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1.
Arq. ciências saúde UNIPAR ; 26(2): 107-112, maio-ago. 2022.
Article in Portuguese | LILACS | ID: biblio-1372953

ABSTRACT

O objetivo deste estudo é apresentar uma revisão atualizada sobre o papel dos polimorfismos genéticos na etiologia da endometriose. Trata-se de uma pesquisa bibliográfica feita no PubMed utilizando os descritores "polymorphism and endometriosis". Foram identificados 36 artigos e após aplicação dos critérios de inclusão foram selecionados 17 artigos para a amostra final. Os principais resultados foram: 1) cerca de 60% dos artigos foram publicados em 2019; 2) em 35,3% dos estudos o número de casos e controles investigados foi menor que 100; 3) a maioria dos trabalhos investigou de um a dois polimorfismos por gene; 4) a produção científica sobre endometriose é maior em países orientais; 5) houve heterogeneidade quanto aos periódicos onde os trabalhos foram publicados; 6) as principais técnicas para detecção de polimorfismos foi a PCR-RFLP e o PCR em tempo real, com frequências semelhantes. Em suma, os polimorfismos genéticos podem estar implicados na etiologia da endometriose.


The aim of this study is to present an updated review on the role of genetic polymorphisms in the etiology of endometriosis. This is a literature review made on PubMed using the descriptors "polymorphism and endometriosis". A total 36 articles were identified and, after applying the inclusion criteria, 17 articles were selected for the final sample. The main results were: 1) approximately 60% of the articles were published in 2019; 2) 35.3% of the studies investigated less than 100 cases and controls; 3) most studies investigated one to two polymorphisms per gene; 4) scientific production on endometriosis is higher in Eastern countries; 5) heterogeneity was observed regarding the journals where works were published; 6) the main techniques for detecting polymorphisms were PCR-RFLP and real-time PCR, with similar frequencies. In summary, it can be concluded that genetic polymorphisms may be implicated in the etiology of endometriosis.


Subject(s)
Humans , Female , Polymorphism, Genetic , Endometriosis/diagnosis , Biomarkers , Polymerase Chain Reaction , Infertility, Female/diagnosis
2.
FEMINA ; 50(3): 178-183, 20220331. graf
Article in Portuguese | LILACS | ID: biblio-1367572

ABSTRACT

Objetivo: Analisar o perfil epidemiológico e clínico e a assistência médica fornecida às pacientes acompanhadas no ambulatório específico para endometriose em um hospital universitário público brasileiro. Métodos: Trata-se de um estudo transversal retrospectivo. Foram incluídos os prontuários médicos de 153 pacientes com endometriose acompanhadas em nosso ambulatório desde sua criação, em fevereiro de 2017, até abril de 2020. Os dados coletados foram utilizados para estabelecer os sintomas mais prevalentes, os métodos diagnósticos utilizados, os locais acometidos com maior frequência, o tratamento clínico estabelecido e as características epidemiológicas da população estudada. Resultados: A idade média das pacientes foi de 35,2 ± 7,23 anos. Os sintomas mais prevalentes foram dismenorreia (88,2%), dispareunia (65,4%) e infertilidade (52,9%). O ovário foi o local mais acometido (60,1%). A coexistência de doenças autoimunes foi identificada em 7,2% das pacientes. Cerca de 47,7% das pacientes foram diagnosticadas com ressonância magnética pélvica e 45% foram tratadas com dienogeste. Conclusão: O reconhecimento da epidemiologia da endometriose, os sintomas mais frequentes e as comorbidades associadas à doença podem permitir aos profissionais de saúde melhorar sua capacidade diagnóstica e realizar uma assistência clínica individualizada e eficiente.(AU)


Objective: To analyze the epidemiological and clinical profile and the medical assistance provided to patients followed up in the specific outpatient clinic of endometriosis in a Brazilian public university hospital. Methods: It was a cross-sectional retrospective study. Medical records of 153 patients with endometriosis followed up in our specific outpatient clinic, since its creation, in February 2017, until April 2020 were included. Data collected was used to establish the most prevalent symptoms, diagnostic methods used, most frequent sites of involvement, clinical treatment and epidemiological characteristics of the study population. Results: The mean age of patients was 35.2 ± 7.23 years old. The most prevalent symptoms were dysmenorrhea (88.2%), dyspareunia (65.4%) and infertility (52.9%). Ovary was the most affected site (60.1%). The coexistence of autoimmune disease was identified in 7.2% patients. About 47.7% were diagnosed by pelvic magnetic resonance imaging (MRI) and 45% were treated with dienogest. Conclusion: The recognition of endometriosis epidemiology, the most frequent symptoms and the comorbidities associated with the disease may enable health care professionals to improve the diagnostic capacity and to perform an individualized and efficient clinical assistance.(AU)


Subject(s)
Humans , Female , Endometriosis/drug therapy , Endometriosis/epidemiology , Health Profile , Brazil/epidemiology , Medical Records , Cross-Sectional Studies , Endometriosis/diagnosis , Endometriosis/diagnostic imaging
3.
Medicina (B.Aires) ; 82(1): 147-150, feb. 2022. graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1365140

ABSTRACT

Resumen El síndrome de endometriosis torácica (TES) es un trastorno poco común caracterizado por la presencia de tejido endometrial ectópico en la cavidad torácica. La manifestación clínica típica es un neumotórax espontáneo, que generalmente se presenta con dolor torácico, disnea y/o tos. El diagnóstico requiere un alto nivel de sospecha clínica junto con una historia ginecológica completa. Los estudios de imáge nes pueden ayudar con el diagnóstico, pero el gold standard es la cirugía toracoscópica videoasistida (VATS). Se ha demostrado que el tratamiento quirúrgico en combinación con al menos 6 meses de tratamiento médico hormonal mejora el pronóstico y reduce la recurrencia de esta entidad. Presentamos el caso de una paciente de 40 años con antecedentes de endometriosis pélvica y múltiples episodios de neumotórax, que consultó en nuestra institución por un nuevo episodio de neumotórax espontáneo. Se realizó una VATS donde se identificaron nódulos en la pleura parietal y orificios diafragmáticos. En el postoperatorio continuó con tratamiento hormonal. A los 6 meses de seguimiento refirió mejoría del dolor y no presentó nuevos episodios de neumotórax.


Abstract. Thoracic endometriosis syndrome (TES) is a rare disorder characterized by the presence of ectopic endometrial tissue in the chest cavity. The typical clinical manifestation is a spontaneous pneumothorax, which usually presents with chest pain, dyspnea, and/or cough. The diagnosis requires a high level of clinical suspicion and a complete gynecological history. Imaging studies can help with the diagnosis, although the gold standard is video-assisted thoracoscopic surgery (VATS). Surgical treatment in combination with at least 6 months of hormonal medical treatment has been shown to improve the prognosis and reduce the recurrence of this entity. We present the case of a 40-year-old patient with a history of pelvic endometriosis and multiple episodes of pneumothorax, who consulted at our institution for a new episode of spon taneous pneumothorax. A VATS was performed where nodules in the parietal pleura and diaphragmatic orifices were identified. In the postoperative period, she continued with hormonal treatment. At 6 months of follow-up, she reported improvement in pain and did not present new episodes of pneumothorax.

4.
Article in Chinese | WPRIM | ID: wpr-927395

ABSTRACT

OBJECTIVE@#To observe the clinical therapeutic effect of CO2 laser moxibustion on endometriosis related pelvic pain of cold coagulation and blood stasis.@*METHODS@#A total of 76 patients with endometriosis related pelvic pain of cold coagulation and blood stasis were randomized into a laser moxibustion group and a sham laser moxibustion group, 38 cases in each group. In the laser moxibustion group, moxibustion was applied at bilateral Zigong (EX-CA 1) using CO2 laser moxibustion instrument. In the sham laser moxibustion group, the manipulation of moxibustion was same as the laser moxibustion group, without laser output. The treatment was given once every other day, 30 min each time, 3 times a week for 4 weeks in both groups. Before and after treatment and follow-up of 3 months after treatment, the scores of Gracely box scale (GBS) and visual analogue scale (VAS) were observed, the usage of non-steroidal anti-inflammatory drug for the duration of the treatment and the average days of taking drugs were recorded in both groups.@*RESULTS@#Compared before treatment, the GBS and VAS scores were decreased after treatment and during follow-up in the laser moxibustion group (P<0.05), while those in the sham moxibustion group had no significant differences (P>0.05). Compared with the sham moxibustion group, the GBS and VAS scores were decreased after treatment and during follow-up (P<0.05), the cases and average days of taking drugs were less in the laser moxibustion group (P<0.05).@*CONCLUSION@#CO2 laser moxibustion can improve the pain symptom in patients with endometriosis related pelvic pain of cold coagulation and blood stasis, and reduce the use of analgesic drugs.


Subject(s)
Acupuncture Points , Carbon Dioxide , Endometriosis/complications , Female , Humans , Moxibustion , Pelvic Pain/therapy , Treatment Outcome
5.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1354998

ABSTRACT

Objetivo: determinar o número de mulheres diagnosticadas com endometriose em consultórios médicos particulares do munícipio de Cruz Alta ­ RS. Método: transversal, prospectivo e descritivo, com cinco médicos ginecologistas que responderam à um questionário sobre as formas de diagnóstico e tratamento da endometriose. Resultados: os resultados demonstraram que a média de mulheres com endometriose foi de quatro pacientes por médico (total de 20 pacientes). A forma de diagnóstico mais utilizada foi a videolaparoscopia, relatada por 80% dos médicos, e as principais formas de tratamento foram por meio dos Análogos do Gonadotrofina (GnRH), como a Gosserrelina e os progestogénos como o Dienogest®. Conclusão: verifica-se que houve um número elevado de mulheres diagnosticadas com endometriose em consultórios particulares no município de Cruz Alta


Objective: to determine the number of patients diagnosed with endometrioses in private medical consultancies in the municipality of Cruz Alta ­ RS. Method: cross-sectional, prospective and descriptive, with five gynecologist doctors who will answer a question about the forms of diagnosis and treatment of endometriose. Results: the results showed that by means of women with endometrium, there were four patients per doctor (total of 20 patients). The most commonly used form of diagnosis was videolaparoscopy, reported by 80% of doctors, and the main forms of treatment were by two Gonadotrophin Analogs (GnRH), such as Gosserrelin and progestogens such as Dienogest®. Conclusion: it was verified that there was a high number of patients diagnosed with endometrioses in private clinics in municipal Cruz Alta


Objetivo: determinar el número de mulheres diagnosticadas con endometriose en consultas médicas particulares del municipio de Cruz Alta ­ RS. Método: transversal, prospectivo y descriptivo, con cinco médicos ginecologistas que responden a un cuestionario sobre formas de diagnóstico y tratamiento de la endometriosis. Resultados: los resultados demostraron que un medio de mulheres com endometriosis de cuarto pacientes por médico (total de 20 pacientes). Una forma de diagnóstico más precisa para una videolaparoscopia, relatada por 80% de dos médicos, y como formas principales de tratamiento de forma por medio de Análogos do Gonadotrofina (GnRH), como Gosserrelina y os progestogénos como o Dienogest®. Conclusión: verifique que tiene un número elevado de multas diagnosticadas con endometrio en consultas particulares no municipales de Cruz Alta


Subject(s)
Humans , Female , Adult , Gonadotropin-Releasing Hormone , Combined Modality Therapy , Endometriosis , Progestins
6.
Rev. cienc. salud ; 20(1): 1-7, ene.-abr. 2022. ilus
Article in Spanish | LILACS, COLNAL | ID: biblio-1367571

ABSTRACT

Introducción: la endometriosis es una de las patologías ginecológicas más frecuentes, que se entiende como la implantación intrapélvica de tejido endometrial, sensible, en la gran mayoría de casos, al influjo hormonal. Extrauterinamente, se caracteriza por la presencia de glándulas y estroma endometrial en órganos o tejidos no ginecológicos. Sin embargo, la piel corresponde a uno de los sitios con menor fre-cuencia de implantación, ya sea de forma primaria o secundaria. Se calcula la incidencia de endometrio-sis cutánea en la zona umbilical en menos del 1 % de los casos. Presentación del caso: mujer de 36 años de edad, quien consulta con Cirugía General por un cuadro clínico de dos años de evolución, consistente en lesiones sobrelevantadas de la piel en la región umbilical, de color café oscuro, las cuales describe como dolorosas y sangrantes en el momento del ciclo menstrual. A pesar de haber sido resecadas en dos ocasiones, se encontró persistencia del cuadro. Discusión: la endometriosis cutánea primaria umbilical representa del 0.5 al 1.0 % de todas las pacientes con endometriosis ectópica, y el ombligo es uno de los sitios menos comunes de implantación. Esta condición afecta alrededor del 5 al 15 % de mujeres en edad fértil, y del 3 al 5 % de mujeres en edad menopaúsica. La presentación clínica más común se basa en una masa palpable, sangrado umbilical y dolor regular o irregular abdominal. Al asociar la endometriosis extrapélvica con la presencia de endometriosis pélvica, solamente alrededor del 20 % de las pacientes presentará esta última


Introduction: Endometriosis is one of the most frequent gynecological pathologies, understood as an intrapelvic implantation of endometrial tissue, sensitive to hormonal influence in most cases. At the extrauterine level, it is characterized by the presence of endometrial glands and stroma in the non-gy-necological organs or tissues. However, the skin corresponds to one of the sites with the least frequency of implantation, either primary or secondary, with the incidence of cutaneous endometriosis being calculated at the umbilical level in <1% of the cases. Case presentation: A 36-year-old female patient presented to the General Surgery department with a two-year history of dark brown, raised skin lesions in the umbilical region, which she described as painful, and bleeding at the time of the menstrual cycle. Despite having been resected twice, the condition still persisted. Discussion: Umbilical primary cutane-ous endometriosis represents 0.5%­1.0% of all patients with ectopic endometriosis, with the navel being one of the least common implantation sites. This condition affects about 5%−15% of women of childbear-ing age, and 3%−5% women of menopausal age. The most common clinical presentation is based on the palpable mass, umbilical bleeding, regular or irregular abdominal pain. Associating extrapelvic endo-metriosis with the presence of pelvic endometriosis, only about 20% of the patients will have the latter


Introdução: a endometriose é uma das patologias ginecológicas mais frequentes, entendida como o implante intrapélvico de tecido endometrial, sensível na grande maioria dos casos à influência hor-monal. No nível extrauterino, é caracterizada pela presença de glândulas e estroma endometriais em órgãos ou tecidos não ginecológicos. Porém, a pele corresponde a um dos locais com menor frequência de implantação, seja ela primária ou secundária, calculando-se a incidência de endometriose cutânea ao nível umbilical em menos de 1% dos casos. Apresentação do caso: paciente do sexo feminino, com 36 anos de idade, que consulta para Cirurgia Geral devido a quadro clínico de 2 anos de evolução, cons-tituído por lesões cutâneas elevadas na região umbilical, de coloração marrom-escura, que descreve como dolorosas e com sangramento no momento do ciclo menstrual. Apesar de ter sido ressecado em 2 ocasiões, o quadro era persistente. Discussão: a endometriose cutânea primária umbilical representa 0.5%-1.0% de todas as pacientes com endometriose ectópica, sendo o umbigo um dos locais de implan-tação menos comuns. Essa condição afeta cerca de 5% a 15% das mulheres em idade reprodutiva e 3% a 5% das mulheres em menopausa. A apresentação clínica mais comum baseia-se em massa palpável, sangramento umbilical, dor abdominal regular ou irregular. Ao associar a endometriose extrapélvica à presença de endometriose pélvica, apenas cerca de 20% das pacientes a apresentarão


Subject(s)
Humans , Female , Adult , Endometriosis , Skin , General Surgery , Umbilicus , Incidence
7.
Cad. Saúde Pública (Online) ; 38(2): e00226320, 2022. graf
Article in English | LILACS | ID: biblio-1360278

ABSTRACT

Abstract: The topics of endometriosis and pain imply far-reaching problems for women's health. Using a qualitative research approach, this paper addresses the subjective experience and effects of pain, the methods for dealing with these issues, and the needs of affected women in Austria. Data were collected by problem-focused interviews conducted with ten women suffering from endometriosis, which were later transcribed and subjected to qualitative content analysis. Findings are therefore described using content-related categories. Results show that negative thoughts and feelings like fear, despair, and anger are associated with endometriosis and pain. Moreover, predominantly negative impacts and changes are found in various areas of life, such as the well-being and psyche of those affected, their attitude towards life in general, partnerships, social life, leisure time and work-life balance. In dealing with endometriosis and pain, both Western biomedicine and complementary medicine treatments are used. Support from one's inner circle of friends and exchange and interaction with others affected by the disease are seen to be invaluable. Attending physicians as well as patients themselves and their private, social, and working environment should encourage open communication about endometriosis and the related pain.


Resumo: O tema da endometriose e dor tem implicações relevantes para a saúde das mulheres. O artigo procura contextualizar a experiência subjetiva e os efeitos da dor, os métodos para lidar com essas questões e as necessidades das mulheres afetadas por essa condição na Áustria. Foi escolhida uma abordagem qualitativa para examinar esses temas. Foram realizadas entrevistas focadas em problemas com dez mulheres com história de endometriose. Após a transcrição do material, foi realizada a análise qualitativa do conteúdo. Assim, os achados são retratados com o uso de categorias relacionadas ao conteúdo. Os resultados mostram que pensamentos e sentimentos negativos como medo, desesperança e raiva estão associados com a endometriose e dor. Além disso, são encontrados impactos e mudanças predominantemente negativos em vários domínios da vida, tais como o bem-estar e o estado psicológicos das mulheres afetadas, a atitude geral em relação à vida, parcerias, vida social, tempo de lazer e equilíbrio entre trabalho e vida pessoal. Tanto a medicina ocidental quanto os tratamentos da medicina complementar são utilizados no manejo da endometriose e da dor. O apoio do círculo próximo de amigas e as trocas e interação com outras pessoas afetadas pela doença são vistos como extremamente úteis. Os médicos atendentes e as próprias pacientes e seus ambientes privados, sociais e laborais devem incentivar a comunicação aberta sobre a endometriose e a dor associada.


Resumen: La endometriosis y su dolor asociado implican problemas profundos para la salud de las mujeres. El objetivo de este trabajo es identificar la experiencia subjetiva y los efectos del dolor, los métodos para tratarlos, así como las necesidades de las mujeres afectadas en Austria. Para el examen de los temas mencionados anteriormente, se eligió un enfoque de investigación cualitativo. Las entrevistas enfocadas en los problemas se realizaron con diez mujeres que sufrían endometriosis. Tras la transcripción material de los datos, el análisis se realizó usando un análisis cualitativo de contenido. Por lo tanto, los resultados se describen usando categorías relacionadas con el contenido. Los resultados muestran que los pensamientos negativos y los sentimientos como miedo, desesperación, y enfado están conectados con la endometriosis y el dolor. Además, predominantemente se encontraron impactos negativos y cambios en varias áreas de la vida, tales como: bienestar, psique de quienes se veían afectadas, su actitud ante la vida en general, relaciones, vida social, equilibrio entre tiempo de ocio y trabajo. Para enfrentarse a la endometriosis y el dolor, se utilizan tratamientos biomédicos occidentales, así como medicina complementaria. El apoyo del círculo íntimo de los afectados, como son los amigos, así como el intercambio e interacción con otras personas afectadas por la enfermedad parecen ser muy útiles. Ir al médico, el entorno privado, social y laboral de las pacientes, así como ellas mismas, deben estar y ser animadas para una comunicación abierta sobre la endometriosis y el dolor relacionado con la misma.


Subject(s)
Endometriosis/complications , Endometriosis/therapy , Pain/etiology , Quality of Life , Austria , Brazil , Qualitative Research
8.
Braz. j. med. biol. res ; 55: e11948, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1374707

ABSTRACT

Endometriosis (EMS) is one of the most prevalent causes for female infertility. Herein, we investigated the effect of the repaglinide (RG), L-carnitine (LC), and bone marrow mesenchymal stem cell-conditioned medium (BMSC-CM) supplementation during in vitro maturation (IVM) on the quality, maturation, and fertilization rates, as well as embryonic quality and development of oocytes derived from normal and EMS mouse model. Immature oocytes were collected from two groups of normal and EMS-induced female NMRI mice at 6-8 weeks of age. Oocytes were cultured in IVM medium unsupplemented (control group), or supplemented with 1 M RG, 0.3 and 0.6 mg/mL LC, and 25 and 50% BMSC-CM. After 24 h of oocyte incubation, IVM rate and antioxidant status were assessed. Subsequently, the rates of fertilization, cleavage, blastulation, and embryonic development were assessed. Our results demonstrated that supplementation of IVM medium with LC and BMSC-CM, especially 50% BMSC-CM, significantly enhanced IVM and fertilization rates, and markedly improved blastocyst development and total blastocyst cell numbers in EMS-induced mice compared to the control group (53.28±0.24 vs 18.09±0.10%). Additionally, LC and BMSC-CM were able to significantly modulate EMS-induced nitro-oxidative stress by boosting total antioxidant capacity (TAC) and mitigating nitric oxide (NO) levels. Collectively, LC and BMSC-CM supplementation improved oocyte quality and IVM rates, pre-implantation developmental competence of oocytes after in vitro fertilization, and enhanced total blastocyst cell numbers probably by attenuating nitro-oxidative stress and accelerating nuclear maturation of oocytes. These outcomes may provide novel approaches to refining the IVM conditions that can advance the efficiency of assisted reproductive technologies in infertile couples.

9.
Rev. ANACEM (Impresa) ; 15(2): 166-171, 20211225.
Article in Spanish, English | LILACS-Express | LILACS | ID: biblio-1352816

ABSTRACT

Introducción: Los tumores benignos de ovario corresponden a un 60-95% de las lesiones anexiales, en edad fértil los más frecuentes corresponden a quistes foliculares y endometriomas. Sin embargo, alrededor del 15% son patología maligna de ovario. Por lo que se debe evaluar aspectos como edad, características ecográficas y la presencia de marcadores tumorales específicos como CA 125. Objetivo general: Describir un reporte de caso y caracterizar la evidencia disponible sobre el abordaje de tumores benignos de ovario. Caso Clínico: Se presenta el caso clínico de una paciente en edad fértil de 43 años, cursando con dolor abdominal asociado a masa anexial, donde destaca la elevación del marcador CA 125 en rango de malignidad, por lo que se solicita valoración por oncología y manejo quirúrgico, confirmándose una masa anexial benigna de características quísticas, sugerente de endometrioma, al descartar patología maligna se realiza quistectomía total. Discusión: La patología anexial es una entidad clínica que puede abarcar características tumorales, ya sean benignas como malignas, por ello frente a lesiones ováricas, siempre se deben descartar estas últimas. Las características ecográficas de la paciente hacían sospechar de un endometrioma, el CA 125 elevado en ella hizo que se optara por un manejo quirúrgico oncológico con biopsia rápida para descartar o confirmar malignidad. Conclusión: Ante la presencia de endometriomas, el tratamiento debe discutirse caso a caso, teniendo en cuenta la sintomatología, deseos de fertilidad futura y tamaño de las lesiones.


Introduction: Benign ovarian tumors correspond to 60-95% of adnexal lesions, in childbearing years the most frequent correspond to follicular cysts and endometriomas. However, about 15% are malignant ovarian pathology. Therefore, aspects such as age, ultrasound characteristics and the presence of specific tumor markers such as CA 125 must be evaluated. General objective: Describe a case report and characterize the available evidence on benign ovarian tumors. Case report: A case of a 43 year old female of childbearing age, presents abdominal pain associated with an adnexal mass, where CA 125 elevations are found in the range of malignancy, for which an oncology evaluation and surgical management. A benign adnexal mass with cystic characteristics is confirmed, suggestive of endometrioma, when malignant pathology is ruled out, a total cystectomy is performed. Discussion: Adnexal pathology is a clinical entity that can include tumor characteristicas, whether benign or malignant, therefore, in the face of ovarian lesions, these should always be ruled out. The sonographic characteristics of the patient made one suspect an endometrioma, the elevated CA 125 in it led to an oncological surgical management with rapid biopsy to rule out or confirm malignancy. Conclusions: In the presence of endometriomas, treatment should be discussed individually, taking into account the symptoms, wishes for future fertility, and size of the lesions. Keywords: Ca-125 antigen, Endometriosis, Ovarian neoplasms

10.
Rev. bras. ginecol. obstet ; 43(12): 919-925, Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1357095

ABSTRACT

Abstract Objective Endometriosis is a hormone-dependent chronic inflammatory disease with symptoms such as pelvic pain, which affect the physical, emotional, and social health of women in reproductive age. The current overview article aims to explore the effect of complementary medicine on the treatment or in mitigating the risk of endometriosis. Methods This is an overview article done in Iran. Two separate researchers systematically searched 3 databases (Medline, Scopus, and Cochrane Central Register Trials) until September 2020. The methodological quality of each study was assessed using the assessment of multiple systematic reviews (AMSTAR) tool. Results The results of two reviews suggested that physical activity, tobacco smoking, diet, coffee and caffeine intake had no effect on mitigating the risk of endometriosis or improving its treatment, but acupuncture successfully reduced pain and related marker (serum CA-125) levels. Conclusion As endometriosis is an annoying disease with many complications and is hard to diagnose and treat, related studies in complementary medicine can help patients with endometriosis. Based on the relevant literature review, among the complementary medicine available for the treatment or to mitigate the risk of endometriosis, only acupuncture seems to alleviate the pain of endometriosis.


Resumo Objetivo A endometriose é uma doença inflamatória crônica hormono-dependente com sintomas como dores pélvicas, que afetam a saúde física, emocional e social de mulheres em idade reprodutiva. O presente artigo de visão geral tem como objetivo explorar o efeito da medicina complementar no tratamento ou na mitigação do risco de endometriose. Métodos Trata-se de um artigo de visão geral feito no Irã. Dois pesquisadores separados pesquisaram sistematicamente 3 bancos de dados (Medline, Scopus e Cochrane Central Register Trials) até setembro de 2020. A qualidade metodológica de cada estudo foi avaliada usando a ferramenta avaliação da qualidade dos relatos de revisão sistemática (AMSTAR, na sigla em inglês). Resultados Os resultados de duas revisões sugeriram que atividade física, tabagismo, dieta, consumo de café e cafeína não tiveram efeito na redução do risco de endometriose ou na melhoria do tratamento, mas a acupuntura reduziu com sucesso a dor e os níveis de marcadores relacionados (CA-125 sérico). Conclusão Como a endometriose é uma doença incômoda, com muitas complicações e de difícil diagnóstico e tratamento, estudos relacionados em medicina complementar podem ajudar pacientes com endometriose. Com base na revisão da literatura relevante, entre os medicamentos complementares disponíveis para o tratamento ou risco de endometriose, apenas a acupuntura parece aliviar a dor da endometriose.


Subject(s)
Humans , Female , Complementary Therapies , Endometriosis/prevention & control , Exercise , Pelvic Pain/etiology , Pelvic Pain/prevention & control , Iran
11.
Rev. bras. ginecol. obstet ; 43(9): 676-681, Sept. 2021. tab
Article in English | LILACS | ID: biblio-1351775

ABSTRACT

Abstract Objective To assess the most common psychological disturbances in women with deep endometriosis and bowel involvement who are waiting surgical treatment and to evaluate what forms of coping are used to solve the problem. Methods This was a cross-sectional observational study of 40 women diagnosed with deep endometriosis and intestinal symptoms. They completed two questionnaires: one for anxiety and depression (Hospital Anxiety and Depression Scale [ HADS]) and the Scale of Mode of Confronting Problems (EMEP, in the Portuguese acronym). Results We found that 77.1% of the patients had anxiety and depression, with anxiety being the most prevalent (87.5% of the patients); 90% of the patients used problem focused and religious introspection as their main modes of confronting problems. Conclusion In the use of the HADS questionary, two psychological aspects were the most present in women with deep endometriosis awaiting surgical treatment: anxiety and depression. The most used forms of coping to solve the problem were problem coping and religious practices.


Resumo Objetivo Avaliar os distúrbios psicológicos mais comuns em mulheres com endometriose profunda e acometimento intestinal que aguardam tratamento cirúrgico e avaliar as formas de enfrentamento que são usadas para resolver o problema. Métodos Estudo observacional transversal com 40 mulheres com diagnóstico de endometriose profunda e acometimento intestinal. As pacientes responderam dois questionários: para ansiedade e depressão (Hospital Anxiety and Depression Scale [HADS, na sigla em inglês) e outro para enfrentamento dos problemas (EMEP). Resultados Constatamos que 77% das pacientess apresentaram ansiedade e depressão, sendo a ansiedade a mais prevalente (87,5%); 90% das pacientes usaram a forma religiosa e focada no problema como sua principal estratégia de enfrentamento. Conclusão Os aspectos psicológicos mais encontrados em mulheres com endometriose profunda e intestinal que aguardam tratamento cirúrgico são ansiedade e depressão. As formas mais usadas de enfrentamento para resolver o problema foram práticas religiosas e focada no problema.


Subject(s)
Humans , Female , Endometriosis/surgery , Endometriosis/complications , Anxiety/etiology , Anxiety/epidemiology , Stress, Psychological , Adaptation, Psychological , Cross-Sectional Studies , Surveys and Questionnaires , Depression/etiology , Depression/epidemiology
12.
Rev. cuba. med. mil ; 50(3): e1295, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1357311

ABSTRACT

Introducción: La factibilidad y seguridad del empleo de la ozonoterapia se evidencia en los resultados expuestos por varios autores, en enfermedades cuyo síntoma fundamental es el dolor crónico. Objetivo: Determinar la evolución clínica de las pacientes con dolor pélvico crónico, tratadas con ozono asociado al tratamiento médico convencional. Métodos: Estudio descriptivo, observacional, retrospectivo, en el que se determinó la evolución clínica de las pacientes con dolor pélvico crónico tratadas con ozono, asociada al tratamiento médico convencional. La muestra fue de 54 mujeres. Las variables utilizadas fueron: edad, causa del dolor pélvico, tiempo de evolución, puntuación de la escala de dolor antes y después de la aplicación de la ozonoterapia y evaluación del tratamiento. Resultados: Prevalecieron las pacientes con edad de 26-35 años. El 57,4 por ciento tenían entre 2 y 2 años de evolución del dolor. La enfermedad inflamatoria pélvica crónica fue la causa de mayor frecuencia con 42,5 por ciento. Antes de la aplicación de la ozonoterapia la media de puntuación en la escala de dolor fue de 6,31, y disminuyó a 3 después del tratamiento, con una evaluación de bien en el 81,1 por ciento de los casos. Conclusiones: Después de la aplicación de la ozonoterapia asociada al tratamiento médico convencional, se produce mejoría clínica, por lo que puede ser una alternativa de tratamiento(AU)


Introduction: The feasibility and safety of the use of ozone therapy is evidenced in the results presented by several authors, in diseases whose main symptom is chronic pain. Objective: To determine the clinical evolution of patients with chronic pelvic pain treated with ozone associated with conventional medical treatment. Methods: Descriptive, observational, retrospective study, in which the clinical evolution of patients with chronic pelvic pain treated from January 2018 to January 2020, with ozone therapy, associated with conventional medical treatment. The sample was 54 women. The variables used were: age, cause of pelvic pain, time of evolution, score on the pain scale before and after the application of ozone therapy, and evaluation of the treatment. Results: Patients aged 26-35 years prevailed. 57,4 percent had between two and four years of pain evolution. Chronic pelvic inflammatory disease was the most frequent cause with 42,5 percent. Before the application of ozone therapy, the mean score on the pain scale was 6.31, and it decreased to 3 after treatment, with an evaluation of good in 81,1percent of the cases. Conclusions: After the application of ozone therapy associated with conventional medical treatment, there is evident clinical improvement, which is why it constitutes an alternative of treatment(AU)


Subject(s)
Humans , Female , Ozone/therapeutic use , Pelvic Pain/therapy , Epidemiology, Descriptive , Cross-Sectional Studies
13.
Rev. argent. cir ; 113(3): 371-374, set. 2021. graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1356944

ABSTRACT

RESUMEN La endometriosis cutánea es infrecuente, pero representa la localización más común fuera de la pelvis. Las formas primarias pueden ubicarse en la cicatriz umbilical, región perianal o inguinal. Presentamos el caso de una paciente con diagnóstico de nódulo de Villar que fue tratada exitosamente con la resec ción de este. La fisiopatología de la entidad no está aún bien definida. La sospecha del cuadro es funda mental para el diagnóstico. Los métodos complementarios de imágenes pueden evaluar diagnósticos diferenciales. El tratamiento es quirúrgico. En la mayoría de los casos el pronóstico es favorable, con bajos porcentajes de recidiva.


ABSTRACT Cutaneous endometriosis is a rare condition but represents the most common extrapelvic location. Primary cutaneous endometriosis may develop in the umbilicus, perianal region or inguinal region. We report the case of a female patient with a diagnosis of Villar's nodule that was successfully treated with surgery. The pathophysiology of this entity is not well defined yet. The clinical suspicion is fundamental for the diagnosis. Complementary imaging test are used to rule out the differential diagnoses. Surgery is indicated in all the cases. The prognosis is favorable in most cases, with low rate of recurrence.

14.
Arch. méd. Camaguey ; 25(4): e7803, 2021. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1339121

ABSTRACT

RESUMEN Fundamento: el dolor pélvico crónico es un problema ginecológico frecuente en las mujeres de edad fértil. Se define como el dolor no cíclico que persiste durante seis meses o más, localizado en la pelvis, en la porción infra umbilical de la pared abdominal anterior, en la región lumbosacra o en la región glútea lo que provoca discapacidad funcional. Las mujeres en edad fértil, son sin lugar a duda el grupo etario fundamental para la salud global y de las futuras generaciones. Muchas mujeres acuden a consulta de Ginecología por presentar dolor pelviano crónico y al realizarles la historia clínica, se observan problemas de fertilidad. Objetivo: caracterizar el comportamiento del dolor pélvico crónico de causa ginecológica en pacientes en edad fértil. Métodos: se realizó un estudio observacional, descriptivo, transversal. La población de estudio estuvo constituida por 123 mujeres con diagnóstico de dolor pélvico crónico de causa ginecológica y en edad fértil, que fueron atendidas en consulta de Ginecología en el Hospital Docente Clínico Quirúrgico Comandante Manuel Fajardo Rivero de Villa Clara durante el período comprendido entre el 1ro de septiembre de 2017 al 30 de septiembre de 2019. Resultados: las mujeres en el estudio eran adultas. La principal causa del dolor fue la endometriosis. La mayoría eran multíparas y presentaron infertilidad. Conclusiones: la mayoría de las pacientes con dolor pélvico crónico en edad fértil eran adultas. La principal causa del dolor pélvico crónico fue la endometriosis, seguido de las adherencias. La mayoría de las mujeres eran multíparas y presentaron infertilidad.


ABSTRACT Background: chronic pelvic pain is a frequent gynecological problem in women of childbearing age. It is defined as non-cyclical pain that persists for six months or more, located in the pelvis, in the infra-umbilical portion of the anterior abdominal wall, in the lumbosacral region or in the gluteal region, causing functional disability. Women of childbearing age are without a doubt the fundamental age group for global health and for future generations. Many women come to the gynecology clinic for having chronic pelvic pain and when the medical history is done, a high incidence of fertility problems is observed. Objective: to characterize the behavior of chronic pelvic pain of gynecological cause in patients of childbearing age. Methods: an observational, descriptive, cross-sectional study was carried out. The study population consisted of 123 patients with a diagnosis of chronic pelvic pain of gynecological cause and of childbearing age, which weretreated in a gynecology consultation at the Comandante Manuel Fajardo Rivero Teaching Clinical Hospital of Villa Clara during the period from September 1st, 2017 to September 30th, 2019. Results: the women in the study were adults. The main cause of pain was endometriosis. Most of the women were multiparous and had infertility. Conclusions: most of the patients with chronic pelvic pain in childbearing age were adults. The main cause of chronic pelvic pain was endometriosis, followed by adhesions. Most of the women were multiparous and had infertility.

15.
Rev. bras. ginecol. obstet ; 43(6): 457-466, June 2021. tab, graf
Article in English | LILACS | ID: biblio-1341145

ABSTRACT

Abstract Objective Abnormalities in the eutopic endometrium of women with endometriosis may be related to disease-associated infertility. Although previous RNA-sequencing analysis did not show differential expression in endometrial transcripts of endometriosis patients, other molecular alterations could impact protein synthesis and endometrial receptivity. Our aim was to screen for functional mutations in the transcripts of eutopic endometria of infertile women with endometriosis and controls during the implantation window. Methods Data from RNA-Sequencing of endometrial biopsies collected during the implantation window from 17 patients (6 infertile women with endometriosis, 6 infertile controls, 5 fertile controls) were analyzed for variant discovery and identification of functional mutations. A targeted study of the alterations found was performed to understand the data into disease's context. Results None of the variants identified was common to other samples within the same group, and no mutation was repeated among patients with endometriosis, infertile and fertile controls. In the endometriosis group, nine predicted deleterious mutations were identified, but only one was previously associated to a clinical condition with no endometrial impact. When crossing the mutated genes with the descriptors endometriosis and/or endometrium, the gene CMKLR1 was associated either with inflammatory response in endometriosis or with endometrial processes for pregnancy establishment. Conclusion Despite no pattern of mutation having been found, we ponder the small sample size and the analysis on RNA-sequencing data. Considering the purpose of the study of screening and the importance of the CMKLR1 gene on endometrial


Resumo Objetivo Anormalidades no endométrio eutópico de mulheres com endometriose podem estar relacionadas à infertilidade associada à doença. Embora a análise prévia de sequenciamento de RNA não tenha evidenciado expressão diferencial em transcritos endometriais de pacientes com endometriose, outras alterações moleculares poderiam afetar a síntese de proteínas e a receptividade endometrial. Nosso objetivo foi rastrear mutações funcionais em transcritos de endométrios eutópicos de mulheres inférteis com endometriose e de controles durante a janela de implantação. Métodos Os dados do sequenciamento de RNA de biópsias endometriais coletados durante a janela de implantação de 17 pacientes (6 mulheres inférteis com endometriose, 6 controles inférteis, 5 controles férteis) foram analisados para a descoberta de variantes e a identificação de mutações funcionais. Um estudo direcionado das alterações encontradas foi realizado para compreender os dados no contexto da doença. Resultados Nenhuma das variantes identificadas foi comuma outras amostras dentro do mesmo grupo, assim como nenhuma mutação se repetiu entre pacientes com endometriose, controles inférteis e férteis. No grupo de endometriose, foram identificadas nove mutações deletérias preditas, mas apenas uma foi previamente associada a uma condição clínica sem impacto endometrial. Ao cruzar os genes mutados com os descritores endometriose e/ou endométrio, o gene CMKLR1 foi associado a resposta inflamatória na endometriose e a processos endometriais para estabelecimento da gravidez. Conclusão Apesar de nenhum padrão de mutação ter sido encontrado, ponderamos o pequeno tamanho da amostra e a análise dos dados de sequenciamento de RNA. Considerando o objetivo do estudo de triagem e a importância do gene CMKLR1 na modulação endometrial, este poderia ser um gene candidato para estudos adicionais que avaliem mutações no endométrio eutópico de pacientes com endometriose.


Subject(s)
Humans , Female , Pregnancy , Embryo Implantation , Sequence Analysis, RNA , Endometriosis/complications , Endometriosis/genetics , Endometrium/metabolism , Infertility, Female/etiology , Mutation , Computer Simulation , Case-Control Studies , Prospective Studies , Receptors, Chemokine/genetics , Infertility, Female/metabolism
16.
Rev. colomb. gastroenterol ; 36(2): 275-279, abr.-jun. 2021. graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1289309

ABSTRACT

Resumen Se presenta el caso de una mujer joven con hallazgo endoscópico incidental en una colonoscopia de seguimiento, que consistía en una lesión en el ciego con histología benigna. Se describe el proceso diagnóstico y el tratamiento quirúrgico. Se revisa la literatura existente y se discuten la incidencia, el cuadro clínico y las indicaciones de tratamiento quirúrgico de una patología rara de baja aparición.


Abstract This is the case of a young patient with an incidental endoscopic finding of a lesion in the cecum during follow-up colonoscopy with benign histology. The diagnostic process and surgical treatment are described. The existing literature was reviewed and the incidence, symptoms and indications of surgical treatment of this rare condition are discussed.

17.
Rev. bras. ginecol. obstet ; 43(2): 119-125, Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1156088

ABSTRACT

Abstract Objective To investigate whether follicular fluid (FF) from infertile women with mild endometriosis (ME) alters in vitro bovine embryo development, and whether the antioxidants N-acetyl-cysteine (NAC) and/or L-carnitine (LC) could prevent such damages. Methods Follicular fluid was obtained from infertile women (11 with ME and 11 control). Bovine oocytes were matured in vitro divided in: No-FF, with 1% of FF from control women (CFF) or ME women (MEFF); with 1.5mM NAC (CFF + NAC, MEFF + NAC), with 0.6mg/mL LC (CFF + LC, MEFF + LC), or both antioxidants (CFF + NAC + LC, MEFF + NAC + LC). After in vitro fertilization, in vitro embryo culture was performed for 9 days. Results A total of 883 presumptive zygotes were cultured in vitro. No differences were observed in cleavage rate (p = 0.5376) and blastocyst formation rate (p = 0.4249). However, the MEFF group (12.5%) had lower hatching rate than the No-FF (42.1%, p = 0.029) and CFF (42.9%, p = 0.036) groups. Addition of antioxidants in the group with CFF did not alter hatching rate (p ≥ 0.56), and in groups with MEFF, just NAC increased the hatching rate [(MEFF: 12.5% versus MEFF + NAC: 44.4% (p = 0.02); vs MEFF + LC: 18.8% (p = 0.79); versus MEFF + NAC + LC: 30.8% (p = 0.22)]. Conclusion Therefore, FF from infertile women with ME added to medium of in vitro maturation of bovine oocytes impairs hatching rate, and NAC prevented these damages, suggesting involvement of oxidative stress in worst of oocyte and embryo quality of women with ME.


Resumo Objetivo Investigar se o fluido folicular (FF) de mulheres inférteis com endometriose leve (ME, na sigla eminglês) altera o desenvolvimento in vitro de embriões bovinos, e se os antioxidantes N-acetil-cisteína (NAC) e/ou L-carnitina (LC) poderiam prevenir possíveis danos. Métodos O FF foi obtido de mulheres inférteis (11 com ME e 11 controles). Oócitos bovinos foram maturados in vitro divididos em: sem FF (No-FF), com 1% de FF de mulheres controle (CFF) ou mulheres comME (MEFF); com 1,5mMde NAC (CFF + NAC, MEFF + NAC), com 0,6mg/mL de LC (CFF + LC, MEFF + LC), ou ambos antioxidantes (CFF + NAC + LC, MEFF + NAC + LC). Depois da fertilização in vitro, o cultivo in vitro de embriões foi realizado por 9 dias. Resultados Um total de 883 zigotos presumidos foram cultivados in vitro. Nenhuma diferença foi observada na taxa de clivagem (p = 0,5376) e na taxa de formação de blastocistos (p = 0,4249). Entretanto, o grupo MEFF (12.5%) teve menor taxa de eclosão de blastocistos do que os grupos No-FF (42,1%, p = 0,029) e CFF (42,9%, p = 0,036). Adição de antioxidantes no grupo comCFF não alterou a taxa de eclosão (p ≥ 0.56), e nos grupos com MEFF, somente a NAC aumentou a taxa de eclosão [(MEFF: 12.5% versus MEFF + NAC: 44.4% (p = 0.02); versus MEFF + LC: 18.8% (p = 0.79); versus MEFF + NAC + LC: 30.8% (p = 0.22)]. Conclusão Portanto, o FF de mulheres inférteis com ME adicionado ao meio de maturação in vitro de oócitos bovinos prejudica a taxa de closão embrionária, e a NAC preveniu esses danos, sugerindo o envolvimento do estresse oxidativo na piora da qualidade oocitária e embrionária de mulheres com ME.


Subject(s)
Animals , Female , Cattle , Endometriosis , Infertility, Female , Oocytes , Follicular Fluid/metabolism , Embryonic Development , Disease Models, Animal
18.
Rev. bras. ginecol. obstet ; 43(1): 28-34, Jan. 2021. tab, graf
Article in English | LILACS | ID: biblio-1156078

ABSTRACT

Abstract Objective To determine embryo quality (mean graduated embryo score [GES]) in infertile patients with endometriosis undergoing in vitro fertilization with embryo transfer (IVF-ET) compared with infertile patients without endometriosis. Methods A case-control study was performed comparing 706 embryos (162 patients) divided into 2 groups: 472 embryos derived from patients without endometriosis (n= 109, infertile patients with tubal infertility) and 234 embryos from patients in the study group (n= 53, infertile patients with peritoneal endometriosis). All patients were subjected to IVF using an oestradiol-antagonist-recombinant follicle-stimulating hormone (FSH) protocol for ovarian stimulation. Themean GESwas performed to evaluate all embryos at 3 points in time: 16 to 18 hours, 25 to 27 hours, and 64 to 67 hours. Embryo evaluation was performed according to the following parameters: fragmentation, nucleolar alignment, polar body apposition, blastomere number/morphology, and symmetry. The primary outcomemeasure was the mean GES score.We also compared fertilization, implantation, and pregnancy rates. Results Although the number of embryos transferred was greater in patients with endometriosis than in the control group (2.38 ± 0.66 versus 2.15 ± 0.54; p= 0.001), the meanGESwas similar inbothgroups (71 ± 19.8 versus 71.9 ± 23.5; p= 0.881). Likewise, the fertilization ratewas similar in all groups, being 61% in patients with endometriosis and 59% in the control group (p= 0.511). No significant differences were observed in the implantation (21% versus 22%; [p= 0.989]) and pregnancy rates (26.4% versus 28.4%; p= 0.989). Conclusion Embryo quality measured by the mean GES was not influenced by peritoneal endometriosis. Likewise, the evaluated reproductive outcomes were similar between infertile patients with and without endometriosis.


Resumo Objetivo Determinar a qualidade do embrião (média de escore embrionário graduado [EEG]) em pacientes inférteis com endometriose submetidas à fertilização in vitro com transferência de embrião (FIV-TE) em comparação com pacientes inférteis sem endometriose. Métodos Realizamos um estudo de caso-controle comparando 706 embriões (162 pacientes) divididos em dois grupos: 472 embriões derivados de pacientes sem endometriose (n = 109, pacientes inférteis com infertilidade tubária) e 234 embriões de pacientes do grupo de estudo (n= 53, inférteis pacientes com endometriose peritoneal). Todos os pacientes foram submetidos à fertilização in vitro usando um protocolo follicle-stimulating hormone (FSH) recombinante de estradiol-antagonista para estimulação ovariana. A média do EEGfoi realizada para avaliar todos osembriõesemtrêsmomentos: de 16 a 18 horas, 25 a 27 horas e 64 a 67 horas.A avaliaçãoembrionária foi realizada de acordo comos seguintes parâmetros: fragmentação, alinhamento nucleolar, aposição do corpo polar, número de blastômeros/morfologia e simetria. A medida de desfecho primário foi o escore médios embrionário (EEG). Também avaliamos como desfechos secundários as taxas de fertilização, implantação e gravidez. Resultados Embora o número de embriões transferidos tenha sido maior em pacientes com endometriose do que no grupo controle (2,38 ± 0,66 versus 2,15 ± 0,54; p = 0,001), o EEGmédio foi semelhante nos dois grupos (71 ± 19,8 versus 71,9 ± 23,5; p = 0,881). Da mesma forma, a taxa de fertilização foi semelhante em todos os grupos, sendo 61% nos pacientes com endometriose e 59% no grupo controle (p = 0,511). Não foram observadas diferenças significativas nas taxas de implantação (21% versus 22%; [p = 0,989]) e nas taxas de gravidez (26,4% versus 28,4%; p = 0,989). Conclusão A qualidade embrionária medida pelo EEGmédio não foi influenciada pela endometriose peritoneal. Da mesma forma, os resultados reprodutivos avaliados foram semelhantes entre pacientes inférteis com e sem endometriose.


Subject(s)
Humans , Female , Pregnancy , Adult , Embryo, Mammalian , Embryo Transfer , Endometriosis , Infertility, Female , Ovulation Induction , Pregnancy Outcome , Fertilization in Vitro , Case-Control Studies , Prospective Studies
19.
Article in Chinese | WPRIM | ID: wpr-888047

ABSTRACT

Endometriosis(EMs) is a stubborn gynecological disease caused by persistent immune-inflammatory effects, and is known as "benign tumor" because of its similar characteristics to malignant tumors. National physician master Professor BAN Xiu-wen believes that the spread of damp-evil is the pathologic foundation for inflammatory response of ectopic endometrium; accumulation of blood stasis is the pathological product of continuous inflammatory attacks, and the combination of dampness and stasis is the main pathogenesis for refractory EMs. Modern researches have shown that immune-inflammatory effect is the key mechanism for development of EMs, and is closely related to cell autophagy, all of which have made it become the hot spots in research of the pathogenesis, diagnosis and treatment of EMs. Therefore, with immune-inflammatory effect as the breakthrough point in this research, and with reference to the related research of autophagy, the correlation between "combination of dampness and stasis" and abnormal autophagy-induced immune inflammatory response in ectopic endometrium was discussed, to provide guidance for the clinical application of traditional Chinese medicine and modern research.


Subject(s)
Autophagy , Endometriosis , Endometrium , Female , Humans , Medicine, Chinese Traditional
20.
Article in Chinese | WPRIM | ID: wpr-910187

ABSTRACT

Objective:To investigate the feasibility, effectiveness and safety of indocyanine green (ICG) navigation in the surgical resection of abdominal wall endometriosis (AWE).Methods:Seven women undergoing surgery for AWE in First Affiliated Hospital of Sun Yat-sen University (from July 1, 2021 to October 1, 2021) were collected. After exposure of the focus, ICG were used intravenously (0.25 mg/kg) as fluorescent dye for the intraoperative evaluation of AWE vascularization. Resection of the AWE was guided by direct visualization of the focus under standard laparoscopy with a near-infrared (NIR) camera head. Surgical margin around the AWE (3, 6, 9 and 12 point) and the margin under the focus were obtained for postoperative pathological examination of endometriosis. Time from injection to fluorescence visualization, the proportion of fluorescence visualization, time of fully resection of AWE, side effects related to the use of ICG, perioperative complications as well as the pathological result of the surgical margins were recorded.Results:ICG fluorescence of the AWE were seen in 5 patients (5/7). The mean time from injection to fluorescence visualization was (46.7±9.8) s. The mean time of fully resection of AWE was (16.4±7.0) minutes. There were no side effects related to the use of ICG. The rate of class-A wound healing was 7/7. All of the surgical margins were confirmed endometriosis-negative by postoperative pathological examination.Conclusion:ICG fluorescence visualization could conduct accurate resection of AWE, which is clinically safe and effective.

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