Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 491
Filter
1.
China Pharmacy ; (12): 507-512, 2022.
Article in Chinese | WPRIM | ID: wpr-920471

ABSTRACT

Trollius chinensis has a wide range of pharmacological effects ,including anti-oxidative ,antibacterial,antiviral, anti-inflammatory,anti-tumor,anti-aging,antipyretic and analgesic effects ,relieving cough and removing phlegm ,viscera protection,and so on. Flavonoids and phenolic acids are the main medicinal components of it ,especially three monomers have a wide range of efficacy and have been studied more ,such as orientin ,vitexin and 2″-O-galactopyranosyl orientin. T. chinensis is mostly used in clinical practice in the form of Chinese patent medicines ,such as Jinlianhua granules ,Jinlianhua capsules , Jinlianhua tablets and Jinlianhua oral liquid. These medicines are used to treatment of upper respiratory tract infection ,pharyngitis, tonsillitis,periodontitis,mumps,oral ulcer ,and hand-foot-mouth disease. They are usually used by combining with Western medicine. Due to its definite curative effect and less adverse drug reactions ,T. chinensis related preparations are more suitable for pediatric population ,and they can be used for the treatment of upper respiratory tract infection in children ,acute suppurative tonsillitis in children ,epidemic mumps in children ,hand-foot-mouth disease in children ,which is also one of its drug characteristics. This paper review the relevant literatures in recent 20 years from the respective of pharmacological effects and clinical applicationin order to provide reference for further promoting rational clinical application of T. chinensis and new drug research and development.

2.
China Pharmacy ; (12): 129-135, 2022.
Article in Chinese | WPRIM | ID: wpr-913100

ABSTRACT

Chinese patent medicine is an important part of pharmaceutical products in China. In order to speed up the establishment of an effective evaluation index system for the variety selection and clinical application of Chinese patent medicine in line with the characteristics of traditional Chinese medicine ,so as to scientifically select drugs and carry out the clinical application evaluation of Chinese patent medicine in a standardized and reasonable manner ,Jiangsu Society of Traditional Chinese Medicine and Traditional Chinese Medicine Special Committee of Nanjing Pharmaceutical Society have organized the formulation of this expert consensus. Consensus experts have used literature research method ,brainstorming method ,analytic hierarchy process , Delphi method ,etc. to build an evaluation index system for the selection and clinical application of Chinese patent medicine , including 24 secondary indicators and 102 tertiary indicators ,from the seven dimensions of safety ,effectiveness,economy, innovation,suitability,accessibility and clinical application (primary indicators ). It is expected to provide decision-making basis for the variety selection and evaluation of Chinese patent medicine by the pharmaceutical management and pharmacotherapeutics committee(group)of medical institutions ,promote medical institutions at all levels to continuously optimize the medication catalogue and medication structure ,and accelerate the formation of the “1 + X ”(“1”for the essential medicine ,“X”for non-essential medicine ) medication model dominated by essential drugs ,promote medical institutions to use Chinese patent medicines scientifically ,reasonably and safely ,so as to improve the quality of pharmaceutical care ,control the irrational drug use and cost ,and better meet the drug use needs of the people.

3.
China Pharmacy ; (12): 378-384, 2022.
Article in Chinese | WPRIM | ID: wpr-913099

ABSTRACT

The volatile oil of Magnolia liliflora ,as the main active part of the medicinal value ,has rich chemical constituents , mainly including cineole ,farnesol,α-pinene,β-pinene,terpineol,cadinene,linalool,citronellol,camphor. It has a wide range of pharmacological effects ,mainly anti-inflammatory and anti-allergic effects. Clinically ,it is mainly used to treat acute and chronic rhinitis,allergic rhinitis and sinusitis. This paper summarizes the research reports on the volatile oil of M. liliflora at home and abroad in the past 10 years,compares the chemical constituents of the volatile oil from M. liliflora under different conditions (origin,variety,part and extraction method ),combs its pharmacological effects and clinical application status ,and looks forward to its development prospect ,in order to provide reference for the further development of the medicinal value of the volatile oil from M. liliflora .

4.
Article in Chinese | WPRIM | ID: wpr-928067

ABSTRACT

Baimai is a complex of structure and function with the characteristics of wide distribution, complex structure, and multi-dimensional functions. Baimai, consisting of the channels in brain, the internal hidden channels connecting the viscera, and the external channels linking the limbs, governs the sensory, motor, and information transmission functions of human. According to Tibetan medicine, Baimai functions via "Long"(Qi) which moves in Baimai. "Long" is rough, light, cold, tiny, hard, and dynamic. The dysfunction of Baimai is manifested as numbness, swelling and pain, stiffness, atrophy, contracture, disability, hyperactivity, etc. The clinical manifestations of Baimai disease are facial paralysis, limb numbness, hemiplegia, contracture and rigidity, pain, opistho-tonos, paralysis, unconsciousness, head tremor, aphasia and tongue stiffness, and other abnormalities in facial consciousness, limb movement, and tactile sensation. Baimai Ointment for external use is used for the treatment of Baimai disease. It is mainly composed of medicinals which are spicy and bitter, warm, soft, mild, heavy, moist, and stable, and thus it is effective for the rough, light, cold, tiny, hard, and dynamic "Long" of Baimai disease. In clinical practice, it is mainly used for musculoskeletal diseases, such as osteoarthritis, scapulohumeral periarthritis, cervical spondylosis, low back pain, myofascitis, and tenosynovitis, nervous system diseases, such as paralysis and shoulder-hand syndrome, and limb stiffness caused by stroke, spastic cerebral palsy, trigeminal neuralgia, and facial neuritis, and limb motor and sensory dysfunction caused by trauma. According to the main symptoms of Baimai disease such as stiffness, rigidity, contraction, numbness, sensory disturbance and pain, clinicians should apply the Baimai Ointment via the inunction treatment of Tibetan medicine and in combination with Huo'ermai therapy and physiotherapy.


Subject(s)
Drugs, Chinese Herbal , Edema , Humans , Medicine, Tibetan Traditional , Pain
5.
Article in Chinese | WPRIM | ID: wpr-927407

ABSTRACT

In order to comprehensively stretch human fascia, adjust the biomechanical balance of fascia system and promote the recovery of physiological function of fascia, a new type of fascia stretching cup is designed. This design is composed of two or more silica gel cups and elastic stretching belts between cups. The bottom surface of the silica gel cup has an annular exhaust groove, which can increase the adsorption capacity of the cup to the skin. In the meanwhile, a removable magnet is placed in the groove at the top of each silica gel cup to assist analgesia. This design is suitable for the prevention and treatment of acute and chronic tendon and bone diseases with imbalance of meridians and tendons.


Subject(s)
Fascia , Humans , Silica Gel , Skin
6.
China Pharmacy ; (12): 1021-1024, 2022.
Article in Chinese | WPRIM | ID: wpr-923609

ABSTRACT

Chloral hydrate is a safe and effective sedative hypnotic medicine. Patients can usually calm down or fall asleep quickly after taking it. It has great clinical value and practical needs in children ’s sedation. However ,the nature of chloral hydrate itself and various factors such as ambient temperature and light affect its stability of the preparation ,most of chloral hydrate preparations are still used in clinic in the form of hospital preparations. Therefore ,developing chloral hydrate preparation with single dose ,long validity period and automatic mass production is the prospect and goal of its subsequent development. Based on it,this study collects and reviews the relevant literatures on various preparations of chloral hydrate and their clinical application by searching the Chinese and English databases.

7.
China Pharmacy ; (12): 897-910, 2022.
Article in Chinese | WPRIM | ID: wpr-923590

ABSTRACT

In order to further s tandardize the clinical application of proton pump inhibitors and provide reference for prescription suitability review ,under the guidance of Guiding Principles for Clinical Use of Proton Pump Inhibitor which was promulgated by the General Office of National Health Commission of the People ’s Republic of China ,Pharmaceutical Admini- stration Committee of Chongqing Hospital Association initiates “the formulation Project on Prescription Review Rules for Proton Pump Inhibitors ”. The First Affiliated Hospital of the Army Medical University takes the lead and cooperates with clinical experts , pharmaceutical experts and evidence-based experts from many domestic medical institutions to discuss the indications ,usage and dosage,medication for special groups and drug interactions of proton pump inhibitors ,and finally forms this consensus. The main contents of the consensus include the basic prescription review rules of omeprazole ,esmeprazole,pantoprazole,rabeprazole, lansoprazole and iprazole (including injection and oral preparations ,calculated by common name ),and 12 prescription review recommendations for some clinical applications not covered on the basic prescription review rules ,in order to provide reference for medical institutions at all levels.

8.
International Eye Science ; (12): 822-826, 2022.
Article in Chinese | WPRIM | ID: wpr-923420

ABSTRACT

@#In clinical practice, many macular diseases in advanced stages such as age-related macular degeneration(ARMD)and Stargardt disease are manifested reduced visual acuity, unstable and even paracentral fixation resulting from the central scotoma followed by the scarring of neovascular fibres or the impairment of photoreceptors and retinal pigment epithelium, which cause great distress to patients' life, work and psychology. For a long time, there have been limited rehabilitation treatments for such patients. However, recent articles have indicated that biofeedback training by using microperimetry is expected to enhance neurosensory adaptation by achieving cortical plasticity, and makes better use of residual retinal function to help those with low vision associated with central scotoma consolidate or establish stable central or paracentral fixation, thereby improving visual function including visual acuity and reading speed. In order to improve the understanding of this rehabilitation therapy, this article will overview the mechanism and protocol of microperimetric biofeedback training(MBFT), the selection of the preferred retinal locus, the clinical application in macular diseases and its prospects.

9.
China Pharmacy ; (12): 358-363, 2021.
Article in Chinese | WPRIM | ID: wpr-872690

ABSTRACT

OBJECTIVE:To understand the current status of clinical understanding of “prohibiting”“avoiding”“using caution ” in the application of TCM ,and to provide reference for standardizing the connotation and rational application of “prohibiting” “avoiding”“using caution ”of TCM. METHODS :Based on the theory of “knowledge-attitude-behavior”,doctor-pharmacist questionnaires and patient questionnaires were designed on the basis of literature research and clinical practice. Through the “Tencent questionnaire ”platform,800 doctor-pharmacist questionnaires were distributed to nearly 300 medical institutions from 32 provinces(cities,autonomous regions )and 800 patient questionnaires were distributed to public patiants who had used TCM nationwide by anonymous online method. After dimensionality reduction of the questionnaire from three dimensions of cognition , attention and behavior ,the cognition ,attention and behavior of “prohibiting”“avoiding”“using caution ”in the application of TCM were evaluated by 10 points system. RESULTS :A total of 703 doctor-pharmacist questionnaires were collected ,including 638 valid questionnaires with recovery rate of 87.9% and effective rate of 90.8%;Cronbach alpha coefficient was 0.90. A total of 644 patient questionnaires were collected ,including 621 valid questionnaires with recovery rate of 80.5% and effective rate of 96.4% . The cognition score of doctors and pharmacists to the terms of “prohibiting”“avoiding”“using caution ”in clinical application of TCM was (7.94±1.21),and that of patients was (5.64±1.54). The score of doctors and pharmacists ’attention to the above terms was (9.47±1.15)(Spearman Rho correlation coefficient with cognition score was 0.077,P>0.05),and the score of behavioral ability of patients was (7.01±1.71)(Spearman Rho correlation coefficient with cognition score was -0.021,P> 0.05). The score of behavior ability was (7.43 ± 1.72) (Spearman Rho correlation coefficient with cognition score was 0.233,P<0.01). TCM textbooks (89.2%),trainingmeetings (66.5%) and herbal prescriptions (58.2%) were the main ways for doctors and pharmacists to learn the above taboos. Medical staff (74.2%)and internet (52.5%)were the main ways for patients to understand the above taboos. CONCLUSIONS :Doctors,pharmacists and patients pay more attention to the terms of “prohibiting”“avoiding”“using caution ”in the clinical application of TCM ,but their cognition and executive power were low. Clinical cognition of “prohibiting”“avoiding”“using caution ”in the application of TCM is relatively vague,and the corresponding clinical practice behavior is lacking. It is yet to establish clinical specialist consensus in the field of TCM and publicize it actively to improve the level of clinical rational drug use.

10.
Article in English | WPRIM | ID: wpr-880754

ABSTRACT

The prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis (ARN). The potential application of artificial intelligence (AI) algorithms in these areas of clinical research has not been reported previously. The present study aims to create a computational algorithm for the automated detection and evaluation of retinal necrosis from retinal fundus photographs. A total of 149 wide-angle fundus photographs from 40 eyes of 32 ARN patients were collected, and the U-Net method was used to construct the AI algorithm. Thereby, a novel algorithm based on deep machine learning in detection and evaluation of retinal necrosis was constructed for the first time. This algorithm had an area under the receiver operating curve of 0.92, with 86% sensitivity and 88% specificity in the detection of retinal necrosis. For the purpose of retinal necrosis evaluation, necrotic areas calculated by the AI algorithm were significantly positively correlated with viral load in aqueous humor samples (

11.
Article in English | WPRIM | ID: wpr-880742

ABSTRACT

Exosomes are nanometer-sized vesicles that contain various types of biologically active components, including proteins, nucleic acids, carbohydrates, and lipids, which vary with the type and physiological state of the cell. In recent years, several studies have showed that exosomes can provide new non-invasive diagnostic and prognostic biomarkers in patients affected by cancers, including bladder cancer (BC), and the lipid bilayer membrane structure makes exosomes as promising delivery vehicles for therapeutic applications. Exosomes have the characteristics of high abundance, high stability, tissue specificity, and wide distribution in body fluids, and are secreted as various types by cells in different states, thereby possessing great potential as biomarkers for BC. Herein, we briefly summarize the functions and roles of exosomes in the occurrence and development of BC and the current progress of research on exosomes in BC, while focusing on potential clinical applications of the diagnosis, treatment, and prognosis of BC.

12.
Chinese Journal of Oncology ; (12): 167-175, 2021.
Article in Chinese | WPRIM | ID: wpr-877501

ABSTRACT

Breast cancer is the most common and fatal malignant tumor in women, which causes great social burden throughout the world. At present, chemotherapy is still the most important treatment manner of advanced breast cancer, and platinum drugs are one of the commonly used chemotherapeutic drugs. Based on the substantial evidence, the expert committee deeply discusses the clinical application of platinum drugs in advanced breast cancer, gives the reasonable suggestions for its clinical usage, effectiveness and adverse effects. This consensus aims to guide physicians to use drugs reasonably and standardize the diagnosis and treatment.


Subject(s)
Breast Neoplasms/drug therapy , Consensus , Female , Humans , Platinum
13.
Article in Chinese | WPRIM | ID: wpr-907687

ABSTRACT

The cause of immune recurrent abortion is closely related to immune abnormalities. At present, the Traditional Chinese Medicine (TCM) syndrome types of immune recurrent abortion mainly include kidney deficiency and blood stasis syndrome, spleen and kidney deficiency syndrome, blood heat syndrome, spleen deficiency syndrome and lung and kidney qi deficiency syndrome; The commonly used TCM compound for treating this disease usually could replenish kidney qi and take effect, so it is considered that the pathogenesis of this disease is mainly kidney deficiency. The mechanism of action of the TCM compound is mainly related to regulating hormone secretion, immune balance and improving local microcirculation.

14.
Article in Chinese | WPRIM | ID: wpr-907635

ABSTRACT

At present, there are five major specific acupuncture treatments mainly including Shugan-Tiaoshen acupuncture therapy, Lingping’s Tongdu-Tiaoshen acupuncture therapy, Zhuang’s Tiaoshen acupuncture therapy, Tong Yuan acupuncture therapy, and Dong ' s Tiaoshen-Jieyu acupuncture therapy. Although there are subtle differences, three commons arefoundthrough comparing and analyzing, including ' Shen’ regared as the core treatment of depression, regulating qi duringtreatment, and Du channel points mainly used.

15.
Article in Chinese | WPRIM | ID: wpr-907619

ABSTRACT

Fire needling therapy has a wide range of indications, mainly including nervous system diseases, such as stroke sequela, post herpetic neuralgia, primary headache and trigeminal neuralgia; dermatological diseases like herpes zoster; orthopedic diseases, such as cervical spondylosis, tennis elbow, arthritis, cervical vertigo, cervical headache; gynecological diseases, such as dysmenorrhea; surgical related diseases, such as varicose veins, benign prostatic hyperplasia. The fire needling therapy has showed definite clinical effect for anti-inflammatory, immune regulation, neuroprotection and repair, endocrine regulation and other functions. However, most of the clinical studies are not standardized in scientific research design, lack of large sample RCT studies, or there is no unified standard for needling specifications. The research of needling mechanism is not enough and needs more experiments.

16.
Article in Chinese | WPRIM | ID: wpr-906505

ABSTRACT

Stroke is a destructive cerebrovascular event caused by the interruption of cerebral blood flow caused by the blockage or rupture of cerebral vessels, which is easy to cause physical disability and multiple functional injuries. The mortality rate of stroke patients in China occupies the first place in the world. How to effectively treat stroke is one of the urgent health problems to be solved. In the clinic, academician WANG Yong-yan observed that 60% of stroke patients with heat-phlegm and sthenic-Fu syndrome. Most of the patients with heat-phlegm and sthenic-Fu syndrome are characterized by stagnation of stool, bad breath and dry pharynx, and so on, After clinical practice, Xinglou Chengqi decoction (XLCQD) was established to treat stroke patients with heat-phlegm and sthenic-Fu syndrome. XLCQD is one of the representative prescriptions for removing phlegm to relax bowels, which is composed of Rhei Radix et Rhizoma, Natrii Sulfas, Trichosanthis Fructus and Arisaema Cum Bile by the ratio of 5∶5∶15∶3. At present, the research on XLCQD is mainly focused on clinical observation and pharmacological mechanism, while the basic research of its pharmacodynamic substance is relatively weak. This paper intends to sort out the chemical composition and pharmacological mechanism of XLCQD, in order to provide the basis for the chemical component identification, drug target prediction and material basis screening of this compound in the later stage. In addition, through the case analysis of XLCQD and modified XLCQD in the treatment of stroke, its rules of clinical application were summarized, in order to provide reference for the clinical application of this compound.

17.
Article in Chinese | WPRIM | ID: wpr-906475

ABSTRACT

Qingxin Lianzi Yin (QXLZY), as an ancient classical formula for clearing the heart and nourishing the Yin, was composed of nine herbs (Scutellariae Radix, Ophiopogonis Radix, Lycii Cortex, Plantaginis Semen, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, Nelumbinis Semen, Poria, Astragali Radix and Ginseng Radix et Rhizoma), coming from Prescriptions of the Bureau of Taiping People's Welfare Pharmacy. It could clear away the heart-fire, promote the interaction of the heart and kidney, replenish Qi and Yin, and stop strangury-turbidity. It was used to treat gonorrhea of urination, seminal emission, restlessness, wasting-thirst and so on. At present, the usage and dosage of QXLZY and its addition and subtraction are different in clinical practice. Most of the studies just focus on its clinical efficacy, and there is few review literature reflecting its historical evolution. Based on this, this paper systematically clarified the historical evolution, composition, preparation, interpretation, function, and modern clinical application of QXLZY. This work has been explained the historical evolution of QXLZY, and found that it was wildly used in modern clinical, especially suitable for the treatment of chronic urinary system diseases. At the same time, QXLZY also had significant therapeutic effects on neurasthenia, stomatitis, diabetic nephropathy and other aspects. Through the comprehensive analysis of ancient and modern literature, this work explores the true connotation of QXLZY from the perspective of traditional Chinese medicine theory, which can point out the direction of the clinical application and positioning of this famous classical formula after it comes into the market, and also can provide reference basis for its subsequent in-depth research and development.

18.
Article in Chinese | WPRIM | ID: wpr-906228

ABSTRACT

Danggui Liuhuang Tang, as one of classical traditional Chinese medicine prescriptions, has been used by major medical experts in clinic since Jin and Yuan dynasties. After review and summarization of relevant literatures on the pharmacological effects and clinical application of Danggui Liuhuang Tang, it was found that Danggui Liuhuang Tang has a wide range of pharmacological activities, and exerts its anti-inflammatory and anti-insulin resistance effects mainly by inhibiting the production of inflammatory factors, such as tumor necrosis factor and interleukin and activating related pathways. In addition, Danggui Liuhuang Tang inhibits the occurrence and development of hepatic fibrosis by attenuating proinflammatory signaling and extracellular matrix accumulation with multiple components, multiple targets, and multiple pathways. Danggui Liuhuang Tang has been widely used in sweat syndromes, with an obvious effect in the treatment of thyroid diseases, diabetes, respiratory tract and other diseases. This paper reviews and summarizes the pharmacological effects and clinical application of Danggui Liuhuang Tang,in an attempt to provide some valuable clues for the subsequent development of Danggui Liuhuang Tang.

19.
Article in Chinese | WPRIM | ID: wpr-906188

ABSTRACT

Objective:To analyze the research status of the external use of medicinal materials and decoction pieces in the 2020 edition of <italic>Chinese Pharmacopoeia</italic> (volume 1), so as to provide reference for the clinical external use research of Chinese medicines. Method:The external function, usage, dosage and other information of medicinal materials and decoction pieces in the 2020 edition of <italic>Chinese Pharmacopoeia</italic> (volume 1) were analyzed and compared. Result:In the 2020 edition of <italic>Chinese Pharmacopoeia</italic> (volume 1), there were 165 kinds of Chinese medicines that could be used externally, including 25 kinds of Chinese medicines that clearly recorded their functions for external use, such as Euphorbiae Semen, Euphorbiae Semen Pulveratum, Arisaematis Rhizoma, Arisaematis Rhizoma Preparatum, Crotonis Fructus, Crotonis Semen Pulveratum, Nardostachyos Radix et Rhizoma, Artemisiae Argyi Folium, Alumen, Stemonae Radix, Genkwa Flos, Cera Flava, Mel, Psoraleae Fructus, Gardeniae Fructus, Calomelas, Bruceae Fructus, Drynariae Rhizoma, Euphorbiae Ebracteolatae Radix, Cuscutae Semen, Phytolaccae Radix, Meretricis Concha, Talcum, Talci Pulvis and Propolis. The amount of Chinese medicine for external use recorded in the 2020 edition of <italic>Chinese Pharmacopoeia</italic> was mostly appropriate for external use, the amount for external use was not clear. The application method for external use focused on beating powder and applying the affected areas, decocting for fumigation and washing, simmering to paste, etc. Clinical external use was used for the treatment of eczema, tinea pedis, chapped skin and other skin diseases. Conclusion:The number of Chinese medicines recorded in the 2020 edition of <italic>Chinese Pharmacopoeia</italic> for external use is increasing, but the function, dosage and usage of these Chinese medicines for external use still need to be improved.

20.
Article in Chinese | WPRIM | ID: wpr-906161

ABSTRACT

Zexietang is derived from Jingui Yaolue (《金匮要略》), which is composed of Alismatis Rhizoma and Atractylodis Macrocephalae Rhizoma, and has the effect of inducing diuresis and invigorating the spleen to produce water. Compared with western medicine in the treatment of related diseases, Zexietang can not only improve the curative effect, but also reduce the occurrence of adverse reactions, so as to achieve long-term stable administration. The authors sorted out and analyzed the chemical composition, pharmacological effect and clinical application of Zexietang in recent years. It was found that the main active components of Zexietang were alismol A and B, 23-acetyl-alismol B and C, atractylenolides (atractylenolide Ⅰ, Ⅱ, Ⅲ) and polysaccharides. Pharmacological experiments showed that they had diuretic, hypolipidemic, anti-inflammatory and others. And it can be used in the treatment of hypertension, hyperlipidemia, vertigo, cerebral vascular insufficiency and other diseases combined with other Chinese materia medica, and the curative effect is obvious. By summarizing the research status of Zexietang in recent years, its active components and pharmacological mechanism can be further clarified, which provides the basis for the clinical application of Zexietang and guides the direction of its further research.

SELECTION OF CITATIONS
SEARCH DETAIL