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1.
Niger. J. Dent. Res. (Online) ; 7(1): 60-66, 2022. figures, tables
Article in English | AIM, AIM | ID: biblio-1354980

ABSTRACT

Objective: This study compared the concentration of salivary lactoferrin in patients with and without chronic periodontitis and investigated correlations with clinical variables of the disease. Methods: The study included 102 participants (51 cases and 51 controls) who presented at the Periodontology Clinic of University of Benin Teaching Hospital and met the selection criteria of '4mm and above' periodontal probing depths (PPD) and positive bleeding on probing (BOP) using community periodontal index (CPI) probe. Healthy participants (controls) were patients that had PPD less than or equal to 3mm, absence of BOP and simplified oral hygiene index (OHI-S) not more than 1.2. Baseline OHI-S and CPI scores were recorded. Saliva samples were collected and analyzed using enzyme-linked immunosorbent assay. All data were analyzed with the Statistical Package for Social Sciences (SPSS) version 22.0. Results: There was a statistically significant difference between the mean (SD) lactoferrin concentration of control participants 5.27(0.59) mg/l and case participants 6.74(0.61) mg/l (p<0.001). Participants with probing pocket depths (PPD) of 6mm or more had a significantly higher mean concentration [6.85(0.06) mg/l] than that of those with PPD 4-5mm [6.71(0.67) mg/l] (p< 0.001)Lactoferrin levels were highest in participants with 'poor' oral hygiene [6.85(0.60) mg/l] and lowest in those with 'good' oral hygiene [6.65(0.83) mg/l]. Conclusion: Salivary lactoferrin levels were higher among participants with chronic periodontitis than those without chronic periodontitis and correlates positively with the main clinical characteristics of the disease


Subject(s)
Saliva , Lactoferrin , Chronic Periodontitis , Health Facilities
2.
Multimed (Granma) ; 25(6): e2251, 2021. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1356534

ABSTRACT

RESUMEN La periodontitis es la enfermedad crónica inflamatoria más común que se observa en humanos. Con el objetivo de identificar los factores de riesgo asociados a la periodontitis crónica en pacientes adultos, se realizó un estudio analítico, de casos y controles en el Policlínico David Moreno Domínguez de Santa Rita, Jiguaní, Granma, de octubre 2017 - agosto 2019. De un universo de 989pacientes atendidos en consulta de Periodoncia, se seleccionó una muestra probabilística de 126 pacientes, entre 35 y 64 años (42 casos y 84 controles). Se realizó examen bucal e interrogatorio. Se aplicó el índice periodontal de Rusell y el IAHB de Love. Para el análisis univariado se empleó la razón de productos cruzados Odds Ratio y el Chi-Cuadrado, con una confiabilidad del 95 % y una probabilidad < 0,05. Mostraron asociación a la periodontitis crónica: el tabaquismo (OR= 9,5372; p= 0,0000), la diabetes mellitus (OR= 6,4339; p= 0,0001), la higiene bucal deficiente (OR=5,693; p=0,0000) y el sexo masculino (OR=2,5294, p= 0,0281). El factor de riesgo que presentó mayor valor de asociación a la periodontitis crónica fue el tabaquismo. La edad no constituyó un riesgo a tener en cuenta para la aparición de la enfermedad.


ABSTRACT Periodontitis is the most common chronic inflammatory disease observed in humans, with the objective of identify the risk factors associated with chronic periodontitis in adult patients. An analytical, case-control study was carried out at the David Moreno Domínguez polyclinic in Santa Rita, Jiguaní, Granma, from October 2017 - August 2019. From a universe of 989 patients seen in the Periodontics clinic, a probabilistic sample was selected of 126 patients between 35 and 64 years old (42 cases and 84 controls). Oral examination and interview were performed. Russell's periodontal index and Love's IAHB were applied. For the univariate analysis, the ratio of crossed products Odds Ratio and Chi-Square were used, with a reliability of 95% and a probability <0.05. Smoking (OR = 9.5372; p = 0.0000), diabetes mellitus (OR = 6.4339; p = 0.0001), poor oral hygiene (OR = 5.693; p = 0.0000) and male sex (OR = 2.5294, p = 0.0281) showed an association with chronic periodontitis. The risk factor that presented the highest value of association with chronic periodontitis was smoking. Age was not a risk to take into account for the onset of the disease.


RESUMO A periodontite é a doença inflamatória crônica mais coman observada em humanos. Como objetivo de identificar os fatores de risco associados à periodontite crônica em pacientes adultos, foi realizado um estudo analítico caso-controle na Policlínica David Moreno Domínguez em Santa Rita, Jiguaní, Granma, de outubro de 2017 a agosto de 2019. De um universo de 989 pacientes atendidos no consultório de Periodontia, foi selecionada uma amostra probabilística de 126 pacientes, com idades entre 35 e 64 anos (42 casos e 84 controles). Exame oral e questionamento foram realizados. O índice periodontal de Russell e o IAHB de Love foram aplicados. Para a anúlese univariada, utilizo u-se a raseo dos produtos cruzados Odds Ratio e o Qui-quadrado, com confiabilidade de 95% e probabilidade <0,05. Eles mostraram associação com periodontite crônica: tabagismo (OR = 9,5372; p = 0,0000), diabetes mellitus (OR = 6,4339; p = 0,0001), higiene bucal precária (OR = 5,693; p = 0,0000) e sexo masculino (OR = 2,5294, p = 0,0281). O fator de risco que apresentou maior valor de associação à periodontite crônica foi o tabagismo. A idade não foi um risco a ser levado em consideração para o início da doença.

3.
Rev. ADM ; 78(1): 22-27, ene.-feb- 2021. ilus, tab
Article in Spanish | LILACS | ID: biblio-1177078

ABSTRACT

Introducción: La periodontitis es una enfermedad infecciosa que afecta a los tejidos de sostén de los dientes, su prevalencia se estima entre el 35 y 45% de la población adulta. Las enfermedades cardiovasculares tienen relación directa con la periodontitis crónica, las bacterias periodontales pueden pasar la barrera epitelial de los tejidos periodontales y lograr la propagación sistémica a través de los vasos sanguíneos, causando la inflamación del endocardio. Objetivo: Determinar prevalencia de enfermedad periodontal como factor de riesgo cardiovascular en adultos de 25 a 60 años en Nacajuca, Tabasco. Material y métodos: Se realizó un estudió observacional, prospectivo, transversal y analítico, con muestra de 40 participantes entre 25 y 60 años, el 52% (21) son hombres y el 49% (19) mujeres, se empleó el sistema no probabilístico por conveniencia. Las variables fueron edad, género, grado de conocimiento sobre enfermedad periodontal, nivel de alimentación, grado de tabaquismo, grado de higiene bucal y grado de periodontitis. Resultado: La prevalencia de enfermedad periodontal como factor de riesgo cardiovascular es 48% (19 personas) con periodontitis crónica moderada y avanzada generalizada. Conclusión: Con base en la revisión bibliográfica, las personas con el grado de periodontitis crónica moderada y avanzada generalizada son propensas a desencadenar una enfermedad cardiovascular (infarto agudo de miocardio). Sin embargo, son necesarios más estudios de experimentación longitudinal, con base en el vínculo que tiene la enfermedad periodontal y cardiovascular (AU)


Introduction: Periodontitis is an infectious disease that affects the tissue of the teeth, its prevalence is estimated between 35 and 45% of the adult population. Cardiovascular diseases are directly related to chronic periodontitis, periodontal bacteria can pass the epithelial barrier of periodontal tissues and achieve systemic propagation through the blood vessels causing Inflammation of the endocardio. Objective: To determine the prevalence of periodontal disease as a cardiovascular risk factor in adults from 25 to 60 years Nacajuca, Tabasco. Material and methods: An observational, prospective, transverse and analytical study was carried out, with a sample of 40 participants between 25 and 60 years, 52% (21) corresponds to the masculine genus and 49% (19) represents the female genus, the non-probabilistic system was employed by Convenience. The variables were age, gender, degree of knowledge on periodontal disease, feeding level, degree of smoking, degree of oral hygiene and degree of periodontitis. Result: the prevalence of periodontal disease as a cardiovascular risk factor is 48% (19 people) with chronically moderate and advanced generalized periodontitis. Conclusion: Based on the bibliographical review people with the degree of chronic periodontitis moderate and advanced generalized are prone to trigger a cardiovascular disease (acute myocardial infarction). However, more studies of longitudinal experimentation are necessary, based on the link which has the periodontal and cardiovascular disease (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Cardiovascular Diseases , Risk Factors , Chronic Periodontitis , Periodontal Diseases , Cross-Sectional Studies , Statistical Analysis , Prospective Studies , Mexico , Myocardial Infarction
4.
Article in Chinese | WPRIM | ID: wpr-908666

ABSTRACT

Objective:To investigate the effect of sodium hyaluronate on chronic periodontitis and its influence on serum hyper sensitive C-reactive protein(hs-CRP), interleukin 8(IL-8) and tumor necrosis factor-α(TNF-α).Methods:Using the random number table method, 98 patients with chronic periodontitis from March 2017 to March 2019 in Hangzhou Xixi Hospital were randomly divided into observation group (49 cases) and control group (49 cases). The control group was treated with tinidazole tablets, and the observation group was treated with sodium hyaluronate on the basis of the control group. The course of treatment was 4 weeks. The total effective rate was compared and the gingival index(GI), sulcus bleeding index (SBI), plaque index (PLI), and the levels of serum hs-CRP, IL-8, TNF-α before and 4 weeks after treatment were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group:93.88%(46/49) vs. 71.43%(35/49), the difference was statistically significant ( χ2=8.612, P<0.05). After treatment of 4 weeks, the scores of GI, SBI and PLI in the observation group were lower than those in the control group: (1.10 ± 0.23 vs. 1.63 ± 0.36, 0.38 ± 0.10 vs.0.71 ± 0.15, 0.83 ± 0.29 vs. 1.36 ± 0.21), the differences were statistically significant ( P<0.05). After treatment of 4 weeks, the levels of hs-CRP, IL-8 and TNF-α in the observation group were lower than those in the control group: (4.53 ± 1.29) mg/L vs. (7.65 ± 1.82) mg/L, (6.17 ± 1.08) ng/L vs. (9.98 ± 1.56) ng/L, (2.27 ± 0.26) μg/L vs. (3.98 ± 0.32) μg/L, the differences were statistically significant ( P<0.05). No obvious adverse reactions occurred in the two groups. Conclusions:Sodium hyaluronate has a significant clinical effect on chronic periodontitis. It can reduce the levels of hs-CRP, IL-8, TNF-α and alleviate the inflammatory reaction.

5.
Article in Chinese | WPRIM | ID: wpr-886565

ABSTRACT

Objective@# To study the changes in levels of interleukin (IL)-6, IL-10, tumor necrosis factor-alpha (TNF-α), and alkaline phosphatase (ALP) in the gingival crevicular fluid (GCF) of patients with severe chronic periodontitis before and after nonsurgical periodontal therapy and to explore the relationship among the levels of these four biomarkers in GCF, their periodontal status and their clinical significance to evaluate the effect of nonsurgical periodontal therapy and periodontitis activity.@*Methods@# In total, 30 patients with severe chronic periodontitis were enrolled in a 1-year longitudinal pilot study (Chinese Clinical Trial Registry: ChiCTR-OCH-13004679). At baseline and 1, 3, 6, and 12 months after nonsurgical therapy, the periodontal clinical indicators plaque index (PLI), probing depth (PD), clinical attachment loss (CAL), sulcus bleeding index (SBI) were recorded. Filter paper strips were used to collect two deep-pocket (probing depth ≥ 6 mm) and two shallow-pocket (probing depth ≤ 4 mm) periodontal sites for each patient and weighed. The levels of interleukin IL-6, IL-10, TNF-α, and ALP in GCF were assessed using enzyme-linked immunosorbent assay. Meanwhile, 30 healthy sites of 15 subjects with healthy periodontium were used as the baseline controls for patients with severe chronic periodontitis.@*Results @#At the baseline, the TNF-α, ALP and IL-6 levels in GCF of the disease sites of patients with periodontitis were significantly higher than those in healthy periodontal sites of the control group (P < 0.001), and the levels of IL-10 were significantly lower than those in the control group (P < 0.001). In patients with severe chronic periodontitis, the levels of TNF-α, ALP and IL-6 in GCF at deep-pocket sites were significantly higher than those at shallow-pocket sites (P <0.001), and the IL-10 levels were significantly lower than those at shallow-pocket sites (P < 0.001). 1, 3, 6, and 12 months after nonsurgical treatment, the levels of TNF-α and ALP in GCF at the shallow- and deep-pocket sites in patients with chronic periodontitis significantly decreased, the level of IL-10 significantly increased (P < 0.005), and the level of IL-6 in GCF at the deep-pocket sites significantly decreased (P < 0.005). However, there was no significant difference in IL-6 level at shallow-pocket sites (P > 0.05). 1, 3, 6, and 12 months after nonsurgical treatment, the periodontal clinical indicators were improved compared with the baseline. In addition, there was a significant correlation between the levels of these four biomarkers and the periodontal clinical parameters (P < 0.05). During the two follow-up visits after nonsurgical periodontal therapy, the sites with more than 2-mm increase in attachment loss had significant differences in the levels of the four biomarkers in the GCF compared with the previous visit time (P < 0.005).@*Conclusion@#The detection of the levels of these four biomarkers in GCF has strong clinical significance for assessing the severity of periodontitis and the efficacy of nonsurgical periodontal therapy. Increased levels of TNF-α, ALP, and IL-6 and decreased IL-10 levels in GCF may indicate periodontitis progression at this site.

6.
Article in Chinese | WPRIM | ID: wpr-862452

ABSTRACT

Objective @# To detect the composition of the subgingival microbiota in generalized aggressive periodontitis (GAgP) and severe chronic periodontitis (SCP) patients tested by high-throughput sequencing (HTS) technologies, analyze its diversity and function by using bioinformatics, and observe changes in the subgingival microbiota before and after periodontal initial therapy.@* Methods@#Eleven patients with GAgP and 14 patients with SCP who visited the Department of Periodontics in Stomatological Hospital of Kunming Medical University from September 2018 to May 2019 were recruited, and subgingival plaque samples were collected at baseline and 6 weeks after initial therapy. Then, the genomic DNA was distracted and sequenced by the Illumina MiSeq high-throughput sequencing platform. QIIME (quantitative insights in microbial ecology), Mothur, SPSS and other software were used to analyze community information. LEfSe difference analysis (linear discriminant analysis effect size), network analysis, and the KEGG PATHWAY database (https://www.kegg.jp/kegg/pathway.html) were used to predict community function. @* Results @# At baseline, the dominant microbiota of GAgP and SCP patients were similar, including Bacteroidetes, Porphyromonas and Porphyromonas endodontalis. Six weeks after initial therapy, as the periodontal pocket became shallower, the variation trend of the microbiota of GAgP and SCP patients was similar. The relative abundance of gram-negative bacteria, such as Bacteroidetes, Porphyromonas and Porphyromonas endodontalis, decreased, while the relative abundance of gram-positive bacteria, such as Proteobacteria, Actinomyces and Rothia aeria, increased. Actinobacteria were significantly increased biomarkers of the subgingival microbiota in GAgP after treatment. Streptococcus is an important genus that connects the microbiota related to periodontitis and the microbiota related to periodontal health. Community function prediction result showed that initial treatment can reduce the functions of amino acid metabolism, methane metabolism, and peptidase in GAgP and SCP patients.@*Conclusion@#The subgingival microbiota of GAgP and SCP patients are similar. Streptococcus, as an early colonizer, may play an important role in promoting plaque biofilm formation and maturation in the process of subgingival flora from health to imbalance. Initial therapy can change the composition and structure of the subgingival microbiota, reduce community diversity, and reduce the functions of amino acid metabolism, methane metabolism, and peptidase in GAgP and SCP patients.

7.
Article in Chinese | WPRIM | ID: wpr-876465

ABSTRACT

@#Chronic periodontitis is an infectious disease caused by plaque as the initiating factor. Clinically, it manifests as irreversible loss of hard tissue, leading to the destruction of surrounding periodontal tissue, including the deep periodontal pocket, loss of attachment, and finally, tooth loss. Interleukin-18 (IL-18) can promote inflammation and regulate immune function and plays an important role in mediating the host immune response and inflammatory response. An increase in IL-18 in vivo can induce the production of interferon and inflammatory factors, such as interleukin, tumor necrosis factor and matrix metalloproteinase, thus mediating the dual reaction of immunity and inflammation. These inflammatory factors are involved in the occurrence and development of chronic periodontitis. Many clinical studies have shown that the levels of IL-18 in serum, saliva, gingival crevicular fluid and gingival tissue samples of patients with chronic periodontitis may be positively correlated with the severity of periodontitis; however, as a candidate gene, IL-18 is involved in the susceptibility polymorphism of periodontitis. Understanding how to quantify the level of IL-18 in clinical studies and apply it to diagnostic tools and new sites identified by new methods (genome-wide association studies and omics research) will also deepen our understanding of the pathogenesis of IL-18 in chronic periodontitis and provide new ideas for future precision medicine and the formulation of personalized programs. In this paper, the structure, biological function and association between IL-18 and periodontitis are reviewed.

8.
Article in Chinese | WPRIM | ID: wpr-875971

ABSTRACT

Objective@# To investigate the influence of mechanical debridement on the subgingival microbiome in chronic periodontitis by 16S rRNA high-throughput sequencing.@*Methods@#Patients with generalized moderate to severe chronic periodontitis were recruited into this study and received oral hygiene instruction and supragingival scaling. One week later, they received ultrasonic and manual subgingival scaling and root planning. Clinical parameters were recorded and subgingival plaques were sampled at baseline and 3 months and 6 months after treatment. The comprehensive profiles of the subgingival microbiome were analyzed by sequencing the V3-4 region of 16S rRNA with the Illumina MiSeq platform.@*Results @#Alpha diversity analysis showed that the richness and diversity of the subgingival community were consistent before and after treatment, but a significant difference in community structure was detected only between baseline and month 3 by principal coordinates analysis (PCoA). After 3 months, the clinical parameter as probing depth (PD) decreased significantly and the relative abundances of the genera related to periodontitis such as Porphyromonas, Treponema, Tannerella, and Filifactor decreased significantly. Meanwhile, the relative abundances of the genera associated with periodontal health increased, such as Capnocytophaga, Kingella. Six months later, however, less genera related to periodontitis decreased significantly from the baseline level, such as Filifactor. PD decreased significantly compared with baseline, but increased significantly compared with 3 months after treatment. @* Conclusion@#Mechanical debridement alone could relieve periodontal inflammation and balance microbial dysbiosis and the greater efficacy occurred 3 months after treatment.

9.
Rev. cienc. salud (Bogotá) ; 18(3): 30-40, dic. 2020. tab
Article in English | LILACS, COLNAL | ID: biblio-1289151

ABSTRACT

Abstract Introduction: Adjunctive treatment for periodontal disease is quite varied and depends on many factors. This study aims to compare the effectiveness of 0.12% chlorhexidine and essential oils associated with scaling and root planing in the treatment of chronic periodontitis. Material and methods: The sample included 42 patients randomly assigned to three groups. Decrease in periodontal status was measured with the World Health Organization's periodontal probe by analyzing probe depth values and level of clinical insertion at 3, 4, and 5 months. Statistical analysis of the progress of the three therapies was conducted using Student's t, Anova, and Tukey tests with a significance level of p < 0.05. Results: The obtained values demonstrated that 0.12% chlorhexidine is more effective in all of its follow ups, whereas no significant difference existed between essential oils and the control group. A significant difference was observed over time in each separate treatment. Conclusión: Chlorhexidine at a 0.12% concentration associated with root scaling and planing is better than essential oil therapies for the treatment of chronic periodontitis.


Resumen Introducción: el tratamiento coadyuvante de la enfermedad periodontal es muy variado y depende de muchos factores. El objetivo del presente artículo fue comparar la efectividad entre clorhexidina al 0.12 % y aceites esenciales asociados al raspado y alisado radicular en el tratamiento de periodontitis crónica. Materiales y métodos: la muestra estuvo conformada por 42 pacientes distribuidos aleatoriamente en 3 grupos. La disminución del estado periodontal se midió con la sonda periodontal de la Organización Mundial de la Salud, analizando los valores profundidad al sondaje y el nivel de inserción clínica a los 3, 4 y 5 meses. Para el análisis estadístico de la evolución de las 3 terapias se empleó la t de Student, análisis de varianza y test de Tukey con un nivel de significancia de p < 0.05. Resultados: los valores obtenidos demostraron que la clorhexidina al 0.12 % es más efectiva en todos sus controles; mientras que no existe diferencia significativa entre aceites esenciales y el grupo control. Existe diferencia significativa a través del tiempo en cada tratamiento por separado. Conclusión: la clorhexidina al 0.12 %> asociada al raspado y alisado radicular es superior a los tratamientos con aceites esenciales en el tratamiento de la periodontitis crónica.


Resumo Introdução: o tratamento coadjuvante da doença periodontal é muito variado e depende de muitos fatores. O objetivo do presente estudo foi comprar a efetividade entre clorexidina ao 0.12% e aceites essenciais associados à raspagem e alisamento radicular no tratamento de periodontite crónica. Materiais e métodos: a amostra esteve conformada por 42 pacientes distribuídos aleatoriamente em 3 grupos. A diminuição de estado periodontal se mediu com a sonda periodontal as Organização Mundial da Saúde analisando os valores profundidade à sondagem e nível de inserção clínica aos 3, 4 e 5 meses. A análise estatística da evolução das 3 terapias, se realizou empregando t de Student, Anova e teste de Tukey com um nível de significancia de p < 0.05. Resultados: os valores obtidos demostraram que a clorexidina ao 0.12% é mais efetiva em todos seus controles, enquanto não existe diferença significativa entre aceites essenciais e o grupo controle. Existe diferença significativa através do tempo em cada tratamento por separado. Conclusão: a clorexidina ao 0.12% associada à raspagem e alisamento radicular é superior aos tratamentos com aceites essenciais no tratamento da periodontite crónica.


Subject(s)
Humans , Chronic Periodontitis , Periodontal Diseases , Oils, Volatile , Chlorhexidine , Mouthwashes
10.
Article | IMSEAR | ID: sea-215327

ABSTRACT

Periodontal disease is a chronic inflammatory disease of gum which surrounds and supports the teeth. Globally, periodontal disease is one of the most common oral diseases. Unhealthy periodontium has been connected to systemic conditions like pulmonary and cardiovascular diseases. Periodontal disease affects individuals of all ages, but it is most commonly seen in elderly patients. According to the World Health Organization, nearly 65 % of people have respiratory problems due to periodontal disease. Peak Expiratory Flow Rate (PEFR) is defined as the maximum rate and speed of expiration of an individual. We wanted to determine and compare PEFR in acute and chronic periodontitis. METHODSThe present case control study was carried out among patients in the 20 - 40 years age group, who were attending outpatient department of Saveetha Dental College and Hospitals. Study participants were grouped into three categories as ‘normal individuals’, ‘patients with acute periodontitis’ and ‘patients with chronic periodontitis’; each group had 20 people. Spirometer was used to detect the peak expiratory flow rate. Statistical analysis was done using SPSS. P value of less than or equal to 0.05 was taken as statistically significant. RESULTSResults were obtained and expressed as mean ± SD. The Tukey HSD Post-hoc Test was used. Significance value is < 0.05. PEFRs are 420 ± 21.37 and 317 ± 21.05 in control and periodontitis individuals, respectively. P values for these criteria were < 0.05. Males have a high PEFR when compared to females in normal individuals group. This difference was statistically not significant. Females have a high PEFR when compared to males in patients with acute periodontitis. This difference was statistically not significant. Males have a high PEFR when compared to females with chronic periodontitis. When compared within and between groups, it was statistically significant (p = 0.0001). CONCLUSIONSPeriodontitis could be a key source of respiratory disorders. This study shows that acute periodontitis expiratory flow rate was greater than chronic periodontitis expiratory flow rate. Proper maintenance of oral health and early detection of periodontitis may aid in reducing the frequency of respiratory problems due to periodontitis.

11.
Article | IMSEAR | ID: sea-205199

ABSTRACT

Background: With increase in the resistance to antibiotics, the paradigm of periodontal treatment in recent years is slowly shifting from specific bacteria elimination to altering bacterial ecology by probiotics. With this objective in mind, the present study was carried out to assess the use of a symbiotic preparation as a guided pocket recolonisation (GPR) procedure in patients with chronic periodontal disease. Materials and methods: Total 180 patients with chronic periodontitis with presence of true periodontal pockets; 4 mm-6 mm in depth involving minimum 3 or more quadrants were selected and divided into 3 groups wherein the first group only scaling and root planing was done without GPR application; in the 2nd group, GPR was carried out as a single application following SRP and in the 3rd group, multiple applications of GPR with SRP was done. Clinical measurements; microbiological analysis of periodontal pathogens by anaerobic culture and biochemical assessment of alkaline phosphatase and interleukin-6 using ELISA and spectrophotometry was carried out at baseline, 3 and 6 months respectively. Results: All the 3 groups showed significant changes in clinical (p<0.05) as well as in microbiological and biochemical parameters (p<0.05) within the groups. Intergroup comparisons revealed significant changes in group 2 and 3 with biochemical parameters. Positive correlation was observed with clinical parameters and alkaline phosphatase levels and P. intermedia counts in group 1 and 3. Conclusion: Within the limitations of the present study, it could be concluded that symbiotic therapy may have some additional benefit to Scaling and root planing.

12.
Article in English | LILACS, BBO | ID: biblio-1135545

ABSTRACT

Abstract Objective: To analyze whether the FokI polymorphism (rs228570) present in the vitamin D receptor gene in type 2 diabetics is related to chronic periodontitis's clinical status and evaluates the influence of chronic periodontitis on the perception of quality of life. Material and Methods: It is a clinical and laboratory study, composed of a sample of 59 individuals with previous diagnosis of type 2 Diabetes Mellitus and chronic periodontitis, of both sexes. On clinical examination, socio-epidemiological data and quality of life of patients with the Oral Health Impact Profile (OHIP-14) were recorded and a periogram was performed. Subsequently, saliva was collected spontaneously in sterile Falcon tubes (15 ml) and stored in the freezer at -20 °C. The purification of the genetic material was done with a PROMEGA kit (Wizard®), and the polymorphism studied was FokI (rs228570), found in the vitamin D receptor promoting region, with rs: 228570. After extraction of saliva DNA and purification, genotyping was performed by real-time PCR using specific allele probes (TaqMan® System). Results: The polymorphism of the vitamin D receptor gene was not positively associated with the severity and clinical characteristics of periodontitis, but suggested a relationship with the extent of the disease. Periodontitis also had no positive association with patients' perception of quality of life. Conclusion: The perception of quality of life of patients with chronic periodontitis and type 2 diabetes mellitus was compromised by the systemic condition, secondary to oral health, although some dimensions of OHIP-14 have been more frequently mentioned, such as psychological discomfort, physical pain and physical disability.


Subject(s)
Humans , Polymorphism, Genetic , Quality of Life , Receptors, Calcitriol , Diabetes Mellitus, Type 2/diagnosis , Chronic Periodontitis/pathology , Periodontitis/pathology , Brazil , Chi-Square Distribution , Oral Health , Statistics, Nonparametric , Real-Time Polymerase Chain Reaction/methods
13.
Article in Chinese | WPRIM | ID: wpr-847433

ABSTRACT

BACKGROUND: Whole-genome expression profiling is a technical method for gene expression research, with high sensitivity and specificity. This technique can be used to detect differential genes related to chronic periodontitis in the whole genome, therefore efficiently and quickly finding chronic periodontitis-related factors. OBJECTIVE: To screen genes related to chronic periodontitis by using the whole-genome expression profiling. METHODS: Normal periodontal ligament tissue of 15 patients with orthodontic extraction was selected as control group, and periodontal tissue of 21 patients with chronic periodontitis was selected as experimental group. To screen up-regulated and down-regulated genes. the genome-wide expression profile chips of four chronic periodontitis tissues and four healthy tissues were compared. The expression of the differential gene PI3K-Akt signal pathway was verified by real-time PCR (7 normal cases and 13 cases of chronic periodontitis) and western blot (4 normal cases and 4 cases of chronic periodontitis). The experimental protocol was approved by the Ethics Committee of the First Affiliated Hospital of Hainan Medical University (approval No. HNM20180034) and informed consent was obtained from each patient. RESULTS AND CONCLUSION: Analysis of the whole genome expression profile chip revealed that 1 565 up-regulated genes and 1 849 down-regulated genes were significantly differentially expressed in chronic periodontitis samples. The enrichment analysis revealed that the expression of PI3K-Akt signaling pathway was significantly different in chronic periodontitis (P < 0.001). Real-time PCR and western blot assay results indicated that PI3K and Akt expression was higher in the experimental group than in the control group (P < 0.05). All the findings indicate that the genome-wide expression profile chip is fast and highly sensitive to screen the changes in chronic periodontitis-related genes. Significantly differential expression of PI3K-Akt signal pathway in chronic periodontitis provides an experimental basis for the treatment of chronic periodontitis.

14.
Article in Chinese | WPRIM | ID: wpr-843150

ABSTRACT

Objective: To analyze the prevalence of chronic periodontitis (CP) in the peritoneal dialysis patients based on a single-center population, and explore the correlation between the severity of CP and the adequacy of peritoneal dialysis. Methods: A total of 57 patients undergoing peritoneal dialysis in the Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from December 2018 to December 2019 were included in the study. Baseline data, indicators of dialysis adequacy, including Kt/V, creatinine clearance rate, etc., and other related biochemical indicators were collected, and at the same time the CP-related indicators including clinical attachment loss, gingival index and probing depth were collected. The indicators of dialysis adequacy or their control rates of the patients with different severity of CP were compared. Pearson correlation analysis and linear regression analysis were used to explore the correlation between CP-related indexes and the indicators of dialysis adequacy. Results: All the patients undergoing peritoneal dialysis included in this study have moderate to severe CP. The prevalence of moderate CP was 24.6%, and the prevalence of severe CP was 75.4%. The proportion of moderate to severe anemia in the severe CP group was higher than that in the moderate CP group (28.0% vs 14.3%), but the difference was not statistically significant (P>0.05). Between the moderate and severe CP group, there was no statistical difference in the indicators of dialysis adequacy and their control rates (P>0.05). And there was no correlation between CP-related indexes and the indicators of dialysis adequacy as well (P>0.05). Conclusion: The prevalence of moderate to severe CP is very high in the peritoneal dialysis patients, in whom those with severe CP may have a tendency to develop moderate to severe anemia. There is no correlation between the severity of CP and dialysis adequacy.

15.
Article in English | WPRIM | ID: wpr-825490

ABSTRACT

@#Introduction: Chronic kidney disease (CKD) is associated with periodontal disease due to its hyperinflammatory state. Limited studies have explored the prevalence of periodontal disease among CKD patients in Malaysia. Objective: To assess the periodontal status of pre-dialysis CKD patients in Hospital Universiti Sains Malaysia. Methods: A total of 46 pre-dialysis CKD patients who attended the nephrology clinic at Hospital Universiti Sains Malaysia were enrolled in this study. Periodontal examination was performed using the periodontal probing depth (PPD), clinical attachment loss (CAL) and plaque index. Results: The majority of the CKD patients were Malay (95.7%) and 80.4% were males. The mean age of the patients was 58.5 years. Using PPD measurement, 37 (74.0%) of the patients had mild periodontitis, 9 (20.0%) had moderate periodontitis and 3 (6.0%) had no periodontitis. Based on CAL measurement, 12 (26%) patients had mild periodontitis, 29 (63.0%) had moderate periodontitis and 5 (11%) had severe periodontitis. The mean (standard deviation [SD]) value of mild and moderate-to-severe periodontitis by PPD measurement were 4.26 (0.26) and 5.24 (0.36), respectively. The mean of mild and moderate-to-severe periodontitis by CAL measurement were 2.66 (0.62) and 4.98 (0.73), respectively. There was no correlation between the periodontal parameters and estimated glomerular filtration rate (PPD: r = −0.160, P = 0.914; CAL: r = −0.135, P = 0.372; plaque index: r = 0.005, P = 0.974). Conclusion: This study revealed a greater prevalence and severity of chronic periodontitis among CKD patients. Thus, the periodontal health of CKD patients’ needs to be screened and monitored.

16.
Article in Chinese | WPRIM | ID: wpr-828865

ABSTRACT

OBJECTIVE@#To evaluate the clinical efficacy of ultrasound subgingival scaling combined with manual root planing for treatment of chronic periodontitis in elderly patients.@*METHODS@#Forty elderly patients with chronic periodontitis were randomly divided into test group for treatment with ultrasound and Gracey subgingival curette for subgingival scaling combined with manual root planing and control group treated with ultrasound subgingival curette scaling (=20). We compared plaque index (PLI), bleeding index (BI), probing depth (PD), and attachment loss (AL) between the two groups before and at 6 weeks and 12 weeks after the treatment.@*RESULTS@#After periodontal treatment, PLI, BI, PD and AL all decreased significantly in both groups compared with the levels before the treatment ( < 0.05). The patients in the test group showed significantly more obvious decrease of PD and AL than those in the control group ( < 0.05), but the reduction of PLI and BI was comparable between the two groups (>0.05).@*CONCLUSIONS@#Ultrasound subgingival scaling combined with manual root planing produces better therapeutic effect than ultrasonic subgingival scaling alone for treatment of chronic periodontitis in elderly patients.


Subject(s)
Aged , Chronic Periodontitis , Therapeutics , Dental Scaling , Humans , Root Planing , Treatment Outcome , Ultrasonography
17.
Article in Chinese | WPRIM | ID: wpr-827543

ABSTRACT

OBJECTIVE@#To evaluate the clinical efficacy of clarithromycin (CLM) in the adjuvant treatment of chronic periodontitis systematically, obtain reasonable conclusions through evidence-based medicine, and provide guidance for clinical rational drug use.@*METHODS@#Literature about CLM in the adjuvant treatment of chronic periodontitis was searched in CNKI, VIP, Wanfang, Chinese Biomedical Literature Database, PubMed, ScienceDirect, and Embase databases from inception to February 2019 using a computer. Meta-analysis was performed on the homogeneous study using RevMan 5.3 software after two independent reviewers screened the literature, evaluated the quality of the study, extracted the data, and evaluated the risk of bias in the included studies.@*RESULTS@#Six randomized controlled trials were included in 316 subjects. The meta-analysis showed that compared with the scaling and root planning (SRP) group, the probing depth (PD) was reduced in patients with CLM and SRP [MD=-1.00, 95%CI (-1.55, -0.45), P=0.000 04]. Clinical attachment loss was obtained [MD=-0.03, 95%CI (0.43, 0.65), P<0.000 01], and the difference between the groups was statistically significant. The modified sulcus bleeding index (mSBI) was reduced [MD=-0.01, 95%CI (-0.14, 0.19), P=0.66]. No significant difference was observed between the groups, but the decrease in mSBI was more significant in CLM combined with SRP group.@*CONCLUSIONS@#CLM combined with subgingival SRP can achieve remarkable results in treating chronic periodontitist.


Subject(s)
Anti-Bacterial Agents , Therapeutic Uses , Chronic Periodontitis , Drug Therapy , Clarithromycin , Dental Scaling , Humans , Periodontal Index , Root Planing , Treatment Outcome
18.
Article in Chinese | WPRIM | ID: wpr-827526

ABSTRACT

OBJECTIVE@#To evaluate the effect of scaling and root planing (SRP) on serum C-reactive protein (CRP) levels in patients with moderate to severe chronic periodontitis.@*METHODS@#We searched the PubMed, Web of Science, EMBASE, Cochrane, CNKI, Wanfang, and VIP databases from the inception to July 8th, 2019. Two reviewers independently screened literature, extracted data, and evaluated the bias risk of included studies. Then, a meta-analysis was performed using RevMan 5.3 software.@*RESULTS@#A total of 13 randomized controlled clinical trials and 12 prospective clinical trials were included. Meta-analysis showed that serum CRP levels decreased at 2 and 3 months after SRP (P<0.05), and no significant difference in serum CRP levels was found at 6 months (P=0.49).@*CONCLUSIONS@#SRP can reduce serum CRP levels in systematically healthy patients with moderate to severe chronic periodontitis at 2 and 3 months after SRP.


Subject(s)
C-Reactive Protein , Chronic Periodontitis , Dental Scaling , Humans , Prospective Studies , Root Planing
19.
Rev. habanera cienc. méd ; 18(5): 741-751, sept.-oct. 2019. graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1093901

ABSTRACT

RESUMEN Introducción: En pacientes adultos con periodontitis el tratamiento de Ortodoncia constituye un reto, por las condiciones biomecánicas que impone la edad, y el estado de afectación del periodonto; principal responsable de los movimientos ortodóncicos. Objetivo: Describir el tratamiento ortodóncico realizado en paciente adulta con periodontitis crónica controlada y los resultados conseguidos. Presentación del caso: Paciente femenina de 41 años, con periodontitis crónica tratada. Diastemas y extrusión en incisivos, pérdida de la inserción periodontal y exposición del cemento radicular. Apiñamiento incisivo inferior, con extrusión e incremento de la curva de Spee. Trauma oclusal interincisivo. El plan de tratamiento incluyó control de la periodontitis, la extracción de un incisivo inferior y la intrusión dentaria incisiva bimaxilar. El tratamiento duró año y medio. Los resultados fueron excelentes. Se devolvió la función perdida; se consiguió incrementar la inserción periodontal, con la consiguiente disminución de la movilidad dentaria. Se corrigió la estética afectada y se obtuvo la satisfacción de la paciente. Conclusiones: A partir de la aplicación del tratamiento de Ortodoncia se consiguió corregir las anomalías de posición dentarias y de la oclusión, devolver a la paciente adulta portadora de periodontitis crónica la estética perdida y una oclusión funcional. Las decisiones terapéuticas consideraron el estado del periodonto, el control de la enfermedad y la edad de la paciente. Las fuerzas aplicadas fueron extremadamente controladas y el tiempo de tratamiento el menor posible. La motivación y el cuidado de la higiene bucal contribuyeron a los resultados alcanzados.


ABSTRACT Introduction: The orthodontic treatment is a challenge in adult patients with periodontitis because of the biomechanical conditions imposed by age and the state of involvement of the periodontium, which is the main responsible for orthodontic movements. Objective: To describe the orthodontic treatment performed in an adult patient with controlled chronic periodontitis and to show the results obtained. Case Presentation: Forty-one years old female patient with chronic periodontitis. She presented diastemas and incisors extrusion, loss of periodontal insertion and exposure of the root cement, lower incisor crowding with extrusion and increase of the curve of Spee. She also had interincisive occlusal trauma. The treatment plan included the control of periodontitis, the removal of a lower incisor and the intrusion of bimaxillary incisor. The treatment lasted a year and a half. The results were excellent. The lost function was restored and periodontal insertion was increased with the consequent decrease in tooth mobility. The affected aesthetics was corrected obtaining patient satisfaction. Conclusions: From the application of the orthodontic treatment, it was possible to correct the dental position and occlusion anomalies and give the patient back the lost esthetics and a functional occlusion. Therapeutic decisions considered the state of the periodontium, the control of the disease and the age of the patient. The applied forces were extremely controlled and the treatment time was as short as possible. The motivation and care of oral hygiene contributed to the results achieved.

20.
J. health sci. (Londrina) ; 21(3): https://seer.pgsskroton.com/index.php/JHealthSci/article/view/6772, 24/09/2019.
Article in English | LILACS-Express | LILACS | ID: biblio-1051496

ABSTRACT

Antimicrobial Photodynamic Therapy (aPDT) is a promising approach with several clinical applications, including the treatment of periodontal diseases, by acting as an adjuvant to the conventional treatment of periodontal disease by allowing reduction of periodontopathogens, with no systemic side effects and minimal possibilities of bacterial resistance. Objective: To verify, through the scientific literature, the effectiveness of Antimicrobial Photodynamic Therapy associated with conventional periodontal treatment. Methodology: The literature review was conducted in the MEDLINE databases - PubMed, Scopus and Web of Science. The articles were selected through the analysis of titles and abstracts published in the period from 2007 to 2018. Selected articles were published in their entirety and with free or controlled access, of the type clinical trial on the subject, without restriction of languages. The terms used were: "Periodontal diseases"; "Chronic Periodontitis" and "Photochemotherapy." Results: 84 articles were found, and 20 clinical trials that met the inclusion criteria were analyzed. There were different clinical protocols for the association of aPDT with the conventional treatment of periodontal disease. a number of different clinical outcomes were found for each of the proposed clinical protocols. Conclusion: Considering the clinical trials investigated, conflicting results regarding the efficacy of aPTD as an adjuvant treatment of the conventional treatment of periodontal disease are observed. and lack of standardization of clinical parameters and protocols. (AU)


A terapia fotodinâmica antimicrobiana (aPDT) é uma abordagem promissora com várias aplicações clínicas, incluindo o tratamento das doenças periodontais, ao atuar como um adjuvante ao tratamento convencional da doença periodontal por permitir redução de periodontopatógenos, com ausência de efeitos sistêmicos colaterais e mínimas possibilidades de resistência bacteriana. O objetivo deste estudo é verificar, por meio da literatura científica, a eficácia da terapia fotodinâmica antimicrobiana associada ao tratamento periodontal convencional. A revisão de literatura foi conduzida nas bases de dados MEDLINE ­ PubMed, Scopus e Web of Science. Os artigos foram selecionados através da análise de títulos e de resumos publicados no período de 2007 a 2018. Foram selecionados artigos publicados na íntegra e com acesso livre e gratuito, ou controlado, do tipo ensaio clínico sobre o tema, sem restrição de idiomas. Os termos utilizados foram: Periodontal diseases; Chronic Periodontitis e Photochemotherapy. Foram encontrados 84 artigos, e 20 ensaios clínicos que atenderam os critérios de inclusão, foram analisados. Observou-se diferentes protocolos clínicos para a associação da aPDT com o tratamento convencional da doença periodontal. Também foram encontrados diferentes desfechos clínicos para cada um dos protocolos clínicos propostos. Conclusão: Considerando os ensaios clínicos pesquisados, observa-se resultados conflitantes frente à eficácia da aPDT como tratamento adjuvante do tratamento convencional da doença periodontal. Observa-se, ainda, uma produção literária escassa e a falta de uma padronização dos parâmetros e dos protocolos clínicos. (AU)

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