisis de las histo rias clínicas (n = 36). Las edades de los pacientes estuvieron entre 18 y 87 años, y 23 (63.9%) fueron mujeres. La extensión de la superficie corporal afectada más prevalente varió entre 30 y 50% (p = 0.03), y entre 71% y 100% en pacientes de menor edad, relacionándose con intentos de femicidio. En el 69.4% la profundidad de la quemadura fue grado 4, y en el 50% de los casos se observaron lesiones por inhalación, con una alta mortali dad (p = 0.04). El Candida score resultó de 3 en el 77.7% de los casos. Se usaron vías centrales y ventilación mecánica. Todos los pacientes recibieron tratamiento antibiótico y en 33 (91.7%) antifúngicos. La escisión qui rúrgica de la quemadura se practicó en 33 (91.7%) y los autoinjertos de piel en 29 (80.6%). La infección fúngica se desarrolló en una media de 21.4 días del ingreso en UCI. Se estudiaron 52 muestras de levaduras que se aislaron de urocultivo (42.3%), hemocultivo (26.9%), biopsia cutánea (9.6%), punta de catéter (15.4%) y aspirado traqueal (5.8%). Por cultivo microbiológico y métodos moleculares se identificaron a Candida albicans (53.8%), C. tropicalis (23.1%), C. parapsilosis sensu stricto (13.5%), C. krusei (5.8%), C. glabrata (1.9%) y C. dubliniensis (1.9%). Las infecciones fúngicas representan severas complicaciones en quemados con factores de riesgo.


Abstract A retrospective analysis of fungal infections was carried out in a health-care burn center between 2011 and 2014 using the patients' medical records (n = 36). Patients ranged from 18 to 87 years of age, with 23 (63.9%) being women. The most prevalent widespread total body surface area affected (TBSA) was 30-50% (p = 0.03), and 71-100% in younger patients, mainly associated with femicide. Fourth degree burns were revealed in 69.4% of the patients while in 50%, inhalation injuries were observed to represent a higher mortality rate (p = 0.04). The Candida score was 3 in 77.7% of cases respectively. Central venous catheter and mechanical ventilation were used. All patients received antibiotic treatment and 91.7% antifungal treatment. Surgical excision of the burn was performed in 33 (91.7%) patients, and skin autografting in 29 (80.6%). The median of the fungal infection devel oped was 21.4 days after admission to the ICU. The specimens analyzed involved 52 yeast samples isolated from different cultures: urine (42.3%), blood (26.9%), skin biopsy (9.6%), catheter tip (15.4%) and tracheal aspirate (5.8%). The use of microbiological culture and molecular methods allowed for the identification of Candida albicans (53.8%), C. tropicalis (23.1%), C. parapsilosis sensu stricto (13.5%), C. krusei (5.8%), C. glabrata (1.9%) and C. dubliniensis (1.9%). Fungal infections observed in skin burns lead to severe complications in at-risk patients.


Subject(s)
Humans , Female , Candida , Mycoses/drug therapy , Retrospective Studies , Risk Factors , Antifungal Agents
16.
Vitae (Medellín) ; 28(3): 1-7, 2021-08-11. Ilustraciones
Article in English | LILACS, COLNAL | ID: biblio-1363276

ABSTRACT

Background: The bulb of Allium cepa Linnaeus (onion) is used in traditional medicine as an antidiabetic, antioxidant, antihypertensive, anti-inflammatory, and antihyperlipidemic, among others. The lack of information or little knowledge about the effects of Allium cepa L. on skin lesions, specifically burn wounds, arouses interest in studying its effects on these skin disorders. Objective: This study assessed the wound healing activity of Allium cepa L. on second-degree burns induced in Holtzman rats. Method: Thirty-two albino rats were randomly distributed into four groups of 8 rats each, including the Healthy group, the Control group, the Experimental group (Alliumcepa L.), and the Standard group (1% silver sulfadiazine). Burn wounds were induced, and topical treatments were performed daily for 21 days. The reduction of the burned body area (mm2) was determined during the experimental time. Albino rats were sacrificed with an excess of surgical anesthesia to obtain tissue samples for histopathological analysis. Results: Standard and experimental groups significantly reduced burned body area (p<0.01) compared to the control group. Histopathological studies showed hyperemic chorion in the Control group, fibroblasts, and collagen in the Standard group, and dermis composed of a reticular stratum of fibroblasts, collagen, and few blood vessels in the Experimental group. Conclusion: Allium cepa L. revealed wound-healing activity on burns induced in Holtzman rats and reduced the damage produced by burns


Antecedentes: El bulbo de Alliumcepa L. (cebolla) se utiliza en medicina tradicional como antidiabético, antioxidante, antihipertensivo, antiinflamatorio, anti hiperlipidémico entre otros. La falta de información o muy poco conocimiento acerca de los efectos de Allium. cepa L. en lesiones cutáneas, específicamente en las heridas por quemaduras, despierta el interés por estudiar sus efectos en estas afectaciones cutáneas. Objetivo: El objetivo de este estudio fue evaluar la actividad cicatrizante de Allium. cepa L. en quemaduras de segundo grado inducidas en ratas Holtzman. Método: Se utilizaron treinta y dos ratas albinas distribuidas al azar en cuatro grupos de ocho ratas cada uno, incluyendo el Grupo sano, el Grupo Control, el Grupo Experimental (Allium cepa L.) y el Grupo Estándar (Sulfadiazina de plata al 1%). Se indujo la herida por quemadura, y los tratamientos tópicos se realizaron diariamente durante 21 días. La reducción del área corporal quemada (mm2) se determinó durante el tiempo de experimentación, luego los animales fueron sacrificados con exceso de anestesia quirúrgica para obtener las muestras de tejidos para el estudio histopatológico. Resultados: Los grupos estándar y experimental mostraron reducción significativa en el área corporal quemada (p<0,01) comparadas al grupo control. El estudio histopatológico evidenció corion hiperémico en el grupo control; fibroblastos y colágeno en el grupo estándar y dermis integrada por un estrato reticular de fibroblastos, colágeno y pocos vasos sanguíneos en el grupo experimental. Conclusión: Alliumcepa L. reveló actividad cicatrizante en quemaduras inducidas en ratas Holtzman, y disminuyó el daño producido por las quemaduras


Subject(s)
Humans , Phytochemicals , Silver Sulfadiazine , Burns , Onions , Histology
17.
Rev. bras. cir. plást ; 36(2): 173-180, abr.jun.2021. ilus
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1368032

ABSTRACT

Introdução: Queimaduras são lesões decorrentes da ação do calor e representam um grave problema de saúde pública no mundo devido às sequelas físicas ou psicológicas de caráter permanente, e exigem investimento especializado e de qualidade. O objetivo é conhecer o perfil de pacientes internados em um centro de tratamento de queimados do norte do Paraná no ano de 2012. Métodos: Pesquisa retrospectiva, descritiva e de análise quantitativa, realizada no ano de 2013, com dados coletados em 241 prontuários clínicos de pacientes atendidos em um centro de tratamentos de queimados do norte do Paraná em 2012. Foram realizadas análises de percentual e incidência dos casos. Resultados: Reinternações estiveram presentes em 8% dos casos, 70% dos foram homens e 59% eram adultos; os pacientes tinham como origem a regional de saúde local em 44% dos casos; o tempo para internação foi igual ou maior que 3 dias em 38% dos casos e o tempo médio de permanência foi de 17 dias. Destacaram-se acidentes em ambiente doméstico em 75,5%; foram os principais agentes causais o álcool líquido: 32%, seguido por escaldo: 31%; as partes do corpo mais atingidas foram face, membros superiores, tronco e membros inferiores. Houve óbito em 14%, chegando a 44% dos idosos atendidos. Conclusão: Queimaduras são um problema que acomete ambos os sexos e diferentes faixas etárias, desencadeando consequências físicas, emocionais e socioeconômicas. Estas lesões são um desafio para as políticas públicas e para o sistema de saúde, exigindo investimentos em serviços e tratamentos especializados, além das estratégias de prevenção.


Introduction: Burns are injuries arising from heat and represent a serious public health problem in the world due to physical or psychological sequelae of permanent character, and require specialized investment and quality. The objective is to know the profile of patients hospitalized in a burn treatment center in northern Paraná in 2012. Methods: Retrospective, descriptive and quantitative analysis research, conducted in 2013, with data collected from 241 clinical records of patients treated at a burn treatment center in northern Paraná in 2012. Analyses of percentage and incidence of cases were performed. Results: Readmission was present in 8% of the cases,70% of them were men, and 59% were adults; the patients had as their origin the patients originated from the regional health center in 44% of cases in 44% of the cases; the time to hospital stay was equal to or greater than three days in 38% of the cases and the mean length of stay was 17 days. Accidents in the domestic environment stood out in 75.5%; were the main causal agents of liquid alcohol: 32%, followed by scalding: 31%; the parts of the body most affected were face, upper limbs, trunk and lower limbs. There was death in 14%, reaching 44% of the elderly attended. Conclusion: Burns is a problem that affects both sexes and different age groups, triggering physical, emotional and socioeconomic consequences. These injuries are a challenge for public policies and the health system, requiring investments in specialized services and treatments, in addition to prevention strategies.

18.
Rev. bras. cir. plást ; 36(2): 181-187, abr.jun.2021. ilus
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1368033

ABSTRACT

Introdução: Queimaduras são lesões causadas por agentes externos aos tecidos orgânicos, nas quais há destruição do revestimento epitelial e/ou mucosas em profundidade e extensão variáveis. Objetiva-se neste estudo analisar o perfil epidemiológico de pacientes queimados, admitidos no Hospital de Clínicas da Universidade Federal de Uberlândia, Minas Gerais, Brasil. Métodos: A obtenção dos dados ocorreu por meio do levantamento de prontuários de pacientes admitidos no pronto socorro e unidade de queimados do Hospital de Clínicas, no período de 01 de janeiro de 2015 a 31 de dezembro de 2019. Resultados: Dos 305 pacientes analisados, 59,2% foram do sexo masculino, a faixa etária de 0 a 9 anos foi a de maior representatividade (24,03%) e a etnia parda a de maior número de episódios (42,53%). Quanto ao tempo de internação, 57% dos casos ficaram internados menos de 10 dias e a média do tempo de internação total foi de 26,61 dias. Constatou-se que o incidente de maior frequência foi a exposição a agentes explosivos ou à combustão de substâncias inflamáveis (43,51%) e que o álcool líquido foi o agente etiológico mais comum (30,51%). Conclusão: Observa-se a relevância do perfil epidemiológico, já que esse identifica os principais grupos de risco. De acordo com as referências utilizadas, fica em evidencia a importância da prevenção e da fiscalização com foco na redução da morbidade e mortalidade.


Introduction: Burns are lesions caused by agents external to organic tissues, in which there is the destruction of the epithelial lining and/or mucous membranes in varying depth and extension. This study aims to analyze the epidemiological profile of burned patients admitted to the Clinical Hospital of the Federal University of Uberlândia, Minas Gerais, Brazil. Methods: Data were obtained by collecting medical records of patients admitted to the emergency room and burn Unit of the Hospital de Clínicas, from January 1, 2015, to December 31, 2019. Results: Of the 305 patients analyzed, 59.2% were male, the age group from 0 to 9 years was the most representative (24.03%) and brown ethnicity with the highest number of episodes (42.53%). Regarding hospitalization length, 57% of the cases were hospitalized less than ten days and the mean total hospitalization time was 26.61 days. It was found that the most frequent incident was exposure to explosive agents or combustion of flammable substances (43.51%) and that liquid alcohol was the most common etiological agent (30.51%). Conclusion: The relevance of the epidemiological profile is observed since it identifies the main risk groups. According to the references used, the importance of prevention and surveillance is highlighted, focusing on reducing morbidity and mortality.

19.
Rev. chil. infectol ; 38(3)jun. 2021.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388253

ABSTRACT

Resumen Sphingobacterium multivorum es un bacilo gramnegativo no fermentador, que infrecuentemente causa enfermedad en humanos. En la literatura médica existen escasos reportes de infecciones causadas por este microorganismo, en general, en hospederos con alguna comorbilidad. Presentamos el primer caso reportado, según nuestro conocimiento, de una infección de piel y tejidos blandos por Sphingobacterium multivorum en un paciente pediátrico gran quemado.


Abstract Sphingobacterium multivorum is a non-fermentative gram-negative bacillus that rarely causes human infections. In the medical literature, the few reported cases of infections resulting from S. multivorum usually occurred in patients with an associated comorbidity. We present the first case report, according our knowledge, of a skin and soft tissue infection by S. multivorum infection in a pediatric patient after a burn injury.

20.
Arch. argent. pediatr ; 119(5): 325-330, oct. 2021. tab
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1292087

ABSTRACT

Introducción. Las infecciones con bacteriemias en pacientes quemados son causa frecuente de complicaciones y aumento de días de internación. El conocimiento de los microorganismos causales y la identificación de factores de riesgo asociados permiten disminuir las complicaciones infecciosas, la morbimortalidad y los costos en cuidados de la salud. Este trabajo evalúa el grado de asociación entre los factores de riesgo y los episodios de bacteriemias en pacientes quemados, e identifica los microorganismos aislados más frecuentemente en hemocultivos. Población y métodos. Estudio de casos y controles realizado en la Unidad de Cuidados Críticos de Quemados del Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" entre el 1 de junio de 2014 y el 30 de septiembre de 2019 en pacientes que presentaron episodios de bacteriemia con hemocultivo positivo (casos) y los que presentaron hemocultivos negativos (controles). Resultados. Durante el período estudiado se identificaron 29 casos de bacteriemias. La mediana de días de internación al momento del episodio de bacteriemia fue de 23 días. El microorganismo más frecuentemente identificado fue Pseudomonas (7 casos). El único factor de riesgo con el que se pudo establecer asociación significativa fue la presencia de acceso venoso central con 7 días o más (OR 3,18; IC 95 %: 1,20-8,38). La mortalidad global fue del 9,1 %, en los casos fue del 13,8 %, y en los controles, del 3,4 %. Conclusiones. Los accesos venosos centrales con duración mayor a 7 días son un factor de riesgo independiente de bacteriemias en niños quemados críticos. No se pudo establecer una asociación estadísticamente significativa con otros factores de riesgos analizados. Pseudomonas, Acinetobacter y Staphylococcus coagulasa negativo fueron los microorganismos más frecuentemente identificados en las bacteriemias


Introduction. Infections due to bacteremia in burn patients are a common cause of complications and an extended length of stay. Knowing causative microorganisms and identifying associated risk factors allow to reduce infectious complications, morbidity, mortality, and health care expenditure. This study assesses the extent of the association between risk factors and bacteremia in burn patients and identifies the most common microorganisms found in blood cultures. Population and methods. Case-control study conducted at the Burn Intensive Care Unit of Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" between June 1st, 2014 and September 30th, 2019 in patients with bacteremia events and a positive blood culture (cases) and patients with a negative blood culture (controls). Results. During the study period, 29 cases of bacteremia were identified. The median length of stay at the time of bacteremia was 23 days. The most commonly identified microorganism was Pseudomonas (7 cases). The only risk factor that showed a significant association was the presence of a central venous line for 7 days or more (OR: 3.18; 95 % confidence interval: 1.20- 8.38). The overall mortality rate was 9.1%; 13.8% for cases and 3.4% for controls. Conclusions. Central venous lines for more than 7 days are an independent risk factor for bacteremia in critically ill burn children. No statistically significant association was established with other studied risk factors. Pseudomonas, Acinetobacter, and coagulase-negative Staphylococcus were the most common microorganisms found in bacteremia


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Burns/complications , Bacteremia/etiology , Bacteremia/epidemiology , Staphylococcus , Intensive Care Units, Pediatric , Case-Control Studies , Indicators of Morbidity and Mortality , Retrospective Studies , Risk Factors , Infections
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