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Article in Chinese | WPRIM | ID: wpr-752342

ABSTRACT

Objective To investigate the clinical and imaging features of myelin oligodendrocyte glycoprotein antibody(MOG)encephalomyelitis in children. Methods The clinical,laboratory finding,imaging and follow-up data of 13 children with MOG encephalomyelitis(MOG-EM)diagnosed by Children's Hospital of Nanjing Medical Univer-sity from December 2016 to December 2018 were retrospectively analyzed. Results Among the 13 children,4 cases were male and 9 cases were female,the median age was 8 years old and 1 month. Symptoms of the first episode included fever,drowsiness in 2 cases,visual acuity in 5 cases,convulsions in 3 cases,urinary retention in 2 cases,and ataxia in 2 cases. Abnormalities were found in 12 cases by the head magnetic resonance imaging(MRI),most of which showed ex-tensive or isolated subcortical white matter lesions,and a few deep gray matter nuclei and brainstem were involved;3 ca-ses of spinal MRI abnormalities,mainly characterized by long segmental transverse myelitis;6 cases optic nerve MRI ab-normalities were found in 6 cases,manifested as disease side optic nerve or optic chiasm abnormal signals;the titer of serum MOG antibody was 1: 10-1: 320 in 13 cases. All children responded well to glucocorticoids and gamma globu-lin,and all symptoms were alleviated after treatment. Two patients had recurrence during the follow-up period,which was characterized by optic neuritis. After azathioprine addition,there was no recurrence after 1 to 2 years of follow-up. Conclusions Children with MOG antibody encephalomyelitis present a decline in visual acuity commonly. The images are mainly acute disseminated encephalomyelitis-like changes,immunosuppressive therapy is effective,generally with a better prognosis.

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